1 Lectura, exploración de los datos y obtención de los muestras de train y test:

1.1 Recopilación de los datos:

Los datos empleados pertenecen al “Hepatitis C Virus (HCV) for Egyptian patients” de la UCI Machine Learning Repository en el enlace https://archive-beta.ics.uci.edu/dataset/503/hepatitis+c+virus+hcv+for+egyptian+patients. En nuestro caso los datos se encuentran en el archivo HCV-Egy-Data.csv.

Este conjunto de datos corresponde al análisis de varias características útiles para determinar los grados de fibrosis hepática (FH). Desde el enlace al repositorio de la UCI podemos observar una descripción de los atributos:

Contenido y descripción del conjunto de datos HCV-Egy-Data
Variables Descripción
Age Edad del paciente
Gender Sexo del paciente
BMI Índice de masa corporal
Fever Fiebre
Nausea/Vomiting Nausea o vómito
Headache Dolor de cabeza
Diarrhea Diarrea
Fatigue/Bone ache Fatiga generalizada/Dolor de huesos
Jaundice Ictericia
Epigastria pain Dolor epigastrico
WBC Leucocitos
RBC Globulos rojos
HGB Hemoglobina
Plat Plaquetas
AST.1 Aspartato aminotrasferasa de 1 semana
ALT.1 Alanina transaminasa de 1 semana
ALT.4 Alanina transaminasa de 4 semanas
ALT.12 Alanina transaminasa de 12 semanas
ALT.24 Alanina transaminasa de 24 semanas
ALT.36 Alanina transaminasa de 36 semanas
ALT.48 Alanina transaminasa de 48 semanas
ALT.after.24.w Alanina transaminasa después de 48 semanas
RNA.Base RNA Base
RNA.4 RNA 4 semanas
RNA.12 RNA 12 semanas
RNA.EOT RNA al finalizar el tratamiento
RNA.EF RNA Factor de elongación
Baseline.histological.Grading Clasificación histológica de referencia
Baselinehistological.staging Estadificación histológica

Tras tener una idea general que cuales son los datos del fichero HCV-Egy-Data.csv procedemos a cargar, explorar y preparar los datos:

# Cargamos los datos
HCV <- read.csv(file.path(params$folder.data,params$myfile), header=TRUE)

1.2 Explorar y preparar los datos:

Exploramos los datos y los preparamos para realizar los análisis posteriores. Primero nombramos correctamente las columnas/variables del conjunto de datos.

# Nombramos correctamente las columnas del conjunto de datos
variables <- c("Age","Gender","BMI","Fever","Nausea.Vomiting","Headache","Diarrhea","Fatigue.Boneache","Jaundice","Epigastria.pain","WBC","RBC","HGB","Plat","AST.1","ALT.1","ALT.4","ALT.12","ALT.24","ALT.36","ALT.48","ALT.after.24.w","RNA.Base","RNA.4", "RNA.12", "RNA.EOT","RNA.EF","BH.grading", "BH.staging")
colnames(HCV) <-  variables

El conjunto de datos HCV está formado por 29 variables con 1385 registros y no contiene valores NA, por tanto no tenemos valores faltantes. Mostramos los primeros 6 registros del conjunto HCV para familiarizarnos con los datos:

Primeros 6 registros del conjunto de datos HCV.
Age Gender BMI Fever Nausea.Vomiting Headache Diarrhea Fatigue.Boneache Jaundice Epigastria.pain WBC RBC HGB Plat AST.1 ALT.1 ALT.4 ALT.12 ALT.24 ALT.36 ALT.48 ALT.after.24.w RNA.Base RNA.4 RNA.12 RNA.EOT RNA.EF BH.grading BH.staging
56 1 35 2 1 1 1 2 2 2 7425 4248807 14 112132 99 84 52 109 81 5 5 5 655330 634536 288194 5 5 13 2
46 1 29 1 2 2 1 2 2 1 12101 4429425 10 129367 91 123 95 75 113 57 123 44 40620 538635 637056 336804 31085 4 2
57 1 33 2 2 2 2 1 1 1 4178 4621191 12 151522 113 49 95 107 116 5 5 5 571148 661346 5 735945 558829 4 4
49 2 33 1 2 1 2 1 2 1 6490 4794631 10 146457 43 64 109 80 88 48 77 33 1041941 449939 585688 744463 582301 10 3
59 1 32 1 1 2 1 2 2 2 3661 4606375 11 187684 99 104 67 48 120 94 90 30 660410 738756 3731527 338946 242861 11 1
58 2 22 2 2 2 1 2 2 1 11785 3882456 15 131228 66 104 121 96 65 73 114 29 1157452 1086852 5 5 5 4 4

1.2.1 Tipos de variables

Comprobamos la estructura de las variables y observamos que tenemos variables categóricas y numéricas, las variables Gender, Fever, Nausea.Vomiting, Headache, Diarrhea, Fatigue.Bone ache, Jaundice, Epigastria.pain, BH.grading, BH.staging son numéricas pero deben ser categóricas, por tanto deben ser transformadas a factor ya que es el objeto de R adecuado.

# Estructura del conjunto de datos:
str(HCV)
'data.frame':   1385 obs. of  29 variables:
 $ Age             : int  56 46 57 49 59 58 42 48 44 45 ...
 $ Gender          : int  1 1 1 2 1 2 2 2 1 1 ...
 $ BMI             : int  35 29 33 33 32 22 26 30 23 30 ...
 $ Fever           : int  2 1 2 1 1 2 1 1 1 2 ...
 $ Nausea.Vomiting : int  1 2 2 2 1 2 1 1 1 1 ...
 $ Headache        : int  1 2 2 1 2 2 2 2 2 2 ...
 $ Diarrhea        : int  1 1 2 2 1 1 2 2 2 2 ...
 $ Fatigue.Boneache: int  2 2 1 1 2 2 2 1 2 1 ...
 $ Jaundice        : int  2 2 1 2 2 2 2 1 1 1 ...
 $ Epigastria.pain : int  2 1 1 1 2 1 2 2 2 2 ...
 $ WBC             : int  7425 12101 4178 6490 3661 11785 11620 7335 10480 6681 ...
 $ RBC             : num  4248807 4429425 4621191 4794631 4606375 ...
 $ HGB             : int  14 10 12 10 11 15 12 11 12 12 ...
 $ Plat            : num  112132 129367 151522 146457 187684 ...
 $ AST.1           : int  99 91 113 43 99 66 78 119 93 55 ...
 $ ALT.1           : int  84 123 49 64 104 104 57 112 83 68 ...
 $ ALT.4           : num  52 95 95 109 67 121 113 80 55 72 ...
 $ ALT.12          : int  109 75 107 80 48 96 118 127 102 127 ...
 $ ALT.24          : int  81 113 116 88 120 65 107 45 97 81 ...
 $ ALT.36          : int  5 57 5 48 94 73 84 96 122 125 ...
 $ ALT.48          : int  5 123 5 77 90 114 80 53 39 43 ...
 $ ALT.after.24.w  : int  5 44 5 33 30 29 28 39 45 30 ...
 $ RNA.Base        : int  655330 40620 571148 1041941 660410 1157452 325694 641129 591441 1151206 ...
 $ RNA.4           : int  634536 538635 661346 449939 738756 1086852 1034008 72050 757361 230488 ...
 $ RNA.12          : int  288194 637056 5 585688 3731527 5 275095 787295 5 267320 ...
 $ RNA.EOT         : int  5 336804 735945 744463 338946 5 214566 370605 371090 275295 ...
 $ RNA.EF          : int  5 31085 558829 582301 242861 5 635157 506296 203042 555516 ...
 $ BH.grading      : int  13 4 4 10 11 4 12 12 5 4 ...
 $ BH.staging      : int  2 2 4 3 1 4 4 3 2 2 ...

La variable Gender (Género) debería ser categórica con dos niveles, Male (Masculino), Female (Femenino), por lo que tenemos que codificarla correctamente.

# Variable class es un factor con dos niveles:
HCV$Gender <- factor(HCV$Gender, levels = c(1,2), labels = c("Male","Female"))

Transformamos las variables Fever, Nausea.Vomiting, Headache, Diarrhea, Fatigue.Boneache, Jaundice, Epigastria.pain, las cuales son categóricas con dos niveles, Absent (Ausente), Present (Presente).

# Variable class es un factor con dos niveles:
HCV$Fever <- factor(HCV$Fever, levels = c(1,2), labels = c("Absent","Present"))
HCV$Nausea.Vomiting <- factor(HCV$Nausea.Vomiting, levels = c(1,2), labels = c("Absent","Present"))
HCV$Headache <- factor(HCV$Headache, levels = c(1,2), labels = c("Absent","Present"))
HCV$Diarrhea <- factor(HCV$Diarrhea, levels = c(1,2), labels = c("Absent","Present"))
HCV$Fatigue.Boneache <- factor(HCV$Fatigue.Boneache, levels = c(1,2), labels = c("Absent","Present"))
HCV$Jaundice <- factor(HCV$Jaundice, levels = c(1,2), labels = c("Absent","Present"))
HCV$Epigastria.pain <- factor(HCV$Epigastria.pain, levels = c(1,2), labels = c("Absent","Present"))

La variable BH.staging refleja los estados de fibrosis del paciente por tanto deben ser cambiadas a factor ya que de esta forma nos servirá para la mayoría de algoritmos a emplear. Tiene cinco niveles: Sin Fibrosis (F0), Fibrosis portal sin septos (F1), Fibrosis portal con algunos septos (F2), Numerosos septos sin cirrosis (F3) y cirrosis (F4).

# Variable class es un factor con dos niveles:
HCV$BH.staging <- factor(HCV$BH.staging, levels = c(1,2,3,4), labels = c("F1","F2","F3","F4"))

Comprobamos que los cambios se han efectuado correctamente:

# Estructura del conjunto de datos:
str(HCV)
'data.frame':   1385 obs. of  29 variables:
 $ Age             : int  56 46 57 49 59 58 42 48 44 45 ...
 $ Gender          : Factor w/ 2 levels "Male","Female": 1 1 1 2 1 2 2 2 1 1 ...
 $ BMI             : int  35 29 33 33 32 22 26 30 23 30 ...
 $ Fever           : Factor w/ 2 levels "Absent","Present": 2 1 2 1 1 2 1 1 1 2 ...
 $ Nausea.Vomiting : Factor w/ 2 levels "Absent","Present": 1 2 2 2 1 2 1 1 1 1 ...
 $ Headache        : Factor w/ 2 levels "Absent","Present": 1 2 2 1 2 2 2 2 2 2 ...
 $ Diarrhea        : Factor w/ 2 levels "Absent","Present": 1 1 2 2 1 1 2 2 2 2 ...
 $ Fatigue.Boneache: Factor w/ 2 levels "Absent","Present": 2 2 1 1 2 2 2 1 2 1 ...
 $ Jaundice        : Factor w/ 2 levels "Absent","Present": 2 2 1 2 2 2 2 1 1 1 ...
 $ Epigastria.pain : Factor w/ 2 levels "Absent","Present": 2 1 1 1 2 1 2 2 2 2 ...
 $ WBC             : int  7425 12101 4178 6490 3661 11785 11620 7335 10480 6681 ...
 $ RBC             : num  4248807 4429425 4621191 4794631 4606375 ...
 $ HGB             : int  14 10 12 10 11 15 12 11 12 12 ...
 $ Plat            : num  112132 129367 151522 146457 187684 ...
 $ AST.1           : int  99 91 113 43 99 66 78 119 93 55 ...
 $ ALT.1           : int  84 123 49 64 104 104 57 112 83 68 ...
 $ ALT.4           : num  52 95 95 109 67 121 113 80 55 72 ...
 $ ALT.12          : int  109 75 107 80 48 96 118 127 102 127 ...
 $ ALT.24          : int  81 113 116 88 120 65 107 45 97 81 ...
 $ ALT.36          : int  5 57 5 48 94 73 84 96 122 125 ...
 $ ALT.48          : int  5 123 5 77 90 114 80 53 39 43 ...
 $ ALT.after.24.w  : int  5 44 5 33 30 29 28 39 45 30 ...
 $ RNA.Base        : int  655330 40620 571148 1041941 660410 1157452 325694 641129 591441 1151206 ...
 $ RNA.4           : int  634536 538635 661346 449939 738756 1086852 1034008 72050 757361 230488 ...
 $ RNA.12          : int  288194 637056 5 585688 3731527 5 275095 787295 5 267320 ...
 $ RNA.EOT         : int  5 336804 735945 744463 338946 5 214566 370605 371090 275295 ...
 $ RNA.EF          : int  5 31085 558829 582301 242861 5 635157 506296 203042 555516 ...
 $ BH.grading      : int  13 4 4 10 11 4 12 12 5 4 ...
 $ BH.staging      : Factor w/ 4 levels "F1","F2","F3",..: 2 2 4 3 1 4 4 3 2 2 ...

Observamos que ahora todas las variables están correctamente guardadas en función de los datos que contienen.

1.2.2 Número de observaciones y valores ausentes

Tras guardar los datos correctamente en R, comprobamos el número de pacientes en cada estado hepático.

Cantidad de pacientes en cada uno de los estados de fibrosis hepática.
F1 F2 F3 F4
336 332 355 362

Como podemos observar no existen datos para el estado F0 de FH ya que todos los pacientes de este estudio presentan algún grado de fibrosis.

Poncentaje de muestras en cada uno de los estados de FH en el conjunto de datos HCV.
F1 F2 F3 F4
0.24 0.24 0.26 0.26

Observamos que el número de pacientes por cada estado de FH se encuentra balanceado.

Ahora observamos el número de muestras de cada género. En donde encontramos que en el estudio existen más hombre que mujeres con un 3% de diferencia.

Cantidad de muestras de cada género en el conjunto de datos HCV.
Male Female
707 678
Poncentaje de hombres y mujeres en el conjunto de datos HCV.
Male Female
0.51 0.49

1.2.3 Distribución variable respuesta

Vamos a estudiar la distribución de la variable respuesta, ya que, es la variable que nos interesa predecir. Observamos la variable BH.staging esta balanceada.

Gráfico de barras variable respuesta.

Gráfico de barras variable respuesta.

Los modelos predictivos deben de tener un porcentaje de acierto superior a lo esperado por azar o a un determinado nivel basal. En problemas de clasificación, el nivel basal es el que se obtiene si se asignan todas las observaciones a la clase mayoritaria (la moda).

# Porcentaje de aciertos si se predice para todas las observaciones que padecen LD.
n_observaciones <- nrow(HCV)
predicciones <- rep(x = "F4",  n_observaciones)
mean(predicciones == HCV$BH.staging) * 100 
[1] 26.13718
# porcentaje mínimo que hay que superar con los modelos predictivos

Debido a que los datos están balanceados el porcentaje mínimo que hay que intentar superar con los modelos predictivos es del 26.14%.

1.2.4 Distribución de las variables continuas

Exploramos los datos de las variables continuas. Realizamos un breve resumen estadístico de las variables numéricas del conjunto:

Estadísticas descriptivas de las variables numéricas
Min. 1st Qu. Median Mean 3rd Qu. Max.
Age 32 39 46 46.32 54 61
BMI 22 25 29 28.61 32 35
WBC 2991 5219 7498 7533.39 9902 12101
RBC 3816422 4121374 4438465 4422129.61 4721279 5018451
HGB 10 11 13 12.59 14 15
Plat 93013 124479 157916 158348.06 190314 226464
AST.1 39 60 83 82.77 105 128
ALT.1 39 62 83 83.92 106 128
ALT.4 39 61 82 83.41 107 128
ALT.12 39 60 84 83.51 106 128
ALT.24 39 61 83 83.71 107 128
ALT.36 5 61 84 83.12 106 128
ALT.48 5 61 83 83.63 106 128
ALT.after.24.w 5 28 34 33.44 40 45
RNA.Base 11 269253 593103 590951.22 886791 1201086
RNA.4 5 270893 597869 600895.65 909093 1201715
RNA.12 5 5 234359 288753.61 524819 3731527
RNA.EOT 5 5 251376 287660.34 517806 808450
RNA.EF 5 5 244049 291378.29 527864 810333
BH.grading 3 6 10 9.76 13 16

El resumen estadístico de las variables numéricas nos dice que la distribución de las variables es aparentemente normal debemos analizar por separado a las variables RNA.12, RNA.EOT, RNA.EF, en donde la media se separa de la mediana para comprender cuales son las razones.

Observamos que se puede mejorar la calidad de los datos si normalizamos los mismos. Aplicamos una función de normalización para graficar los datos en la misma escala.

Creamos una función para normalizar los datos en base a mínimos y máximos para que tengan valores entre 0 y 1 y poder observar todos los datos a la misma escala.

Se realiza un gráfico de boxplot para observar la distribución de los datos con escala entre 0 y 1.

Boxplots de las variables numéricas.

Boxplots de las variables numéricas.

Se pueden observar valores atípicos en las variables de ALT.after.24.w y RNA.12

Tratamiento de valores atípicos

Se analiza cada uno de los valores atípicos y considerando las referencias bibliográficas de las pruebas PCR para detección de Virus de la hepatitis C se considera que estos datos pertenecen a un caso excepcional y no a un error, sin embargo sabemos que los valores atípicos si pueden influir en los modelos de aprendizaje por tanto y considerando que se tiene una cantidad suficiente de datos se eliminaran los outliers para la exploración de datos.

Utilizamos la prueba de Grubbs para detectar un valor atipico en la variable RNA.12 ya que tenemos una gran cantidad de datos, esta prueba nos ayuda a detectar un único valor atípico mediante un test de hipótesis nula la cual establece que no hay valores atípicos en los datos, con una significancia de valor p = 0.05.


    Grubbs test for one outlier

data:  mynum$RNA.12
G = 12.06506, U = 0.89475, p-value < 2.2e-16
alternative hypothesis: highest value 3731527 is an outlier

En este caso se rechaza la hipótesis nula, y nos dice que el valor atípico es de 3731527, el cual procederemos a eliminar en nuestra base de datos.

Ahora realizamos la prueba para los valores atípicos de la variable ALT.after.24.w


    Grubbs test for one outlier

data:  mynum$ALT.after.24.w
G = 4.02036, U = 0.98831, p-value = 0.03839
alternative hypothesis: lowest value 5 is an outlier

Nuevamente se rechaza la hipótesis nula, por tanto procedemos a eliminar los datos con valores atípicos.

Se realiza gráficos de dispersión enfrentando todas las variables numéricas entre sí:

Gráficos de dispersión entre las variables numéricas.

Gráficos de dispersión entre las variables numéricas.

Los cocientes de relación más altos entre las variables son 0.41 y 0.42 de las variables RNA.EOT y RNA.EF con RNA.12 respectivamente por lo cual se observa que no existe una correlación entre las variables. Respecto a la distribución de los datos podemos observar que estos tienen distribuciones uniformes, excepto por las variables RNA.12, RNA.EOT y RNA.EF que tienen una asimetría hacia la derecha.

Gráficos variable Age.

Gráficos variable Age.

Estadísticas descriptivas de Age por clase.
BH.staging media mediana min max
F1 46.3 46 32 61
F2 46.3 46 32 61
F3 46.3 46 32 61
F4 46.3 46 32 61 

 Test Chi-cuadrado:
Estadístico de prueba =  100.8949 
p-valor =  0.1464164
Gráficos variable BMI.

Gráficos variable BMI.

Estadísticas descriptivas de BMI por clase.
BH.staging media mediana min max
F1 28.59 29 22 35
F2 28.59 29 22 35
F3 28.59 29 22 35
F4 28.59 29 22 35 

 Test Chi-cuadrado:
Estadístico de prueba =  41.53371 
p-valor =  0.3608916
Gráficos variable WBC.

Gráficos variable WBC.

Estadísticas descriptivas de WBC por clase.
BH.staging media mediana min max
F1 7538.8 7514 2991 12101
F2 7538.8 7514 2991 12101
F3 7538.8 7514 2991 12101
F4 7538.8 7514 2991 12101 

 Test Chi-cuadrado:
Estadístico de prueba =  3914.194 
p-valor =  0.4332662
Gráficos variable RBC.

Gráficos variable RBC.

Estadísticas descriptivas de RBC por clase.
BH.staging media mediana min max
F1 4422279 4438465 3816422 5018451
F2 4422279 4438465 3816422 5018451
F3 4422279 4438465 3816422 5018451
F4 4422279 4438465 3816422 5018451 

 Test Chi-cuadrado:
Estadístico de prueba =  4138.969 
p-valor =  0.4884442
Gráficos variable HGB.

Gráficos variable HGB.

Estadísticas descriptivas de HGB por clase.
BH.staging media mediana min max
F1 12.59 13 10 15
F2 12.59 13 10 15
F3 12.59 13 10 15
F4 12.59 13 10 15 

 Test Chi-cuadrado:
Estadístico de prueba =  16.86688 
p-valor =  0.3268846
Gráficos variable Plat.

Gráficos variable Plat.

Estadísticas descriptivas de Plat por clase.
BH.staging media mediana min max
F1 158347.2 157916 93013 226464
F2 158347.2 157916 93013 226464
F3 158347.2 157916 93013 226464
F4 158347.2 157916 93013 226464 

 Test Chi-cuadrado:
Estadístico de prueba =  4118.969 
p-valor =  0.4577108
Gráficos variable AST.1.

Gráficos variable AST.1.

Estadísticas descriptivas de AST.1 por clase.
BH.staging media mediana min max
F1 82.76 83 39 128
F2 82.76 83 39 128
F3 82.76 83 39 128
F4 82.76 83 39 128 

 Test Chi-cuadrado:
Estadístico de prueba =  253.8403 
p-valor =  0.7088866
Gráficos variable ALT.1.

Gráficos variable ALT.1.

Estadísticas descriptivas de ALT.1 por clase.
BH.staging media mediana min max
F1 83.92 83 39 128
F2 83.92 83 39 128
F3 83.92 83 39 128
F4 83.92 83 39 128 

 Test Chi-cuadrado:
Estadístico de prueba =  278.2291 
p-valor =  0.3057136
Gráficos variable ALT.4.

Gráficos variable ALT.4.

Estadísticas descriptivas de ALT.4 por clase.
BH.staging media mediana min max
F1 83.44 83 39 128
F2 83.44 83 39 128
F3 83.44 83 39 128
F4 83.44 83 39 128 

 Test Chi-cuadrado:
Estadístico de prueba =  236.8042 
p-valor =  0.9082989
Gráficos variable ALT.12.

Gráficos variable ALT.12.

Estadísticas descriptivas de ALT.12 por clase.
BH.staging media mediana min max
F1 83.5 84 39 128
F2 83.5 84 39 128
F3 83.5 84 39 128
F4 83.5 84 39 128 

 Test Chi-cuadrado:
Estadístico de prueba =  261.0173 
p-valor =  0.5917102
Gráficos variable ALT.24.

Gráficos variable ALT.24.

Estadísticas descriptivas de ALT.24 por clase.
BH.staging media mediana min max
F1 83.65 83 39 128
F2 83.65 83 39 128
F3 83.65 83 39 128
F4 83.65 83 39 128 

 Test Chi-cuadrado:
Estadístico de prueba =  268.104 
p-valor =  0.4694888
Gráficos variable ALT.36.

Gráficos variable ALT.36.

Estadísticas descriptivas de ALT.36 por clase.
BH.staging media mediana min max
F1 83.28 84 39 128
F2 83.28 84 39 128
F3 83.28 84 39 128
F4 83.28 84 39 128 

 Test Chi-cuadrado:
Estadístico de prueba =  274.8358 
p-valor =  0.3577012
Gráficos variable ALT.48.

Gráficos variable ALT.48.

Estadísticas descriptivas de ALT.48 por clase.
BH.staging media mediana min max
F1 83.8 84 39 128
F2 83.8 84 39 128
F3 83.8 84 39 128
F4 83.8 84 39 128 

 Test Chi-cuadrado:
Estadístico de prueba =  255.0925 
p-valor =  0.6894139
Gráficos variable ALT.after.24.w.

Gráficos variable ALT.after.24.w.

Estadísticas descriptivas de ALT.after.24.w por clase.
BH.staging media mediana min max
F1 33.5 34 22 45
F2 33.5 34 22 45
F3 33.5 34 22 45
F4 33.5 34 22 45 

 Test Chi-cuadrado:
Estadístico de prueba =  62.84167 
p-valor =  0.6856197
Gráficos variable RNA.Base.

Gráficos variable RNA.Base.

Estadísticas descriptivas de RNA.Base por clase.
BH.staging media mediana min max
F1 591180.9 593103 11 1201086
F2 591180.9 593103 11 1201086
F3 591180.9 593103 11 1201086
F4 591180.9 593103 11 1201086 

 Test Chi-cuadrado:
Estadístico de prueba =  4143 
p-valor =  0.4708002
Gráficos variable RNA.4.

Gráficos variable RNA.4.

Estadísticas descriptivas de RNA.4 por clase.
BH.staging media mediana min max
F1 600412.7 595314 5 1201715
F2 600412.7 595314 5 1201715
F3 600412.7 595314 5 1201715
F4 600412.7 595314 5 1201715 

 Test Chi-cuadrado:
Estadístico de prueba =  4138.994 
p-valor =  0.4883351
Gráficos variable RNA.12.

Gráficos variable RNA.12.

Estadísticas descriptivas de RNA.12 por clase.
BH.staging media mediana min max
F1 286679.2 234359 5 810028
F2 286679.2 234359 5 810028
F3 286679.2 234359 5 810028
F4 286679.2 234359 5 810028 

 Test Chi-cuadrado:
Estadístico de prueba =  2993.046 
p-valor =  0.5014837
Gráficos variable RNA.EOT.

Gráficos variable RNA.EOT.

Estadísticas descriptivas de RNA.EOT por clase.
BH.staging media mediana min max
F1 287715.2 251376 5 808450
F2 287715.2 251376 5 808450
F3 287715.2 251376 5 808450
F4 287715.2 251376 5 808450 

 Test Chi-cuadrado:
Estadístico de prueba =  2996.029 
p-valor =  0.5015711
Gráficos variable RNA.EF.

Gráficos variable RNA.EF.

Estadísticas descriptivas de RNA.EF por clase.
BH.staging media mediana min max
F1 291641.7 244418 5 810333
F2 291641.7 244418 5 810333
F3 291641.7 244418 5 810333
F4 291641.7 244418 5 810333 

 Test Chi-cuadrado:
Estadístico de prueba =  3002.071 
p-valor =  0.5013494
Gráficos variable BH.grading.

Gráficos variable BH.grading.

Estadísticas descriptivas de BH.grading por clase.
BH.staging media mediana min max
F1 9.76 10 3 16
F2 9.76 10 3 16
F3 9.76 10 3 16
F4 9.76 10 3 16 

 Test Chi-cuadrado:
Estadístico de prueba =  32.03351 
p-valor =  0.7777465

Se realiza una tabla resumen de los valores obtenidos.

Boxplots de variables continuas por clase de BH.staging

Boxplots de variables continuas por clase de BH.staging

Hemos normalizado las variables para poder visualizarlas en un solo gráfico, dentro de los gráficos de cajas existen tres variables que tienen una distribución distinta como también los hemos observado en el gráfico de densidad, se consideran una distribución uniforme truncada hacia la izquierda, sin embargo ya que se realizado el Test Chi-cuadrado cuyo p-valor nos indica que se acepta la hipótesis nula, asegurando que mantienen una distribución uniforme.

1.2.5 Distribución de las variables cualitativas

En total tenemos 8 variables cualitativas.

Gráficos variable Gender.

Gráficos variable Gender.

Poncentaje de muestras de cada estadío de FH por Gender en el conjunto de datos.
F1 F2 F3 F4
Male 0.24 0.26 0.23 0.27
Female 0.24 0.22 0.29 0.25
Gráficos variable Fever.

Gráficos variable Fever.

Poncentaje de muestras de cada estadío de FH por Fever en el conjunto de datos.
F1 F2 F3 F4
Absent 0.23 0.24 0.25 0.28
Present 0.25 0.24 0.26 0.24
Gráficos variable Nausea.Vomiting.

Gráficos variable Nausea.Vomiting.

Poncentaje de muestras de cada estadío de FH por Nausea.Vomiting en el conjunto de datos.
F1 F2 F3 F4
Absent 0.26 0.25 0.24 0.25
Present 0.22 0.23 0.27 0.27
Gráficos variable Headache

Gráficos variable Headache

Poncentaje de muestras de cada estadío de FH por Headache en el conjunto de datos.
F1 F2 F3 F4
Absent 0.24 0.24 0.26 0.26
Present 0.25 0.24 0.25 0.26
Gráficos variable Diarrhea

Gráficos variable Diarrhea

Poncentaje de muestras de cada estadío de FH por Diarrhea en el conjunto de datos.
F1 F2 F3 F4
Absent 0.23 0.25 0.26 0.26
Present 0.25 0.23 0.25 0.26
Gráficos variable Fatigue.Boneache

Gráficos variable Fatigue.Boneache

Poncentaje de muestras de cada estadío de FH por Fatigue.Boneache en el conjunto de datos.
F1 F2 F3 F4
Absent 0.25 0.23 0.27 0.25
Present 0.23 0.25 0.25 0.27
Gráficos variable Jaundice

Gráficos variable Jaundice

Poncentaje de muestras de cada estadío de FH por Jaundice en el conjunto de datos.
F1 F2 F3 F4
Absent 0.26 0.22 0.26 0.25
Present 0.23 0.26 0.25 0.27
Gráficos variable Epigastria.pain

Gráficos variable Epigastria.pain

Poncentaje de muestras de cada estadío de FH por Epigastria.pain en el conjunto de datos.
F1 F2 F3 F4
Absent 0.21 0.25 0.27 0.27
Present 0.27 0.23 0.24 0.26

Como se puede observar en los gráficos y las proporciones en las tablas son semejantes entre los grupos, por tanto no se sospecha de alguna diferencia estadísticamente significativa entre los mismos.

1.2.6 Selección de variables

Buscaremos las relaciones que puedan existir entre las variables

Correlación entre variables continuas

Considerando que la distribución de las variables es uniforme utilizaremos para la correlación el método de Spearman.

# Crear matriz de correlación
corr_mat <- cor(x = mynum.norm, method = "spearman")
colnames(corr_mat) <- names(mynum.norm)

# Crear corrplot con etiquetas de título y significancia
corrplot(corr_mat, method = "color", 
         title = "Correlación entre variables numéricas",
         tl.col = "black", tl.pos = "n", 
         mar = c(2, 1, 3, 1))

corr_mat
                         Age           BMI          WBC          RBC
Age             1.000000e+00 -2.697598e-02  0.017346285 -0.003250116
BMI            -2.697598e-02  1.000000e+00  0.037996220 -0.002756251
WBC             1.734628e-02  3.799622e-02  1.000000000  0.008365064
RBC            -3.250116e-03 -2.756251e-03  0.008365064  1.000000000
HGB            -1.346177e-02  5.997404e-02  0.007211737  0.042209841
Plat           -1.613839e-03 -3.630193e-03 -0.013155218  0.034194997
AST.1          -2.071666e-02 -2.470297e-05 -0.006318532  0.014572461
ALT.1           6.781301e-03  3.583009e-02 -0.038879669  0.010662759
ALT.4           3.196612e-02  2.662224e-03 -0.014125104 -0.029854826
ALT.12          1.935010e-02 -6.091079e-02 -0.003728601  0.016937427
ALT.24         -4.395136e-05  5.571100e-03 -0.009768910  0.014521580
ALT.36         -6.659803e-03 -2.197531e-02 -0.045965023  0.048223756
ALT.48          2.816311e-02  1.068905e-03 -0.018168701 -0.058306939
ALT.after.24.w  7.176556e-03 -1.080194e-02  0.011200993  0.006522119
RNA.Base        2.077794e-02 -1.558458e-02  0.014803004  0.005794526
RNA.4          -1.133849e-02  3.555795e-02  0.022664875  0.018093935
RNA.12         -1.932151e-02 -2.149649e-02 -0.039336107 -0.067766722
RNA.EOT        -5.130286e-02 -2.555149e-02 -0.019720903 -0.031623516
RNA.EF         -3.682528e-02 -4.489250e-02 -0.042460781 -0.012911041
BH.grading     -3.973584e-02 -2.393833e-02  0.029504155 -0.017467679
                         HGB         Plat         AST.1        ALT.1
Age            -0.0134617685 -0.001613839 -2.071666e-02  0.006781301
BMI             0.0599740394 -0.003630193 -2.470297e-05  0.035830090
WBC             0.0072117366 -0.013155218 -6.318532e-03 -0.038879669
RBC             0.0422098411  0.034194997  1.457246e-02  0.010662759
HGB             1.0000000000 -0.007516561 -1.258791e-02 -0.014523142
Plat           -0.0075165606  1.000000000 -4.447343e-03  0.046214537
AST.1          -0.0125879098 -0.004447343  1.000000e+00  0.037949039
ALT.1          -0.0145231419  0.046214537  3.794904e-02  1.000000000
ALT.4           0.0216958629 -0.025727845  8.137227e-03 -0.032283250
ALT.12         -0.0072591607 -0.041746382 -1.215106e-02 -0.044694783
ALT.24          0.0066981537 -0.004400589 -1.458897e-02 -0.041890540
ALT.36         -0.0396093534  0.002441219 -7.686043e-03 -0.016715133
ALT.48         -0.0327107416 -0.005981120 -9.058620e-03  0.029240228
ALT.after.24.w -0.0246369855 -0.035748502  2.120943e-03 -0.007038551
RNA.Base       -0.0528185590 -0.039655767 -3.432854e-03  0.034882064
RNA.4          -0.0003533722 -0.039857847 -1.033735e-02 -0.013687496
RNA.12          0.0127061367  0.043738983 -1.145836e-02  0.009511748
RNA.EOT        -0.0061691849  0.037606338 -4.288664e-02 -0.028658286
RNA.EF          0.0035481322  0.008469466 -8.738575e-03 -0.018706350
BH.grading      0.0207820734  0.033181397 -2.497076e-02 -0.012852154
                      ALT.4        ALT.12        ALT.24        ALT.36
Age             0.031966124  0.0193501045 -4.395136e-05 -0.0066598029
BMI             0.002662224 -0.0609107887  5.571100e-03 -0.0219753149
WBC            -0.014125104 -0.0037286007 -9.768910e-03 -0.0459650229
RBC            -0.029854826  0.0169374268  1.452158e-02  0.0482237564
HGB             0.021695863 -0.0072591607  6.698154e-03 -0.0396093534
Plat           -0.025727845 -0.0417463821 -4.400589e-03  0.0024412187
AST.1           0.008137227 -0.0121510597 -1.458897e-02 -0.0076860430
ALT.1          -0.032283250 -0.0446947826 -4.189054e-02 -0.0167151327
ALT.4           1.000000000  0.0031361421  2.713221e-02  0.0141986244
ALT.12          0.003136142  1.0000000000  2.203490e-02 -0.0006370239
ALT.24          0.027132212  0.0220348963  1.000000e+00 -0.0078870641
ALT.36          0.014198624 -0.0006370239 -7.887064e-03  1.0000000000
ALT.48         -0.007019825  0.0131558494 -9.633634e-02 -0.0168930153
ALT.after.24.w  0.015592430 -0.0197839579 -2.639300e-02 -0.0300172598
RNA.Base       -0.012105897 -0.0360096773  9.036060e-03 -0.0076068253
RNA.4          -0.009380897 -0.0163838506 -3.882051e-02 -0.0296143242
RNA.12          0.014877520 -0.0171655802  3.651826e-03  0.0143817313
RNA.EOT         0.048432454 -0.0279837611 -5.917538e-04  0.0260545124
RNA.EF          0.015079926 -0.0251411594  1.582293e-02  0.0181743137
BH.grading     -0.026185381 -0.0038256167 -2.194802e-03  0.0089611399
                     ALT.48 ALT.after.24.w     RNA.Base         RNA.4
Age             0.028163106    0.007176556  0.020777939 -0.0113384878
BMI             0.001068905   -0.010801940 -0.015584578  0.0355579511
WBC            -0.018168701    0.011200993  0.014803004  0.0226648747
RBC            -0.058306939    0.006522119  0.005794526  0.0180939350
HGB            -0.032710742   -0.024636986 -0.052818559 -0.0003533722
Plat           -0.005981120   -0.035748502 -0.039655767 -0.0398578469
AST.1          -0.009058620    0.002120943 -0.003432854 -0.0103373517
ALT.1           0.029240228   -0.007038551  0.034882064 -0.0136874960
ALT.4          -0.007019825    0.015592430 -0.012105897 -0.0093808971
ALT.12          0.013155849   -0.019783958 -0.036009677 -0.0163838506
ALT.24         -0.096336341   -0.026392995  0.009036060 -0.0388205084
ALT.36         -0.016893015   -0.030017260 -0.007606825 -0.0296143242
ALT.48          1.000000000    0.006620724  0.019652518 -0.0040512609
ALT.after.24.w  0.006620724    1.000000000  0.027929973  0.0376994945
RNA.Base        0.019652518    0.027929973  1.000000000  0.0202476482
RNA.4          -0.004051261    0.037699495  0.020247648  1.0000000000
RNA.12          0.024724319   -0.016008194 -0.003811067 -0.0389631541
RNA.EOT        -0.003858986    0.015741358  0.012455161 -0.0005597583
RNA.EF          0.007583896    0.008218462  0.011118219 -0.0537898540
BH.grading      0.039053295    0.022796550 -0.017975698 -0.0490383618
                     RNA.12       RNA.EOT        RNA.EF    BH.grading
Age            -0.019321511 -0.0513028578 -0.0368252838 -0.0397358400
BMI            -0.021496493 -0.0255514882 -0.0448924980 -0.0239383273
WBC            -0.039336107 -0.0197209033 -0.0424607814  0.0295041546
RBC            -0.067766722 -0.0316235165 -0.0129110410 -0.0174676790
HGB             0.012706137 -0.0061691849  0.0035481322  0.0207820734
Plat            0.043738983  0.0376063382  0.0084694658  0.0331813968
AST.1          -0.011458358 -0.0428866363 -0.0087385748 -0.0249707633
ALT.1           0.009511748 -0.0286582856 -0.0187063498 -0.0128521537
ALT.4           0.014877520  0.0484324543  0.0150799257 -0.0261853807
ALT.12         -0.017165580 -0.0279837611 -0.0251411594 -0.0038256167
ALT.24          0.003651826 -0.0005917538  0.0158229261 -0.0021948024
ALT.36          0.014381731  0.0260545124  0.0181743137  0.0089611399
ALT.48          0.024724319 -0.0038589856  0.0075838960  0.0390532950
ALT.after.24.w -0.016008194  0.0157413577  0.0082184620  0.0227965496
RNA.Base       -0.003811067  0.0124551606  0.0111182188 -0.0179756978
RNA.4          -0.038963154 -0.0005597583 -0.0537898540 -0.0490383618
RNA.12          1.000000000  0.6046914218  0.6138921400 -0.0499342972
RNA.EOT         0.604691422  1.0000000000  0.6070418348 -0.0422752815
RNA.EF          0.613892140  0.6070418348  1.0000000000  0.0000676806
BH.grading     -0.049934297 -0.0422752815  0.0000676806  1.0000000000
# Calcular el coeficiente de correlación de Spearman
cor.test(HCV$RNA.12, HCV$RNA.EOT, method = "spearman")

    Spearman's rank correlation rho

data:  HCV$RNA.12 and HCV$RNA.EOT
S = 173526496, p-value < 2.2e-16
alternative hypothesis: true rho is not equal to 0
sample estimates:
      rho 
0.6046914 
cor.test(HCV$RNA.12, HCV$RNA.EF, method = "spearman")

    Spearman's rank correlation rho

data:  HCV$RNA.12 and HCV$RNA.EF
S = 169487705, p-value < 2.2e-16
alternative hypothesis: true rho is not equal to 0
sample estimates:
      rho 
0.6138921 
cor.test(HCV$RNA.EOT, HCV$RNA.EF, method = "spearman")

    Spearman's rank correlation rho

data:  HCV$RNA.EOT and HCV$RNA.EF
S = 172494747, p-value < 2.2e-16
alternative hypothesis: true rho is not equal to 0
sample estimates:
      rho 
0.6070418

Como podemos observar varias correlaciones regulares y tres correlaciones buenas entre las variables, las correlaciones más altas no superan un factor de correlación de 0.61, sin embargo al realizar el test de correlación de Spearman se confirma que existe una correlación positiva y moderada entre las dos variables.

Variables con varianza cero o próxima a cero

En una distribución uniforme es muy poco probable que la varianza sea igual a cero ya que cada valor tiene la misma probabilidad de aparecer, y en esta base de datos tampoco se manejan datos muy pequeños por los que se pueda confundir una varianza cercana a cero, sin embargo realizaremos este paso para confirmarlo.

# Varianza de las variables numéricas
round(apply(mynum.norm, 2, var),2)
           Age            BMI            WBC            RBC            HGB 
          0.09           0.10           0.09           0.08           0.12 
          Plat          AST.1          ALT.1          ALT.4         ALT.12 
          0.08           0.09           0.08           0.09           0.09 
        ALT.24         ALT.36         ALT.48 ALT.after.24.w       RNA.Base 
          0.09           0.05           0.04           0.03           0.09 
         RNA.4         RNA.12        RNA.EOT         RNA.EF     BH.grading 
          0.09           0.01           0.11           0.11           0.10 
library(caret)
nearZeroVar(mynum.norm, saveMetrics = TRUE)
                freqRatio percentUnique zeroVar   nzv
Age              1.036364     2.1723389   FALSE FALSE
BMI              1.044643     1.0137581   FALSE FALSE
WBC              1.000000    94.2070963   FALSE FALSE
RBC              2.000000    99.9275887   FALSE FALSE
HGB              1.097872     0.4344678   FALSE FALSE
Plat             1.000000    99.2758870   FALSE FALSE
AST.1            1.181818     6.5170167   FALSE FALSE
ALT.1            1.200000     6.5170167   FALSE FALSE
ALT.4            1.038462     6.5170167   FALSE FALSE
ALT.12           1.000000     6.5170167   FALSE FALSE
ALT.24           1.080000     6.5170167   FALSE FALSE
ALT.36           1.041667     6.5170167   FALSE FALSE
ALT.48           1.041667     6.5170167   FALSE FALSE
ALT.after.24.w   1.043478     1.7378711   FALSE FALSE
RNA.Base         2.000000    99.9275887   FALSE FALSE
RNA.4            2.000000    99.9275887   FALSE FALSE
RNA.12         383.000000    72.3388849   FALSE FALSE
RNA.EOT        382.000000    72.4112962   FALSE FALSE
RNA.EF         380.000000    72.5561188   FALSE FALSE
BH.grading       1.150000     1.0137581   FALSE FALSE

Se comprueba que ninguna de las variables tiene una varianza igual a cero.

1.3 Preprocesamiento de datos

1.3.1 Selección de predictores:

La selección de predictores es un paso necesario para identificar las variables más relevantes que contribuyen a la predicción del objetivo, en este caso de los estadios de FH. Después de haber realizado el análisis exploratorio de datos se ha filtrado con la técnica Ramdow Forest y una filtración Gini.

Importancia de las variables con Random Forest

El índice Gini en Random Forest es utilizado para medir la importancia de las variables en la predicción de la variable respuesta, por tanto nos será de ayuda al momento de mejorar el modelo.

Las variables con menos importancia son las variables cualitativas relacionadas con la sintomatología del paciente.

1.3.2 Partición de datos training y test

# Particion de los datos train/test

set.seed(77)
## Muestras que pertenecen al conjunto train
n_train <- createDataPartition(HCV$BH.staging, p = 0.7, list = FALSE)

## Eliminamos las variables con menos importancia
HCV2<- HCV3

HCV2 <- HCV2 %>% 
         select(-Epigastria.pain, -Gender, -Headache, -Nausea.Vomiting, -Jaundice, -Fatigue.Boneache, -Fever, -Diarrhea, -RNA.12, -RNA.EOT, -RNA.EF, -HGB, -BH.grading)

## Creamos los conjuntos train y test:
train.d <- HCV2[n_train,]
test.d <- HCV2[-n_train,]

## Variable objetivo por conjunto de datos
label_train <- HCV2[n_train,length(HCV2)]
label_test <- HCV2[-n_train,length(HCV2)]

Considerando que tanto predictores como variable respuesta tienen una distribución uniforme los datos al ser escogidos al azar deberían mantener la distribución, sin embargo para asegurarse de ello usamos la función createDataPartition para mantener la proporción en la partición de datos.

También hay que destacar que aunque los datos tienen una distribución uniforme han sido normalizados considerando que existen una gran variabilidad entre una variable y otra.

De los 1381 registros iniciales, el conjunto train contiene 968 registros y el conjunto test contiene 413 registros. Los porcentajes parecen indicar que los datos se han dividido equitativamente entre los subconjuntos de datos.

Porcentaje de cada tipo de localización en los conjuntos train y test.
F1 F2 F3 F4
% Train 0.24 0.24 0.26 0.26
% Test 0.24 0.24 0.26 0.26

1.3.3 Preparación de datos

# Preparamos los conjuntos de datos para que sean preprocesados
data_train <- train.d
data_test  <- test.d
data_tn <- data_train
data_tt <- data_test
data_tn2 <- data_train
data_tt2 <- data_test

En el preprocesado de los datos, se han generado un total de 29 variables (28 predictores y la variable respuesta).

2 Creación de modelos predictivos:

Utilizamos el paquete caret para generar y entrenar los diferentes modelos de aprendizaje automático, proporcionando diferentes hiperparámetros y buscando el modelo con mejor rendimiento.

2.1 Modelo k-Nearest Neighbor (KNN)

Generamos el modelo KNN

# Cargar el paquete caret
library(caret)

particiones <- 20
repeticiones <- 20
hiperparámetros <- data.frame(k = c(5,10,15,20,25,30))

set.seed(12345)
seed <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seed[[i]] <- sample.int(1000, nrow(hiperparámetros))
}
seed[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)

# Entrenamiento
control_train <- trainControl(
  method = "repeatedcv",
  number = particiones,
  repeats = repeticiones,
  seed = seed,
  returnResamp = "final",
  verboseIter = FALSE,
  allowParallel = TRUE
)

# Ajuste del modelo
set.seed(23456)
modelo_knn <- caret::train(
  BH.staging ~ .,
  data = data_tn,
  method = "knn",
  tuneGrid = hiperparámetros,
  metric = "Accuracy",
  trControl = control_train
)

modelo_knn
k-Nearest Neighbors 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (20 fold, repeated 20 times) 
Summary of sample sizes: 920, 921, 920, 920, 920, 918, ... 
Resampling results across tuning parameters:

  k   Accuracy   Kappa        
   5  0.2511215   0.0003088570
  10  0.2507081  -0.0006665558
  15  0.2655902   0.0185926854
  20  0.2631094   0.0152153544
  25  0.2616867   0.0133653206
  30  0.2574146   0.0071132299

Accuracy was used to select the optimal model using the largest value.
The final value used for the model was k = 15.
# Gráfico
ggplot(modelo_knn, highlight = TRUE) +
  labs(title = "Evolución del accuracy del modelo KNN") +
  theme_bw()

# Obtener la matriz de confusión
predicciones_knn <- predict(modelo_knn, newdata = data_tt, type = "raw")
conf_mat_knn <- caret::confusionMatrix(
  factor(predicciones_knn, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)

# Crear objeto stats_class_knn con las estadísticas extraídas
stats_class_knn <- data.frame(
  model = "KNN",
  precision = conf_mat_knn$overall["Accuracy"],
  FN = conf_mat_knn$table[2,1],
  FP = conf_mat_knn$table[1,2],
  error.rate = 1 - conf_mat_knn$overall["Accuracy"],
  kappa = conf_mat_knn$overall["Kappa"],
  sensibilidad = mean(conf_mat_knn$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_knn$byClass[,"Specificity"]),
  precisión = mean(conf_mat_knn$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_knn$byClass[,"Recall"]),
  f.medida = mean(conf_mat_knn$byClass[,"F1"])
)

stats_class_knn
         model precision FN FP error.rate      kappa sensibilidad especificidad
Accuracy   KNN 0.2615012 24 15  0.7384988 0.01361743    0.2606731     0.7533485
         precisión recuperación  f.medida
Accuracy 0.2607384    0.2606731 0.2583652

2.2 Modelo Naive Bayes (NB)

Generamos el modelo NB.

particiones <- 10
repeticiones <- 10

# Definir los hiperparámetros para Naive Bayes
hiperparámetros <- expand.grid(
  laplace = c(0, 1, 2, 3),
  usekernel = c(FALSE, TRUE),
  adjust = c(FALSE, TRUE)
)

set.seed(12345)
seed <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seed[[i]] <- sample.int(1000, nrow(hiperparámetros))
}
seed[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)

# Entrenamiento
control_train <- trainControl(
  method = "repeatedcv",
  number = particiones,
  repeats = repeticiones,
  seed = seed,
  returnResamp = "final",
  verboseIter = FALSE,
  allowParallel = TRUE
)

# Ajuste del modelo Naive Bayes
set.seed(23456)
modelo_nb <- caret::train(
  BH.staging ~ .,
  data = data_tn,
  method = "naive_bayes",
  tuneGrid = hiperparámetros,
  metric = "Accuracy",
  trControl = control_train
)


modelo_nb
Naive Bayes 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (10 fold, repeated 10 times) 
Summary of sample sizes: 872, 872, 872, 871, 871, 871, ... 
Resampling results across tuning parameters:

  laplace  usekernel  adjust  Accuracy   Kappa      
  0        FALSE      FALSE   0.2295835  -0.02930784
  0        FALSE       TRUE   0.2295835  -0.02930784
  0         TRUE      FALSE         NaN          NaN
  0         TRUE       TRUE   0.2231781  -0.03834394
  1        FALSE      FALSE   0.2295835  -0.02930784
  1        FALSE       TRUE   0.2295835  -0.02930784
  1         TRUE      FALSE         NaN          NaN
  1         TRUE       TRUE   0.2231781  -0.03834394
  2        FALSE      FALSE   0.2295835  -0.02930784
  2        FALSE       TRUE   0.2295835  -0.02930784
  2         TRUE      FALSE         NaN          NaN
  2         TRUE       TRUE   0.2231781  -0.03834394
  3        FALSE      FALSE   0.2295835  -0.02930784
  3        FALSE       TRUE   0.2295835  -0.02930784
  3         TRUE      FALSE         NaN          NaN
  3         TRUE       TRUE   0.2231781  -0.03834394

Accuracy was used to select the optimal model using the largest value.
The final values used for the model were laplace = 0, usekernel = FALSE
 and adjust = FALSE.
# Gráfico
ggplot(modelo_nb, highlight = TRUE) +
  labs(title = "Evolución del accuracy del modelo NB") +
  theme_bw()

# Obtener la matriz de confusión
predicciones_nb <- predict(modelo_nb, newdata = data_tt, type = "raw")
conf_mat_nb <- caret::confusionMatrix(
  factor(predicciones_nb, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)

# Crear objeto stats_class_nb con las estadísticas extraídas
stats_class_nb <- data.frame(
  model = "Naive Bayes",
  precision = conf_mat_nb$overall["Accuracy"],
  FN = conf_mat_nb$table[2,1],
  FP = conf_mat_nb$table[1,2],
  error.rate = 1 - conf_mat_nb$overall["Accuracy"],
  kappa = conf_mat_nb$overall["Kappa"],
  sensibilidad = mean(conf_mat_nb$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_nb$byClass[,"Specificity"]),
  precisión = mean(conf_mat_nb$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_nb$byClass[,"Recall"]),
  f.medida = mean(conf_mat_nb$byClass[,"F1"])
)

stats_class_nb
               model precision FN FP error.rate        kappa sensibilidad
Accuracy Naive Bayes 0.2445521 30 12  0.7554479 -0.009281669    0.2425912
         especificidad precisión recuperación  f.medida
Accuracy     0.7477358 0.2313054    0.2425912 0.2278643

2.3 Modelo Multilayer perceptron (MLP)

Generamos el modelo MLP.

# Número de particiones y repeticiones
particiones  <- 20
repeticiones <- 20

#hiperparametros <- expand.grid(size = c(1:20),
#                                decay = c(0.0001, 0.1, 0.5))

hiperparametros <- expand.grid(size = c(1:5),
                              decay = c(0.0001))


set.seed(123)
seeds <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seeds[[i]] <- sample.int(1000, nrow(hiperparametros)) 
}
seeds[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)


# DEFINICIÓN DEL ENTRENAMIENTO
control_train <- trainControl(method = "repeatedcv", number = particiones,
                              repeats = repeticiones, seeds = seeds,
                              returnResamp = "final", verboseIter = FALSE,
                              allowParallel = TRUE)

# AJUSTE DEL MODELO
set.seed(342)
modelo_mlp <- caret::train(BH.staging ~ ., 
                    data = data_tn,
                    method = "mlpWeightDecay",
                    tuneGrid = hiperparametros,
                    metric = "Accuracy",
                    trControl = control_train,
                    learnFunc = "Std_Backpropagation")
modelo_mlp
Multi-Layer Perceptron 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (20 fold, repeated 20 times) 
Summary of sample sizes: 921, 920, 918, 920, 919, 920, ... 
Resampling results across tuning parameters:

  size  Accuracy   Kappa     
  1     0.2661983  0.01758281
  2     0.2698890  0.02238041
  3     0.2690820  0.02039518
  4     0.2659637  0.01840606
  5     0.2662596  0.01786372

Tuning parameter 'decay' was held constant at a value of 1e-04
Accuracy was used to select the optimal model using the largest value.
The final values used for the model were size = 2 and decay = 1e-04.
# REPRESENTACIÓN GRÁFICA
ggplot(modelo_mlp, highlight = TRUE) +
  labs(title = "Evolución del accuracy del modelo MLP") +
  theme_bw()

# Predicciones
predicciones_mlp <- predict(modelo_mlp, newdata = data_tt,
                            type = "raw")


# Evaluación
conf_mat_mlp <- caret::confusionMatrix(factor(predicciones_mlp, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)
conf_mat_mlp
Confusion Matrix and Statistics

          Reference
Prediction  F1  F2  F3  F4
        F1   0   0   0   0
        F2   1   0   1   1
        F3   0   0   0   0
        F4  99  99 105 107

Overall Statistics
                                          
               Accuracy : 0.2591          
                 95% CI : (0.2175, 0.3042)
    No Information Rate : 0.2615          
    P-Value [Acc > NIR] : 0.5633          
                                          
                  Kappa : -0.0031         
                                          
 Mcnemar's Test P-Value : NA              

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity             0.0000  0.000000    0.0000  0.990741
Specificity             1.0000  0.990446    1.0000  0.006557
Pos Pred Value             NaN  0.000000       NaN  0.260976
Neg Pred Value          0.7579  0.758537    0.7433  0.666667
Prevalence              0.2421  0.239709    0.2567  0.261501
Detection Rate          0.0000  0.000000    0.0000  0.259080
Detection Prevalence    0.0000  0.007264    0.0000  0.992736
Balanced Accuracy       0.5000  0.495223    0.5000  0.498649
stats_class_mlp <- data.frame(model         = "MLP", 
 precision = conf_mat_mlp$overall["Accuracy"],
  FN = conf_mat_mlp$table[2,1],
  FP = conf_mat_mlp$table[1,2],
  error.rate = 1 - conf_mat_mlp$overall["Accuracy"],
  kappa = conf_mat_mlp$overall["Kappa"],
  sensibilidad = mean(conf_mat_mlp$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_mlp$byClass[,"Specificity"]),
  precisión = mean(conf_mat_mlp$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_mlp$byClass[,"Recall"]),
  f.medida = mean(conf_mat_mlp$byClass[,"F1"])
)

stats_class_mlp
         model precision FN FP error.rate        kappa sensibilidad
Accuracy   MLP 0.2590799  1  0  0.7409201 -0.003063687    0.2476852
         especificidad precisión recuperación f.medida
Accuracy     0.7492508       NaN    0.2476852       NA

2.4 Modelo Support vector machine linear kernel (SVM-lineal)

Generamos el modelo SVM-lineal.

# se recurre a validación cruzada repetida como método de validación.
# Número de particiones y repeticiones
particiones  <- 10
repeticiones <- 10

hiperparametros <- data.frame(C = c(40,50,60,70,80,90))

set.seed(123)
seeds <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seeds[[i]] <- sample.int(1000, nrow(hiperparametros)) 
}
seeds[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)


# DEFINICIÓN DEL ENTRENAMIENTO
control_train <- trainControl(method = "repeatedcv", number = particiones,
                              repeats = repeticiones, seeds = seeds,
                              returnResamp = "final", verboseIter = FALSE,
                              allowParallel = TRUE)


# AJUSTE DEL MODELO
set.seed(342)
modelo_svmlineal <- caret::train(BH.staging ~ ., data = data_tn,
                          method = "svmLinear",
                          tuneGrid = hiperparametros,
                          metric = "Accuracy",
                          trControl = control_train)

modelo_svmlineal
Support Vector Machines with Linear Kernel 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (10 fold, repeated 10 times) 
Summary of sample sizes: 871, 871, 870, 873, 872, 870, ... 
Resampling results across tuning parameters:

  C   Accuracy   Kappa      
  40  0.2374332  -0.01855302
  50  0.2369156  -0.01923795
  60  0.2372270  -0.01882160
  70  0.2372270  -0.01882700
  80  0.2371228  -0.01897575
  90  0.2366073  -0.01966175

Accuracy was used to select the optimal model using the largest value.
The final value used for the model was C = 40.
# Predicciones
predicciones_svmlineal <- predict(modelo_svmlineal, newdata = data_tt, type = "raw")

conf_mat_svmlineal <- caret::confusionMatrix(factor(predicciones_svmlineal, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)

conf_mat_svmlineal
Confusion Matrix and Statistics

          Reference
Prediction F1 F2 F3 F4
        F1 12 10 13 15
        F2 32 26 32 28
        F3 16 24 17 16
        F4 40 39 44 49

Overall Statistics
                                          
               Accuracy : 0.2518          
                 95% CI : (0.2107, 0.2966)
    No Information Rate : 0.2615          
    P-Value [Acc > NIR] : 0.6905          
                                          
                  Kappa : -3e-04          
                                          
 Mcnemar's Test P-Value : 6.501e-07       

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity            0.12000   0.26263   0.16038    0.4537
Specificity            0.87859   0.70701   0.81759    0.5967
Pos Pred Value         0.24000   0.22034   0.23288    0.2849
Neg Pred Value         0.75758   0.75254   0.73824    0.7552
Prevalence             0.24213   0.23971   0.25666    0.2615
Detection Rate         0.02906   0.06295   0.04116    0.1186
Detection Prevalence   0.12107   0.28571   0.17676    0.4165
Balanced Accuracy      0.49930   0.48482   0.48898    0.5252
# REPRESENTACIÓN GRÁFICA
ggplot(modelo_svmlineal, highlight = TRUE) +
  labs(title = "Evolución del accuracy del modelo SVMlineal") +
  theme_bw()

stats_class_svmlineal <- data.frame(model = "SVMlineal",
  precision = conf_mat_svmlineal$overall["Accuracy"],
  FN = conf_mat_svmlineal$table[2,1],
  FP = conf_mat_svmlineal$table[1,2],
  error.rate = 1 - conf_mat_svmlineal$overall["Accuracy"],
  kappa = conf_mat_svmlineal$overall["Kappa"],
  sensibilidad = mean(conf_mat_svmlineal$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_svmlineal$byClass[,"Specificity"]),
  precisión = mean(conf_mat_svmlineal$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_svmlineal$byClass[,"Recall"]),
  f.medida = mean(conf_mat_svmlineal$byClass[,"F1"])
)
stats_class_svmlineal 
             model precision FN FP error.rate         kappa sensibilidad
Accuracy SVMlineal  0.251816 32 10   0.748184 -0.0003449006    0.2491768
         especificidad precisión recuperación  f.medida
Accuracy     0.7499779 0.2445249    0.2491768 0.2348939

2.5 Modelo Support vector machine polynomial kernel (SVM-polynomial)

Generamos el modelo SVM-polynomial.

# se recurre a validación cruzada repetida como método de validación.
# Número de particiones y repeticiones
particiones  <- 10
repeticiones <- 10


hiperparametros <- expand.grid(degree = c(2),
                               scale = c(0.1,0.2,0.3,0.5),
                               C = c(10,20,30,40))


set.seed(123)
seeds <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seeds[[i]] <- sample.int(1000, nrow(hiperparametros)) 
}
seeds[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)


# DEFINICIÓN DEL ENTRENAMIENTO
control_train <- trainControl(method = "repeatedcv", number = particiones,
                              repeats = repeticiones, seeds = seeds,
                              returnResamp = "final", verboseIter = FALSE,
                              allowParallel = TRUE)

# AJUSTE DEL MODELO
set.seed(342)
modelo_svmPoly <- caret::train(BH.staging ~ ., data = data_tn,
                        method = "svmPoly",
                        tuneGrid = hiperparametros,
                        metric = "Accuracy",
                        trControl = control_train)

modelo_svmPoly
Support Vector Machines with Polynomial Kernel 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (10 fold, repeated 10 times) 
Summary of sample sizes: 871, 871, 870, 873, 872, 870, ... 
Resampling results across tuning parameters:

  scale  C   Accuracy   Kappa      
  0.1    10  0.2349117  -0.01967680
  0.1    20  0.2346131  -0.01997535
  0.1    30  0.2343134  -0.02036599
  0.1    40  0.2345132  -0.02000844
  0.2    10  0.2342039  -0.02043187
  0.2    20  0.2368814  -0.01681812
  0.2    30  0.2382163  -0.01506727
  0.2    40  0.2365752  -0.01725708
  0.3    10  0.2378125  -0.01559064
  0.3    20  0.2372948  -0.01628814
  0.3    30  0.2362659  -0.01762581
  0.3    40  0.2373915  -0.01614189
  0.5    10  0.2367814  -0.01694943
  0.5    20  0.2374968  -0.01600440
  0.5    30  0.2377040  -0.01571126
  0.5    40  0.2379113  -0.01543251

Tuning parameter 'degree' was held constant at a value of 2
Accuracy was used to select the optimal model using the largest value.
The final values used for the model were degree = 2, scale = 0.2 and C = 30.
# Predicciones
predicciones_svmPoly <- predict(modelo_svmPoly, newdata = data_tt,
                                type = "raw")
predicciones_svmPoly
  [1] F3 F2 F1 F1 F3 F4 F3 F3 F1 F4 F1 F2 F3 F2 F4 F1 F3 F1 F2 F4 F4 F3 F2 F2 F3
 [26] F1 F3 F2 F3 F2 F1 F2 F3 F1 F2 F1 F2 F1 F1 F2 F1 F2 F3 F1 F4 F1 F2 F1 F3 F4
 [51] F2 F1 F2 F4 F2 F2 F4 F2 F2 F3 F3 F1 F4 F3 F2 F1 F4 F3 F2 F3 F2 F1 F2 F4 F4
 [76] F1 F1 F2 F3 F1 F4 F4 F2 F1 F2 F3 F1 F3 F1 F4 F4 F2 F1 F2 F3 F2 F4 F4 F1 F3
[101] F2 F2 F4 F4 F1 F3 F4 F2 F3 F1 F3 F2 F2 F3 F2 F4 F2 F2 F4 F4 F2 F4 F1 F4 F1
[126] F2 F4 F4 F4 F4 F4 F1 F1 F1 F4 F2 F2 F3 F2 F1 F3 F2 F4 F2 F3 F1 F2 F4 F4 F2
[151] F4 F4 F3 F4 F2 F2 F1 F3 F3 F4 F3 F4 F1 F2 F2 F1 F1 F3 F4 F1 F2 F1 F2 F2 F1
[176] F3 F2 F3 F4 F3 F3 F4 F1 F3 F3 F1 F4 F2 F2 F2 F2 F1 F4 F2 F3 F2 F2 F3 F3 F4
[201] F4 F2 F4 F3 F4 F3 F4 F1 F2 F3 F4 F1 F2 F4 F1 F1 F2 F4 F2 F3 F3 F3 F2 F4 F2
[226] F4 F1 F2 F3 F2 F4 F3 F1 F3 F2 F4 F1 F1 F4 F1 F1 F2 F3 F1 F1 F2 F1 F3 F4 F3
[251] F4 F2 F4 F1 F3 F4 F1 F4 F1 F3 F3 F2 F2 F2 F1 F3 F2 F2 F1 F2 F4 F2 F3 F4 F1
[276] F4 F2 F2 F2 F1 F2 F3 F1 F4 F1 F2 F4 F1 F2 F4 F4 F3 F4 F4 F4 F3 F1 F2 F4 F4
[301] F3 F1 F3 F4 F1 F1 F1 F3 F2 F2 F4 F2 F1 F4 F3 F2 F3 F2 F4 F3 F4 F2 F1 F3 F1
[326] F4 F2 F1 F2 F4 F4 F3 F3 F2 F2 F2 F4 F4 F4 F2 F3 F2 F1 F4 F4 F4 F1 F4 F2 F2
[351] F2 F1 F4 F4 F2 F4 F1 F2 F3 F1 F2 F3 F4 F4 F4 F1 F1 F3 F2 F1 F3 F4 F2 F1 F4
[376] F3 F1 F1 F2 F1 F3 F2 F1 F4 F2 F3 F4 F2 F1 F1 F3 F1 F2 F2 F2 F4 F4 F3 F1 F3
[401] F3 F3 F3 F4 F2 F1 F2 F3 F2 F1 F2 F4 F1
Levels: F1 F2 F3 F4
# Evaluación
conf_mat_svmPoly <- caret::confusionMatrix(factor(predicciones_svmPoly, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)
conf_mat_svmPoly
Confusion Matrix and Statistics

          Reference
Prediction F1 F2 F3 F4
        F1 22 21 30 26
        F2 25 32 39 25
        F3 31 14 14 29
        F4 22 32 23 28

Overall Statistics
                                          
               Accuracy : 0.2324          
                 95% CI : (0.1925, 0.2762)
    No Information Rate : 0.2615          
    P-Value [Acc > NIR] : 0.92057         
                                          
                  Kappa : -0.0226         
                                          
 Mcnemar's Test P-Value : 0.02917         

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity            0.22000   0.32323    0.1321    0.2593
Specificity            0.75399   0.71656    0.7590    0.7475
Pos Pred Value         0.22222   0.26446    0.1591    0.2667
Neg Pred Value         0.75159   0.77055    0.7169    0.7403
Prevalence             0.24213   0.23971    0.2567    0.2615
Detection Rate         0.05327   0.07748    0.0339    0.0678
Detection Prevalence   0.23971   0.29298    0.2131    0.2542
Balanced Accuracy      0.48700   0.51990    0.4455    0.5034
# REPRESENTACIÓN GRÁFICA
ggplot(modelo_svmPoly, highlight = TRUE) +
  labs(title = "Evolución del accuracy del modelo SVMpoly") +
  theme_bw()

stats_class_svmPoly <- data.frame(model         = "SVMpoly",
  precision = conf_mat_svmPoly$overall["Accuracy"],
  FN = conf_mat_svmPoly$table[2,1],
  FP = conf_mat_svmPoly$table[1,2],
  error.rate = 1 - conf_mat_svmPoly$overall["Accuracy"],
  kappa = conf_mat_svmPoly$overall["Kappa"],
  sensibilidad = mean(conf_mat_svmPoly$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_svmPoly$byClass[,"Specificity"]),
  precisión = mean(conf_mat_svmPoly$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_svmPoly$byClass[,"Recall"]),
  f.medida = mean(conf_mat_svmPoly$byClass[,"F1"])
)
stats_class_svmPoly
           model precision FN FP error.rate       kappa sensibilidad
Accuracy SVMpoly 0.2324455 25 21  0.7675545 -0.02264455    0.2336418
         especificidad precisión recuperación  f.medida
Accuracy     0.7442632 0.2281107    0.2336418 0.2298138

2.6 Modelo Support vector machine radial kernel (SVM-radial)

Generamos el modelo SVM-radial.

# se recurre a validación cruzada repetida como método de validación.
# Número de particiones y repeticiones
particiones  <- 10
repeticiones <- 10


hiperparametros <- expand.grid(sigma = c(0.1, 0.5, 3,5,10),
                               C = c(10,15,20,40,50))

set.seed(123)
seeds <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seeds[[i]] <- sample.int(1000, nrow(hiperparametros)) 
}
seeds[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)


# DEFINICIÓN DEL ENTRENAMIENTO
control_train <- trainControl(method = "repeatedcv", number = particiones,
                              repeats = repeticiones, seeds = seeds,
                              returnResamp = "final", verboseIter = FALSE,
                              allowParallel = TRUE)

# AJUSTE DEL MODELO
set.seed(342)
modelo_svmRadial <- caret::train(BH.staging ~ ., data = data_tn,
                          method = "svmRadial",
                          tuneGrid = hiperparametros,
                          metric = "Accuracy",
                          trControl = control_train)
modelo_svmRadial
Support Vector Machines with Radial Basis Function Kernel 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (10 fold, repeated 10 times) 
Summary of sample sizes: 871, 871, 870, 873, 872, 870, ... 
Resampling results across tuning parameters:

  sigma  C   Accuracy   Kappa       
   0.1   10  0.2482211  -0.002431678
   0.1   15  0.2484274  -0.002163353
   0.1   20  0.2484274  -0.002163353
   0.1   40  0.2484274  -0.002163353
   0.1   50  0.2484274  -0.002163353
   0.5   10  0.2674095   0.013904974
   0.5   15  0.2674095   0.013904974
   0.5   20  0.2674095   0.013904974
   0.5   40  0.2674095   0.013904974
   0.5   50  0.2674095   0.013904974
   3.0   10  0.2603350   0.000000000
   3.0   15  0.2603350   0.000000000
   3.0   20  0.2603350   0.000000000
   3.0   40  0.2603350   0.000000000
   3.0   50  0.2603350   0.000000000
   5.0   10  0.2603350   0.000000000
   5.0   15  0.2603350   0.000000000
   5.0   20  0.2603350   0.000000000
   5.0   40  0.2603350   0.000000000
   5.0   50  0.2603350   0.000000000
  10.0   10  0.2603350   0.000000000
  10.0   15  0.2603350   0.000000000
  10.0   20  0.2603350   0.000000000
  10.0   40  0.2603350   0.000000000
  10.0   50  0.2603350   0.000000000

Accuracy was used to select the optimal model using the largest value.
The final values used for the model were sigma = 0.5 and C = 10.
# Predicciones
predicciones_svmRadial <- predict(modelo_svmRadial, newdata = data_tt,
                                  type = "raw")

# Evaluación
conf_mat_svmRadial <- caret::confusionMatrix(factor(predicciones_svmRadial, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)
conf_mat_svmRadial
Confusion Matrix and Statistics

          Reference
Prediction F1 F2 F3 F4
        F1  7  7  6  3
        F2  3  3 11 10
        F3 36 28 40 35
        F4 54 61 49 60

Overall Statistics
                                          
               Accuracy : 0.2663          
                 95% CI : (0.2243, 0.3118)
    No Information Rate : 0.2615          
    P-Value [Acc > NIR] : 0.4299          
                                          
                  Kappa : 0.0121          
                                          
 Mcnemar's Test P-Value : <2e-16          

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity            0.07000  0.030303   0.37736    0.5556
Specificity            0.94888  0.923567   0.67752    0.4623
Pos Pred Value         0.30435  0.111111   0.28777    0.2679
Neg Pred Value         0.76154  0.751295   0.75912    0.7460
Prevalence             0.24213  0.239709   0.25666    0.2615
Detection Rate         0.01695  0.007264   0.09685    0.1453
Detection Prevalence   0.05569  0.065375   0.33656    0.5424
Balanced Accuracy      0.50944  0.476935   0.52744    0.5089
# REPRESENTACIÓN GRÁFICA
ggplot(modelo_svmRadial, highlight = TRUE) +
  labs(title = "Evolución del accuracy del modelo SVMradial") +
  theme_bw()

stats_class_svmRadial <- data.frame(model         = "SVMradial",
   precision = conf_mat_svmRadial$overall["Accuracy"],
  FN = conf_mat_svmRadial$table[2,1],
  FP = conf_mat_svmRadial$table[1,2],
  error.rate = 1 - conf_mat_svmRadial$overall["Accuracy"],
  kappa = conf_mat_svmRadial$overall["Kappa"],
  sensibilidad = mean(conf_mat_svmRadial$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_svmRadial$byClass[,"Specificity"]),
  precisión = mean(conf_mat_svmRadial$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_svmRadial$byClass[,"Recall"]),
  f.medida = mean(conf_mat_svmRadial$byClass[,"F1"])
)
stats_class_svmRadial
             model precision FN FP error.rate      kappa sensibilidad
Accuracy SVMradial 0.2663438  3  7  0.7336562 0.01208652    0.2583043
         especificidad precisión recuperación  f.medida
Accuracy      0.753067 0.2427715    0.2583043 0.2123541

2.7 Modelo Decision tree C5.0 sin hiperparámetros (C5.0)

Generamos el modelo C5.0.

# se recurre a validación cruzada repetida como método de validación.
# Número de particiones y repeticiones
particiones  <- 10
repeticiones <- 10

hiperparametros <- data.frame(parameter = "none")


set.seed(123)
seeds <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seeds[[i]] <- sample.int(1000, nrow(hiperparametros)) 
}
seeds[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)


# DEFINICIÓN DEL ENTRENAMIENTO
control_train <- trainControl(method = "repeatedcv", number = particiones,
                              repeats = repeticiones, seeds = seeds,
                              returnResamp = "final", verboseIter = FALSE,
                              allowParallel = TRUE)

# AJUSTE DEL MODELO
set.seed(342)
modelo_C5.0Tree <- caret::train(BH.staging ~ ., data = data_tn,
                         method = "C5.0Tree",
                         tuneGrid = hiperparametros,
                         metric = "Accuracy",
                         trControl = control_train)
modelo_C5.0Tree
Single C5.0 Tree 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (10 fold, repeated 10 times) 
Summary of sample sizes: 871, 871, 870, 873, 872, 870, ... 
Resampling results:

  Accuracy   Kappa      
  0.2475711  -0.00405449
summary(modelo_C5.0Tree$finalModel)

Call:
C50:::C5.0.default(x = x, y = y, weights = wts)


C5.0 [Release 2.07 GPL Edition]     Mon Apr 24 12:24:29 2023
-------------------------------

Class specified by attribute `outcome'

Read 968 cases (16 attributes) from undefined.data

Decision tree:

BMI <= 0.4615385:
:...AST.1 > 0.7640449:
:   :...ALT.1 <= 0.05617978:
:   :   :...RBC <= 0.6272686: F3 (6)
:   :   :   RBC > 0.6272686: F1 (4)
:   :   ALT.1 > 0.05617978:
:   :   :...ALT.48 <= 0.08988764:
:   :       :...RNA.4 <= 0.4694727:
:   :       :   :...ALT.4 <= 0.5168539: F4 (4/1)
:   :       :   :   ALT.4 > 0.5168539: F3 (2)
:   :       :   RNA.4 > 0.4694727:
:   :       :   :...RBC <= 0.7754056: F2 (4/1)
:   :       :       RBC > 0.7754056: F4 (4)
:   :       ALT.48 > 0.08988764:
:   :       :...RNA.4 > 0.8480108:
:   :           :...ALT.24 <= 0.6179775: F4 (2)
:   :           :   ALT.24 > 0.6179775:
:   :           :   :...WBC <= 0.6020856: F1 (6/1)
:   :           :       WBC > 0.6020856: F3 (2)
:   :           RNA.4 <= 0.8480108:
:   :           :...Age > 0.4827586:
:   :               :...RBC > 0.8265383: F3 (3/1)
:   :               :   RBC <= 0.8265383:
:   :               :   :...ALT.12 <= 0.3033708: F3 (9/1)
:   :               :       ALT.12 > 0.3033708:
:   :               :       :...Plat > 0.6226405: F2 (13)
:   :               :           Plat <= 0.6226405:
:   :               :           :...ALT.1 > 0.6179775: F3 (5)
:   :               :               ALT.1 <= 0.6179775:
:   :               :               :...ALT.1 <= 0.4269663: F3 (2)
:   :               :                   ALT.1 > 0.4269663: F2 (4)
:   :               Age <= 0.4827586:
:   :               :...ALT.36 > 0.7865168:
:   :                   :...BMI <= 0.1538462: F4 (4/1)
:   :                   :   BMI > 0.1538462: F3 (3)
:   :                   ALT.36 <= 0.7865168:
:   :                   :...ALT.after.24.w > 0.7826087: F2 (4)
:   :                       ALT.after.24.w <= 0.7826087:
:   :                       :...Age > 0.3448276:
:   :                           :...RNA.Base <= 0.6924855: F1 (5/1)
:   :                           :   RNA.Base > 0.6924855: F4 (4/1)
:   :                           Age <= 0.3448276:
:   :                           :...ALT.1 > 0.752809: F1 (3/1)
:   :                               ALT.1 <= 0.752809:
:   :                               :...RNA.4 <= 0.373249: F1 (3/1)
:   :                                   RNA.4 > 0.373249:
:   :                                   :...ALT.24 <= 0.7191011: F2 (8/1)
:   :                                       ALT.24 > 0.7191011: F3 (2)
:   AST.1 <= 0.7640449:
:   :...ALT.12 <= 0.04494382:
:       :...ALT.after.24.w <= 0.08695652: F2 (3/1)
:       :   ALT.after.24.w > 0.08695652:
:       :   :...RBC <= 0.4163593: F1 (3/1)
:       :       RBC > 0.4163593:
:       :       :...ALT.4 <= 0.2134831: F1 (3/1)
:       :           ALT.4 > 0.2134831: F3 (8)
:       ALT.12 > 0.04494382:
:       :...ALT.after.24.w <= 0.4782609:
:           :...Age <= 0.06896552:
:           :   :...Plat > 0.6581442: F1 (4)
:           :   :   Plat <= 0.6581442:
:           :   :   :...Plat > 0.4399442: F4 (4)
:           :   :       Plat <= 0.4399442:
:           :   :       :...Age > 0.03448276: F4 (2)
:           :   :           Age <= 0.03448276:
:           :   :           :...ALT.1 <= 0.6853933: F1 (7/1)
:           :   :               ALT.1 > 0.6853933: F4 (3/1)
:           :   Age > 0.06896552:
:           :   :...ALT.36 <= 0.08988764:
:           :       :...RNA.Base <= 0.3228641: F2 (4)
:           :       :   RNA.Base > 0.3228641: F4 (4/1)
:           :       ALT.36 > 0.08988764:
:           :       :...Plat <= 0.05252864:
:           :           :...ALT.1 <= 0.1460674: F3 (3)
:           :           :   ALT.1 > 0.1460674: F2 (3)
:           :           Plat > 0.05252864:
:           :           :...ALT.1 > 0.752809:
:           :               :...RNA.4 > 0.7888218:
:           :               :   :...Age <= 0.4137931: F2 (5)
:           :               :   :   Age > 0.4137931: F1 (3/1)
:           :               :   RNA.4 <= 0.7888218:
:           :               :   :...RBC <= 0.3398761: F3 (5/1)
:           :               :       RBC > 0.3398761:
:           :               :       :...ALT.24 <= 0.1011236: F3 (2)
:           :               :           ALT.24 > 0.1011236:
:           :               :           :...ALT.4 <= 0.1573034: F2 (2)
:           :               :               ALT.4 > 0.1573034:
:           :               :               :...ALT.48 <= 0.6516854: F1 (14/1)
:           :               :                   ALT.48 > 0.6516854:
:           :               :                   :...WBC > 0.4070252: F4 (4)
:           :               :                       WBC <= 0.4070252:
:           :               :                       :...Age <= 0.6896552: F2 (2)
:           :               :                           Age > 0.6896552: F1 (2)
:           :               ALT.1 <= 0.752809:
:           :               :...ALT.4 > 0.9325843: F2 (5/1)
:           :                   ALT.4 <= 0.9325843:
:           :                   :...Plat > 0.812478:
:           :                       :...RNA.4 <= 0.2695684:
:           :                       :   :...WBC <= 0.3960483: F4 (2)
:           :                       :   :   WBC > 0.3960483: F3 (3)
:           :                       :   RNA.4 > 0.2695684:
:           :                       :   :...ALT.4 <= 0.7191011:
:           :                       :       :...WBC <= 0.2881449: F3 (2)
:           :                       :       :   WBC > 0.2881449: F1 (9/1)
:           :                       :       ALT.4 > 0.7191011:
:           :                       :       :...WBC <= 0.5615807: F1 (2)
:           :                       :           WBC > 0.5615807: F4 (2)
:           :                       Plat <= 0.812478:
:           :                       :...ALT.12 <= 0.4831461:
:           :                           :...RNA.4 <= 0.1410989: F4 (5)
:           :                           :   RNA.4 > 0.1410989:
:           :                           :   :...Plat <= 0.1263235: F1 (3/1)
:           :                           :       Plat > 0.1263235:
:           :                           :       :...WBC > 0.5037321:
:           :                           :           :...ALT.12 <= 0.2134831: F4 (2)
:           :                           :           :   ALT.12 > 0.2134831: [S1]
:           :                           :           WBC <= 0.5037321:
:           :                           :           :...ALT.48 > 0.8089887: F2 (3)
:           :                           :               ALT.48 <= 0.8089887:
:           :                           :               :...ALT.1 <= 0.3033708: [S2]
:           :                           :                   ALT.1 > 0.3033708: [S3]
:           :                           ALT.12 > 0.4831461:
:           :                           :...Plat > 0.6268818:
:           :                               :...RNA.4 <= 0.1373751: F2 (2)
:           :                               :   RNA.4 > 0.1373751: F4 (14/2)
:           :                               Plat <= 0.6268818:
:           :                               :...ALT.12 > 0.7865168:
:           :                                   :...RBC <= 0.8629725: F1 (7)
:           :                                   :   RBC > 0.8629725: F3 (2)
:           :                                   ALT.12 <= 0.7865168:
:           :                                   :...ALT.24 > 0.8426966:
:           :                                       :...ALT.12 <= 0.5842696: F1 (3)
:           :                                       :   ALT.12 > 0.5842696: F4 (2)
:           :                                       ALT.24 <= 0.8426966:
:           :                                       :...RNA.Base <= 0.1421885: F3 (3)
:           :                                           RNA.Base > 0.1421885: [S4]
:           ALT.after.24.w > 0.4782609:
:           :...ALT.12 > 0.7640449:
:               :...ALT.after.24.w > 0.9565217:
:               :   :...ALT.36 <= 0.4269663: F3 (3)
:               :   :   ALT.36 > 0.4269663:
:               :   :   :...Age <= 0.1724138: F3 (2)
:               :   :       Age > 0.1724138: F4 (2)
:               :   ALT.after.24.w <= 0.9565217:
:               :   :...WBC > 0.8446762:
:               :       :...ALT.24 <= 0.3820225: F1 (2)
:               :       :   ALT.24 > 0.3820225: F3 (4)
:               :       WBC <= 0.8446762:
:               :       :...Plat > 0.8774456: F1 (4)
:               :           Plat <= 0.8774456:
:               :           :...ALT.4 <= 0.3820225:
:               :               :...WBC <= 0.8316136: F1 (8/1)
:               :               :   WBC > 0.8316136: F4 (2)
:               :               ALT.4 > 0.3820225:
:               :               :...RBC <= 0.1343212: F3 (3/1)
:               :                   RBC > 0.1343212: F4 (12/1)
:               ALT.12 <= 0.7640449:
:               :...RBC > 0.8252838:
:                   :...Plat <= 0.5872193:
:                   :   :...ALT.after.24.w <= 0.8695652: F3 (8/1)
:                   :   :   ALT.after.24.w > 0.8695652: F1 (4/1)
:                   :   Plat > 0.5872193:
:                   :   :...ALT.24 > 0.2808989: F2 (10/2)
:                   :       ALT.24 <= 0.2808989:
:                   :       :...RBC <= 0.8555975: F3 (2)
:                   :           RBC > 0.8555975: F4 (2)
:                   RBC <= 0.8252838:
:                   :...AST.1 <= 0.07865169:
:                       :...ALT.4 <= 0.8764045: F4 (13/2)
:                       :   ALT.4 > 0.8764045: F1 (2)
:                       AST.1 > 0.07865169:
:                       :...ALT.24 > 0.6629214:
:                           :...ALT.36 > 0.5168539: F4 (14/4)
:                           :   ALT.36 <= 0.5168539:
:                           :   :...ALT.after.24.w <= 0.8260869:
:                           :       :...AST.1 <= 0.3370787: F3 (3)
:                           :       :   AST.1 > 0.3370787: F1 (5/1)
:                           :       ALT.after.24.w > 0.8260869:
:                           :       :...RNA.Base <= 0.2988623: F1 (2/1)
:                           :           RNA.Base > 0.2988623: F4 (6/1)
:                           ALT.24 <= 0.6629214:
:                           :...ALT.12 <= 0.4269663:
:                               :...ALT.1 <= 0.4157303:
:                               :   :...RBC > 0.3016891: F3 (7/1)
:                               :   :   RBC <= 0.3016891:
:                               :   :   :...WBC <= 0.5536773: F1 (3)
:                               :   :       WBC > 0.5536773: F2 (2)
:                               :   ALT.1 > 0.4157303:
:                               :   :...Age <= 0.5517241: F1 (9/2)
:                               :       Age > 0.5517241:
:                               :       :...ALT.1 <= 0.8539326: F4 (6/1)
:                               :           ALT.1 > 0.8539326: F3 (2)
:                               ALT.12 > 0.4269663:
:                               :...ALT.48 <= 0.4494382:
:                                   :...ALT.4 > 0.9101124: F3 (2)
:                                   :   ALT.4 <= 0.9101124:
:                                   :   :...ALT.after.24.w <= 0.9130435: F4 (11/2)
:                                   :       ALT.after.24.w > 0.9130435: F2 (2)
:                                   ALT.48 > 0.4494382:
:                                   :...ALT.36 <= 0.02247191: F4 (2)
:                                       ALT.36 > 0.02247191:
:                                       :...ALT.24 > 0.505618:
:                                           :...Age <= 0.3448276: F4 (2)
:                                           :   Age > 0.3448276: F2 (2)
:                                           ALT.24 <= 0.505618:
:                                           :...ALT.after.24.w > 0.8260869:
:                                               :...ALT.12 <= 0.5505618: F2 (3)
:                                               :   ALT.12 > 0.5505618: F1 (3/1)
:                                               ALT.after.24.w <= 0.8260869:
:                                               :...ALT.36 > 0.6629214: F3 (4)
:                                                   ALT.36 <= 0.6629214: [S5]
BMI > 0.4615385:
:...Plat > 0.971068:
    :...Age <= 0.5862069: F2 (7/1)
    :   Age > 0.5862069:
    :   :...ALT.12 <= 0.6292135: F3 (4/1)
    :       ALT.12 > 0.6292135: F2 (2)
    Plat <= 0.971068:
    :...Age > 0.5517241:
        :...RNA.4 <= 0.4070092:
        :   :...BMI <= 0.5384616:
        :   :   :...RNA.4 <= 0.04654451: F1 (2)
        :   :   :   RNA.4 > 0.04654451:
        :   :   :   :...RNA.4 > 0.2394163: F4 (2)
        :   :   :       RNA.4 <= 0.2394163:
        :   :   :       :...Age <= 0.6896552: F2 (3/1)
        :   :   :           Age > 0.6896552: F3 (4)
        :   :   BMI > 0.5384616:
        :   :   :...ALT.48 > 0.741573:
        :   :       :...Age <= 0.7586207:
        :   :       :   :...ALT.1 <= 0.8089887: F4 (6)
        :   :       :   :   ALT.1 > 0.8089887: F1 (2)
        :   :       :   Age > 0.7586207:
        :   :       :   :...RBC <= 0.2869931: F1 (3/1)
        :   :       :       RBC > 0.2869931: F2 (5/1)
        :   :       ALT.48 <= 0.741573:
        :   :       :...Age > 0.7931035:
        :   :           :...ALT.after.24.w <= 0.04347826: F1 (2)
        :   :           :   ALT.after.24.w > 0.04347826:
        :   :           :   :...AST.1 <= 0.5168539: F2 (10)
        :   :           :       AST.1 > 0.5168539:
        :   :           :       :...ALT.24 <= 0.2696629: F3 (3/1)
        :   :           :           ALT.24 > 0.2696629: F2 (7/2)
        :   :           Age <= 0.7931035:
        :   :           :...ALT.24 > 0.9101124: F1 (4/1)
        :   :               ALT.24 <= 0.9101124:
        :   :               :...ALT.36 > 0.3707865:
        :   :                   :...RNA.4 <= 0.3351882: F2 (14/1)
        :   :                   :   RNA.4 > 0.3351882: F1 (3/1)
        :   :                   ALT.36 <= 0.3707865:
        :   :                   :...BMI > 0.9230769: F1 (2/1)
        :   :                       BMI <= 0.9230769:
        :   :                       :...Plat <= 0.394347: F4 (3)
        :   :                           Plat > 0.394347: F1 (5/1)
        :   RNA.4 > 0.4070092:
        :   :...Plat > 0.8752651:
        :       :...BMI <= 0.6923077: F1 (2/1)
        :       :   BMI > 0.6923077: F2 (6)
        :       Plat <= 0.8752651:
        :       :...BMI > 0.7692308:
        :           :...ALT.1 <= 0.3932584:
        :           :   :...BMI <= 0.8461539:
        :           :   :   :...ALT.24 <= 0.5280899: F1 (3/1)
        :           :   :   :   ALT.24 > 0.5280899: F2 (5)
        :           :   :   BMI > 0.8461539:
        :           :   :   :...ALT.after.24.w <= 0.6521739:
        :           :   :       :...ALT.4 <= 0.7191011: F3 (8/1)
        :           :   :       :   ALT.4 > 0.7191011: F1 (4)
        :           :   :       ALT.after.24.w > 0.6521739:
        :           :   :       :...ALT.1 <= 0.3033708: F2 (5/1)
        :           :   :           ALT.1 > 0.3033708: F1 (2)
        :           :   ALT.1 > 0.3932584:
        :           :   :...ALT.1 <= 0.7752809:
        :           :       :...WBC <= 0.2667398: F2 (3/1)
        :           :       :   WBC > 0.2667398: F4 (7/1)
        :           :       ALT.1 > 0.7752809:
        :           :       :...Plat <= 0.3123768: F2 (2)
        :           :           Plat > 0.3123768:
        :           :           :...ALT.4 > 0.1235955: F3 (6)
        :           :               ALT.4 <= 0.1235955:
        :           :               :...Plat <= 0.6354542: F4 (3)
        :           :                   Plat > 0.6354542: F1 (2/1)
        :           BMI <= 0.7692308:
        :           :...RBC > 0.917794:
        :               :...ALT.12 <= 0.4831461: F2 (3)
        :               :   ALT.12 > 0.4831461: F1 (2/1)
        :               RBC <= 0.917794:
        :               :...Age <= 0.5862069:
        :                   :...ALT.12 > 0.5955056: F3 (2)
        :                   :   ALT.12 <= 0.5955056:
        :                   :   :...ALT.4 <= 0.752809: F1 (2/1)
        :                   :       ALT.4 > 0.752809: F2 (2)
        :                   Age > 0.5862069:
        :                   :...RNA.Base > 0.7824873:
        :                       :...ALT.1 <= 0.4494382: F4 (4/1)
        :                       :   ALT.1 > 0.4494382: F1 (2)
        :                       RNA.Base <= 0.7824873:
        :                       :...WBC > 0.6543359:
        :                           :...Age <= 0.7241379: F3 (5)
        :                           :   Age > 0.7241379:
        :                           :   :...WBC <= 0.8279912: F3 (3)
        :                           :       WBC > 0.8279912:
        :                           :       :...ALT.4 <= 0.3370787: F1 (5)
        :                           :           ALT.4 > 0.3370787: F3 (3/1)
        :                           WBC <= 0.6543359:
        :                           :...ALT.4 > 0.7865168: F4 (3)
        :                               ALT.4 <= 0.7865168:
        :                               :...ALT.48 <= 0.1910112: F4 (4/1)
        :                                   ALT.48 > 0.1910112:
        :                                   :...RBC > 0.61062: F1 (3)
        :                                       RBC <= 0.61062: [S6]
        Age <= 0.5517241:
        :...ALT.36 <= 0.01123596:
            :...ALT.48 <= 0.6404495: F2 (5)
            :   ALT.48 > 0.6404495: F4 (2)
            ALT.36 > 0.01123596:
            :...ALT.36 <= 0.05617978:
                :...RNA.Base <= 0.5175647: F3 (5)
                :   RNA.Base > 0.5175647: F4 (5/1)
                ALT.36 > 0.05617978:
                :...BMI <= 0.6153846:
                    :...ALT.24 > 0.8426966: F4 (11/2)
                    :   ALT.24 <= 0.8426966:
                    :   :...RNA.4 <= 0.3422182:
                    :       :...ALT.1 > 0.741573: F1 (5)
                    :       :   ALT.1 <= 0.741573:
                    :       :   :...ALT.24 <= 0.1685393: F1 (2)
                    :       :       ALT.24 > 0.1685393:
                    :       :       :...BMI <= 0.5384616: F3 (5/1)
                    :       :           BMI > 0.5384616: F2 (5/1)
                    :       RNA.4 > 0.3422182:
                    :       :...Plat <= 0.05295577: F1 (3)
                    :           Plat > 0.05295577:
                    :           :...AST.1 > 0.8651685: F2 (7)
                    :               AST.1 <= 0.8651685:
                    :               :...ALT.1 <= 0.4269663:
                    :                   :...Plat > 0.7610209: F2 (5)
                    :                   :   Plat <= 0.7610209:
                    :                   :   :...RBC <= 0.4778271: F2 (2)
                    :                   :       RBC > 0.4778271: F3 (6)
                    :                   ALT.1 > 0.4269663:
                    :                   :...ALT.48 > 0.8314607: F2 (2)
                    :                       ALT.48 <= 0.8314607:
                    :                       :...Age <= 0.1724138:
                    :                           :...Plat <= 0.5160921: F4 (6)
                    :                           :   Plat > 0.5160921: F1 (2)
                    :                           Age > 0.1724138:
                    :                           :...WBC <= 0.3376509: F3 (3/1)
                    :                               WBC > 0.3376509: F4 (5/1)
                    BMI > 0.6153846:
                    :...AST.1 <= 0.247191:
                        :...ALT.48 <= 0.2247191:
                        :   :...Age > 0.2068966: F1 (7/1)
                        :   :   Age <= 0.2068966:
                        :   :   :...ALT.24 <= 0.5280899: F3 (4)
                        :   :       ALT.24 > 0.5280899: F2 (4/1)
                        :   ALT.48 > 0.2247191:
                        :   :...Age <= 0.03448276:
                        :       :...ALT.48 > 0.6966292: F2 (3)
                        :       :   ALT.48 <= 0.6966292:
                        :       :   :...ALT.1 <= 0.6966292: F1 (2)
                        :       :       ALT.1 > 0.6966292: F3 (2)
                        :       Age > 0.03448276:
                        :       :...Plat <= 0.1174064: F3 (8/1)
                        :           Plat > 0.1174064:
                        :           :...ALT.24 <= 0.3033708:
                        :               :...Plat <= 0.3844932: F4 (3/1)
                        :               :   Plat > 0.3844932: F3 (8)
                        :               ALT.24 > 0.3033708:
                        :               :...ALT.24 <= 0.5955056: F4 (4)
                        :                   ALT.24 > 0.5955056:
                        :                   :...AST.1 > 0.1460674: F3 (3)
                        :                       AST.1 <= 0.1460674:
                        :                       :...ALT.12 <= 0.8539326: F4 (6)
                        :                           ALT.12 > 0.8539326: F3 (2)
                        AST.1 > 0.247191:
                        :...RNA.4 > 0.9682636:
                            :...AST.1 <= 0.8876405: F2 (5/1)
                            :   AST.1 > 0.8876405: F3 (2)
                            RNA.4 <= 0.9682636:
                            :...AST.1 <= 0.2808989:
                                :...ALT.36 <= 0.7977528: F2 (6/1)
                                :   ALT.36 > 0.7977528: F1 (4/1)
                                AST.1 > 0.2808989:
                                :...ALT.24 <= 0.3483146:
                                    :...AST.1 > 0.7078652:
                                    :   :...ALT.1 > 0.4269663: F4 (12/1)
                                    :   :   ALT.1 <= 0.4269663:
                                    :   :   :...AST.1 <= 0.8988764: F4 (2)
                                    :   :       AST.1 > 0.8988764: F1 (6/1)
                                    :   AST.1 <= 0.7078652:
                                    :   :...BMI > 0.9230769: F2 (3/1)
                                    :       BMI <= 0.9230769:
                                    :       :...ALT.24 <= 0.03370786: F2 (2)
                                    :           ALT.24 > 0.03370786:
                                    :           :...ALT.12 <= 0.08988764: F4 (4)
                                    :               ALT.12 > 0.08988764:
                                    :               :...Age <= 0.03448276: F4 (2)
                                    :                   Age > 0.03448276: [S7]
                                    ALT.24 > 0.3483146:
                                    :...Plat <= 0.1051622:
                                        :...Age <= 0.3103448: F2 (4/1)
                                        :   Age > 0.3103448: F4 (4)
                                        Plat > 0.1051622:
                                        :...RNA.Base <= 0.4264929:
                                            :...RBC > 0.903514: F2 (2)
                                            :   RBC <= 0.903514:
                                            :   :...ALT.24 <= 0.6629214: F1 (8)
                                            :       ALT.24 > 0.6629214:
                                            :       :...AST.1 > 0.8988764: F1 (4)
                                            :           AST.1 <= 0.8988764: [S8]
                                            RNA.Base > 0.4264929:
                                            :...ALT.24 <= 0.4044944: F2 (3)
                                                ALT.24 > 0.4044944:
                                                :...RNA.4 <= 0.3203851: F3 (10/1)
                                                    RNA.4 > 0.3203851:
                                                    :...RBC > 0.7659233:
                                                        :...BMI <= 0.9230769: F3 (4)
                                                        :   BMI > 0.9230769: F1 (2/1)
                                                        RBC <= 0.7659233:
                                                        :...WBC > 0.4096597: [S9]
                                                            WBC <= 0.4096597: [S10]

SubTree [S1]

ALT.36 <= 0.494382: F4 (3/1)
ALT.36 > 0.494382: F2 (5)

SubTree [S2]

ALT.4 <= 0.3707865: F3 (2)
ALT.4 > 0.3707865: F2 (3/1)

SubTree [S3]

ALT.after.24.w <= 0.1304348: F4 (2)
ALT.after.24.w > 0.1304348: F1 (4/1)

SubTree [S4]

ALT.24 > 0.7865168: F3 (2)
ALT.24 <= 0.7865168:
:...AST.1 <= 0.3483146: F4 (9)
    AST.1 > 0.3483146:
    :...ALT.after.24.w <= 0.2608696: F3 (2)
        ALT.after.24.w > 0.2608696: F4 (5/1)

SubTree [S5]

ALT.after.24.w > 0.7826087: F3 (2)
ALT.after.24.w <= 0.7826087:
:...ALT.12 <= 0.5842696: F2 (6/1)
    ALT.12 > 0.5842696:
    :...BMI <= 0.2307692: F2 (2/1)
        BMI > 0.2307692:
        :...ALT.4 <= 0.6629214: F1 (2)
            ALT.4 > 0.6629214: F3 (2)

SubTree [S6]

ALT.after.24.w <= 0.8695652: F3 (8/1)
ALT.after.24.w > 0.8695652: F1 (4/1)

SubTree [S7]

ALT.1 <= 0.3258427: F3 (3/1)
ALT.1 > 0.3258427:
:...ALT.36 <= 0.6853933: F1 (7)
    ALT.36 > 0.6853933: F3 (3/1)

SubTree [S8]

AST.1 <= 0.3483146: F1 (2)
AST.1 > 0.3483146: F3 (11/2)

SubTree [S9]

RNA.Base <= 0.7343804: F2 (3)
RNA.Base > 0.7343804: F1 (5/1)

SubTree [S10]

BMI <= 0.7692308: F4 (2)
BMI > 0.7692308:
:...AST.1 <= 0.741573: F4 (2)
    AST.1 > 0.741573: F2 (2)


Evaluation on training data (968 cases):

        Decision Tree   
      ----------------  
      Size      Errors  

       229  106(11.0%)   <<


       (a)   (b)   (c)   (d)    <-classified as
      ----  ----  ----  ----
       207     7     7    14    (a): class F1
         8   211     5     8    (b): class F2
        14    10   218     7    (c): class F3
        13     6     7   226    (d): class F4


    Attribute usage:

    100.00% BMI
     78.00% Age
     75.83% AST.1
     75.31% Plat
     60.23% RNA.4
     58.06% ALT.36
     48.24% ALT.after.24.w
     47.73% ALT.12
     47.52% ALT.24
     46.18% ALT.1
     39.88% RBC
     35.74% ALT.48
     27.38% ALT.4
     17.56% WBC
     16.53% RNA.Base


Time: 0.0 secs
#ggplot(modelo_C5.0Tree, highlight = TRUE) +
 # labs(title = "Evolución del accuracy del modelo") +
  #theme_bw()

# Predicciones
predicciones_C5.0Tree <- predict(modelo_C5.0Tree, newdata = data_tt,
                                 type = "raw")

# Evaluación
conf_mat_C5.0Tree <- caret::confusionMatrix(factor(predicciones_C5.0Tree, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)
conf_mat_C5.0Tree
Confusion Matrix and Statistics

          Reference
Prediction F1 F2 F3 F4
        F1 25 21 19 30
        F2 17 24 30 24
        F3 31 27 24 27
        F4 27 27 33 27

Overall Statistics
                                          
               Accuracy : 0.2421          
                 95% CI : (0.2016, 0.2864)
    No Information Rate : 0.2615          
    P-Value [Acc > NIR] : 0.8292          
                                          
                  Kappa : -0.0115         
                                          
 Mcnemar's Test P-Value : 0.6236          

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity            0.25000   0.24242   0.22642   0.25000
Specificity            0.77636   0.77389   0.72313   0.71475
Pos Pred Value         0.26316   0.25263   0.22018   0.23684
Neg Pred Value         0.76415   0.76415   0.73026   0.72910
Prevalence             0.24213   0.23971   0.25666   0.26150
Detection Rate         0.06053   0.05811   0.05811   0.06538
Detection Prevalence   0.23002   0.23002   0.26392   0.27603
Balanced Accuracy      0.51318   0.50815   0.47477   0.48238
stats_class_C5.0Tree <- data.frame(model         = "C5.0Tree",
   precision = conf_mat_C5.0Tree$overall["Accuracy"],
  FN = conf_mat_C5.0Tree$table[2,1],
  FP = conf_mat_C5.0Tree$table[1,2],
  error.rate = 1 - conf_mat_C5.0Tree$overall["Accuracy"],
  kappa = conf_mat_C5.0Tree$overall["Kappa"],
  sensibilidad = mean(conf_mat_C5.0Tree$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_C5.0Tree$byClass[,"Specificity"]),
  precisión = mean(conf_mat_C5.0Tree$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_C5.0Tree$byClass[,"Recall"]),
  f.medida = mean(conf_mat_C5.0Tree$byClass[,"F1"])
)
stats_class_C5.0Tree
            model precision FN FP error.rate       kappa sensibilidad
Accuracy C5.0Tree 0.2421308 17 21  0.7578692 -0.01151035    0.2422098
         especificidad precisión recuperación f.medida
Accuracy     0.7470311 0.2432038    0.2422098 0.242583

2.8 Modelo Decision tree C5.0 con hiperparámetros (C5.0)

Generamos el modelo C5.0.

# se recurre a validación cruzada repetida como método de validación.
# Número de particiones y repeticiones
particiones  <- 10
repeticiones <- 10


hiperparametros <- expand.grid(trials = c(15:20),
                               model = "tree",
                               winnow = c(FALSE))

set.seed(123)
seeds <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seeds[[i]] <- sample.int(1000, nrow(hiperparametros)) 
}
seeds[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)


# DEFINICIÓN DEL ENTRENAMIENTO
control_train <- trainControl(method = "repeatedcv", number = particiones,
                              repeats = repeticiones, seeds = seeds,
                              returnResamp = "final", verboseIter = FALSE,
                              allowParallel = TRUE)

# AJUSTE DEL MODELO
set.seed(342)
modelo_C5.0 <- caret::train(BH.staging ~ ., data = data_tn,
                     method = "C5.0",
                     tuneGrid = hiperparametros,
                     metric = "Accuracy",
                     trControl = control_train)
modelo_C5.0
C5.0 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (10 fold, repeated 10 times) 
Summary of sample sizes: 871, 871, 870, 873, 872, 870, ... 
Resampling results across tuning parameters:

  trials  Accuracy   Kappa      
  15      0.2251110  -0.03415999
  16      0.2282371  -0.03002798
  17      0.2246499  -0.03485805
  18      0.2267852  -0.03207986
  19      0.2271063  -0.03160798
  20      0.2251228  -0.03427994

Tuning parameter 'model' was held constant at a value of tree
Tuning
 parameter 'winnow' was held constant at a value of FALSE
Accuracy was used to select the optimal model using the largest value.
The final values used for the model were trials = 16, model = tree and winnow
 = FALSE.
summary(modelo_C5.0$finalModel)

Call:
(function (x, y, trials = 1, rules = FALSE, weights = NULL, control
 fuzzyThreshold = FALSE, sample = 0, earlyStopping = TRUE, label =
 "outcome", seed = 680L))


C5.0 [Release 2.07 GPL Edition]     Mon Apr 24 12:25:33 2023
-------------------------------

Class specified by attribute `outcome'

Read 968 cases (16 attributes) from undefined.data

-----  Trial 0:  -----

Decision tree:

BMI <= 0.4615385:
:...AST.1 > 0.7640449:
:   :...ALT.1 <= 0.05617978:
:   :   :...RBC <= 0.6272686: F3 (6)
:   :   :   RBC > 0.6272686: F1 (4)
:   :   ALT.1 > 0.05617978:
:   :   :...ALT.48 <= 0.08988764:
:   :       :...RNA.4 <= 0.4694727:
:   :       :   :...ALT.4 <= 0.5168539: F4 (4/1)
:   :       :   :   ALT.4 > 0.5168539: F3 (2)
:   :       :   RNA.4 > 0.4694727:
:   :       :   :...RBC <= 0.7754056: F2 (4/1)
:   :       :       RBC > 0.7754056: F4 (4)
:   :       ALT.48 > 0.08988764:
:   :       :...RNA.4 > 0.8480108:
:   :           :...ALT.24 <= 0.6179775: F4 (2)
:   :           :   ALT.24 > 0.6179775:
:   :           :   :...WBC <= 0.6020856: F1 (6/1)
:   :           :       WBC > 0.6020856: F3 (2)
:   :           RNA.4 <= 0.8480108:
:   :           :...Age > 0.4827586:
:   :               :...RBC > 0.8265383: F3 (3/1)
:   :               :   RBC <= 0.8265383:
:   :               :   :...ALT.12 <= 0.3033708: F3 (9/1)
:   :               :       ALT.12 > 0.3033708:
:   :               :       :...Plat > 0.6226405: F2 (13)
:   :               :           Plat <= 0.6226405:
:   :               :           :...ALT.1 > 0.6179775: F3 (5)
:   :               :               ALT.1 <= 0.6179775:
:   :               :               :...ALT.1 <= 0.4269663: F3 (2)
:   :               :                   ALT.1 > 0.4269663: F2 (4)
:   :               Age <= 0.4827586:
:   :               :...ALT.36 > 0.7865168:
:   :                   :...BMI <= 0.1538462: F4 (4/1)
:   :                   :   BMI > 0.1538462: F3 (3)
:   :                   ALT.36 <= 0.7865168:
:   :                   :...ALT.after.24.w > 0.7826087: F2 (4)
:   :                       ALT.after.24.w <= 0.7826087:
:   :                       :...Age > 0.3448276:
:   :                           :...RNA.Base <= 0.6924855: F1 (5/1)
:   :                           :   RNA.Base > 0.6924855: F4 (4/1)
:   :                           Age <= 0.3448276:
:   :                           :...ALT.1 > 0.752809: F1 (3/1)
:   :                               ALT.1 <= 0.752809:
:   :                               :...RNA.4 <= 0.373249: F1 (3/1)
:   :                                   RNA.4 > 0.373249:
:   :                                   :...ALT.24 <= 0.7191011: F2 (8/1)
:   :                                       ALT.24 > 0.7191011: F3 (2)
:   AST.1 <= 0.7640449:
:   :...ALT.12 <= 0.04494382:
:       :...ALT.after.24.w <= 0.08695652: F2 (3/1)
:       :   ALT.after.24.w > 0.08695652:
:       :   :...RBC <= 0.4163593: F1 (3/1)
:       :       RBC > 0.4163593:
:       :       :...ALT.4 <= 0.2134831: F1 (3/1)
:       :           ALT.4 > 0.2134831: F3 (8)
:       ALT.12 > 0.04494382:
:       :...ALT.after.24.w <= 0.4782609:
:           :...Age <= 0.06896552:
:           :   :...Plat > 0.6581442: F1 (4)
:           :   :   Plat <= 0.6581442:
:           :   :   :...Plat > 0.4399442: F4 (4)
:           :   :       Plat <= 0.4399442:
:           :   :       :...Age > 0.03448276: F4 (2)
:           :   :           Age <= 0.03448276:
:           :   :           :...ALT.1 <= 0.6853933: F1 (7/1)
:           :   :               ALT.1 > 0.6853933: F4 (3/1)
:           :   Age > 0.06896552:
:           :   :...ALT.36 <= 0.08988764:
:           :       :...RNA.Base <= 0.3228641: F2 (4)
:           :       :   RNA.Base > 0.3228641: F4 (4/1)
:           :       ALT.36 > 0.08988764:
:           :       :...Plat <= 0.05252864:
:           :           :...ALT.1 <= 0.1460674: F3 (3)
:           :           :   ALT.1 > 0.1460674: F2 (3)
:           :           Plat > 0.05252864:
:           :           :...ALT.1 > 0.752809:
:           :               :...RNA.4 > 0.7888218:
:           :               :   :...Age <= 0.4137931: F2 (5)
:           :               :   :   Age > 0.4137931: F1 (3/1)
:           :               :   RNA.4 <= 0.7888218:
:           :               :   :...RBC <= 0.3398761: F3 (5/1)
:           :               :       RBC > 0.3398761:
:           :               :       :...ALT.24 <= 0.1011236: F3 (2)
:           :               :           ALT.24 > 0.1011236:
:           :               :           :...ALT.4 <= 0.1573034: F2 (2)
:           :               :               ALT.4 > 0.1573034:
:           :               :               :...ALT.48 <= 0.6516854: F1 (14/1)
:           :               :                   ALT.48 > 0.6516854:
:           :               :                   :...WBC > 0.4070252: F4 (4)
:           :               :                       WBC <= 0.4070252:
:           :               :                       :...Age <= 0.6896552: F2 (2)
:           :               :                           Age > 0.6896552: F1 (2)
:           :               ALT.1 <= 0.752809:
:           :               :...ALT.4 > 0.9325843: F2 (5/1)
:           :                   ALT.4 <= 0.9325843:
:           :                   :...Plat > 0.812478:
:           :                       :...RNA.4 <= 0.2695684:
:           :                       :   :...WBC <= 0.3960483: F4 (2)
:           :                       :   :   WBC > 0.3960483: F3 (3)
:           :                       :   RNA.4 > 0.2695684:
:           :                       :   :...ALT.4 <= 0.7191011:
:           :                       :       :...WBC <= 0.2881449: F3 (2)
:           :                       :       :   WBC > 0.2881449: F1 (9/1)
:           :                       :       ALT.4 > 0.7191011:
:           :                       :       :...WBC <= 0.5615807: F1 (2)
:           :                       :           WBC > 0.5615807: F4 (2)
:           :                       Plat <= 0.812478:
:           :                       :...ALT.12 <= 0.4831461:
:           :                           :...RNA.4 <= 0.1410989: F4 (5)
:           :                           :   RNA.4 > 0.1410989:
:           :                           :   :...Plat <= 0.1263235: F1 (3/1)
:           :                           :       Plat > 0.1263235:
:           :                           :       :...WBC > 0.5037321:
:           :                           :           :...ALT.12 <= 0.2134831: F4 (2)
:           :                           :           :   ALT.12 > 0.2134831: [S1]
:           :                           :           WBC <= 0.5037321:
:           :                           :           :...ALT.48 > 0.8089887: F2 (3)
:           :                           :               ALT.48 <= 0.8089887:
:           :                           :               :...ALT.1 <= 0.3033708: [S2]
:           :                           :                   ALT.1 > 0.3033708: [S3]
:           :                           ALT.12 > 0.4831461:
:           :                           :...Plat > 0.6268818:
:           :                               :...RNA.4 <= 0.1373751: F2 (2)
:           :                               :   RNA.4 > 0.1373751: F4 (14/2)
:           :                               Plat <= 0.6268818:
:           :                               :...ALT.12 > 0.7865168:
:           :                                   :...RBC <= 0.8629725: F1 (7)
:           :                                   :   RBC > 0.8629725: F3 (2)
:           :                                   ALT.12 <= 0.7865168:
:           :                                   :...ALT.24 > 0.8426966:
:           :                                       :...ALT.12 <= 0.5842696: F1 (3)
:           :                                       :   ALT.12 > 0.5842696: F4 (2)
:           :                                       ALT.24 <= 0.8426966:
:           :                                       :...RNA.Base <= 0.1421885: F3 (3)
:           :                                           RNA.Base > 0.1421885: [S4]
:           ALT.after.24.w > 0.4782609:
:           :...ALT.12 > 0.7640449:
:               :...ALT.after.24.w > 0.9565217:
:               :   :...ALT.36 <= 0.4269663: F3 (3)
:               :   :   ALT.36 > 0.4269663:
:               :   :   :...Age <= 0.1724138: F3 (2)
:               :   :       Age > 0.1724138: F4 (2)
:               :   ALT.after.24.w <= 0.9565217:
:               :   :...WBC > 0.8446762:
:               :       :...ALT.24 <= 0.3820225: F1 (2)
:               :       :   ALT.24 > 0.3820225: F3 (4)
:               :       WBC <= 0.8446762:
:               :       :...Plat > 0.8774456: F1 (4)
:               :           Plat <= 0.8774456:
:               :           :...ALT.4 <= 0.3820225:
:               :               :...WBC <= 0.8316136: F1 (8/1)
:               :               :   WBC > 0.8316136: F4 (2)
:               :               ALT.4 > 0.3820225:
:               :               :...RBC <= 0.1343212: F3 (3/1)
:               :                   RBC > 0.1343212: F4 (12/1)
:               ALT.12 <= 0.7640449:
:               :...RBC > 0.8252838:
:                   :...Plat <= 0.5872193:
:                   :   :...ALT.after.24.w <= 0.8695652: F3 (8/1)
:                   :   :   ALT.after.24.w > 0.8695652: F1 (4/1)
:                   :   Plat > 0.5872193:
:                   :   :...ALT.24 > 0.2808989: F2 (10/2)
:                   :       ALT.24 <= 0.2808989:
:                   :       :...RBC <= 0.8555975: F3 (2)
:                   :           RBC > 0.8555975: F4 (2)
:                   RBC <= 0.8252838:
:                   :...AST.1 <= 0.07865169:
:                       :...ALT.4 <= 0.8764045: F4 (13/2)
:                       :   ALT.4 > 0.8764045: F1 (2)
:                       AST.1 > 0.07865169:
:                       :...ALT.24 > 0.6629214:
:                           :...ALT.36 > 0.5168539: F4 (14/4)
:                           :   ALT.36 <= 0.5168539:
:                           :   :...ALT.after.24.w <= 0.8260869:
:                           :       :...AST.1 <= 0.3370787: F3 (3)
:                           :       :   AST.1 > 0.3370787: F1 (5/1)
:                           :       ALT.after.24.w > 0.8260869:
:                           :       :...RNA.Base <= 0.2988623: F1 (2/1)
:                           :           RNA.Base > 0.2988623: F4 (6/1)
:                           ALT.24 <= 0.6629214:
:                           :...ALT.12 <= 0.4269663:
:                               :...ALT.1 <= 0.4157303:
:                               :   :...RBC > 0.3016891: F3 (7/1)
:                               :   :   RBC <= 0.3016891:
:                               :   :   :...WBC <= 0.5536773: F1 (3)
:                               :   :       WBC > 0.5536773: F2 (2)
:                               :   ALT.1 > 0.4157303:
:                               :   :...Age <= 0.5517241: F1 (9/2)
:                               :       Age > 0.5517241:
:                               :       :...ALT.1 <= 0.8539326: F4 (6/1)
:                               :           ALT.1 > 0.8539326: F3 (2)
:                               ALT.12 > 0.4269663:
:                               :...ALT.48 <= 0.4494382:
:                                   :...ALT.4 > 0.9101124: F3 (2)
:                                   :   ALT.4 <= 0.9101124:
:                                   :   :...ALT.after.24.w <= 0.9130435: F4 (11/2)
:                                   :       ALT.after.24.w > 0.9130435: F2 (2)
:                                   ALT.48 > 0.4494382:
:                                   :...ALT.36 <= 0.02247191: F4 (2)
:                                       ALT.36 > 0.02247191:
:                                       :...ALT.24 > 0.505618:
:                                           :...Age <= 0.3448276: F4 (2)
:                                           :   Age > 0.3448276: F2 (2)
:                                           ALT.24 <= 0.505618:
:                                           :...ALT.after.24.w > 0.8260869:
:                                               :...ALT.12 <= 0.5505618: F2 (3)
:                                               :   ALT.12 > 0.5505618: F1 (3/1)
:                                               ALT.after.24.w <= 0.8260869:
:                                               :...ALT.36 > 0.6629214: F3 (4)
:                                                   ALT.36 <= 0.6629214: [S5]
BMI > 0.4615385:
:...Plat > 0.971068:
    :...Age <= 0.5862069: F2 (7/1)
    :   Age > 0.5862069:
    :   :...ALT.12 <= 0.6292135: F3 (4/1)
    :       ALT.12 > 0.6292135: F2 (2)
    Plat <= 0.971068:
    :...Age > 0.5517241:
        :...RNA.4 <= 0.4070092:
        :   :...BMI <= 0.5384616:
        :   :   :...RNA.4 <= 0.04654451: F1 (2)
        :   :   :   RNA.4 > 0.04654451:
        :   :   :   :...RNA.4 > 0.2394163: F4 (2)
        :   :   :       RNA.4 <= 0.2394163:
        :   :   :       :...Age <= 0.6896552: F2 (3/1)
        :   :   :           Age > 0.6896552: F3 (4)
        :   :   BMI > 0.5384616:
        :   :   :...ALT.48 > 0.741573:
        :   :       :...Age <= 0.7586207:
        :   :       :   :...ALT.1 <= 0.8089887: F4 (6)
        :   :       :   :   ALT.1 > 0.8089887: F1 (2)
        :   :       :   Age > 0.7586207:
        :   :       :   :...RBC <= 0.2869931: F1 (3/1)
        :   :       :       RBC > 0.2869931: F2 (5/1)
        :   :       ALT.48 <= 0.741573:
        :   :       :...Age > 0.7931035:
        :   :           :...ALT.after.24.w <= 0.04347826: F1 (2)
        :   :           :   ALT.after.24.w > 0.04347826:
        :   :           :   :...AST.1 <= 0.5168539: F2 (10)
        :   :           :       AST.1 > 0.5168539:
        :   :           :       :...ALT.24 <= 0.2696629: F3 (3/1)
        :   :           :           ALT.24 > 0.2696629: F2 (7/2)
        :   :           Age <= 0.7931035:
        :   :           :...ALT.24 > 0.9101124: F1 (4/1)
        :   :               ALT.24 <= 0.9101124:
        :   :               :...ALT.36 > 0.3707865:
        :   :                   :...RNA.4 <= 0.3351882: F2 (14/1)
        :   :                   :   RNA.4 > 0.3351882: F1 (3/1)
        :   :                   ALT.36 <= 0.3707865:
        :   :                   :...BMI > 0.9230769: F1 (2/1)
        :   :                       BMI <= 0.9230769:
        :   :                       :...Plat <= 0.394347: F4 (3)
        :   :                           Plat > 0.394347: F1 (5/1)
        :   RNA.4 > 0.4070092:
        :   :...Plat > 0.8752651:
        :       :...BMI <= 0.6923077: F1 (2/1)
        :       :   BMI > 0.6923077: F2 (6)
        :       Plat <= 0.8752651:
        :       :...BMI > 0.7692308:
        :           :...ALT.1 <= 0.3932584:
        :           :   :...BMI <= 0.8461539:
        :           :   :   :...ALT.24 <= 0.5280899: F1 (3/1)
        :           :   :   :   ALT.24 > 0.5280899: F2 (5)
        :           :   :   BMI > 0.8461539:
        :           :   :   :...ALT.after.24.w <= 0.6521739:
        :           :   :       :...ALT.4 <= 0.7191011: F3 (8/1)
        :           :   :       :   ALT.4 > 0.7191011: F1 (4)
        :           :   :       ALT.after.24.w > 0.6521739:
        :           :   :       :...ALT.1 <= 0.3033708: F2 (5/1)
        :           :   :           ALT.1 > 0.3033708: F1 (2)
        :           :   ALT.1 > 0.3932584:
        :           :   :...ALT.1 <= 0.7752809:
        :           :       :...WBC <= 0.2667398: F2 (3/1)
        :           :       :   WBC > 0.2667398: F4 (7/1)
        :           :       ALT.1 > 0.7752809:
        :           :       :...Plat <= 0.3123768: F2 (2)
        :           :           Plat > 0.3123768:
        :           :           :...ALT.4 > 0.1235955: F3 (6)
        :           :               ALT.4 <= 0.1235955:
        :           :               :...Plat <= 0.6354542: F4 (3)
        :           :                   Plat > 0.6354542: F1 (2/1)
        :           BMI <= 0.7692308:
        :           :...RBC > 0.917794:
        :               :...ALT.12 <= 0.4831461: F2 (3)
        :               :   ALT.12 > 0.4831461: F1 (2/1)
        :               RBC <= 0.917794:
        :               :...Age <= 0.5862069:
        :                   :...ALT.12 > 0.5955056: F3 (2)
        :                   :   ALT.12 <= 0.5955056:
        :                   :   :...ALT.4 <= 0.752809: F1 (2/1)
        :                   :       ALT.4 > 0.752809: F2 (2)
        :                   Age > 0.5862069:
        :                   :...RNA.Base > 0.7824873:
        :                       :...ALT.1 <= 0.4494382: F4 (4/1)
        :                       :   ALT.1 > 0.4494382: F1 (2)
        :                       RNA.Base <= 0.7824873:
        :                       :...WBC > 0.6543359:
        :                           :...Age <= 0.7241379: F3 (5)
        :                           :   Age > 0.7241379:
        :                           :   :...WBC <= 0.8279912: F3 (3)
        :                           :       WBC > 0.8279912:
        :                           :       :...ALT.4 <= 0.3370787: F1 (5)
        :                           :           ALT.4 > 0.3370787: F3 (3/1)
        :                           WBC <= 0.6543359:
        :                           :...ALT.4 > 0.7865168: F4 (3)
        :                               ALT.4 <= 0.7865168:
        :                               :...ALT.48 <= 0.1910112: F4 (4/1)
        :                                   ALT.48 > 0.1910112:
        :                                   :...RBC > 0.61062: F1 (3)
        :                                       RBC <= 0.61062: [S6]
        Age <= 0.5517241:
        :...ALT.36 <= 0.01123596:
            :...ALT.48 <= 0.6404495: F2 (5)
            :   ALT.48 > 0.6404495: F4 (2)
            ALT.36 > 0.01123596:
            :...ALT.36 <= 0.05617978:
                :...RNA.Base <= 0.5175647: F3 (5)
                :   RNA.Base > 0.5175647: F4 (5/1)
                ALT.36 > 0.05617978:
                :...BMI <= 0.6153846:
                    :...ALT.24 > 0.8426966: F4 (11/2)
                    :   ALT.24 <= 0.8426966:
                    :   :...RNA.4 <= 0.3422182:
                    :       :...ALT.1 > 0.741573: F1 (5)
                    :       :   ALT.1 <= 0.741573:
                    :       :   :...ALT.24 <= 0.1685393: F1 (2)
                    :       :       ALT.24 > 0.1685393:
                    :       :       :...BMI <= 0.5384616: F3 (5/1)
                    :       :           BMI > 0.5384616: F2 (5/1)
                    :       RNA.4 > 0.3422182:
                    :       :...Plat <= 0.05295577: F1 (3)
                    :           Plat > 0.05295577:
                    :           :...AST.1 > 0.8651685: F2 (7)
                    :               AST.1 <= 0.8651685:
                    :               :...ALT.1 <= 0.4269663:
                    :                   :...Plat > 0.7610209: F2 (5)
                    :                   :   Plat <= 0.7610209:
                    :                   :   :...RBC <= 0.4778271: F2 (2)
                    :                   :       RBC > 0.4778271: F3 (6)
                    :                   ALT.1 > 0.4269663:
                    :                   :...ALT.48 > 0.8314607: F2 (2)
                    :                       ALT.48 <= 0.8314607:
                    :                       :...Age <= 0.1724138:
                    :                           :...Plat <= 0.5160921: F4 (6)
                    :                           :   Plat > 0.5160921: F1 (2)
                    :                           Age > 0.1724138:
                    :                           :...WBC <= 0.3376509: F3 (3/1)
                    :                               WBC > 0.3376509: F4 (5/1)
                    BMI > 0.6153846:
                    :...AST.1 <= 0.247191:
                        :...ALT.48 <= 0.2247191:
                        :   :...Age > 0.2068966: F1 (7/1)
                        :   :   Age <= 0.2068966:
                        :   :   :...ALT.24 <= 0.5280899: F3 (4)
                        :   :       ALT.24 > 0.5280899: F2 (4/1)
                        :   ALT.48 > 0.2247191:
                        :   :...Age <= 0.03448276:
                        :       :...ALT.48 > 0.6966292: F2 (3)
                        :       :   ALT.48 <= 0.6966292:
                        :       :   :...ALT.1 <= 0.6966292: F1 (2)
                        :       :       ALT.1 > 0.6966292: F3 (2)
                        :       Age > 0.03448276:
                        :       :...Plat <= 0.1174064: F3 (8/1)
                        :           Plat > 0.1174064:
                        :           :...ALT.24 <= 0.3033708:
                        :               :...Plat <= 0.3844932: F4 (3/1)
                        :               :   Plat > 0.3844932: F3 (8)
                        :               ALT.24 > 0.3033708:
                        :               :...ALT.24 <= 0.5955056: F4 (4)
                        :                   ALT.24 > 0.5955056:
                        :                   :...AST.1 > 0.1460674: F3 (3)
                        :                       AST.1 <= 0.1460674:
                        :                       :...ALT.12 <= 0.8539326: F4 (6)
                        :                           ALT.12 > 0.8539326: F3 (2)
                        AST.1 > 0.247191:
                        :...RNA.4 > 0.9682636:
                            :...AST.1 <= 0.8876405: F2 (5/1)
                            :   AST.1 > 0.8876405: F3 (2)
                            RNA.4 <= 0.9682636:
                            :...AST.1 <= 0.2808989:
                                :...ALT.36 <= 0.7977528: F2 (6/1)
                                :   ALT.36 > 0.7977528: F1 (4/1)
                                AST.1 > 0.2808989:
                                :...ALT.24 <= 0.3483146:
                                    :...AST.1 > 0.7078652:
                                    :   :...ALT.1 > 0.4269663: F4 (12/1)
                                    :   :   ALT.1 <= 0.4269663:
                                    :   :   :...AST.1 <= 0.8988764: F4 (2)
                                    :   :       AST.1 > 0.8988764: F1 (6/1)
                                    :   AST.1 <= 0.7078652:
                                    :   :...BMI > 0.9230769: F2 (3/1)
                                    :       BMI <= 0.9230769:
                                    :       :...ALT.24 <= 0.03370786: F2 (2)
                                    :           ALT.24 > 0.03370786:
                                    :           :...ALT.12 <= 0.08988764: F4 (4)
                                    :               ALT.12 > 0.08988764:
                                    :               :...Age <= 0.03448276: F4 (2)
                                    :                   Age > 0.03448276: [S7]
                                    ALT.24 > 0.3483146:
                                    :...Plat <= 0.1051622:
                                        :...Age <= 0.3103448: F2 (4/1)
                                        :   Age > 0.3103448: F4 (4)
                                        Plat > 0.1051622:
                                        :...RNA.Base <= 0.4264929:
                                            :...RBC > 0.903514: F2 (2)
                                            :   RBC <= 0.903514:
                                            :   :...ALT.24 <= 0.6629214: F1 (8)
                                            :       ALT.24 > 0.6629214:
                                            :       :...AST.1 > 0.8988764: F1 (4)
                                            :           AST.1 <= 0.8988764: [S8]
                                            RNA.Base > 0.4264929:
                                            :...ALT.24 <= 0.4044944: F2 (3)
                                                ALT.24 > 0.4044944:
                                                :...RNA.4 <= 0.3203851: F3 (10/1)
                                                    RNA.4 > 0.3203851:
                                                    :...RBC > 0.7659233:
                                                        :...BMI <= 0.9230769: F3 (4)
                                                        :   BMI > 0.9230769: F1 (2/1)
                                                        RBC <= 0.7659233:
                                                        :...WBC > 0.4096597: [S9]
                                                            WBC <= 0.4096597: [S10]

SubTree [S1]

ALT.36 <= 0.494382: F4 (3/1)
ALT.36 > 0.494382: F2 (5)

SubTree [S2]

ALT.4 <= 0.3707865: F3 (2)
ALT.4 > 0.3707865: F2 (3/1)

SubTree [S3]

ALT.after.24.w <= 0.1304348: F4 (2)
ALT.after.24.w > 0.1304348: F1 (4/1)

SubTree [S4]

ALT.24 > 0.7865168: F3 (2)
ALT.24 <= 0.7865168:
:...AST.1 <= 0.3483146: F4 (9)
    AST.1 > 0.3483146:
    :...ALT.after.24.w <= 0.2608696: F3 (2)
        ALT.after.24.w > 0.2608696: F4 (5/1)

SubTree [S5]

ALT.after.24.w > 0.7826087: F3 (2)
ALT.after.24.w <= 0.7826087:
:...ALT.12 <= 0.5842696: F2 (6/1)
    ALT.12 > 0.5842696:
    :...BMI <= 0.2307692: F2 (2/1)
        BMI > 0.2307692:
        :...ALT.4 <= 0.6629214: F1 (2)
            ALT.4 > 0.6629214: F3 (2)

SubTree [S6]

ALT.after.24.w <= 0.8695652: F3 (8/1)
ALT.after.24.w > 0.8695652: F1 (4/1)

SubTree [S7]

ALT.1 <= 0.3258427: F3 (3/1)
ALT.1 > 0.3258427:
:...ALT.36 <= 0.6853933: F1 (7)
    ALT.36 > 0.6853933: F3 (3/1)

SubTree [S8]

AST.1 <= 0.3483146: F1 (2)
AST.1 > 0.3483146: F3 (11/2)

SubTree [S9]

RNA.Base <= 0.7343804: F2 (3)
RNA.Base > 0.7343804: F1 (5/1)

SubTree [S10]

BMI <= 0.7692308: F4 (2)
BMI > 0.7692308:
:...AST.1 <= 0.741573: F4 (2)
    AST.1 > 0.741573: F2 (2)

-----  Trial 1:  -----

Decision tree:

ALT.48 > 0.9438202:
:...WBC <= 0.06355653:
:   :...BMI <= 0.6153846: F2 (10.7/1.6)
:   :   BMI > 0.6153846: F3 (2.3)
:   WBC > 0.06355653:
:   :...WBC > 0.9231614: F2 (3.6)
:       WBC <= 0.9231614:
:       :...ALT.4 <= 0.1460674: F3 (5.5/2.3)
:           ALT.4 > 0.1460674:
:           :...ALT.after.24.w > 0.7391304:
:               :...ALT.1 <= 0.7752809: F3 (6.2/2.3)
:               :   ALT.1 > 0.7752809: F4 (3.6)
:               ALT.after.24.w <= 0.7391304:
:               :...ALT.48 <= 0.9662921: F2 (12.5/5.5)
:                   ALT.48 > 0.9662921:
:                   :...Plat <= 0.8756548: F4 (12.2/1.6)
:                       Plat > 0.8756548: F1 (2.3/0.8)
ALT.48 <= 0.9438202:
:...ALT.4 > 0.9213483:
    :...ALT.48 > 0.7640449: F1 (11/0.8)
    :   ALT.48 <= 0.7640449:
    :   :...BMI > 0.6923077:
    :       :...RNA.4 <= 0.1295362: F1 (5.6)
    :       :   RNA.4 > 0.1295362: F2 (6.2)
    :       BMI <= 0.6923077:
    :       :...RNA.4 <= 0.2307412:
    :           :...ALT.36 <= 0.5280899: F4 (12.3/1.6)
    :           :   ALT.36 > 0.5280899: F1 (3.9/1.6)
    :           RNA.4 > 0.2307412:
    :           :...AST.1 > 0.8876405: F2 (2.3)
    :               AST.1 <= 0.8876405:
    :               :...ALT.after.24.w > 0.7391304: F3 (6.2/1.6)
    :                   ALT.after.24.w <= 0.7391304:
    :                   :...ALT.36 > 0.7865168: F3 (4.7/2.3)
    :                       ALT.36 <= 0.7865168:
    :                       :...Plat > 0.7179264: F2 (4.7/0.8)
    :                           Plat <= 0.7179264:
    :                           :...ALT.1 <= 0.4044944: F1 (5.1)
    :                               ALT.1 > 0.4044944: F4 (4.7/1.6)
    ALT.4 <= 0.9213483:
    :...ALT.after.24.w > 0.8260869:
        :...ALT.36 > 0.8764045:
        :   :...BMI <= 0: F1 (2.8)
        :   :   BMI > 0:
        :   :   :...WBC <= 0.4088913: F4 (6.7/1.6)
        :   :       WBC > 0.4088913:
        :   :       :...AST.1 <= 0.3932584: F4 (3.1)
        :   :           AST.1 > 0.3932584: F2 (5.5/0.8)
        :   ALT.36 <= 0.8764045:
        :   :...ALT.after.24.w > 0.9565217:
        :       :...ALT.48 > 0.741573: F1 (3.1)
        :       :   ALT.48 <= 0.741573:
        :       :   :...WBC <= 0.3937431:
        :       :       :...RNA.4 <= 0.4928535: F3 (13)
        :       :       :   RNA.4 > 0.4928535: F2 (5.5/2.3)
        :       :       WBC > 0.3937431:
        :       :       :...Age <= 0.7586207: F4 (12.2/3.9)
        :       :           Age > 0.7586207: F3 (2.3)
        :       ALT.after.24.w <= 0.9565217:
        :       :...WBC <= 0.0273326: F3 (3.6)
        :           WBC > 0.0273326:
        :           :...AST.1 > 0.6404495:
        :               :...RNA.Base <= 0.3474912:
        :               :   :...ALT.after.24.w <= 0.9130435: F1 (10.3/0.8)
        :               :   :   ALT.after.24.w > 0.9130435: F3 (2.3/0.8)
        :               :   RNA.Base > 0.3474912:
        :               :   :...RNA.4 <= 0.6511205: F3 (12.2/3.1)
        :               :       RNA.4 > 0.6511205: F4 (7/3.1)
        :               AST.1 <= 0.6404495:
        :               :...RNA.Base > 0.8249535:
        :                   :...ALT.4 <= 0.5168539: F1 (13.8/0.8)
        :                   :   ALT.4 > 0.5168539: F4 (3.9/1.6)
        :                   RNA.Base <= 0.8249535:
        :                   :...ALT.48 > 0.8651685: F2 (5.9/0.8)
        :                       ALT.48 <= 0.8651685:
        :                       :...AST.1 > 0.4269663: F4 (12.6/1.6)
        :                           AST.1 <= 0.4269663:
        :                           :...Age > 0.7241379: F1 (7.5/1.6)
        :                               Age <= 0.7241379:
        :                               :...ALT.4 <= 0.2134831: F1 (5.5/2.3)
        :                                   ALT.4 > 0.2134831:
        :                                   :...ALT.12 > 0.6067415: F4 (6.2/3.1)
        :                                       ALT.12 <= 0.6067415:
        :                                       :...ALT.36 <= 0.5168539: F2 (3.9/0.8)
        :                                           ALT.36 > 0.5168539: F3 (3.9/0.8)
        ALT.after.24.w <= 0.8260869:
        :...ALT.36 <= 0.02247191:
            :...ALT.36 <= 0.01123596:
            :   :...ALT.12 <= 0.1910112: F1 (2.3/0.8)
            :   :   ALT.12 > 0.1910112: F2 (12.2/1.6)
            :   ALT.36 > 0.01123596:
            :   :...ALT.48 <= 0.505618: F3 (5.5/1.6)
            :       ALT.48 > 0.505618: F4 (2.3/0.8)
            ALT.36 > 0.02247191:
            :...ALT.12 > 0.8876405:
                :...WBC > 0.8140505:
                :   :...ALT.48 <= 0.4382023: F2 (6.3/0.8)
                :   :   ALT.48 > 0.4382023: F3 (5.5/0.8)
                :   WBC <= 0.8140505:
                :   :...BMI > 0.9230769: F1 (5.9)
                :       BMI <= 0.9230769:
                :       :...WBC > 0.556202:
                :           :...ALT.after.24.w <= 0.6086956: F1 (13.4/1.6)
                :           :   ALT.after.24.w > 0.6086956: F4 (3.1/0.8)
                :           WBC <= 0.556202:
                :           :...RNA.Base <= 0.295656: F4 (10.1/3.9)
                :               RNA.Base > 0.295656:
                :               :...ALT.after.24.w > 0.4782609: F1 (7/1.6)
                :                   ALT.after.24.w <= 0.4782609:
                :                   :...ALT.4 <= 0.5617977:
                :                       :...ALT.24 <= 0.6853933: F2 (6.2/1.6)
                :                       :   ALT.24 > 0.6853933: F3 (3.1/0.8)
                :                       ALT.4 > 0.5617977:
                :                       :...ALT.24 <= 0.741573: F3 (6.2/1.6)
                :                           ALT.24 > 0.741573: F1 (2.3)
                ALT.12 <= 0.8876405:
                :...ALT.12 > 0.8089887:
                    :...AST.1 <= 0.1348315: F1 (3.1/0.8)
                    :   AST.1 > 0.1348315:
                    :   :...ALT.36 <= 0.5955056:
                    :       :...RBC <= 0.3472113: F3 (4.3)
                    :       :   RBC > 0.3472113:
                    :       :   :...ALT.1 <= 0.3033708: F4 (3.9/1.6)
                    :       :       ALT.1 > 0.3033708: F2 (19.7/1.6)
                    :       ALT.36 > 0.5955056:
                    :       :...BMI > 0.5384616: F2 (7/3.9)
                    :           BMI <= 0.5384616:
                    :           :...ALT.36 <= 0.7078652: F1 (2.3/0.8)
                    :               ALT.36 > 0.7078652:
                    :               :...ALT.24 > 0.8089887: F4 (3.1/0.8)
                    :                   ALT.24 <= 0.8089887:
                    :                   :...ALT.36 <= 0.9101124: F3 (8.7)
                    :                       ALT.36 > 0.9101124: F4 (3.1/0.8)
                    ALT.12 <= 0.8089887:
                    :...ALT.36 <= 0.1910112:
                        :...Age > 0.8965517:
                        :   :...ALT.24 <= 0.5842696: F1 (5.9/0.8)
                        :   :   ALT.24 > 0.5842696: F2 (5.5/2.3)
                        :   Age <= 0.8965517:
                        :   :...ALT.36 <= 0.05617978:
                        :       :...ALT.4 <= 0.1685393: F3 (3.9/1.6)
                        :       :   ALT.4 > 0.1685393: F4 (9/0.8)
                        :       ALT.36 > 0.05617978:
                        :       :...AST.1 <= 0.06741573:
                        :           :...ALT.36 <= 0.1685393: F4 (5.9)
                        :           :   ALT.36 > 0.1685393: F1 (2.3)
                        :           AST.1 > 0.06741573:
                        :           :...RNA.4 <= 0.171692:
                        :               :...Age > 0.4827586: F4 (3.1)
                        :               :   Age <= 0.4827586:
                        :               :   :...ALT.4 <= 0.8314607: F1 (4.7/0.8)
                        :               :       ALT.4 > 0.8314607: F3 (2.3/0.8)
                        :               RNA.4 > 0.171692:
                        :               :...ALT.12 <= 0.3033708:
                        :                   :...ALT.after.24.w <= 0.2173913: F1 (5.5/2.3)
                        :                   :   ALT.after.24.w > 0.2173913:
                        :                   :   :...ALT.24 <= 0.4157303: F3 (4.7/1.6)
                        :                   :       ALT.24 > 0.4157303: F2 (4.7)
                        :                   ALT.12 > 0.3033708:
                        :                   :...ALT.24 > 0.8764045: F4 (5.1/1.6)
                        :                       ALT.24 <= 0.8764045:
                        :                       :...RBC <= 0.3201445: F2 (8.2/1.6)
                        :                           RBC > 0.3201445:
                        :                           :...Age > 0.7586207: F4 (2.3/0.8)
                        :                               Age <= 0.7586207:
                        :                               :...BMI <= 0.3846154: F2 (5.1)
                        :                                   BMI > 0.3846154: [S1]
                        ALT.36 > 0.1910112:
                        :...ALT.36 <= 0.2022472: F3 (11.8/2.3)
                            ALT.36 > 0.2022472:
                            :...ALT.24 > 0.9775281:
                                :...AST.1 <= 0.7191011: F2 (8.7/0.8)
                                :   AST.1 > 0.7191011: F3 (2.3/0.8)
                                ALT.24 <= 0.9775281:
                                :...ALT.36 > 0.9662921:
                                    :...AST.1 <= 0.6966292: F1 (13.4/3.1)
                                    :   AST.1 > 0.6966292: F3 (6.7/1.6)
                                    ALT.36 <= 0.9662921:
                                    :...AST.1 > 0.988764:
                                        :...RBC <= 0.2635369: F2 (2.3/0.8)
                                        :   RBC > 0.2635369: F4 (7.9/0.8)
                                        AST.1 <= 0.988764:
                                        :...ALT.48 <= 0.08988764:
                                            :...AST.1 <= 0.1235955: F3 (3.6)
                                            :   AST.1 > 0.1235955:
                                            :   :...ALT.1 <= 0.1460674: F1 (9.5/2.3)
                                            :       ALT.1 > 0.1460674:
                                            :       :...Age > 0.7241379: F4 (8.7)
                                            :           Age <= 0.7241379: [S2]
                                            ALT.48 > 0.08988764:
                                            :...ALT.after.24.w <= 0.1304348:
                                                :...ALT.36 > 0.6741573:
                                                :   :...ALT.12 > 0.6516854: F2 (7.1)
                                                :   :   ALT.12 <= 0.6516854:
                                                :   :   :...BMI > 0.4615385: F3 (11.4/2.3)
                                                :   :       BMI <= 0.4615385: [S3]
                                                :   ALT.36 <= 0.6741573:
                                                :   :...Age <= 0.03448276: F1 (4.3/0.8)
                                                :       Age > 0.03448276: [S4]
                                                ALT.after.24.w > 0.1304348:
                                                :...AST.1 <= 0.1348315:
                                                    :...BMI <= 0.1538462: F4 (11/0.8)
                                                    :   BMI > 0.1538462:
                                                    :   :...RNA.4 > 0.4756364: [S5]
                                                    :       RNA.4 <= 0.4756364: [S6]
                                                    AST.1 > 0.1348315:
                                                    :...ALT.48 <= 0.2134831:
                                                        :...WBC > 0.5979144: [S7]
                                                        :   WBC <= 0.5979144: [S8]
                                                        ALT.48 > 0.2134831: [S9]

SubTree [S1]

ALT.36 <= 0.1123596: F2 (5.5/1.6)
ALT.36 > 0.1123596: F4 (6.7/0.8)

SubTree [S2]

ALT.24 > 0.8539326: F1 (3.1/0.8)
ALT.24 <= 0.8539326:
:...ALT.36 > 0.6516854:
    :...ALT.24 <= 0.2247191: F1 (3.9/1.6)
    :   ALT.24 > 0.2247191: F4 (6.2/1.6)
    ALT.36 <= 0.6516854:
    :...RNA.Base <= 0.08317132: F2 (2.3/0.8)
        RNA.Base > 0.08317132:
        :...ALT.1 <= 0.6741573: F3 (7/2.3)
            ALT.1 > 0.6741573: F4 (4.7)

SubTree [S3]

ALT.4 <= 0.505618: F2 (4.7/2.3)
ALT.4 > 0.505618: F4 (9.5/1.6)

SubTree [S4]

RNA.Base > 0.3891023: F4 (21.2/6.2)
RNA.Base <= 0.3891023:
:...RNA.Base > 0.2514181: F2 (4.7/0.8)
    RNA.Base <= 0.2514181:
    :...Plat <= 0.3457599: F4 (5.5/2.3)
        Plat > 0.3457599: F3 (3.1/0.8)

SubTree [S5]

RNA.4 <= 0.8287466: F3 (12.3)
RNA.4 > 0.8287466: F4 (5.5/2.3)

SubTree [S6]

BMI > 0.4615385: F4 (4.7/0.8)
BMI <= 0.4615385:
:...Plat <= 0.4985126: F1 (2.3/0.8)
    Plat > 0.4985126: F2 (6.7/0.8)

SubTree [S7]

ALT.48 <= 0.1685393: F2 (5.5/0.8)
ALT.48 > 0.1685393: F4 (2.3/0.8)

SubTree [S8]

ALT.after.24.w <= 0.3043478: F1 (3.9/2.3)
ALT.after.24.w > 0.3043478:
:...RBC <= 0.05493545: F4 (3.6)
    RBC > 0.05493545: F3 (24.5/4.7)

SubTree [S9]

ALT.after.24.w > 0.6956522:
:...ALT.36 > 0.8202247: F1 (8.7/1.6)
:   ALT.36 <= 0.8202247:
:   :...RNA.4 <= 0.4600195: F2 (11.4/2.3)
:       RNA.4 > 0.4600195:
:       :...AST.1 <= 0.2359551: F3 (5.1/0.8)
:           AST.1 > 0.2359551:
:           :...Age > 0.7586207: F1 (3.9/1.6)
:               Age <= 0.7586207:
:               :...BMI <= 0.2307692: F4 (2.3)
:                   BMI > 0.2307692:
:                   :...RNA.4 <= 0.6389204: F4 (2.3/0.8)
:                       RNA.4 > 0.6389204: F2 (7/3.1)
ALT.after.24.w <= 0.6956522:
:...Age <= 0.03448276: F1 (8.6/2.3)
    Age > 0.03448276:
    :...ALT.24 > 0.7977528:
        :...RBC > 0.9270417: F4 (4.3/0.8)
        :   RBC <= 0.9270417:
        :   :...ALT.4 > 0.8651685: F3 (7.1/1.6)
        :       ALT.4 <= 0.8651685:
        :       :...ALT.12 <= 0.5393258: F1 (17.3/3.1)
        :           ALT.12 > 0.5393258: F3 (4.7/0.8)
        ALT.24 <= 0.7977528:
        :...ALT.4 > 0.741573:
            :...AST.1 <= 0.3370787: F3 (3.9/2.3)
            :   AST.1 > 0.3370787:
            :   :...RNA.Base > 0.822892: F2 (5.9/0.8)
            :       RNA.Base <= 0.822892:
            :       :...WBC > 0.8243688: F1 (9.5/0.8)
            :           WBC <= 0.8243688:
            :           :...Plat <= 0.5135443: F1 (6.2/2.3)
            :               Plat > 0.5135443: F2 (3.1)
            ALT.4 <= 0.741573:
            :...RNA.4 <= 0.1204916:
                :...ALT.24 <= 0.2359551: F2 (3.9/1.6)
                :   ALT.24 > 0.2359551: F4 (4.7)
                RNA.4 > 0.1204916:
                :...ALT.36 > 0.9213483: F4 (5.1/1.6)
                    ALT.36 <= 0.9213483:
                    :...RBC > 0.6041094:
                        :...ALT.48 > 0.7078652: F3 (17.8/1.6)
                        :   ALT.48 <= 0.7078652:
                        :   :...WBC <= 0.3929748: F1 (7.5/0.8)
                        :       WBC > 0.3929748:
                        :       :...WBC <= 0.7781559: F3 (10.9/3.1)
                        :           WBC > 0.7781559: F1 (4.7/0.8)
                        RBC <= 0.6041094:
                        :...ALT.1 <= 0.1123596: F3 (5.9)
                            ALT.1 > 0.1123596:
                            :...AST.1 > 0.6853933: F3 (6.2/2.3)
                                AST.1 <= 0.6853933:
                                :...ALT.12 > 0.5730337: F3 (3.1/1.6)
                                    ALT.12 <= 0.5730337:
                                    :...ALT.24 <= 0.1460674: F2 (3.1)
                                        ALT.24 > 0.1460674:
                                        :...Age > 0.6896552: F2 (3.1/0.8)
                                            Age <= 0.6896552:
                                            :...WBC <= 0.1912184: F4 (3.1/0.8)
                                                WBC > 0.1912184: F1 (5.5/0.8)

-----  Trial 2:  -----

Decision tree:

ALT.4 > 0.9213483:
:...RNA.4 > 0.8668897: F3 (5.8/1.9)
:   RNA.4 <= 0.8668897:
:   :...ALT.24 <= 0.3707865:
:       :...WBC > 0.6912184: F1 (5.5/0.6)
:       :   WBC <= 0.6912184:
:       :   :...ALT.12 <= 0.4606742: F1 (9.1/1.9)
:       :       ALT.12 > 0.4606742: F2 (3.8)
:       ALT.24 > 0.3707865:
:       :...WBC <= 0.5097695:
:           :...Plat > 0.8046474: F1 (2.9/0.6)
:           :   Plat <= 0.8046474:
:           :   :...Age <= 0.3793103: F1 (5.7/1.4)
:           :       Age > 0.3793103: F4 (19.3/3.8)
:           WBC > 0.5097695:
:           :...RBC <= 0.3930546: F3 (3.2/1.3)
:               RBC > 0.3930546:
:               :...ALT.after.24.w > 0.7391304: F1 (2/0.6)
:                   ALT.after.24.w <= 0.7391304:
:                   :...ALT.24 <= 0.8988764: F2 (7.3)
:                       ALT.24 > 0.8988764: F1 (2)
ALT.4 <= 0.9213483:
:...ALT.after.24.w > 0.8260869:
    :...ALT.48 > 0.8764045:
    :   :...ALT.after.24.w <= 0.8695652: F4 (3.4)
    :   :   ALT.after.24.w > 0.8695652:
    :   :   :...Age > 0.7241379: F2 (10.1/1.3)
    :   :       Age <= 0.7241379:
    :   :       :...BMI <= 0.5384616: F1 (4/0.6)
    :   :           BMI > 0.5384616: F4 (3.3/1.9)
    :   ALT.48 <= 0.8764045:
    :   :...RNA.4 > 0.9640629: F3 (7.7/1.3)
    :       RNA.4 <= 0.9640629:
    :       :...RNA.4 > 0.5644889:
    :           :...ALT.1 <= 0.4157303:
    :           :   :...ALT.after.24.w <= 0.9130435:
    :           :   :   :...ALT.4 <= 0.8314607: F1 (11/1.9)
    :           :   :   :   ALT.4 > 0.8314607: F2 (2.6/1.3)
    :           :   :   ALT.after.24.w > 0.9130435:
    :           :   :   :...ALT.48 <= 0.494382: F1 (5.3/2.6)
    :           :   :       ALT.48 > 0.494382: F2 (3.8/1.3)
    :           :   ALT.1 > 0.4157303:
    :           :   :...RNA.4 > 0.9402926: F3 (4.1/1.4)
    :           :       RNA.4 <= 0.9402926:
    :           :       :...AST.1 > 0.8988764: F1 (4.7/1.3)
    :           :           AST.1 <= 0.8988764:
    :           :           :...AST.1 <= 0.2022472: F1 (3.8/1.3)
    :           :               AST.1 > 0.2022472: F4 (22.2/5.2)
    :           RNA.4 <= 0.5644889:
    :           :...ALT.4 <= 0.1460674:
    :               :...RNA.Base <= 0.3900789: F2 (2.6/0.6)
    :               :   RNA.Base > 0.3900789: F4 (7.8/1.3)
    :               ALT.4 > 0.1460674:
    :               :...Plat > 0.6354542: F3 (15/3.2)
    :                   Plat <= 0.6354542:
    :                   :...AST.1 > 0.8651685: F3 (5.7/1.4)
    :                       AST.1 <= 0.8651685:
    :                       :...AST.1 > 0.4044944: F1 (19.7/2.5)
    :                           AST.1 <= 0.4044944:
    :                           :...ALT.12 <= 0.5280899:
    :                               :...ALT.4 <= 0.3258427: F2 (2.6/1.3)
    :                               :   ALT.4 > 0.3258427: F3 (8.5/2.5)
    :                               ALT.12 > 0.5280899:
    :                               :...Plat <= 0.2032356: F3 (2.6)
    :                                   Plat > 0.2032356: F1 (10.3/1.9)
    ALT.after.24.w <= 0.8260869:
    :...ALT.1 <= 0.1123596:
        :...RBC <= 0.03764967: F4 (4.9/0.6)
        :   RBC > 0.03764967:
        :   :...BMI <= 0.1538462:
        :       :...RBC <= 0.4163593: F3 (3.9)
        :       :   RBC > 0.4163593: F4 (5.1/1.3)
        :       BMI > 0.1538462:
        :       :...ALT.1 <= 0.02247191:
        :           :...ALT.48 <= 0.2359551:
        :           :   :...RBC <= 0.6664548: F2 (3.3/0.6)
        :           :   :   RBC > 0.6664548: F3 (2.8)
        :           :   ALT.48 > 0.2359551:
        :           :   :...AST.1 <= 0.258427: F1 (2.8)
        :           :       AST.1 > 0.258427: F2 (10.2/2.6)
        :           ALT.1 > 0.02247191:
        :           :...AST.1 > 0.9325843: F3 (5.9/1.4)
        :               AST.1 <= 0.9325843:
        :               :...ALT.24 <= 0.1123596: F2 (2.5/0.6)
        :                   ALT.24 > 0.1123596:
        :                   :...WBC <= 0.1: F2 (3.9/1.3)
        :                       WBC > 0.1:
        :                       :...AST.1 <= 0.06741573: F1 (4.2/0.6)
        :                           AST.1 > 0.06741573:
        :                           :...ALT.4 > 0.7640449: F3 (9.3/1.4)
        :                               ALT.4 <= 0.7640449:
        :                               :...ALT.1 <= 0.06741573:
        :                                   :...ALT.12 <= 0.1910112: F1 (4.7/1.3)
        :                                   :   ALT.12 > 0.1910112: F3 (11.7/1.9)
        :                                   ALT.1 > 0.06741573:
        :                                   :...BMI <= 0.5384616: F1 (8.5)
        :                                       BMI > 0.5384616:
        :                                       :...ALT.4 <= 0.4606742: F1 (4.8/0.6)
        :                                           ALT.4 > 0.4606742: F3 (2.6)
        ALT.1 > 0.1123596:
        :...ALT.after.24.w > 0.6086956:
            :...ALT.4 > 0.7865168:
            :   :...ALT.1 <= 0.7303371: F3 (9.3/1.9)
            :   :   ALT.1 > 0.7303371: F1 (6.1/1.9)
            :   ALT.4 <= 0.7865168:
            :   :...RBC > 0.61062:
            :       :...RNA.4 <= 0.454385:
            :       :   :...WBC <= 0.07091109: F3 (2/0.6)
            :       :   :   WBC > 0.07091109: F2 (17.1/2.5)
            :       :   RNA.4 > 0.454385:
            :       :   :...ALT.after.24.w > 0.7826087: F4 (3.3/0.6)
            :       :       ALT.after.24.w <= 0.7826087:
            :       :       :...Plat <= 0.6583615: F3 (19/6.4)
            :       :           Plat > 0.6583615: F2 (6.4/1.9)
            :       RBC <= 0.61062:
            :       :...Age > 0.5172414:
            :           :...ALT.after.24.w > 0.7826087:
            :           :   :...ALT.12 <= 0.5393258: F3 (3.9/0.6)
            :           :   :   ALT.12 > 0.5393258: F1 (2.5/1.3)
            :           :   ALT.after.24.w <= 0.7826087:
            :           :   :...ALT.36 > 0.8089887: F4 (5/1.4)
            :           :       ALT.36 <= 0.8089887:
            :           :       :...Age <= 0.7241379:
            :           :           :...AST.1 <= 0.7752809: F1 (5.5/0.6)
            :           :           :   AST.1 > 0.7752809: F2 (2.9)
            :           :           Age > 0.7241379:
            :           :           :...ALT.12 <= 0.2022472: F4 (2.5/0.6)
            :           :               ALT.12 > 0.2022472: F2 (9.2)
            :           Age <= 0.5172414:
            :           :...ALT.36 <= 0.03370786: F2 (4/0.6)
            :               ALT.36 > 0.03370786:
            :               :...ALT.48 > 0.8651685:
            :                   :...RNA.Base <= 0.6867923: F2 (3.9/1.3)
            :                   :   RNA.Base > 0.6867923: F4 (2.5/1.3)
            :                   ALT.48 <= 0.8651685:
            :                   :...ALT.12 > 0.3483146: F4 (25.8/3.2)
            :                       ALT.12 <= 0.3483146:
            :                       :...BMI <= 0.4615385: F1 (4/0.6)
            :                           BMI > 0.4615385:
            :                           :...Plat <= 0.7990798: F4 (7.3/1.9)
            :                               Plat > 0.7990798: F1 (2.5/1.3)
            ALT.after.24.w <= 0.6086956:
            :...RNA.Base > 0.9777441:
                :...BMI <= 0.6923077: F1 (6.2/0.6)
                :   BMI > 0.6923077: F2 (6.5)
                RNA.Base <= 0.9777441:
                :...ALT.48 <= 0.08988764:
                    :...WBC > 0.9710209: F2 (3.6)
                    :   WBC <= 0.9710209:
                    :   :...RBC > 0.7907788:
                    :       :...ALT.after.24.w <= 0.4347826: F4 (11.2/1.3)
                    :       :   ALT.after.24.w > 0.4347826: F1 (5.7/2)
                    :       RBC <= 0.7907788:
                    :       :...ALT.after.24.w > 0.4347826: F4 (10.4/1.4)
                    :           ALT.after.24.w <= 0.4347826:
                    :           :...RNA.4 <= 0.7591565:
                    :               :...Plat <= 0.07447677: F2 (2.6)
                    :               :   Plat > 0.07447677: F3 (10/3.9)
                    :               RNA.4 > 0.7591565:
                    :               :...AST.1 <= 0.494382: F1 (3.2/0.6)
                    :                   AST.1 > 0.494382: F2 (3.4)
                    ALT.48 > 0.08988764:
                    :...Age > 0.7931035:
                        :...ALT.after.24.w > 0.5652174:
                        :   :...Plat <= 0.5066878: F3 (3.4)
                        :   :   Plat > 0.5066878: F4 (5.7/0.6)
                        :   ALT.after.24.w <= 0.5652174:
                        :   :...BMI <= 0.5384616:
                        :       :...AST.1 > 0.7977528: F3 (9.7/1.3)
                        :       :   AST.1 <= 0.7977528:
                        :       :   :...ALT.24 <= 0.3033708: F4 (7.9/1.3)
                        :       :       ALT.24 > 0.3033708:
                        :       :       :...ALT.after.24.w <= 0.173913:
                        :       :           :...RNA.4 <= 0.3898644: F3 (6/1.3)
                        :       :           :   RNA.4 > 0.3898644: F4 (5.1/0.6)
                        :       :           ALT.after.24.w > 0.173913:
                        :       :           :...Age <= 0.862069:
                        :       :               :...RNA.4 <= 0.5140375: F1 (5)
                        :       :               :   RNA.4 > 0.5140375: F3 (6.2/1.3)
                        :       :               Age > 0.862069:
                        :       :               :...ALT.1 <= 0.6966292: F1 (7.3/1.9)
                        :       :                   ALT.1 > 0.6966292: F4 (2.5/0.6)
                        :       BMI > 0.5384616:
                        :       :...RNA.4 <= 0.4341563:
                        :           :...ALT.12 <= 0.494382: F1 (8.5/1.3)
                        :           :   ALT.12 > 0.494382: F2 (7.3/1.3)
                        :           RNA.4 > 0.4341563:
                        :           :...RBC > 0.7769297:
                        :               :...RBC <= 0.8945807: F1 (4.8)
                        :               :   RBC > 0.8945807: F2 (2)
                        :               RBC <= 0.7769297:
                        :               :...ALT.36 <= 0.2808989: F1 (2.9)
                        :                   ALT.36 > 0.2808989:
                        :                   :...ALT.36 > 0.8764045: F4 (2.9)
                        :                       ALT.36 <= 0.8764045: [S1]
                        Age <= 0.7931035:
                        :...ALT.48 > 0.9438202:
                            :...RBC <= 0.218647: F1 (4/1.3)
                            :   RBC > 0.218647:
                            :   :...RNA.4 <= 0.5562931:
                            :       :...Plat <= 0.2321526: F2 (4.3)
                            :       :   Plat > 0.2321526: F4 (11.9/5.2)
                            :       RNA.4 > 0.5562931:
                            :       :...RNA.4 <= 0.7738556: F3 (2.5/0.6)
                            :           RNA.4 > 0.7738556: F4 (4.2/0.6)
                            ALT.48 <= 0.9438202:
                            :...Age > 0.4827586:
                                :...WBC > 0.9082327: F3 (12.5/1.9)
                                :   WBC <= 0.9082327:
                                :   :...RNA.4 <= 0.4655524:
                                :       :...ALT.4 > 0.5168539:
                                :       :   :...ALT.24 > 0.5393258: F4 (12.3/1.9)
                                :       :   :   ALT.24 <= 0.5393258:
                                :       :   :   :...RBC <= 0.568844: F2 (3.8/1.9)
                                :       :   :       RBC > 0.568844: F1 (3.3)
                                :       :   ALT.4 <= 0.5168539:
                                :       :   :...Plat <= 0.2729466:
                                :       :       :...BMI <= 0.8461539: F4 (5.2)
                                :       :       :   BMI > 0.8461539: F3 (2.3)
                                :       :       Plat > 0.2729466:
                                :       :       :...BMI > 0.6923077: F1 (4.7/2)
                                :       :           BMI <= 0.6923077:
                                :       :           :...ALT.36 <= 0.6292135: F2 (8.3/3.2)
                                :       :               ALT.36 > 0.6292135: F3 (6.9/1.3)
                                :       RNA.4 > 0.4655524:
                                :       :...ALT.12 > 0.7078652: F2 (17.7/5.8)
                                :           ALT.12 <= 0.7078652:
                                :           :...BMI <= 0: F4 (4.9/2)
                                :               BMI > 0:
                                :               :...ALT.4 <= 0.4831461: F3 (16.5/1.3)
                                :                   ALT.4 > 0.4831461:
                                :                   :...RNA.4 <= 0.7096421: F3 (8.2/2)
                                :                       RNA.4 > 0.7096421: F2 (5.9/1.3)
                                Age <= 0.4827586:
                                :...ALT.4 <= 0.03370786:
                                    :...RNA.4 <= 0.2248704: F1 (3.5)
                                    :   RNA.4 > 0.2248704: F2 (7.4/0.6)
                                    ALT.4 > 0.03370786:
                                    :...AST.1 > 0.9213483:
                                        :...BMI <= 0.6153846: F2 (4.7/0.6)
                                        :   BMI > 0.6153846:
                                        :   :...RNA.4 <= 0.8584142: F4 (6.2/0.6)
                                        :       RNA.4 > 0.8584142: F1 (2/0.6)
                                        AST.1 <= 0.9213483:
                                        :...WBC > 0.9534577:
                                            :...WBC <= 0.9710209: F2 (5.7)
                                            :   WBC > 0.9710209: F4 (4.8/1.3)
                                            WBC <= 0.9534577:
                                            :...ALT.1 > 0.8764045:
                                                :...ALT.48 > 0.6516854: F3 (5.3/1.9)
                                                :   ALT.48 <= 0.6516854: [S2]
                                                ALT.1 <= 0.8764045:
                                                :...BMI <= 0.3846154:
                                                    :...ALT.after.24.w <= 0.04347826: [S3]
                                                    :   ALT.after.24.w > 0.04347826:
                                                    :   :...ALT.1 > 0.7191011: [S4]
                                                    :       ALT.1 <= 0.7191011:
                                                    :       :...ALT.4 <= 0.2247191: [S5]
                                                    :           ALT.4 > 0.2247191: [S6]
                                                    BMI > 0.3846154:
                                                    :...BMI <= 0.4615385: [S7]
                                                        BMI > 0.4615385: [S8]

SubTree [S1]

ALT.after.24.w <= 0.4782609: F3 (8.6/0.6)
ALT.after.24.w > 0.4782609: F4 (2)

SubTree [S2]

ALT.after.24.w <= 0.5217391: F1 (14.1/1.9)
ALT.after.24.w > 0.5217391: F2 (2.8/1.4)

SubTree [S3]

RNA.Base <= 0.1106484: F1 (2)
RNA.Base > 0.1106484: F2 (3.9/0.6)

SubTree [S4]

ALT.48 <= 0.5730337: F2 (3.2/1.3)
ALT.48 > 0.5730337: F3 (6.5/0.6)

SubTree [S5]

ALT.4 <= 0.1797753: F4 (5.9/2)
ALT.4 > 0.1797753: F1 (4.7)

SubTree [S6]

RBC <= 0.0630459: F1 (2.9)
RBC > 0.0630459:
:...ALT.1 > 0.4494382: F1 (7.8/2.6)
    ALT.1 <= 0.4494382:
    :...BMI > 0.3076923: F4 (4.5/1.3)
        BMI <= 0.3076923:
        :...ALT.24 > 0.8988764: F1 (2/0.6)
            ALT.24 <= 0.8988764:
            :...ALT.12 <= 0.8202247: F3 (19/2.6)
                ALT.12 > 0.8202247: F4 (3.3/0.6)

SubTree [S7]

ALT.1 <= 0.3932584: F2 (4.2/0.6)
ALT.1 > 0.3932584: F4 (6.2/1.3)

SubTree [S8]

ALT.after.24.w <= 0.04347826: F3 (5.9/0.6)
ALT.after.24.w > 0.04347826:
:...ALT.36 <= 0.06741573: F4 (3.9/0.6)
    ALT.36 > 0.06741573:
    :...ALT.48 <= 0.2022472: F2 (5.5/0.6)
        ALT.48 > 0.2022472:
        :...ALT.24 > 0.8314607:
            :...ALT.48 <= 0.8089887: F3 (10.6/0.6)
            :   ALT.48 > 0.8089887: F2 (2.3)
            ALT.24 <= 0.8314607:
            :...RBC > 0.7936847:
                :...RNA.4 <= 0.3203851: F1 (4/0.6)
                :   RNA.4 > 0.3203851: F3 (3.9)
                RBC <= 0.7936847:
                :...RNA.4 <= 0.1508733:
                    :...WBC <= 0.2165752: F1 (2.6/0.6)
                    :   WBC > 0.2165752: F3 (5.2/0.6)
                    RNA.4 > 0.1508733:
                    :...ALT.after.24.w <= 0.2608696:
                        :...Plat <= 0.4733648: F2 (3.5)
                        :   Plat > 0.4733648: F4 (4.7)
                        ALT.after.24.w > 0.2608696:
                        :...ALT.after.24.w > 0.5217391:
                            :...ALT.1 <= 0.5842696: F3 (3.8/1.9)
                            :   ALT.1 > 0.5842696: F4 (4.5/0.6)
                            ALT.after.24.w <= 0.5217391:
                            :...ALT.12 > 0.752809: F3 (3.9/1.3)
                                ALT.12 <= 0.752809:
                                :...ALT.1 <= 0.6404495: F1 (3.2)
                                    ALT.1 > 0.6404495: F2 (4.1)

-----  Trial 3:  -----

Decision tree:

ALT.12 > 0.8876405:
:...ALT.after.24.w > 0.8260869:
:   :...BMI <= 0: F1 (3.4/1)
:   :   BMI > 0:
:   :   :...BMI > 0.6923077: F3 (2.1/1)
:   :       BMI <= 0.6923077:
:   :       :...BMI <= 0.1538462: F3 (6.1/1.2)
:   :           BMI > 0.1538462: F4 (8.9/1.5)
:   ALT.after.24.w <= 0.8260869:
:   :...WBC > 0.8140505:
:       :...BMI > 0.8461539: F2 (4.2/0.5)
:       :   BMI <= 0.8461539:
:       :   :...ALT.4 <= 0.7078652: F4 (4.5/1)
:       :       ALT.4 > 0.7078652: F3 (2.3)
:       WBC <= 0.8140505:
:       :...ALT.36 > 0.4606742:
:           :...ALT.12 <= 0.9213483: F1 (13.4/4.2)
:           :   ALT.12 > 0.9213483:
:           :   :...Age <= 0.4827586:
:           :       :...ALT.12 <= 0.9662921: F3 (3.4/1.1)
:           :       :   ALT.12 > 0.9662921: F2 (5.5/1.5)
:           :       Age > 0.4827586:
:           :       :...ALT.after.24.w <= 0.3043478: F3 (9.2/2.1)
:           :           ALT.after.24.w > 0.3043478: F1 (5.2/1)
:           ALT.36 <= 0.4606742:
:           :...ALT.4 <= 0.07865169: F1 (8.4)
:               ALT.4 > 0.07865169:
:               :...Age > 0.8965517: F2 (3.9/1.1)
:                   Age <= 0.8965517:
:                   :...WBC > 0.7529089: F4 (3.6)
:                       WBC <= 0.7529089:
:                       :...ALT.4 <= 0.3033708: F4 (2.8/0.5)
:                           ALT.4 > 0.3033708: F1 (16.2/3.1)
ALT.12 <= 0.8876405:
:...ALT.4 > 0.9213483:
    :...Plat > 0.5567062:
    :   :...ALT.36 <= 0.741573: F2 (11.7/2.8)
    :   :   ALT.36 > 0.741573:
    :   :   :...ALT.4 <= 0.9775281: F1 (6.3/1)
    :   :       ALT.4 > 0.9775281: F3 (3.4/0.5)
    :   Plat <= 0.5567062:
    :   :...ALT.after.24.w <= 0.1304348: F2 (4.9/1.2)
    :       ALT.after.24.w > 0.1304348:
    :       :...Age > 0.7931035: F1 (7.7/0.5)
    :           Age <= 0.7931035:
    :           :...RNA.4 <= 0.3938995:
    :               :...ALT.24 <= 0.3370787: F2 (2.3)
    :               :   ALT.24 > 0.3370787: F4 (10.5/1.1)
    :               RNA.4 > 0.3938995:
    :               :...ALT.36 > 0.8876405: F4 (2.2)
    :                   ALT.36 <= 0.8876405:
    :                   :...Age <= 0.6551724: F1 (12/3.3)
    :                       Age > 0.6551724: F4 (2.3/0.5)
    ALT.4 <= 0.9213483:
    :...AST.1 <= 0.07865169:
        :...ALT.after.24.w <= 0.6086956:
        :   :...AST.1 <= 0.01123596:
        :   :   :...ALT.48 <= 0.4606742: F2 (4.5/1.6)
        :   :   :   ALT.48 > 0.4606742:
        :   :   :   :...ALT.36 <= 0.3932584: F2 (4.1/1.2)
        :   :   :       ALT.36 > 0.3932584: F4 (3.4)
        :   :   AST.1 > 0.01123596:
        :   :   :...BMI <= 0.07692308: F4 (4.6/1.8)
        :   :       BMI > 0.07692308:
        :   :       :...ALT.36 > 0.1910112: F3 (25.5/8.3)
        :   :           ALT.36 <= 0.1910112:
        :   :           :...ALT.1 <= 0.6966292: F1 (2.6/1.1)
        :   :               ALT.1 > 0.6966292: F4 (3.9/1)
        :   ALT.after.24.w > 0.6086956:
        :   :...ALT.after.24.w > 0.9565217:
        :       :...RNA.4 <= 0.3898644: F3 (2.8)
        :       :   RNA.4 > 0.3898644: F4 (3.7)
        :       ALT.after.24.w <= 0.9565217:
        :       :...RNA.4 <= 0.2566892: F4 (8.9/0.5)
        :           RNA.4 > 0.2566892:
        :           :...Age <= 0.2758621: F4 (3.5)
        :               Age > 0.2758621:
        :               :...ALT.after.24.w <= 0.7391304: F4 (2.8/0.5)
        :                   ALT.after.24.w > 0.7391304: F1 (5.3)
        AST.1 > 0.07865169:
        :...ALT.1 <= 0.1123596:
            :...ALT.1 <= 0:
            :   :...ALT.36 > 0.5393258: F2 (4.5)
            :   :   ALT.36 <= 0.5393258:
            :   :   :...ALT.24 <= 0.4382023: F1 (4.3)
            :   :       ALT.24 > 0.4382023: F4 (2.3/0.5)
            :   ALT.1 > 0:
            :   :...ALT.after.24.w <= 0.04347826:
            :       :...ALT.36 <= 0.247191: F4 (2.5)
            :       :   ALT.36 > 0.247191:
            :       :   :...BMI <= 0.8461539: F2 (7.1/1.6)
            :       :       BMI > 0.8461539: F3 (2.2)
            :       ALT.after.24.w > 0.04347826:
            :       :...ALT.12 <= 0.03370786: F2 (4/0.5)
            :           ALT.12 > 0.03370786:
            :           :...Age <= 0.4827586:
            :               :...ALT.48 <= 0.6067415: F3 (24.2/7.3)
            :               :   ALT.48 > 0.6067415: F1 (7.7/1.6)
            :               Age > 0.4827586:
            :               :...Age <= 0.7241379:
            :                   :...BMI <= 0.4615385: F1 (5.2/1.5)
            :                   :   BMI > 0.4615385:
            :                   :   :...ALT.36 <= 0.6179775: F2 (3.9/1.1)
            :                   :       ALT.36 > 0.6179775: F4 (3.2)
            :                   Age > 0.7241379:
            :                   :...ALT.24 <= 0.2359551: F4 (2.3/1)
            :                       ALT.24 > 0.2359551:
            :                       :...RNA.Base <= 0.7824873: F3 (12.3/2.9)
            :                           RNA.Base > 0.7824873: F1 (3.4/1)
            ALT.1 > 0.1123596:
            :...RNA.Base <= 0.02612077:
                :...WBC <= 0.08364435: F1 (2.2)
                :   WBC > 0.08364435:
                :   :...RNA.Base <= 0.008851238: F3 (3.9)
                :       RNA.Base > 0.008851238:
                :       :...ALT.24 <= 0.1910112: F3 (2.3)
                :           ALT.24 > 0.1910112: F2 (15.8/2.8)
                RNA.Base > 0.02612077:
                :...Plat > 0.9386891:
                    :...ALT.12 <= 0.3033708:
                    :   :...WBC <= 0.4299671: F3 (4/1)
                    :   :   WBC > 0.4299671: F2 (11.1/1)
                    :   ALT.12 > 0.3033708:
                    :   :...AST.1 > 0.9662921: F2 (2.5)
                    :       AST.1 <= 0.9662921:
                    :       :...RBC <= 0.7853205: F4 (13.9/2)
                    :           RBC > 0.7853205: F2 (3.4/1.6)
                    Plat <= 0.9386891:
                    :...ALT.48 <= 0.06741573:
                        :...RBC > 0.7907788:
                        :   :...AST.1 > 0.6179775: F4 (6.4)
                        :   :   AST.1 <= 0.6179775:
                        :   :   :...ALT.4 <= 0.247191: F4 (2.2)
                        :   :       ALT.4 > 0.247191: F1 (7.5/1)
                        :   RBC <= 0.7907788:
                        :   :...AST.1 <= 0.5280899:
                        :       :...Plat <= 0.1595642: F3 (3.4/1)
                        :       :   Plat > 0.1595642:
                        :       :   :...RNA.4 <= 0.8480108: F4 (13.9/3.1)
                        :       :       RNA.4 > 0.8480108: F3 (2.3/1)
                        :       AST.1 > 0.5280899:
                        :       :...Age <= 0.137931: F1 (2.3)
                        :           Age > 0.137931:
                        :           :...RBC <= 0.391696: F4 (4.6/1.5)
                        :               RBC > 0.391696: F2 (6.8/0.5)
                        ALT.48 > 0.06741573:
                        :...WBC <= 0.06992316:
                            :...BMI <= 0: F1 (2.3)
                            :   BMI > 0:
                            :   :...AST.1 > 0.7752809: F3 (7.3/1.5)
                            :       AST.1 <= 0.7752809:
                            :       :...ALT.1 <= 0.4606742:
                            :           :...RBC <= 0.5360187: F4 (2.9/0.5)
                            :           :   RBC > 0.5360187: F3 (6)
                            :           ALT.1 > 0.4606742:
                            :           :...Plat > 0.6867015: F3 (4/1.6)
                            :               Plat <= 0.6867015:
                            :               :...Plat > 0.1839102: F2 (13)
                            :                   Plat <= 0.1839102:
                            :                   :...BMI <= 0.3076923: F2 (3.6)
                            :                       BMI > 0.3076923: F4 (2.9)
                            WBC > 0.06992316:
                            :...ALT.24 <= 0.1685393:
                                :...WBC > 0.8902305:
                                :   :...AST.1 <= 0.505618: F2 (5.7/0.5)
                                :   :   AST.1 > 0.505618:
                                :   :   :...ALT.36 <= 0.4831461: F3 (4.6/1.1)
                                :   :       ALT.36 > 0.4831461: F1 (4.3/1.2)
                                :   WBC <= 0.8902305:
                                :   :...Plat <= 0.07994695: F1 (5.5/1.5)
                                :       Plat > 0.07994695:
                                :       :...Age <= 0.1034483:
                                :           :...ALT.after.24.w <= 0.3913043: F4 (5.1/0.5)
                                :           :   ALT.after.24.w > 0.3913043: F1 (4.7)
                                :           Age > 0.1034483:
                                :           :...RNA.Base > 0.9477385:
                                :               :...RBC <= 0.2768078: F1 (2.5)
                                :               :   RBC > 0.2768078: F4 (3.6)
                                :               RNA.Base <= 0.9477385:
                                :               :...ALT.1 > 0.9213483:
                                :                   :...Plat <= 0.5311762: F3 (3.4)
                                :                   :   Plat > 0.5311762: F2 (3.6/1.1)
                                :                   ALT.1 <= 0.9213483:
                                :                   :...ALT.12 <= 0.5280899:
                                :                       :...BMI <= 0.8461539: F4 (22.7/6)
                                :                       :   BMI > 0.8461539: F2 (7.2/2.6)
                                :                       ALT.12 > 0.5280899:
                                :                       :...ALT.4 > 0.4382023: [S1]
                                :                           ALT.4 <= 0.4382023: [S2]
                                ALT.24 > 0.1685393:
                                :...ALT.after.24.w > 0.9130435:
                                    :...RNA.4 > 0.609365:
                                    :   :...ALT.1 <= 0.4494382: F1 (3.2/1.5)
                                    :   :   ALT.1 > 0.4494382: F4 (7/1.2)
                                    :   RNA.4 <= 0.609365:
                                    :   :...BMI > 0.6923077: F3 (7.3/0.5)
                                    :       BMI <= 0.6923077:
                                    :       :...ALT.12 <= 0.1460674: F3 (5.7/1.1)
                                    :           ALT.12 > 0.1460674: F1 (12.5/2.3)
                                    ALT.after.24.w <= 0.9130435:
                                    :...ALT.12 > 0.7977528:
                                        :...RBC <= 0.4123253:
                                        :   :...ALT.4 <= 0.4494382: F4 (3.8/1.5)
                                        :   :   ALT.4 > 0.4494382: F1 (3.5/0.5)
                                        :   RBC > 0.4123253:
                                        :   :...Age <= 0.3103448: F2 (12.5/1.2)
                                        :       Age > 0.3103448: [S3]
                                        ALT.12 <= 0.7977528:
                                        :...Age > 0.7241379:
                                            :...ALT.after.24.w > 0.6521739:
                                            :   :...ALT.24 <= 0.3033708: F3 (2.9)
                                            :   :   ALT.24 > 0.3033708:
                                            :   :   :...ALT.1 <= 0.3370787: F1 (2.3/0.5)
                                            :   :       ALT.1 > 0.3370787: F2 (21.4/3.8)
                                            :   ALT.after.24.w <= 0.6521739:
                                            :   :...ALT.12 <= 0.03370786: F4 (2.9)
                                            :       ALT.12 > 0.03370786:
                                            :       :...ALT.1 <= 0.3595506: [S4]
                                            :           ALT.1 > 0.3595506:
                                            :           :...ALT.4 > 0.8089887: [S5]
                                            :               ALT.4 <= 0.8089887: [S6]
                                            Age <= 0.7241379:
                                            :...ALT.1 > 0.8539326:
                                                :...ALT.4 <= 0.03370786: F3 (3.6)
                                                :   ALT.4 > 0.03370786:
                                                :   :...Plat <= 0.2402005: [S7]
                                                :       Plat > 0.2402005:
                                                :       :...RBC > 0.803508: F2 (3.5/1.2)
                                                :           RBC <= 0.803508:
                                                :           :...Age <= 0.06896552: [S8]
                                                :               Age > 0.06896552: [S9]
                                                ALT.1 <= 0.8539326:
                                                :...ALT.12 > 0.4157303:
                                                    :...ALT.48 > 0.9438202: F4 (5.8)
                                                    :   ALT.48 <= 0.9438202:
                                                    :   :...ALT.1 > 0.5730337:
                                                    :       :...Plat <= 0.3866588: [S10]
                                                    :       :   Plat > 0.3866588: [S11]
                                                    :       ALT.1 <= 0.5730337: [S12]
                                                    ALT.12 <= 0.4157303:
                                                    :...RNA.Base <= 0.1034706: [S13]
                                                        RNA.Base > 0.1034706:
                                                        :...ALT.48 > 0.8202247: [S14]
                                                            ALT.48 <= 0.8202247:
                                                            :...RBC > 0.9123615: [S15]
                                                                RBC <= 0.9123615: [S16]

SubTree [S1]

ALT.4 <= 0.8202247: F4 (8.9/1)
ALT.4 > 0.8202247: F2 (2.1/1)

SubTree [S2]

ALT.24 > 0.05617978: F3 (7)
ALT.24 <= 0.05617978:
:...ALT.12 <= 0.741573: F4 (4.6/0.5)
    ALT.12 > 0.741573: F3 (4.9/1.2)

SubTree [S3]

ALT.after.24.w <= 0.173913: F2 (4.4/0.5)
ALT.after.24.w > 0.173913:
:...ALT.4 <= 0.3146068: F4 (2.9)
    ALT.4 > 0.3146068: F3 (8.8/2.6)

SubTree [S4]

ALT.after.24.w > 0.4782609: F1 (6.3/1.6)
ALT.after.24.w <= 0.4782609:
:...ALT.4 <= 0.3370787: F1 (4.7/1.6)
    ALT.4 > 0.3370787: F2 (10.1/0.5)

SubTree [S5]

ALT.12 <= 0.3932584: F3 (4.5/1.7)
ALT.12 > 0.3932584: F4 (5.7/1.1)

SubTree [S6]

Plat > 0.7286869: F4 (2.8)
Plat <= 0.7286869:
:...Plat <= 0.01514413: F3 (2.7/1.1)
    Plat > 0.01514413:
    :...ALT.36 <= 0.3370787: F1 (9.2/1.1)
        ALT.36 > 0.3370787:
        :...ALT.4 <= 0.5617977: F3 (5.7/2.1)
            ALT.4 > 0.5617977: F1 (6.5/0.5)

SubTree [S7]

ALT.1 <= 0.9662921: F2 (6.4/1.8)
ALT.1 > 0.9662921: F4 (3.2)

SubTree [S8]

ALT.1 <= 0.9438202: F1 (2.1)
ALT.1 > 0.9438202: F3 (4/1.2)

SubTree [S9]

BMI > 0.3846154: F1 (15.6/1)
BMI <= 0.3846154:
:...ALT.36 <= 0.8988764: F4 (4/0.5)
    ALT.36 > 0.8988764: F1 (2.1)

SubTree [S10]

WBC <= 0.3199781: F2 (2)
WBC > 0.3199781:
:...ALT.12 <= 0.5730337: F4 (5.5/1.6)
    ALT.12 > 0.5730337: F3 (5.9/0.5)

SubTree [S11]

ALT.4 > 0.6966292: F2 (5.2/0.5)
ALT.4 <= 0.6966292:
:...ALT.24 <= 0.5393258: F2 (3.7/0.5)
    ALT.24 > 0.5393258: F3 (7.8/1.6)

SubTree [S12]

RNA.4 <= 0.3030731: F4 (16.3/2.3)
RNA.4 > 0.3030731:
:...ALT.48 <= 0.4719101:
    :...BMI <= 0.3846154: F1 (5.2/2.3)
    :   BMI > 0.3846154:
    :   :...RNA.Base <= 0.7122203: F4 (9.7/0.5)
    :       RNA.Base > 0.7122203: F2 (3.6)
    ALT.48 > 0.4719101:
    :...BMI <= 0.3076923:
        :...AST.1 <= 0.4157303: F2 (2.3)
        :   AST.1 > 0.4157303: F3 (4.1/0.5)
        BMI > 0.3076923:
        :...Plat <= 0.6304561: F1 (9.2/1)
            Plat > 0.6304561: F3 (2.9/0.5)

SubTree [S13]

RNA.Base <= 0.0443486: F4 (4.2/1.7)
RNA.Base > 0.0443486: F1 (8.2/1)

SubTree [S14]

ALT.1 <= 0.5280899: F2 (6.9/1)
ALT.1 > 0.5280899: F3 (8.2/1.7)

SubTree [S15]

AST.1 <= 0.6067415: F4 (4.8)
AST.1 > 0.6067415: F3 (3.4/1.1)

SubTree [S16]

ALT.12 > 0.3707865: F3 (8.2/1.6)
ALT.12 <= 0.3707865:
:...ALT.12 <= 0.1348315: F3 (16.9/5.5)
    ALT.12 > 0.1348315:
    :...RNA.4 > 0.7930099:
        :...RNA.Base <= 0.4821797: F3 (2.1)
        :   RNA.Base > 0.4821797: F4 (4/1.2)
        RNA.4 <= 0.7930099:
        :...WBC <= 0.5304061:
            :...ALT.36 <= 0.5842696: F3 (5.1/1.1)
            :   ALT.36 > 0.5842696: F1 (6.7/2)
            WBC > 0.5304061:
            :...RNA.Base > 0.6795371: F1 (4.7)
                RNA.Base <= 0.6795371:
                :...RNA.4 <= 0.1410989: F4 (2.8/1.2)
                    RNA.4 > 0.1410989:
                    :...RBC <= 0.2451413: F2 (2.7)
                        RBC > 0.2451413: F1 (4.9/1)

-----  Trial 4:  -----

Decision tree:

BMI > 0.4615385:
:...WBC <= 0.04643249:
:   :...ALT.4 <= 0.2134831: F2 (4)
:   :   ALT.4 > 0.2134831:
:   :   :...ALT.48 > 0.752809: F3 (3.7/1.1)
:   :       ALT.48 <= 0.752809:
:   :       :...RNA.Base <= 0.1958179: F1 (6.1)
:   :           RNA.Base > 0.1958179:
:   :           :...ALT.after.24.w <= 0.3913043: F1 (4/1)
:   :               ALT.after.24.w > 0.3913043: F3 (5/0.4)
:   WBC > 0.04643249:
:   :...ALT.after.24.w > 0.5217391:
:       :...AST.1 <= 0.1348315:
:       :   :...ALT.after.24.w > 0.8695652: F1 (6.8/1.8)
:       :   :   ALT.after.24.w <= 0.8695652:
:       :   :   :...ALT.12 > 0.8426966: F1 (3.4/0.9)
:       :   :       ALT.12 <= 0.8426966:
:       :   :       :...AST.1 <= 0.06741573: F4 (5.6)
:       :   :           AST.1 > 0.06741573: F3 (4.3/1.4)
:       :   AST.1 > 0.1348315:
:       :   :...ALT.12 > 0.3932584:
:       :       :...BMI > 0.9230769: F2 (7.8/4.2)
:       :       :   BMI <= 0.9230769:
:       :       :   :...AST.1 > 0.741573:
:       :       :       :...RNA.4 > 0.7758369: F1 (4.1/1.4)
:       :       :       :   RNA.4 <= 0.7758369:
:       :       :       :   :...ALT.4 <= 0.5617977: F4 (13.7)
:       :       :       :       ALT.4 > 0.5617977:
:       :       :       :       :...ALT.1 <= 0.3820225: F1 (2.8)
:       :       :       :           ALT.1 > 0.3820225: F4 (7.4/2.9)
:       :       :       AST.1 <= 0.741573:
:       :       :       :...RBC > 0.9025032: F2 (6.5/1)
:       :       :           RBC <= 0.9025032:
:       :       :           :...ALT.4 <= 0.06741573: F3 (4/1.4)
:       :       :               ALT.4 > 0.06741573:
:       :       :               :...Age > 0.8275862: F2 (5.9/1.1)
:       :       :                   Age <= 0.8275862:
:       :       :                   :...ALT.1 <= 0.1573034: F2 (5.2/2.4)
:       :       :                       ALT.1 > 0.1573034:
:       :       :                       :...RNA.4 > 0.8100964: F4 (11.7/1)
:       :       :                           RNA.4 <= 0.8100964:
:       :       :                           :...Age <= 0.1724138: F2 (5/1.9)
:       :       :                               Age > 0.1724138:
:       :       :                               :...RNA.4 <= 0.7061995: F4 (13.6/2.5)
:       :       :                                   RNA.4 > 0.7061995: F2 (5.6/1.3)
:       :       ALT.12 <= 0.3932584:
:       :       :...ALT.12 > 0.3707865:
:       :           :...RNA.4 <= 0.2267619: F1 (3.4)
:       :           :   RNA.4 > 0.2267619: F3 (5)
:       :           ALT.12 <= 0.3707865:
:       :           :...ALT.after.24.w <= 0.5652174: F4 (4.9/2)
:       :               ALT.after.24.w > 0.5652174:
:       :               :...ALT.24 > 0.8651685:
:       :                   :...AST.1 <= 0.6292135: F3 (4.6/1)
:       :                   :   AST.1 > 0.6292135: F2 (6/0.4)
:       :                   ALT.24 <= 0.8651685:
:       :                   :...Age > 0.7586207:
:       :                       :...Age <= 0.8965517: F2 (11.2/2.3)
:       :                       :   Age > 0.8965517: F4 (3)
:       :                       Age <= 0.7586207:
:       :                       :...ALT.4 > 0.7977528:
:       :                           :...RNA.4 > 0.8333284: F3 (3.8)
:       :                           :   RNA.4 <= 0.8333284:
:       :                           :   :...ALT.1 <= 0.3258427: F3 (2.5/0.4)
:       :                           :       ALT.1 > 0.3258427: F1 (7.4/1)
:       :                           ALT.4 <= 0.7977528:
:       :                           :...ALT.12 > 0.2808989: F2 (4.8/0.4)
:       :                               ALT.12 <= 0.2808989:
:       :                               :...ALT.4 <= 0.2808989:
:       :                                   :...RBC <= 0.564325: F1 (9.5/3.2)
:       :                                   :   RBC > 0.564325: F3 (2.3/0.4)
:       :                                   ALT.4 > 0.2808989:
:       :                                   :...RNA.Base > 0.5666882:
:       :                                       :...RBC <= 0.5659373: F3 (6.5/1.1)
:       :                                       :   RBC > 0.5659373: F4 (2.4)
:       :                                       RNA.Base <= 0.5666882:
:       :                                       :...Plat <= 0.2321526: F1 (2.4/0.9)
:       :                                           Plat > 0.2321526:
:       :                                           :...ALT.36 <= 0.7303371: F2 (5.8/0.4)
:       :                                               ALT.36 > 0.7303371: F4 (2.6)
:       ALT.after.24.w <= 0.5217391:
:       :...ALT.after.24.w > 0.4347826:
:           :...ALT.12 <= 0.04494382: F2 (5.6/0.4)
:           :   ALT.12 > 0.04494382:
:           :   :...ALT.24 <= 0.2359551:
:           :       :...ALT.1 <= 0.7865168: F1 (2.8/0.4)
:           :       :   ALT.1 > 0.7865168: F4 (4.4)
:           :       ALT.24 > 0.2359551:
:           :       :...ALT.after.24.w <= 0.4782609:
:           :           :...AST.1 <= 0.1123596: F3 (2.6)
:           :           :   AST.1 > 0.1123596: F1 (11.1/2.5)
:           :           ALT.after.24.w > 0.4782609:
:           :           :...RBC <= 0.3063387: F1 (4.1)
:           :               RBC > 0.3063387:
:           :               :...WBC <= 0.1418222: F3 (2.6)
:           :                   WBC > 0.1418222:
:           :                   :...RBC <= 0.7555608: F2 (4.7)
:           :                       RBC > 0.7555608: F1 (2.3/0.8)
:           ALT.after.24.w <= 0.4347826:
:           :...ALT.48 > 0.8426966:
:               :...Age <= 0.137931: F2 (4.7/1.1)
:               :   Age > 0.137931:
:               :   :...BMI > 0.7692308:
:               :       :...Age > 0.7241379: F1 (2.5)
:               :       :   Age <= 0.7241379:
:               :       :   :...ALT.4 <= 0.4494382: F1 (3.9/1.1)
:               :       :       ALT.4 > 0.4494382: F4 (7.6)
:               :       BMI <= 0.7692308:
:               :       :...BMI <= 0.5384616: F2 (2.5)
:               :           BMI > 0.5384616:
:               :           :...Plat > 0.7601966: F4 (2.6/1.1)
:               :               Plat <= 0.7601966:
:               :               :...Age <= 0.7931035: F3 (6.3/2.4)
:               :                   Age > 0.7931035: F1 (4.7/0.4)
:               ALT.48 <= 0.8426966:
:               :...WBC <= 0.09363337: F2 (6.5/0.9)
:                   WBC > 0.09363337:
:                   :...ALT.12 <= 0.1797753:
:                       :...ALT.4 <= 0.3595506:
:                       :   :...WBC <= 0.4979144: F1 (10/2.2)
:                       :   :   WBC > 0.4979144: F3 (3.6)
:                       :   ALT.4 > 0.3595506:
:                       :   :...ALT.1 <= 0.3820225: F4 (6.1/0.4)
:                       :       ALT.1 > 0.3820225:
:                       :       :...RNA.4 <= 0.2295246: F4 (3/0.4)
:                       :           RNA.4 > 0.2295246:
:                       :           :...ALT.12 <= 0.1123596: F2 (6.4)
:                       :               ALT.12 > 0.1123596: F1 (2.2)
:                       ALT.12 > 0.1797753:
:                       :...ALT.48 > 0.8202247: F2 (4.8)
:                           ALT.48 <= 0.8202247:
:                           :...ALT.4 <= 0.05617978:
:                               :...ALT.after.24.w <= 0.3478261: F1 (8.3/1.6)
:                               :   ALT.after.24.w > 0.3478261: F3 (5.7/2.2)
:                               ALT.4 > 0.05617978:
:                               :...Plat > 0.9282733:
:                                   :...ALT.24 <= 0.741573: F2 (3.7)
:                                   :   ALT.24 > 0.741573: F4 (2.9)
:                                   Plat <= 0.9282733:
:                                   :...ALT.12 > 0.7977528:
:                                       :...BMI > 0.9230769: F1 (2.3/0.9)
:                                       :   BMI <= 0.9230769:
:                                       :   :...RNA.Base <= 0.542564: F3 (15.1/1.8)
:                                       :       RNA.Base > 0.542564: F2 (9.9/1.6)
:                                       ALT.12 <= 0.7977528:
:                                       :...ALT.48 > 0.5842696:
:                                           :...RNA.Base > 0.7295456: F4 (6.2/1.8)
:                                           :   RNA.Base <= 0.7295456:
:                                           :   :...Plat <= 0.2682108: F4 (3.4)
:                                           :       Plat > 0.2682108: F3 (9.2/2.7)
:                                           ALT.48 <= 0.5842696:
:                                           :...ALT.4 <= 0.6853933:
:                                               :...ALT.after.24.w > 0.08695652:
:                                               :   :...AST.1 <= 0.1011236: F2 (5.3/2.3)
:                                               :   :   AST.1 > 0.1011236: F3 (20.6/4.9)
:                                               :   ALT.after.24.w <= 0.08695652:
:                                               :   :...ALT.1 <= 0.2022472: F2 (4.1/1.9)
:                                               :       ALT.1 > 0.2022472:
:                                               :       :...Age <= 0.2758621: F4 (3.2/1.3)
:                                               :           Age > 0.2758621: F3 (4)
:                                               ALT.4 > 0.6853933:
:                                               :...ALT.48 > 0.4382023: F3 (5.6/0.8)
:                                                   ALT.48 <= 0.4382023:
:                                                   :...BMI <= 0.6923077: F2 (3.9/1.4)
:                                                       BMI > 0.6923077:
:                                                       :...WBC <= 0.2931943: F1 (3.4/0.4)
:                                                           WBC > 0.2931943: [S1]
BMI <= 0.4615385:
:...AST.1 > 0.6966292:
    :...ALT.1 <= 0.05617978:
    :   :...RBC <= 0.6272686: F3 (4.3/0.4)
    :   :   RBC > 0.6272686: F1 (5)
    :   ALT.1 > 0.05617978:
    :   :...RNA.4 <= 0.1096454:
    :       :...RBC <= 0.1361606: F3 (3.7/0.4)
    :       :   RBC > 0.1361606:
    :       :   :...Plat <= 0.6185191: F4 (11.8/1.9)
    :       :       Plat > 0.6185191: F2 (3.1)
    :       RNA.4 > 0.1096454:
    :       :...ALT.48 > 0.9438202: F2 (5.8)
    :           ALT.48 <= 0.9438202:
    :           :...RNA.4 <= 0.1684916: F1 (3.3)
    :               RNA.4 > 0.1684916:
    :               :...BMI > 0.3846154:
    :                   :...WBC > 0.3660812: F3 (8.8/2.4)
    :                   :   WBC <= 0.3660812:
    :                   :   :...RNA.Base <= 0.3681011: F4 (2.5)
    :                   :       RNA.Base > 0.3681011: F1 (4/0.4)
    :                   BMI <= 0.3846154:
    :                   :...RNA.4 > 0.8480108:
    :                       :...ALT.48 <= 0.1011236: F2 (3.8/1.9)
    :                       :   ALT.48 > 0.1011236:
    :                       :   :...BMI > 0.3076923: F1 (2.9/0.9)
    :                       :       BMI <= 0.3076923:
    :                       :       :...BMI <= 0.07692308: F1 (5.4/0.9)
    :                       :           BMI > 0.07692308: F3 (4.7)
    :                       RNA.4 <= 0.8480108:
    :                       :...Age > 0.4482759:
    :                           :...AST.1 <= 0.7303371: F4 (3.5/1.1)
    :                           :   AST.1 > 0.7303371:
    :                           :   :...BMI > 0.1538462:
    :                           :       :...ALT.12 <= 0.5955056: F2 (11/1.3)
    :                           :       :   ALT.12 > 0.5955056: F3 (3.1/0.4)
    :                           :       BMI <= 0.1538462:
    :                           :       :...ALT.4 > 0.505618: F3 (7.6)
    :                           :           ALT.4 <= 0.505618:
    :                           :           :...ALT.4 <= 0.1797753: F3 (5.6/0.9)
    :                           :               ALT.4 > 0.1797753: F2 (4.2)
    :                           Age <= 0.4482759:
    :                           :...RNA.Base <= 0.1106484: F1 (2.2)
    :                               RNA.Base > 0.1106484:
    :                               :...BMI > 0.3076923:
    :                                   :...ALT.after.24.w <= 0.5652174: F1 (3.1/1)
    :                                   :   ALT.after.24.w > 0.5652174: F2 (2.8)
    :                                   BMI <= 0.3076923:
    :                                   :...BMI <= 0.07692308:
    :                                       :...ALT.1 <= 0.4831461: F4 (4.4/0.8)
    :                                       :   ALT.1 > 0.4831461: F2 (3.8)
    :                                       BMI > 0.07692308:
    :                                       :...AST.1 > 0.9325843: F4 (2.5)
    :                                           AST.1 <= 0.9325843:
    :                                           :...WBC <= 0.1086718: F4 (3.2/1)
    :                                               WBC > 0.1086718:
    :                                               :...ALT.1 <= 0.1460674: F2 (2.6)
    :                                                   ALT.1 > 0.1460674: F3 (9.6/1.3)
    AST.1 <= 0.6966292:
    :...AST.1 > 0.6179775:
        :...ALT.12 <= 0.3707865:
        :   :...RBC <= 0.4879217: F1 (5/1)
        :   :   RBC > 0.4879217: F2 (5.6/2.7)
        :   ALT.12 > 0.3707865:
        :   :...RNA.Base <= 0.123665: F3 (2.5/0.4)
        :       RNA.Base > 0.123665:
        :       :...WBC <= 0.1587267: F4 (4.2)
        :           WBC > 0.1587267:
        :           :...ALT.48 <= 0.1123596: F4 (2.5)
        :               ALT.48 > 0.1123596: F1 (21.6/4)
        AST.1 <= 0.6179775:
        :...RNA.Base > 0.6363708:
            :...ALT.12 <= 0.03370786: F3 (4)
            :   ALT.12 > 0.03370786:
            :   :...ALT.24 > 0.8426966:
            :       :...AST.1 <= 0.2921348: F4 (6.6/2.7)
            :       :   AST.1 > 0.2921348: F1 (8.2)
            :       ALT.24 <= 0.8426966:
            :       :...ALT.12 <= 0.4269663:
            :           :...ALT.after.24.w > 0.9565217: F3 (2.1/1)
            :           :   ALT.after.24.w <= 0.9565217:
            :           :   :...ALT.48 > 0.8314607: F4 (5.3/2)
            :           :       ALT.48 <= 0.8314607:
            :           :       :...Plat <= 0.2797206: F1 (5.8/1.4)
            :           :           Plat > 0.2797206:
            :           :           :...WBC <= 0.7645444: F4 (11.7/1.9)
            :           :               WBC > 0.7645444: F1 (4.4/0.4)
            :           ALT.12 > 0.4269663:
            :           :...Plat > 0.9565158: F1 (5)
            :               Plat <= 0.9565158:
            :               :...AST.1 > 0.5617977:
            :                   :...ALT.24 <= 0.3707865: F3 (3.9/1)
            :                   :   ALT.24 > 0.3707865: F2 (3.4/1)
            :                   AST.1 <= 0.5617977:
            :                   :...ALT.36 > 0.7977528: F3 (10.2/1.8)
            :                       ALT.36 <= 0.7977528:
            :                       :...ALT.12 <= 0.6516854:
            :                           :...ALT.24 <= 0.08988764: F3 (2.6)
            :                           :   ALT.24 > 0.08988764: F4 (14.4/3.1)
            :                           ALT.12 > 0.6516854:
            :                           :...ALT.12 <= 0.7078652: F3 (2.9)
            :                               ALT.12 > 0.7078652:
            :                               :...WBC <= 0.2755214: F1 (4.7)
            :                                   WBC > 0.2755214:
            :                                   :...Plat <= 0.2797206: F3 (3.7)
            :                                       Plat > 0.2797206:
            :                                       :...ALT.4 <= 0.4269663: F1 (3.7/0.9)
            :                                           ALT.4 > 0.4269663: F4 (4.3/1.1)
            RNA.Base <= 0.6363708:
            :...Age <= 0.1724138:
                :...Age <= 0.03448276:
                :   :...ALT.36 <= 0.3595506: F2 (4.6/1.1)
                :   :   ALT.36 > 0.3595506: F4 (7.1/2.8)
                :   Age > 0.03448276:
                :   :...ALT.after.24.w > 0.4347826: F1 (15.1/3.4)
                :       ALT.after.24.w <= 0.4347826:
                :       :...ALT.4 <= 0.6404495: F4 (10.1/2.3)
                :           ALT.4 > 0.6404495: F3 (2.7)
                Age > 0.1724138:
                :...RNA.Base <= 0.02975085:
                    :...ALT.1 > 0.6741573: F2 (2.4/0.4)
                    :   ALT.1 <= 0.6741573:
                    :   :...RNA.4 <= 0.2949855: F3 (2.4)
                    :       RNA.4 > 0.2949855: F1 (7.3/1)
                    RNA.Base > 0.02975085:
                    :...ALT.after.24.w <= 0.08695652:
                        :...WBC > 0.859056: F3 (2.5/0.4)
                        :   WBC <= 0.859056:
                        :   :...Age <= 0.6206896: F2 (13.9/2.5)
                        :       Age > 0.6206896: F4 (7.5/1.6)
                        ALT.after.24.w > 0.08695652:
                        :...WBC > 0.874314: F4 (10.7/2.3)
                            WBC <= 0.874314:
                            :...RNA.4 > 0.9036831:
                                :...ALT.48 <= 0.4831461: F3 (10.9/1.4)
                                :   ALT.48 > 0.4831461: F1 (3.4/0.4)
                                RNA.4 <= 0.9036831:
                                :...Age <= 0.2413793:
                                    :...RNA.4 <= 0.1096454: F3 (2.3/0.4)
                                    :   RNA.4 > 0.1096454: F4 (6.3/0.8)
                                    Age > 0.2413793:
                                    :...Age <= 0.3103448:
                                        :...RNA.Base <= 0.3949795: F2 (6.1)
                                        :   RNA.Base > 0.3949795: F3 (2.1)
                                        Age > 0.3103448:
                                        :...RNA.4 <= 0.08631617: F4 (8.6/1.3)
                                            RNA.4 > 0.08631617:
                                            :...Age <= 0.3793103:
                                                :...ALT.48 <= 0.7752809: F3 (10.6/3)
                                                :   ALT.48 > 0.7752809: F1 (3.8/1)
                                                Age > 0.3793103:
                                                :...ALT.48 > 0.8764045:
                                                    :...ALT.48 <= 0.9662921: F2 (11.4/1.1)
                                                    :   ALT.48 > 0.9662921: F3 (3.7/1.9)
                                                    ALT.48 <= 0.8764045:
                                                    :...AST.1 > 0.5168539:
                                                        :...WBC <= 0.4299671: F4 (3)
                                                        :   WBC > 0.4299671: F2 (6.7/0.9)
                                                        AST.1 <= 0.5168539:
                                                        :...ALT.24 > 0.7977528: [S2]
                                                            ALT.24 <= 0.7977528: [S3]

SubTree [S1]

RBC <= 0.8784513: F2 (7.1)
RBC > 0.8784513: F1 (2.6)

SubTree [S2]

Plat <= 0.08592667: F1 (2.5/1.1)
Plat > 0.08592667:
:...ALT.4 <= 0.7977528: F3 (4.5)
    ALT.4 > 0.7977528: F4 (2.1)

SubTree [S3]

RBC <= 0.05493545: F2 (3.9/1.1)
RBC > 0.05493545:
:...AST.1 > 0.3146068:
    :...ALT.12 <= 0.6741573: F2 (4.5/0.8)
    :   ALT.12 > 0.6741573: F1 (6.8)
    AST.1 <= 0.3146068:
    :...RNA.Base <= 0.04202569: F2 (2.3/1.1)
        RNA.Base > 0.04202569:
        :...RNA.4 <= 0.2989016: F4 (4.7/0.8)
            RNA.4 > 0.2989016:
            :...ALT.12 <= 0.7640449: F1 (13.4/2.9)
                ALT.12 > 0.7640449: F4 (2.9)

-----  Trial 5:  -----

Decision tree:

ALT.1 <= 0.1235955:
:...Plat > 0.8046474:
:   :...ALT.36 <= 0.2808989: F1 (4.8/0.9)
:   :   ALT.36 > 0.2808989:
:   :   :...WBC <= 0.4256861: F3 (9.3/1.5)
:   :       WBC > 0.4256861: F2 (9.6/2)
:   Plat <= 0.8046474:
:   :...WBC <= 0.2394072:
:       :...RBC <= 0.427889: F2 (7.6/1.2)
:       :   RBC > 0.427889:
:       :   :...ALT.48 <= 0.2359551: F3 (3.2/0.7)
:       :       ALT.48 > 0.2359551:
:       :       :...Plat <= 0.542229: F1 (11.3/0.7)
:       :           Plat > 0.542229: F2 (3.3/0.8)
:       WBC > 0.2394072:
:       :...ALT.12 <= 0.03370786:
:           :...RBC <= 0.4599498: F2 (4.1)
:           :   RBC > 0.4599498: F4 (2.8/0.9)
:           ALT.12 > 0.03370786:
:           :...ALT.1 <= 0:
:               :...ALT.12 <= 0.4719101: F2 (3.9/1.3)
:               :   ALT.12 > 0.4719101: F4 (2.7)
:               ALT.1 > 0:
:               :...Age <= 0.03448276: F1 (4.4)
:                   Age > 0.03448276:
:                   :...ALT.1 <= 0.03370786:
:                       :...RNA.Base > 0.5666882: F4 (5.7/0.3)
:                       :   RNA.Base <= 0.5666882:
:                       :   :...ALT.24 <= 0.4269663: F4 (3.4/0.8)
:                       :       ALT.24 > 0.4269663: F3 (9.1/1.4)
:                       ALT.1 > 0.03370786:
:                       :...ALT.after.24.w <= 0.3913043:
:                           :...ALT.after.24.w <= 0.04347826: F3 (3.4/1.3)
:                           :   ALT.after.24.w > 0.04347826:
:                           :   :...BMI <= 0.6923077: F1 (8.5/1.5)
:                           :       BMI > 0.6923077: F3 (9.4/2.9)
:                           ALT.after.24.w > 0.3913043:
:                           :...ALT.1 > 0.1123596: F2 (4.1/1.7)
:                               ALT.1 <= 0.1123596:
:                               :...Age <= 0.6896552:
:                                   :...Age <= 0.4827586: F3 (6.4/1.5)
:                                   :   Age > 0.4827586: F4 (5.3)
:                                   Age > 0.6896552:
:                                   :...Plat <= 0.2512533: F3 (3.5/1.2)
:                                       Plat > 0.2512533: F1 (4.2/0.3)
ALT.1 > 0.1235955:
:...WBC <= 0.02327113:
    :...Plat > 0.861215: F1 (5.3/1.7)
    :   Plat <= 0.861215:
    :   :...RNA.Base > 0.7096235: F2 (5.8)
    :       RNA.Base <= 0.7096235:
    :       :...Plat <= 0.5482687: F3 (5.5)
    :           Plat > 0.5482687: F2 (4.7/1.6)
    WBC > 0.02327113:
    :...Age > 0.8275862:
        :...RBC > 0.9401246:
        :   :...Plat <= 0.5906887: F3 (6)
        :   :   Plat > 0.5906887: F2 (2.8)
        :   RBC <= 0.9401246:
        :   :...RNA.4 <= 0.4928535:
        :       :...Age <= 0.862069:
        :       :   :...WBC <= 0.3787047: F3 (4)
        :       :   :   WBC > 0.3787047: F2 (8.7/1.5)
        :       :   Age > 0.862069:
        :       :   :...AST.1 <= 0.06741573: F4 (4.8/0.9)
        :       :       AST.1 > 0.06741573:
        :       :       :...RBC <= 0.1844323:
        :       :           :...ALT.12 <= 0.2808989: F3 (3.9/1.5)
        :       :           :   ALT.12 > 0.2808989: F2 (9.1)
        :       :           RBC > 0.1844323:
        :       :           :...AST.1 > 0.8089887: F3 (4.7/1.2)
        :       :               AST.1 <= 0.8089887:
        :       :               :...BMI > 0.5384616:
        :       :                   :...RBC <= 0.342911: F1 (4.9/0.8)
        :       :                   :   RBC > 0.342911: F2 (7/1.7)
        :       :                   BMI <= 0.5384616:
        :       :                   :...ALT.4 > 0.7191011: F1 (5.9)
        :       :                       ALT.4 <= 0.7191011:
        :       :                       :...ALT.36 <= 0.6179775: F1 (8.9/2.8)
        :       :                           ALT.36 > 0.6179775: F4 (4.8/2)
        :       RNA.4 > 0.4928535:
        :       :...ALT.12 <= 0.1797753: F4 (6.1/1)
        :           ALT.12 > 0.1797753:
        :           :...ALT.36 > 0.8426966:
        :               :...RNA.4 <= 0.8260288: F4 (4.9)
        :               :   RNA.4 > 0.8260288: F3 (4.9/2.1)
        :               ALT.36 <= 0.8426966:
        :               :...Age > 0.9655172: F4 (5.1/2.5)
        :                   Age <= 0.9655172:
        :                   :...RNA.4 <= 0.7080036:
        :                       :...BMI <= 0.1538462: F1 (2.8)
        :                       :   BMI > 0.1538462:
        :                       :   :...ALT.after.24.w <= 0.8695652: F3 (10.9/1.1)
        :                       :       ALT.after.24.w > 0.8695652: F1 (3.5/0.9)
        :                       RNA.4 > 0.7080036:
        :                       :...AST.1 <= 0.1797753: F1 (5.8)
        :                           AST.1 > 0.1797753:
        :                           :...RNA.4 <= 0.8188623:
        :                               :...RNA.Base <= 0.5865454: F2 (3.4/0.3)
        :                               :   RNA.Base > 0.5865454: F4 (2.4)
        :                               RNA.4 > 0.8188623:
        :                               :...ALT.1 <= 0.5955056: F1 (5/1)
        :                                   ALT.1 > 0.5955056: F3 (5.6/1.4)
        Age <= 0.8275862:
        :...RNA.Base > 0.9228824:
            :...BMI > 0.3846154:
            :   :...AST.1 <= 0.3033708: F3 (8.4/2)
            :   :   AST.1 > 0.3033708:
            :   :   :...ALT.12 <= 0.3258427: F1 (9.2/3.2)
            :   :       ALT.12 > 0.3258427:
            :   :       :...ALT.12 <= 0.8202247: F2 (7.2/0.8)
            :   :           ALT.12 > 0.8202247: F4 (3.4/1.1)
            :   BMI <= 0.3846154:
            :   :...AST.1 > 0.7191011: F3 (3.6)
            :       AST.1 <= 0.7191011:
            :       :...ALT.1 <= 0.4606742: F1 (8.1)
            :           ALT.1 > 0.4606742:
            :           :...ALT.1 <= 0.7191011: F3 (6.9/2.3)
            :               ALT.1 > 0.7191011:
            :               :...RBC <= 0.7577587: F1 (5.7/0.3)
            :                   RBC > 0.7577587: F4 (2.4)
            RNA.Base <= 0.9228824:
            :...ALT.48 > 0.9438202:
                :...ALT.1 > 0.8651685: F1 (4.5/2.3)
                :   ALT.1 <= 0.8651685:
                :   :...ALT.4 <= 0.1235955: F3 (4.5/1.9)
                :       ALT.4 > 0.1235955:
                :       :...BMI <= 0.2307692: F2 (8.6/2.4)
                :           BMI > 0.2307692:
                :           :...ALT.12 <= 0.06741573: F2 (2.8)
                :               ALT.12 > 0.06741573: F4 (17.6/3.1)
                ALT.48 <= 0.9438202:
                :...WBC <= 0.06355653:
                    :...RBC > 0.6630681: F1 (5.9/1.6)
                    :   RBC <= 0.6630681:
                    :   :...ALT.after.24.w <= 0.3913043: F3 (3.5/0.9)
                    :       ALT.after.24.w > 0.3913043:
                    :       :...ALT.24 <= 0.4719101: F4 (6.7)
                    :           ALT.24 > 0.4719101:
                    :           :...RNA.Base <= 0.5038445: F3 (4.2)
                    :               RNA.Base > 0.5038445: F4 (2.4)
                    WBC > 0.06355653:
                    :...ALT.36 <= 0.1685393:
                        :...ALT.12 > 0.8876405:
                        :   :...ALT.48 > 0.6179775: F2 (3/1.2)
                        :   :   ALT.48 <= 0.6179775:
                        :   :   :...ALT.after.24.w <= 0.6521739: F1 (5.3)
                        :   :       ALT.after.24.w > 0.6521739: F4 (2.9/0.8)
                        :   ALT.12 <= 0.8876405:
                        :   :...RNA.4 <= 0.3265264:
                        :       :...ALT.4 > 0.8876405: F2 (2.2)
                        :       :   ALT.4 <= 0.8876405:
                        :       :   :...WBC <= 0.3660812: F3 (5.2)
                        :       :       WBC > 0.3660812:
                        :       :       :...RBC <= 0.1144723: F1 (3.8/0.9)
                        :       :           RBC > 0.1144723:
                        :       :           :...Age > 0.4482759: F4 (7.8/0.3)
                        :       :               Age <= 0.4482759:
                        :       :               :...Age <= 0.2068966: F4 (3.3/0.7)
                        :       :                   Age > 0.2068966: F3 (3.3/0.3)
                        :       RNA.4 > 0.3265264:
                        :       :...ALT.after.24.w > 0.9565217: F4 (3.8/0.7)
                        :           ALT.after.24.w <= 0.9565217:
                        :           :...Age > 0.6206896:
                        :               :...BMI <= 0.4615385: F2 (7.2/1.7)
                        :               :   BMI > 0.4615385: F3 (5.4)
                        :               Age <= 0.6206896:
                        :               :...RNA.4 <= 0.5406513: F2 (12.1)
                        :                   RNA.4 > 0.5406513:
                        :                   :...RBC <= 0.415267:
                        :                       :...BMI > 0.5384616: F2 (6.8/2.7)
                        :                       :   BMI <= 0.5384616:
                        :                       :   :...RNA.4 <= 0.8075259: F3 (4)
                        :                       :       RNA.4 > 0.8075259: F1 (2.4/0.8)
                        :                       RBC > 0.415267:
                        :                       :...ALT.12 > 0.5393258: F2 (3.9)
                        :                           ALT.12 <= 0.5393258:
                        :                           :...ALT.24 > 0.494382: F4 (6)
                        :                               ALT.24 <= 0.494382:
                        :                               :...Plat <= 0.5191718: F4 (2.1)
                        :                                   Plat > 0.5191718: F2 (4.7)
                        ALT.36 > 0.1685393:
                        :...RNA.4 <= 0.02513668:
                            :...ALT.24 > 0.6179775: F1 (7.2)
                            :   ALT.24 <= 0.6179775:
                            :   :...ALT.12 <= 0.4494382: F2 (2.5/0.7)
                            :       ALT.12 > 0.4494382: F4 (4.1/0.9)
                            RNA.4 > 0.02513668:
                            :...ALT.48 > 0.6292135:
                                :...AST.1 <= 0.1011236:
                                :   :...ALT.4 <= 0.1235955: F4 (4.5)
                                :   :   ALT.4 > 0.1235955: F3 (12.7/4.1)
                                :   AST.1 > 0.1011236:
                                :   :...Age <= 0: F1 (3.9)
                                :       Age > 0:
                                :       :...AST.1 <= 0.1685393:
                                :           :...RBC <= 0.5050003: F3 (6/0.3)
                                :           :   RBC > 0.5050003: F2 (4.1)
                                :           AST.1 > 0.1685393:
                                :           :...ALT.36 > 0.8764045: [S1]
                                :               ALT.36 <= 0.8764045:
                                :               :...ALT.24 <= 0.2134831:
                                :                   :...ALT.4 <= 0.5955056:
                                :                   :   :...RBC <= 0.6882355: F4 (9.3/1.7)
                                :                   :   :   RBC > 0.6882355: F3 (4.3/1.5)
                                :                   :   ALT.4 > 0.5955056: [S2]
                                :                   ALT.24 > 0.2134831:
                                :                   :...ALT.24 <= 0.4269663: [S3]
                                :                       ALT.24 > 0.4269663:
                                :                       :...ALT.12 <= 0.1348315: [S4]
                                :                           ALT.12 > 0.1348315: [S5]
                                ALT.48 <= 0.6292135:
                                :...ALT.48 > 0.5842696:
                                    :...Plat > 0.5311762: F2 (7.2)
                                    :   Plat <= 0.5311762:
                                    :   :...RBC > 0.9205809: F2 (2.7)
                                    :       RBC <= 0.9205809:
                                    :       :...ALT.36 <= 0.2808989: F3 (2.6/0.9)
                                    :           ALT.36 > 0.2808989: F4 (9.4/0.7)
                                    ALT.48 <= 0.5842696:
                                    :...BMI > 0.9230769:
                                        :...ALT.36 > 0.8202247: F2 (3.5)
                                        :   ALT.36 <= 0.8202247:
                                        :   :...ALT.4 > 0.8651685: F2 (3/0.9)
                                        :       ALT.4 <= 0.8651685:
                                        :       :...ALT.36 <= 0.6853933: F4 (8.2/1.9)
                                        :           ALT.36 > 0.6853933: F3 (2.1)
                                        BMI <= 0.9230769:
                                        :...Age <= 0.2068966:
                                            :...AST.1 <= 0.247191:
                                            :   :...Age <= 0: F2 (3.6/0.8)
                                            :   :   Age > 0:
                                            :   :   :...ALT.4 > 0.505618: F3 (7.9)
                                            :   :       ALT.4 <= 0.505618: [S6]
                                            :   AST.1 > 0.247191:
                                            :   :...BMI <= 0.1538462:
                                            :       :...Plat <= 0.3357562: F1 (4.4/1)
                                            :       :   Plat > 0.3357562: [S7]
                                            :       BMI > 0.1538462:
                                            :       :...ALT.1 > 0.9550562: F4 (4.9)
                                            :           ALT.1 <= 0.9550562:
                                            :           :...ALT.36 <= 0.3707865: [S8]
                                            :               ALT.36 > 0.3707865:
                                            :               :...ALT.4 <= 0.3033708: [S9]
                                            :                   ALT.4 > 0.3033708: [S10]
                                            Age > 0.2068966:
                                            :...ALT.24 <= 0.3707865:
                                                :...ALT.36 <= 0.6179775:
                                                :   :...ALT.48 > 0.4494382: [S11]
                                                :   :   ALT.48 <= 0.4494382:
                                                :   :   :...RBC > 0.1235278: F4 (21.5/2.1)
                                                :   :       RBC <= 0.1235278: [S12]
                                                :   ALT.36 > 0.6179775:
                                                :   :...RNA.4 > 0.6600503: [S13]
                                                :       RNA.4 <= 0.6600503:
                                                :       :...Age <= 0.2758621: F3 (2.1)
                                                :           Age > 0.2758621: [S14]
                                                ALT.24 > 0.3707865:
                                                :...Age <= 0.2413793:
                                                    :...BMI <= 0.5384616: F4 (4.4)
                                                    :   BMI > 0.5384616: F1 (2.7/0.9)
                                                    Age > 0.2413793:
                                                    :...RBC <= 0.1213149: [S15]
                                                        RBC > 0.1213149: [S16]

SubTree [S1]

ALT.after.24.w > 0.7826087: F2 (4.2/1.5)
ALT.after.24.w <= 0.7826087:
:...RBC <= 0.5174941: F2 (5.6/0.3)
    RBC > 0.5174941: F3 (4.8/0.8)

SubTree [S2]

RNA.4 <= 0.2534222: F4 (2.6)
RNA.4 > 0.2534222:
:...ALT.36 <= 0.4044944: F3 (4.9)
    ALT.36 > 0.4044944: F1 (4.6/2.4)

SubTree [S3]

RNA.4 <= 0.9264123: F1 (22.7/6.4)
RNA.4 > 0.9264123: F3 (3.6/1.3)

SubTree [S4]

ALT.4 > 0.6292135: F4 (4.3/2.1)
ALT.4 <= 0.6292135:
:...RNA.Base <= 0.4491626: F2 (4/1.2)
    RNA.Base > 0.4491626: F3 (5.1)

SubTree [S5]

ALT.4 > 0.4157303: F1 (17.4/5.8)
ALT.4 <= 0.4157303:
:...RNA.Base <= 0.6258585:
    :...AST.1 <= 0.6404495: F3 (4.8/0.8)
    :   AST.1 > 0.6404495: F2 (4.2/1)
    RNA.Base > 0.6258585:
    :...Age <= 0.3103448: F4 (6.7/0.7)
        Age > 0.3103448: F1 (3.1/0.8)

SubTree [S6]

RNA.Base <= 0.5988144: F1 (6.8/0.7)
RNA.Base > 0.5988144: F3 (2.6/0.3)

SubTree [S7]

RNA.Base <= 0.5175647: F4 (8.5/1.5)
RNA.Base > 0.5175647: F2 (5.9)

SubTree [S8]

RBC > 0.6041094: F1 (6.8)
RBC <= 0.6041094:
:...ALT.24 <= 0.3820225: F1 (3.2/0.8)
    ALT.24 > 0.3820225: F3 (2.9)

SubTree [S9]

ALT.36 <= 0.7078652: F4 (5.5/1)
ALT.36 > 0.7078652: F3 (4.3/0.7)

SubTree [S10]

ALT.36 <= 0.505618: F4 (4.8/0.7)
ALT.36 > 0.505618:
:...ALT.48 <= 0.3258427: F2 (5.6/1.7)
    ALT.48 > 0.3258427: F1 (4.5/0.8)

SubTree [S11]

ALT.1 <= 0.4157303: F1 (5/0.8)
ALT.1 > 0.4157303: F3 (7.4/1.2)

SubTree [S12]

Age <= 0.3103448: F4 (2.3/1.2)
Age > 0.3103448: F2 (3.7)

SubTree [S13]

RNA.4 <= 0.9045269: F2 (5.8/0.7)
RNA.4 > 0.9045269: F4 (4.4/1.6)

SubTree [S14]

RBC <= 0.5629756: F2 (3.5/1.2)
RBC > 0.5629756: F1 (10.5/1)

SubTree [S15]

ALT.36 > 0.8876405: F1 (2.1)
ALT.36 <= 0.8876405:
:...ALT.48 <= 0.5617977: F3 (14.1/2.7)
    ALT.48 > 0.5617977: F4 (2.9)

SubTree [S16]

ALT.after.24.w > 0.6521739:
:...WBC <= 0.2394072:
:   :...BMI <= 0.3076923: F3 (2.8/0.7)
:   :   BMI > 0.3076923: F2 (5/1.6)
:   WBC > 0.2394072:
:   :...ALT.4 <= 0.6179775: F4 (16.7/4.1)
:       ALT.4 > 0.6179775:
:       :...Plat <= 0.5066878: F3 (3.5)
:           Plat > 0.5066878: F4 (5.1/2.2)
ALT.after.24.w <= 0.6521739:
:...WBC <= 0.1493963: F4 (9.5/2.6)
    WBC > 0.1493963:
    :...ALT.36 <= 0.2921348: F3 (6.9)
        ALT.36 > 0.2921348:
        :...ALT.24 > 0.8539326:
            :...Plat <= 0.2095301: F4 (2.4/1.2)
            :   Plat > 0.2095301: F2 (7.9)
            ALT.24 <= 0.8539326:
            :...ALT.1 <= 0.4494382:
                :...ALT.12 <= 0.741573: F3 (9.4/0.7)
                :   ALT.12 > 0.741573: F4 (4.9)
                ALT.1 > 0.4494382:
                :...ALT.4 <= 0.3033708: F3 (5)
                    ALT.4 > 0.3033708:
                    :...RNA.Base > 0.5853523: F4 (5.5/2.7)
                        RNA.Base <= 0.5853523:
                        :...ALT.4 <= 0.7640449: F2 (6.3/0.9)
                            ALT.4 > 0.7640449: F1 (4.4/1.1)

-----  Trial 6:  -----

Decision tree:

ALT.48 > 0.9775281:
:...ALT.36 <= 0.1123596: F4 (4.7)
:   ALT.36 > 0.1123596:
:   :...ALT.4 <= 0.3820225: F2 (5.1/0.6)
:       ALT.4 > 0.3820225:
:       :...AST.1 <= 0.4269663: F3 (7.8)
:           AST.1 > 0.4269663:
:           :...Plat > 0.5482687: F4 (2.5)
:               Plat <= 0.5482687:
:               :...ALT.after.24.w <= 0.7826087: F3 (3.9/0.6)
:                   ALT.after.24.w > 0.7826087: F2 (2.4)
ALT.48 <= 0.9775281:
:...ALT.1 <= 0.08988764:
    :...BMI <= 0.07692308:
    :   :...Age <= 0.5517241: F3 (5.4)
    :   :   Age > 0.5517241: F4 (4.2/1.5)
    :   BMI > 0.07692308:
    :   :...ALT.1 > 0.06741573:
    :       :...ALT.after.24.w <= 0.5217391: F1 (8.1/0.6)
    :       :   ALT.after.24.w > 0.5217391:
    :       :   :...RNA.4 <= 0.4313345: F1 (2.9)
    :       :       RNA.4 > 0.4313345: F4 (3.5/1.1)
    :       ALT.1 <= 0.06741573:
    :       :...ALT.1 > 0.05617978: F3 (5.8/1.3)
    :           ALT.1 <= 0.05617978:
    :           :...BMI <= 0.1538462:
    :               :...WBC <= 0.3489572: F1 (4.5)
    :               :   WBC > 0.3489572: F4 (2.2)
    :               BMI > 0.1538462:
    :               :...Plat > 0.6101341:
    :                   :...ALT.24 <= 0.6966292: F2 (18.1/4.7)
    :                   :   ALT.24 > 0.6966292: F1 (3.2/1.5)
    :                   Plat <= 0.6101341:
    :                   :...BMI <= 0.4615385: F3 (11.7/4.5)
    :                       BMI > 0.4615385:
    :                       :...Plat <= 0.3105634: F2 (6.3/2.1)
    :                           Plat > 0.3105634: F1 (13.7/3.1)
    ALT.1 > 0.08988764:
    :...ALT.after.24.w > 0.7826087:
        :...ALT.36 > 0.8764045:
        :   :...ALT.4 > 0.8764045: F1 (2.6)
        :   :   ALT.4 <= 0.8764045:
        :   :   :...RBC <= 0.3577825: F2 (2.5/1.1)
        :   :       RBC > 0.3577825:
        :   :       :...WBC <= 0.7923161: F4 (9.9/0.7)
        :   :           WBC > 0.7923161: F2 (6.4/0.9)
        :   ALT.36 <= 0.8764045:
        :   :...BMI <= 0:
        :       :...Plat > 0.8699598: F2 (2.5)
        :       :   Plat <= 0.8699598:
        :       :   :...Plat <= 0.483833: F1 (3/0.3)
        :       :       Plat > 0.483833: F4 (4.3)
        :       BMI > 0:
        :       :...Age <= 0.5862069:
        :           :...ALT.48 <= 0.2247191:
        :           :   :...RBC <= 0.1783875: F2 (3.1/1.6)
        :           :   :   RBC > 0.1783875:
        :           :   :   :...ALT.12 > 0.5393258: F1 (14.2/3.1)
        :           :   :       ALT.12 <= 0.5393258:
        :           :   :       :...Plat <= 0.4785652: F3 (4.4)
        :           :   :           Plat > 0.4785652: F1 (2.1)
        :           :   ALT.48 > 0.2247191:
        :           :   :...ALT.24 > 0.8764045: F2 (5.5/1.9)
        :           :       ALT.24 <= 0.8764045:
        :           :       :...AST.1 > 0.8089887:
        :           :           :...RNA.4 <= 0.736255: F1 (5/2.3)
        :           :           :   RNA.4 > 0.736255: F3 (3.8)
        :           :           AST.1 <= 0.8089887:
        :           :           :...ALT.24 <= 0.1235955:
        :           :               :...RBC <= 0.8901707: F3 (5.7/0.3)
        :           :               :   RBC > 0.8901707: F1 (2.1/0.6)
        :           :               ALT.24 > 0.1235955:
        :           :               :...ALT.after.24.w <= 0.9130435:
        :           :                   :...WBC <= 0.6035126: F4 (17.1/3.4)
        :           :                   :   WBC > 0.6035126:
        :           :                   :   :...RBC <= 0.3504433: F4 (2.7)
        :           :                   :       RBC > 0.3504433: F3 (6.9/0.6)
        :           :                   ALT.after.24.w > 0.9130435:
        :           :                   :...ALT.48 <= 0.4606742: F3 (6.3)
        :           :                       ALT.48 > 0.4606742:
        :           :                       :...RNA.4 <= 0.2636218: F1 (4.6/1.9)
        :           :                           RNA.4 > 0.2636218: F4 (6.6/0.3)
        :           Age > 0.5862069:
        :           :...ALT.48 <= 0.1011236: F3 (6.6)
        :               ALT.48 > 0.1011236:
        :               :...WBC <= 0.1086718: F2 (5.5/0.6)
        :                   WBC > 0.1086718:
        :                   :...RNA.4 > 0.5628213:
        :                       :...ALT.48 > 0.8876405: F3 (3.5/1.4)
        :                       :   ALT.48 <= 0.8876405:
        :                       :   :...ALT.24 <= 0.2022472: F4 (2.3/0.3)
        :                       :       ALT.24 > 0.2022472: F1 (11.6/1.4)
        :                       RNA.4 <= 0.5628213:
        :                       :...AST.1 > 0.7752809:
        :                           :...ALT.after.24.w <= 0.8695652: F2 (3.4)
        :                           :   ALT.after.24.w > 0.8695652: F3 (7.6/1)
        :                           AST.1 <= 0.7752809:
        :                           :...ALT.1 <= 0.2921348: F3 (5.8/0.9)
        :                               ALT.1 > 0.2921348:
        :                               :...ALT.after.24.w > 0.9565217: F3 (4.1/1.5)
        :                                   ALT.after.24.w <= 0.9565217:
        :                                   :...RNA.4 <= 0.07227951: F2 (3.3/0.9)
        :                                       RNA.4 > 0.07227951: F1 (7.9)
        ALT.after.24.w <= 0.7826087:
        :...ALT.after.24.w > 0.7391304:
            :...ALT.1 <= 0.2247191: F1 (2.4/0.7)
            :   ALT.1 > 0.2247191:
            :   :...Plat <= 0.5515208:
            :       :...BMI <= 0.4615385: F3 (7.4/1.9)
            :       :   BMI > 0.4615385: F2 (3/1.2)
            :       Plat > 0.5515208:
            :       :...BMI <= 0.6923077: F2 (9.1)
            :           BMI > 0.6923077:
            :           :...AST.1 <= 0.2808989: F2 (2.3)
            :               AST.1 > 0.2808989: F4 (4/0.3)
            ALT.after.24.w <= 0.7391304:
            :...ALT.4 > 0.9213483:
                :...ALT.after.24.w <= 0.04347826:
                :   :...ALT.1 <= 0.9101124: F1 (4/0.6)
                :   :   ALT.1 > 0.9101124: F3 (2.5)
                :   ALT.after.24.w > 0.04347826:
                :   :...RNA.Base > 0.7953583:
                :       :...RNA.Base <= 0.9279321: F4 (3.2)
                :       :   RNA.Base > 0.9279321: F1 (3.2/0.7)
                :       RNA.Base <= 0.7953583:
                :       :...RNA.Base > 0.6712112: F2 (4.9)
                :           RNA.Base <= 0.6712112:
                :           :...AST.1 <= 0.1460674: F4 (3.8/1.1)
                :               AST.1 > 0.1460674:
                :               :...ALT.4 <= 0.9662921:
                :                   :...AST.1 <= 0.6179775: F2 (7.7/0.6)
                :                   :   AST.1 > 0.6179775: F1 (4.4/0.7)
                :                   ALT.4 > 0.9662921:
                :                   :...ALT.12 <= 0.7078652: F2 (5.3/3)
                :                       ALT.12 > 0.7078652: F1 (2.5)
                ALT.4 <= 0.9213483:
                :...BMI <= 0.4615385:
                    :...RNA.Base > 0.924148:
                    :   :...RBC <= 0.4664646:
                    :   :   :...ALT.36 <= 0.6516854: F4 (5.8/0.6)
                    :   :   :   ALT.36 > 0.6516854: F3 (2.3/0.9)
                    :   :   RBC > 0.4664646:
                    :   :   :...AST.1 <= 0.1685393: F3 (2.7/0.6)
                    :   :       AST.1 > 0.1685393: F1 (10.2/1.9)
                    :   RNA.Base <= 0.924148:
                    :   :...ALT.24 <= 0.2921348:
                    :       :...RNA.Base <= 0.1408122:
                    :       :   :...AST.1 <= 0.4494382: F1 (4)
                    :       :   :   AST.1 > 0.4494382: F3 (2.9/0.8)
                    :       :   RNA.Base > 0.1408122:
                    :       :   :...ALT.48 > 0.8876405:
                    :       :       :...ALT.36 <= 0.6404495: F2 (8.2/0.6)
                    :       :       :   ALT.36 > 0.6404495: F3 (3.6)
                    :       :       ALT.48 <= 0.8876405:
                    :       :       :...Plat > 0.9539007: F3 (3.1)
                    :       :           Plat <= 0.9539007:
                    :       :           :...ALT.24 > 0.1011236:
                    :       :               :...RNA.Base <= 0.4851737:
                    :       :               :   :...ALT.1 <= 0.9662921: F4 (8.2/1.6)
                    :       :               :   :   ALT.1 > 0.9662921: F1 (2.1)
                    :       :               :   RNA.Base > 0.4851737:
                    :       :               :   :...WBC <= 0.8659714: F2 (14.6/4.8)
                    :       :               :       WBC > 0.8659714: F4 (2)
                    :       :               ALT.24 <= 0.1011236:
                    :       :               :...RNA.4 <= 0.3594661:
                    :       :                   :...BMI > 0.1538462: F4 (2.5)
                    :       :                   :   BMI <= 0.1538462:
                    :       :                   :   :...ALT.1 <= 0.4269663: F4 (3.1/0.9)
                    :       :                   :       ALT.1 > 0.4269663: F3 (4.7)
                    :       :                   RNA.4 > 0.3594661:
                    :       :                   :...ALT.48 <= 0.08988764: F1 (2.8/1.3)
                    :       :                       ALT.48 > 0.08988764:
                    :       :                       :...ALT.24 > 0.05617978: F2 (5.7)
                    :       :                           ALT.24 <= 0.05617978:
                    :       :                           :...RBC <= 0.1471878: F2 (5.7/0.6)
                    :       :                               RBC > 0.1471878: [S1]
                    :       ALT.24 > 0.2921348:
                    :       :...ALT.4 > 0.8089887:
                    :           :...ALT.24 <= 0.7078652:
                    :           :   :...ALT.1 <= 0.8314607: F3 (15.1/1.6)
                    :           :   :   ALT.1 > 0.8314607: F4 (2.4/0.9)
                    :           :   ALT.24 > 0.7078652:
                    :           :   :...ALT.12 <= 0.5505618: F2 (6.3/1.9)
                    :           :       ALT.12 > 0.5505618:
                    :           :       :...AST.1 <= 0.4494382: F4 (5)
                    :           :           AST.1 > 0.4494382: F3 (3/1.5)
                    :           ALT.4 <= 0.8089887:
                    :           :...ALT.48 <= 0.03370786:
                    :               :...ALT.1 <= 0.1797753: F3 (2.6/0.9)
                    :               :   ALT.1 > 0.1797753: F4 (10.7/1.7)
                    :               ALT.48 > 0.03370786:
                    :               :...ALT.4 > 0.7640449: F1 (6.3/1.1)
                    :                   ALT.4 <= 0.7640449:
                    :                   :...Age > 0.5517241:
                    :                       :...RNA.Base > 0.7271253:
                    :                       :   :...ALT.1 <= 0.9101124: F1 (6.9/0.8)
                    :                       :   :   ALT.1 > 0.9101124: F3 (2.2)
                    :                       :   RNA.Base <= 0.7271253:
                    :                       :   :...Age <= 0.6896552:
                    :                       :       :...WBC <= 0.3068057: F3 (5.6)
                    :                       :       :   WBC > 0.3068057: [S2]
                    :                       :       Age > 0.6896552:
                    :                       :       :...ALT.48 <= 0.4606742: [S3]
                    :                       :           ALT.48 > 0.4606742:
                    :                       :           :...ALT.36 <= 0.5168539: [S4]
                    :                       :               ALT.36 > 0.5168539: [S5]
                    :                       Age <= 0.5517241:
                    :                       :...ALT.24 > 0.8426966:
                    :                           :...BMI > 0.3846154: F2 (2.2)
                    :                           :   BMI <= 0.3846154:
                    :                           :   :...BMI <= 0.1538462: F3 (3.8/0.9)
                    :                           :       BMI > 0.1538462: F1 (6/0.6)
                    :                           ALT.24 <= 0.8426966:
                    :                           :...RNA.Base > 0.6110709: F4 (17.9/2.9)
                    :                               RNA.Base <= 0.6110709:
                    :                               :...ALT.after.24.w > 0.6086956: [S6]
                    :                                   ALT.after.24.w <= 0.6086956: [S7]
                    BMI > 0.4615385:
                    :...RNA.Base > 0.8605266:
                        :...RNA.4 <= 0.04654451: F3 (2.7/1.1)
                        :   RNA.4 > 0.04654451:
                        :   :...RBC > 0.896332: F4 (5.1/1.6)
                        :       RBC <= 0.896332:
                        :       :...RNA.4 <= 0.14795: F4 (3.2)
                        :           RNA.4 > 0.14795:
                        :           :...Age <= 0.06896552: F4 (2.8/0.7)
                        :               Age > 0.06896552:
                        :               :...ALT.48 > 0.8089887:
                        :                   :...Plat <= 0.2414594: F2 (3)
                        :                   :   Plat > 0.2414594: F4 (4.6/0.6)
                        :                   ALT.48 <= 0.8089887:
                        :                   :...BMI > 0.7692308: F2 (11.6/0.6)
                        :                       BMI <= 0.7692308:
                        :                       :...ALT.36 <= 0.3258427: F1 (2.7)
                        :                           ALT.36 > 0.3258427: F2 (9.5/2.7)
                        RNA.Base <= 0.8605266:
                        :...ALT.after.24.w > 0.6086956:
                            :...BMI > 0.9230769: F3 (4.1/1.8)
                            :   BMI <= 0.9230769:
                            :   :...Plat > 0.8699598: F1 (4.5/0.3)
                            :       Plat <= 0.8699598:
                            :       :...Age <= 0.2068966: F4 (9.8/2.9)
                            :           Age > 0.2068966:
                            :           :...BMI > 0.7692308: F2 (4.2/0.9)
                            :               BMI <= 0.7692308:
                            :               :...ALT.after.24.w <= 0.6956522: F4 (5.7/2.6)
                            :                   ALT.after.24.w > 0.6956522: F1 (2.8)
                            ALT.after.24.w <= 0.6086956:
                            :...BMI <= 0.5384616:
                                :...RBC <= 0.2340792: F1 (5.6/2.3)
                                :   RBC > 0.2340792:
                                :   :...RBC <= 0.846908: F3 (16.1/2.6)
                                :       RBC > 0.846908: F1 (2.4/0.9)
                                BMI > 0.5384616:
                                :...ALT.48 <= 0.04494382:
                                    :...RNA.4 <= 0.528913: F4 (2.7)
                                    :   RNA.4 > 0.528913: F2 (5)
                                    ALT.48 > 0.04494382:
                                    :...ALT.after.24.w <= 0.04347826:
                                        :...Age > 0.8275862: F1 (2.6)
                                        :   Age <= 0.8275862:
                                        :   :...ALT.4 <= 0.2134831: F1 (5.5/2)
                                        :       ALT.4 > 0.2134831: F3 (22.4/8.5)
                                        ALT.after.24.w > 0.04347826:
                                        :...Plat > 0.9235899:
                                            :...ALT.24 <= 0.6741573: F2 (4.5)
                                            :   ALT.24 > 0.6741573: F4 (4.3/1.1)
                                            Plat <= 0.9235899:
                                            :...ALT.1 > 0.8764045: [S8]
                                                ALT.1 <= 0.8764045:
                                                :...ALT.1 <= 0.3820225:
                                                    :...BMI <= 0.6153846: [S9]
                                                    :   BMI > 0.6153846:
                                                    :   :...WBC > 0.8983535: F2 (2.7/0.6)
                                                    :       WBC <= 0.8983535:
                                                    :       :...BMI > 0.8461539: [S10]
                                                    :           BMI <= 0.8461539: [S11]
                                                    ALT.1 > 0.3820225:
                                                    :...ALT.12 > 0.8539326: F3 (11.3/2.2)
                                                        ALT.12 <= 0.8539326:
                                                        :...Plat <= 0.09056508: [S12]
                                                            Plat > 0.09056508:
                                                            :...BMI > 0.9230769: [S13]
                                                                BMI <= 0.9230769: [S14]

SubTree [S1]

ALT.24 <= 0: F2 (2.3/0.9)
ALT.24 > 0: F3 (5.8/0.9)

SubTree [S2]

ALT.48 <= 0.6067415: F1 (4.3/2.1)
ALT.48 > 0.6067415: F2 (4)

SubTree [S3]

RNA.4 <= 0.170616: F4 (6.3)
RNA.4 > 0.170616:
:...ALT.4 <= 0.5505618: F2 (8.4/1.6)
    ALT.4 > 0.5505618: F4 (3.7/0.9)

SubTree [S4]

RBC <= 0.3884507: F1 (4.3/1.4)
RBC > 0.3884507: F2 (4.1)

SubTree [S5]

ALT.48 <= 0.6853933: F3 (5/0.3)
ALT.48 > 0.6853933:
:...RNA.Base <= 0.1841276: F4 (3.9)
    RNA.Base > 0.1841276: F3 (2.7/0.6)

SubTree [S6]

ALT.48 <= 0.6179775: F4 (7.8/1.1)
ALT.48 > 0.6179775: F1 (2.3/0.6)

SubTree [S7]

ALT.36 <= 0.07865169: F4 (4.2/1.7)
ALT.36 > 0.07865169:
:...ALT.4 > 0.7191011: F4 (2.8/0.6)
    ALT.4 <= 0.7191011:
    :...ALT.36 > 0.9775281: F4 (3.4/1.9)
        ALT.36 <= 0.9775281:
        :...Age <= 0.1724138: F1 (11.6/3.1)
            Age > 0.1724138:
            :...ALT.24 > 0.5393258: F2 (6.2/0.3)
                ALT.24 <= 0.5393258:
                :...ALT.after.24.w > 0.3913043: F1 (3.9/0.9)
                    ALT.after.24.w <= 0.3913043:
                    :...Age <= 0.4137931: F2 (3.1)
                        Age > 0.4137931: F1 (5.4/0.6)

SubTree [S8]

ALT.after.24.w <= 0.4782609: F1 (7/0.8)
ALT.after.24.w > 0.4782609: F3 (4.1/1.1)

SubTree [S9]

ALT.48 <= 0.8651685: F2 (4.3)
ALT.48 > 0.8651685: F3 (2.6/0.7)

SubTree [S10]

ALT.48 > 0.5168539: F1 (6.8/0.7)
ALT.48 <= 0.5168539:
:...ALT.4 <= 0.3932584: F3 (4.9)
    ALT.4 > 0.3932584: F1 (2.7/1)

SubTree [S11]

RNA.Base <= 0.0669725: F3 (2.9)
RNA.Base > 0.0669725:
:...ALT.24 <= 0.1348315: F1 (2.7)
    ALT.24 > 0.1348315:
    :...Plat <= 0.5482687: F4 (16.2/4.6)
        Plat > 0.5482687: F3 (3.9/1.6)

SubTree [S12]

BMI > 0.9230769: F3 (2.7)
BMI <= 0.9230769:
:...ALT.1 <= 0.5393258: F2 (5.2)
    ALT.1 > 0.5393258:
    :...ALT.12 <= 0.3595506: F2 (3.4)
        ALT.12 > 0.3595506: F3 (2.9)

SubTree [S13]

ALT.4 <= 0.3483146: F4 (3.9)
ALT.4 > 0.3483146: F2 (4.6/0.9)

SubTree [S14]

ALT.after.24.w <= 0.2173913:
:...ALT.24 <= 0.6853933: F2 (12.5/3.1)
:   ALT.24 > 0.6853933: F3 (2.4)
ALT.after.24.w > 0.2173913:
:...AST.1 <= 0.1348315:
    :...RNA.4 <= 0.6053365: F4 (2.7)
    :   RNA.4 > 0.6053365:
    :   :...RBC <= 0.512243: F4 (3/1.5)
    :       RBC > 0.512243: F2 (4.2)
    AST.1 > 0.1348315:
    :...ALT.after.24.w <= 0.3478261: F1 (10.3/2.2)
        ALT.after.24.w > 0.3478261:
        :...AST.1 <= 0.3370787: F1 (6.6/2.2)
            AST.1 > 0.3370787:
            :...RNA.Base <= 0.08821014: F2 (2.7)
                RNA.Base > 0.08821014: F3 (17.1/5.2)

-----  Trial 7:  -----

Decision tree:

ALT.1 <= 0.1235955:
:...ALT.36 <= 0.05617978:
:   :...RNA.Base <= 0.6427184: F3 (3.6)
:   :   RNA.Base > 0.6427184: F4 (6.4/0.9)
:   ALT.36 > 0.05617978:
:   :...ALT.1 <= 0:
:       :...RNA.4 <= 0.2575646: F4 (4.1/1.7)
:       :   RNA.4 > 0.2575646:
:       :   :...ALT.36 <= 0.5842696: F1 (6.9/1.6)
:       :       ALT.36 > 0.5842696: F2 (2.5)
:       ALT.1 > 0:
:       :...Age > 0.9310345: F1 (4.8/1.9)
:           Age <= 0.9310345:
:           :...ALT.12 <= 0.03370786: F2 (5.6/2)
:               ALT.12 > 0.03370786:
:               :...ALT.after.24.w > 0.8260869:
:                   :...AST.1 <= 0.1910112: F1 (4.6)
:                   :   AST.1 > 0.1910112:
:                   :   :...ALT.36 > 0.6853933: F1 (3.4)
:                   :       ALT.36 <= 0.6853933:
:                   :       :...ALT.after.24.w <= 0.9130435: F4 (5/1.4)
:                   :           ALT.after.24.w > 0.9130435: F3 (5.9)
:                   ALT.after.24.w <= 0.8260869:
:                   :...ALT.24 <= 0.1910112: F2 (8.2/1.7)
:                       ALT.24 > 0.1910112:
:                       :...RNA.4 <= 0.03091095: F2 (3.1)
:                           RNA.4 > 0.03091095:
:                           :...RNA.4 <= 0.6620965:
:                               :...RBC <= 0.3964039:
:                               :   :...ALT.1 <= 0.1123596: F3 (17.8/2.7)
:                               :   :   ALT.1 > 0.1123596: F1 (2.4/1.1)
:                               :   RBC > 0.3964039:
:                               :   :...WBC <= 0.6289791: F1 (17.9/4.6)
:                               :       WBC > 0.6289791: F3 (8/2.7)
:                               RNA.4 > 0.6620965:
:                               :...ALT.after.24.w > 0.5652174: F3 (3.9/1.9)
:                                   ALT.after.24.w <= 0.5652174:
:                                   :...ALT.after.24.w <= 0.1304348: F2 (4.9/1.3)
:                                       ALT.after.24.w > 0.1304348:
:                                       :...ALT.after.24.w <= 0.4782609: F1 (11.6/2)
:                                           ALT.after.24.w > 0.4782609: F2 (2.5)
ALT.1 > 0.1235955:
:...BMI > 0.6923077:
    :...ALT.4 > 0.9213483:
    :   :...ALT.48 <= 0.752809: F2 (9.7/1.5)
    :   :   ALT.48 > 0.752809: F1 (2.4/0.5)
    :   ALT.4 <= 0.9213483:
    :   :...ALT.36 <= 0: F2 (7.9/1.7)
    :       ALT.36 > 0:
    :       :...ALT.36 > 0.9213483:
    :           :...ALT.4 > 0.4269663: F1 (3.6/1.7)
    :           :   ALT.4 <= 0.4269663:
    :           :   :...RNA.4 <= 0.59883: F1 (2.4/0.6)
    :           :       RNA.4 > 0.59883: F4 (5.2)
    :           ALT.36 <= 0.9213483:
    :           :...ALT.36 > 0.7640449:
    :               :...BMI > 0.8461539:
    :               :   :...RBC <= 0.6882355: F2 (13.1/3.9)
    :               :   :   RBC > 0.6882355: F3 (5.6/1.3)
    :               :   BMI <= 0.8461539:
    :               :   :...WBC <= 0.4462129:
    :               :       :...RBC <= 0.6904467: F4 (3/0.5)
    :               :       :   RBC > 0.6904467: F3 (2.9/0.2)
    :               :       WBC > 0.4462129:
    :               :       :...ALT.after.24.w <= 0.6521739: F2 (8.1/0.8)
    :               :           ALT.after.24.w > 0.6521739: F3 (3.6/0.8)
    :               ALT.36 <= 0.7640449:
    :               :...ALT.24 <= 0.1797753:
    :                   :...RNA.Base <= 0.2276536:
    :                   :   :...AST.1 <= 0.4719101: F1 (3.1/0.6)
    :                   :   :   AST.1 > 0.4719101:
    :                   :   :   :...ALT.1 <= 0.4044944: F1 (2.7/0.5)
    :                   :   :       ALT.1 > 0.4044944: F4 (6.8)
    :                   :   RNA.Base > 0.2276536:
    :                   :   :...RNA.Base <= 0.4238328: F2 (5.5/0.9)
    :                   :       RNA.Base > 0.4238328:
    :                   :       :...Age <= 0.2413793: F3 (3.5/0.8)
    :                   :           Age > 0.2413793: F4 (15.9/4.6)
    :                   ALT.24 > 0.1797753:
    :                   :...Plat <= 0.1512016:
    :                       :...ALT.24 <= 0.6516854:
    :                       :   :...ALT.24 > 0.4494382: F4 (6.8/0.5)
    :                       :   :   ALT.24 <= 0.4494382:
    :                       :   :   :...AST.1 <= 0.1235955: F4 (2.6)
    :                       :   :       AST.1 > 0.1235955: F3 (7.9/1.1)
    :                       :   ALT.24 > 0.6516854:
    :                       :   :...ALT.12 > 0.8202247: F3 (4.6/2.1)
    :                       :       ALT.12 <= 0.8202247:
    :                       :       :...ALT.36 <= 0.4494382: F3 (2.5/0.6)
    :                       :           ALT.36 > 0.4494382: F2 (4)
    :                       Plat > 0.1512016:
    :                       :...Plat <= 0.2486081:
    :                           :...WBC <= 0.3002195: F1 (3.9/0.8)
    :                           :   WBC > 0.3002195: F3 (9.1/1)
    :                           Plat > 0.2486081:
    :                           :...RNA.4 > 0.9397534: F2 (6.9/0.9)
    :                               RNA.4 <= 0.9397534:
    :                               :...ALT.24 > 0.9213483:
    :                                   :...ALT.48 > 0.5955056: F3 (5.7/0.9)
    :                                   :   ALT.48 <= 0.5955056:
    :                                   :   :...Plat <= 0.3629422: F3 (2.3)
    :                                   :       Plat > 0.3629422: F2 (10.9/3.4)
    :                                   ALT.24 <= 0.9213483:
    :                                   :...ALT.4 <= 0.08988764: F1 (10.7/2.2)
    :                                       ALT.4 > 0.08988764:
    :                                       :...Plat <= 0.5191718:
    :                                           :...WBC <= 0.1385291: F4 (2.7/0.5)
    :                                           :   WBC > 0.1385291:
    :                                           :   :...BMI <= 0.8461539:
    :                                           :       :...Age <= 0.1724138: F1 (2.8)
    :                                           :       :   Age > 0.1724138: F4 (4.2/1.6)
    :                                           :       BMI > 0.8461539: [S1]
    :                                           Plat > 0.5191718:
    :                                           :...ALT.24 <= 0.258427: F3 (5)
    :                                               ALT.24 > 0.258427:
    :                                               :...AST.1 > 0.7865168: F3 (6.1/1.7)
    :                                                   AST.1 <= 0.7865168:
    :                                                   :...Age > 0.5862069: [S2]
    :                                                       Age <= 0.5862069:
    :                                                       :...RNA.4 <= 0.6912616: [S3]
    :                                                           RNA.4 > 0.6912616: [S4]
    BMI <= 0.6923077:
    :...Age > 0.9655172:
        :...RBC <= 0.1004402: F3 (3.4)
        :   RBC > 0.1004402:
        :   :...AST.1 <= 0.4831461: F1 (4.4/0.4)
        :       AST.1 > 0.4831461: F2 (8.6/1.8)
        Age <= 0.9655172:
        :...ALT.after.24.w <= 0:
            :...ALT.1 <= 0.4494382: F4 (4.5/1.9)
            :   ALT.1 > 0.4494382:
            :   :...ALT.36 <= 0.08988764: F2 (2.8)
            :       ALT.36 > 0.08988764:
            :       :...ALT.4 <= 0.2696629: F2 (2.6/0.9)
            :           ALT.4 > 0.2696629:
            :           :...RNA.Base <= 0.8369943: F1 (10.3/0.7)
            :               RNA.Base > 0.8369943: F3 (2.7/0.6)
            ALT.after.24.w > 0:
            :...RNA.4 <= 0.04120711:
                :...ALT.1 > 0.8202247:
                :   :...RNA.Base <= 0.3972525: F2 (2.4)
                :   :   RNA.Base > 0.3972525: F1 (4.1/0.2)
                :   ALT.1 <= 0.8202247:
                :   :...Plat <= 0.258964: F4 (5)
                :       Plat > 0.258964:
                :       :...ALT.24 <= 0.4382023: F4 (5.2/1.3)
                :           ALT.24 > 0.4382023: F1 (4.3)
                RNA.4 > 0.04120711:
                :...WBC <= 0.01855104:
                    :...Plat > 0.7840106: F2 (3.4/1.3)
                    :   Plat <= 0.7840106:
                    :   :...RNA.Base <= 0.5799838: F3 (4.9)
                    :       RNA.Base > 0.5799838: F2 (5.2/1.2)
                    WBC > 0.01855104:
                    :...AST.1 <= 0.02247191:
                        :...ALT.12 > 0.741573: F1 (4/0.5)
                        :   ALT.12 <= 0.741573:
                        :   :...ALT.24 <= 0.06741573: F1 (2.3)
                        :       ALT.24 > 0.06741573: F4 (6.9)
                        AST.1 > 0.02247191:
                        :...RNA.Base <= 0.5254951:
                            :...ALT.after.24.w > 0.7826087:
                            :   :...Plat <= 0.1760197:
                            :   :   :...BMI <= 0.3076923: F1 (4.9/0.8)
                            :   :   :   BMI > 0.3076923: F2 (2.8/1.1)
                            :   :   Plat > 0.1760197:
                            :   :   :...ALT.36 > 0.8651685: F2 (4.6/2.1)
                            :   :       ALT.36 <= 0.8651685:
                            :   :       :...ALT.48 <= 0.2134831:
                            :   :           :...BMI <= 0.2307692: F1 (4.1/0.7)
                            :   :           :   BMI > 0.2307692: F4 (5.5/0.6)
                            :   :           ALT.48 > 0.2134831:
                            :   :           :...Age > 0.7241379: F1 (5.5/2.7)
                            :   :               Age <= 0.7241379:
                            :   :               :...ALT.1 <= 0.4157303: F3 (7.4/0.2)
                            :   :                   ALT.1 > 0.4157303:
                            :   :                   :...WBC <= 0.7364435: F3 (6.9/1.7)
                            :   :                       WBC > 0.7364435: F4 (4.5/0.5)
                            :   ALT.after.24.w <= 0.7826087:
                            :   :...ALT.12 <= 0.3483146:
                            :       :...RBC <= 0.169807:
                            :       :   :...RNA.4 <= 0.2149778: F1 (2.4)
                            :       :   :   RNA.4 > 0.2149778: F2 (5.4)
                            :       :   RBC > 0.169807:
                            :       :   :...ALT.12 > 0.3033708:
                            :       :       :...BMI <= 0.2307692: F1 (3.4)
                            :       :       :   BMI > 0.2307692: F2 (3.2/0.9)
                            :       :       ALT.12 <= 0.3033708:
                            :       :       :...RNA.Base <= 0.1011311:
                            :       :           :...ALT.48 <= 0.4157303: F4 (2.6)
                            :       :           :   ALT.48 > 0.4157303: F1 (6.4/2.2)
                            :       :           RNA.Base > 0.1011311:
                            :       :           :...Plat <= 0.2432353:
                            :       :               :...Plat <= 0.1760197: F3 (3.2)
                            :       :               :   Plat > 0.1760197: F4 (3.9/0.6)
                            :       :               Plat > 0.2432353:
                            :       :               :...ALT.36 <= 0.3483146: [S5]
                            :       :                   ALT.36 > 0.3483146: [S6]
                            :       ALT.12 > 0.3483146:
                            :       :...ALT.4 <= 0.3146068:
                            :           :...Age > 0.862069: F4 (6/0.6)
                            :           :   Age <= 0.862069:
                            :           :   :...ALT.1 <= 0.494382:
                            :           :       :...ALT.4 > 0.2696629: F3 (6.4)
                            :           :       :   ALT.4 <= 0.2696629:
                            :           :       :   :...RNA.4 <= 0.2005842: F1 (3.1/1.5)
                            :           :       :       RNA.4 > 0.2005842:
                            :           :       :       :...BMI <= 0.3846154: F4 (12/1.3)
                            :           :       :           BMI > 0.3846154: F3 (2.5/0.6)
                            :           :       ALT.1 > 0.494382: [S7]
                            :           ALT.4 > 0.3146068:
                            :           :...ALT.4 <= 0.5393258:
                            :               :...Age <= 0.137931: F4 (3.4/1.3)
                            :               :   Age > 0.137931: F2 (22.7/5.6)
                            :               ALT.4 > 0.5393258:
                            :               :...RNA.4 <= 0.170616: F4 (6.7/1.6)
                            :                   RNA.4 > 0.170616:
                            :                   :...Age > 0.7931035:
                            :                       :...BMI <= 0.3076923: F3 (7.8/0.6)
                            :                       :   BMI > 0.3076923: [S8]
                            :                       Age <= 0.7931035:
                            :                       :...WBC > 0.5120746:
                            :                           :...Age <= 0: F4 (2.5/1.2)
                            :                           :   Age > 0: [S9]
                            :                           WBC <= 0.5120746:
                            :                           :...Age <= 0.5172414: [S10]
                            :                               Age > 0.5172414: [S11]
                            RNA.Base > 0.5254951:
                            :...RNA.4 <= 0.2984472:
                                :...ALT.1 > 0.6179775:
                                :   :...Plat > 0.5436003:
                                :   :   :...BMI <= 0.2307692: F2 (2.8/0.5)
                                :   :   :   BMI > 0.2307692: F4 (14.2/4.8)
                                :   :   Plat <= 0.5436003:
                                :   :   :...WBC <= 0.3489572:
                                :   :       :...AST.1 <= 0.2134831: F1 (2.5/0.7)
                                :   :       :   AST.1 > 0.2134831: F4 (4.2/1.1)
                                :   :       WBC > 0.3489572:
                                :   :       :...ALT.12 <= 0.2134831: F1 (2.2/0.5)
                                :   :           ALT.12 > 0.2134831: F3 (9)
                                :   ALT.1 <= 0.6179775:
                                :   :...Plat > 0.8774456:
                                :       :...ALT.12 <= 0.5505618: F2 (3.2)
                                :       :   ALT.12 > 0.5505618: F3 (3.5/1.3)
                                :       Plat <= 0.8774456:
                                :       :...BMI <= 0.07692308: F4 (4.8/0.9)
                                :           BMI > 0.07692308:
                                :           :...RNA.4 > 0.2695684: F2 (5.4)
                                :               RNA.4 <= 0.2695684:
                                :               :...Age <= 0.5517241: F2 (6.1/1.7)
                                :                   Age > 0.5517241: F4 (10.8/1.3)
                                RNA.4 > 0.2984472:
                                :...AST.1 > 0.6966292:
                                    :...ALT.48 <= 0.1910112:
                                    :   :...Age > 0.6551724: F3 (2)
                                    :   :   Age <= 0.6551724:
                                    :   :   :...RNA.4 <= 0.8416881: F4 (8.9/2.3)
                                    :   :       RNA.4 > 0.8416881: F2 (2.4)
                                    :   ALT.48 > 0.1910112:
                                    :   :...ALT.after.24.w <= 0.173913: F3 (4.2/0.5)
                                    :       ALT.after.24.w > 0.173913:
                                    :       :...ALT.4 <= 0.3033708:
                                    :           :...ALT.1 <= 0.4719101: F2 (4.2)
                                    :           :   ALT.1 > 0.4719101: F3 (4.8/0.5)
                                    :           ALT.4 > 0.3033708:
                                    :           :...RNA.Base <= 0.6028808:
                                    :               :...Age <= 0.2758621: F1 (2.3)
                                    :               :   Age > 0.2758621: F3 (4.2/0.5)
                                    :               RNA.Base > 0.6028808:
                                    :               :...ALT.12 > 0.752809: F1 (8.3/1)
                                    :                   ALT.12 <= 0.752809:
                                    :                   :...RBC > 0.803508: F4 (4.5/1.2)
                                    :                       RBC <= 0.803508: [S12]
                                    AST.1 <= 0.6966292:
                                    :...ALT.36 <= 0.08988764:
                                        :...ALT.1 > 0.8764045: F4 (2.1)
                                        :   ALT.1 <= 0.8764045:
                                        :   :...RBC <= 0.09045705: F1 (2)
                                        :       RBC > 0.09045705:
                                        :       :...ALT.48 <= 0.6516854: F3 (5.5/1.3)
                                        :           ALT.48 > 0.6516854: F2 (4.6/0.9)
                                        ALT.36 > 0.08988764:
                                        :...ALT.12 <= 0.1123596:
                                            :...ALT.12 <= 0.05617978: F3 (3.6/0.7)
                                            :   ALT.12 > 0.05617978: F4 (4.9/0.5)
                                            ALT.12 > 0.1123596:
                                            :...Age > 0.6551724:
                                                :...ALT.36 <= 0.3033708: F1 (10.6/1.3)
                                                :   ALT.36 > 0.3033708:
                                                :   :...ALT.1 <= 0.4606742: [S13]
                                                :       ALT.1 > 0.4606742: [S14]
                                                Age <= 0.6551724:
                                                :...ALT.4 > 0.8651685: F3 (4.5)
                                                    ALT.4 <= 0.8651685:
                                                    :...ALT.48 > 0.9438202: F2 (3.2/0.6)
                                                        ALT.48 <= 0.9438202:
                                                        :...ALT.24 <= 0.1235955: [S15]
                                                            ALT.24 > 0.1235955: [S16]

SubTree [S1]

RNA.Base <= 0.4306309: F1 (4.7)
RNA.Base > 0.4306309:
:...ALT.36 <= 0.6629214: F2 (7.8/1.6)
    ALT.36 > 0.6629214: F1 (2.5)

SubTree [S2]

ALT.48 <= 0.2022472: F4 (2.2)
ALT.48 > 0.2022472: F2 (4.9)

SubTree [S3]

WBC > 0.6816685: F1 (4.6/0.8)
WBC <= 0.6816685:
:...AST.1 <= 0.2359551: F1 (3.2/0.7)
    AST.1 > 0.2359551: F3 (7/1.4)

SubTree [S4]

ALT.24 > 0.752809: F4 (2.8)
ALT.24 <= 0.752809:
:...AST.1 <= 0.2808989: F2 (4.3)
    AST.1 > 0.2808989: F1 (2.2)

SubTree [S5]

ALT.4 <= 0.7191011: F3 (4.7/0.5)
ALT.4 > 0.7191011: F2 (2.6/1.2)

SubTree [S6]

ALT.48 > 0.6629214: F2 (11.5/2.1)
ALT.48 <= 0.6629214:
:...RBC <= 0.5629756: F2 (4.2/0.5)
    RBC > 0.5629756: F1 (2.6)

SubTree [S7]

ALT.after.24.w > 0.6521739: F4 (4.3/1.3)
ALT.after.24.w <= 0.6521739:
:...WBC > 0.584303: F3 (10.2/1.3)
    WBC <= 0.584303:
    :...ALT.36 <= 0.6292135: F2 (9.1/1)
        ALT.36 > 0.6292135: F3 (2.8/1.3)

SubTree [S8]

ALT.12 <= 0.8764045: F1 (5.2/0.5)
ALT.12 > 0.8764045: F3 (2.1)

SubTree [S9]

RNA.4 <= 0.569367: F3 (13.6/2.5)
RNA.4 > 0.569367: F2 (6.1/1.6)

SubTree [S10]

WBC <= 0.1351262: F4 (3.2/0.9)
WBC > 0.1351262:
:...BMI <= 0.2307692: F4 (3.6/1.2)
    BMI > 0.2307692: F1 (8.3/1.7)

SubTree [S11]

ALT.12 <= 0.5168539: F3 (2.1)
ALT.12 > 0.5168539:
:...Age <= 0.7241379: F2 (5.4/0.5)
    Age > 0.7241379: F4 (3.1/0.9)

SubTree [S12]

ALT.12 <= 0.2921348: F1 (6.4/1.2)
ALT.12 > 0.2921348: F2 (5.7)

SubTree [S13]

ALT.36 <= 0.505618: F2 (2.1)
ALT.36 > 0.505618: F1 (5.4/1.8)

SubTree [S14]

RNA.Base <= 0.9733889: F4 (13.6/0.5)
RNA.Base > 0.9733889: F1 (2.5)

SubTree [S15]

RNA.4 <= 0.6667932: F3 (2.8)
RNA.4 > 0.6667932: F1 (3.9/1.1)

SubTree [S16]

Plat > 0.8968086: F3 (2.1)
Plat <= 0.8968086:
:...ALT.after.24.w <= 0.08695652: F2 (4.3/2.5)
    ALT.after.24.w > 0.08695652:
    :...ALT.1 <= 0.3595506: F4 (5.6/1.6)
        ALT.1 > 0.3595506:
        :...RNA.4 <= 0.4365587: F4 (5.2)
            RNA.4 > 0.4365587:
            :...RBC > 0.6150659: F4 (10.7/1.5)
                RBC <= 0.6150659:
                :...ALT.12 <= 0.988764: F1 (14.8/0.5)
                    ALT.12 > 0.988764: F4 (2.3)

-----  Trial 8:  -----

Decision tree:

WBC <= 0.03084522:
:...RBC > 0.8945807: F1 (5.4)
:   RBC <= 0.8945807:
:   :...WBC > 0.01613611:
:       :...BMI <= 0.07692308: F1 (4.1)
:       :   BMI > 0.07692308: F3 (8.6/3.3)
:       WBC <= 0.01613611:
:       :...BMI > 0.7692308: F2 (3.5/1.2)
:           BMI <= 0.7692308:
:           :...RNA.4 <= 0.4198684: F3 (7/1)
:               RNA.4 > 0.4198684: F2 (5.3/1)
WBC > 0.03084522:
:...ALT.48 > 0.9438202:
    :...Plat > 0.9034327: F1 (3.5/0.2)
    :   Plat <= 0.9034327:
    :   :...ALT.4 <= 0.1460674:
    :       :...ALT.1 <= 0.6067415: F3 (4.1)
    :       :   ALT.1 > 0.6067415: F2 (3.8/1.6)
    :       ALT.4 > 0.1460674:
    :       :...ALT.48 > 0.9662921:
    :           :...ALT.36 <= 0.5168539: F4 (14.5/2.1)
    :           :   ALT.36 > 0.5168539:
    :           :   :...WBC <= 0.5047201: F2 (8.7/2.6)
    :           :       WBC > 0.5047201: F3 (2.9)
    :           ALT.48 <= 0.9662921:
    :           :...Age <= 0.3448276: F2 (5.1/1.2)
    :               Age > 0.3448276:
    :               :...ALT.36 > 0.6179775: F4 (6.5/1)
    :                   ALT.36 <= 0.6179775:
    :                   :...Age <= 0.6206896: F4 (3.8/1.6)
    :                       Age > 0.6206896: F2 (8.5)
    ALT.48 <= 0.9438202:
    :...BMI <= 0.4615385:
        :...AST.1 > 0.7191011:
        :   :...ALT.1 <= 0.05617978:
        :   :   :...RBC <= 0.512243: F3 (4)
        :   :   :   RBC > 0.512243: F1 (4.7)
        :   :   ALT.1 > 0.05617978:
        :   :   :...ALT.48 <= 0.08988764:
        :   :       :...RNA.4 <= 0.4694727: F3 (7/2.1)
        :   :       :   RNA.4 > 0.4694727:
        :   :       :   :...RBC <= 0.7754056: F2 (5.8/1.1)
        :   :       :       RBC > 0.7754056: F4 (4.4)
        :   :       ALT.48 > 0.08988764:
        :   :       :...RNA.4 <= 0.1684916:
        :   :           :...Plat > 0.6043042: F2 (4.3/1.5)
        :   :           :   Plat <= 0.6043042:
        :   :           :   :...RNA.4 <= 0.1055954: F4 (4.6)
        :   :           :       RNA.4 > 0.1055954: F1 (2.8)
        :   :           RNA.4 > 0.1684916:
        :   :           :...RNA.4 > 0.8075259:
        :   :               :...ALT.after.24.w <= 0.2608696: F2 (2.1/1)
        :   :               :   ALT.after.24.w > 0.2608696:
        :   :               :   :...ALT.24 <= 0.6179775: F4 (7.6/1.4)
        :   :               :       ALT.24 > 0.6179775:
        :   :               :       :...RNA.Base <= 0.5175647: F3 (2.4)
        :   :               :           RNA.Base > 0.5175647: F1 (5.8/1.2)
        :   :               RNA.4 <= 0.8075259:
        :   :               :...BMI <= 0.1538462:
        :   :                   :...ALT.36 > 0.752809: F3 (4.7/1.4)
        :   :                   :   ALT.36 <= 0.752809:
        :   :                   :   :...ALT.36 <= 0.3258427: F3 (9.2/1.2)
        :   :                   :       ALT.36 > 0.3258427: F2 (11.6/1.2)
        :   :                   BMI > 0.1538462:
        :   :                   :...RBC > 0.8821443: F1 (3.7)
        :   :                       RBC <= 0.8821443:
        :   :                       :...AST.1 <= 0.7640449: F1 (2.7/0.4)
        :   :                           AST.1 > 0.7640449:
        :   :                           :...ALT.after.24.w <= 0.2608696: F3 (4.9/1.6)
        :   :                               ALT.after.24.w > 0.2608696:
        :   :                               :...RBC > 0.7366652: F3 (3.2)
        :   :                                   RBC <= 0.7366652:
        :   :                                   :...RBC > 0.4163593: F2 (8.8/1.9)
        :   :                                       RBC <= 0.4163593:
        :   :                                       :...ALT.36 <= 0.6067415: F3 (5.6/0.8)
        :   :                                           ALT.36 > 0.6067415: F2 (3.8)
        :   AST.1 <= 0.7191011:
        :   :...Age <= 0.137931:
        :       :...ALT.after.24.w <= 0.4782609:
        :       :   :...RNA.4 <= 0.9675812: F1 (18.1/5)
        :       :   :   RNA.4 > 0.9675812: F3 (2.2)
        :       :   ALT.after.24.w > 0.4782609:
        :       :   :...RNA.4 <= 0.7286625: F3 (17.8/7.2)
        :       :       RNA.4 > 0.7286625: F1 (7.3/2)
        :       Age > 0.137931:
        :       :...RBC > 0.8990407:
        :           :...RBC <= 0.9731978: F3 (17.3/3.3)
        :           :   RBC > 0.9731978:
        :           :   :...ALT.1 <= 0.1460674: F4 (3)
        :           :       ALT.1 > 0.1460674:
        :           :       :...ALT.36 <= 0.5842696: F1 (2.5/0.6)
        :           :           ALT.36 > 0.5842696: F2 (5/1.8)
        :           RBC <= 0.8990407:
        :           :...ALT.48 > 0.8764045:
        :               :...RNA.Base <= 0.1147347: F1 (3.5/1.5)
        :               :   RNA.Base > 0.1147347: F2 (12.5/4.3)
        :               ALT.48 <= 0.8764045:
        :               :...RNA.4 <= 0.2949855:
        :                   :...ALT.after.24.w > 0.9565217: F3 (4.5)
        :                   :   ALT.after.24.w <= 0.9565217:
        :                   :   :...ALT.after.24.w > 0.8695652: F1 (5.5/1.8)
        :                   :       ALT.after.24.w <= 0.8695652:
        :                   :       :...ALT.12 > 0.8988764:
        :                   :           :...ALT.36 <= 0.7640449: F3 (4.1/2.1)
        :                   :           :   ALT.36 > 0.7640449: F1 (4.1)
        :                   :           ALT.12 <= 0.8988764:
        :                   :           :...BMI > 0.3846154:
        :                   :               :...RBC <= 0.2986933: F4 (3.8)
        :                   :               :   RBC > 0.2986933: F2 (4.3/1.8)
        :                   :               BMI <= 0.3846154:
        :                   :               :...Plat > 0.8278394: F3 (5.6/0.6)
        :                   :                   Plat <= 0.8278394:
        :                   :                   :...ALT.4 > 0.6067415:
        :                   :                       :...ALT.48 <= 0.3483146: F2 (7.3/1.1)
        :                   :                       :   ALT.48 > 0.3483146: F4 (8.1/1.7)
        :                   :                       ALT.4 <= 0.6067415:
        :                   :                       :...RNA.Base > 0.8355365: F3 (3.3)
        :                   :                           RNA.Base <= 0.8355365: [S1]
        :                   RNA.4 > 0.2949855:
        :                   :...RNA.4 <= 0.4665918:
        :                       :...ALT.after.24.w <= 0.1304348: F4 (5.9/2.7)
        :                       :   ALT.after.24.w > 0.1304348: F1 (28.4/7.4)
        :                       RNA.4 > 0.4665918:
        :                       :...Age <= 0.1724138:
        :                           :...RBC <= 0.4158286: F2 (3)
        :                           :   RBC > 0.4158286: F4 (3.4)
        :                           Age > 0.1724138:
        :                           :...Age <= 0.2068966: F1 (6/1.2)
        :                               Age > 0.2068966:
        :                               :...RNA.4 <= 0.5406513:
        :                                   :...ALT.48 > 0.7191011: F1 (5.1/1.5)
        :                                   :   ALT.48 <= 0.7191011:
        :                                   :   :...ALT.24 <= 0.7865168: F3 (7.9/1.9)
        :                                   :       ALT.24 > 0.7865168: F2 (2.8/1.2)
        :                                   RNA.4 > 0.5406513:
        :                                   :...Plat > 0.8854336:
        :                                       :...ALT.48 <= 0.6067415: F1 (5.4/0.9)
        :                                       :   ALT.48 > 0.6067415: F3 (2.5/0.7)
        :                                       Plat <= 0.8854336:
        :                                       :...Age <= 0.3793103: [S2]
        :                                           Age > 0.3793103:
        :                                           :...RNA.Base > 0.6345674: [S3]
        :                                               RNA.Base <= 0.6345674:
        :                                               :...ALT.4 > 0.7078652: [S4]
        :                                                   ALT.4 <= 0.7078652: [S5]
        BMI > 0.4615385:
        :...ALT.after.24.w > 0.4347826:
            :...ALT.after.24.w <= 0.4782609:
            :   :...ALT.48 > 0.752809: F3 (3.3)
            :   :   ALT.48 <= 0.752809:
            :   :   :...AST.1 <= 0.258427: F2 (5.7/2.8)
            :   :       AST.1 > 0.258427: F1 (8.9/0.6)
            :   ALT.after.24.w > 0.4782609:
            :   :...ALT.4 <= 0.4831461:
            :       :...RBC > 0.9237997: F2 (7/1.1)
            :       :   RBC <= 0.9237997:
            :       :   :...Plat <= 0.2392788:
            :       :       :...ALT.24 <= 0.1235955: F2 (3.6/0.2)
            :       :       :   ALT.24 > 0.1235955:
            :       :       :   :...RNA.4 > 0.8680305: F3 (3)
            :       :       :       RNA.4 <= 0.8680305:
            :       :       :       :...ALT.12 <= 0.1573034: F3 (4.3/1.6)
            :       :       :           ALT.12 > 0.1573034: F4 (12.1/1.1)
            :       :       Plat > 0.2392788:
            :       :       :...WBC <= 0.1654226:
            :       :           :...RNA.Base <= 0.3461807: F2 (2.8)
            :       :           :   RNA.Base > 0.3461807:
            :       :           :   :...ALT.4 <= 0.3033708: F1 (3.2/0.9)
            :       :           :       ALT.4 > 0.3033708: F3 (3)
            :       :           WBC > 0.1654226:
            :       :           :...ALT.36 <= 0.3146068:
            :       :               :...ALT.after.24.w <= 0.6956522:
            :       :               :   :...ALT.after.24.w <= 0.5217391: F1 (3.3)
            :       :               :   :   ALT.after.24.w > 0.5217391: F2 (5.1/0.7)
            :       :               :   ALT.after.24.w > 0.6956522:
            :       :               :   :...AST.1 > 0.6966292: F4 (7.5/0.6)
            :       :               :       AST.1 <= 0.6966292:
            :       :               :       :...Plat <= 0.4018329: F4 (2.1)
            :       :               :           Plat > 0.4018329: F1 (10.6/1.7)
            :       :               ALT.36 > 0.3146068:
            :       :               :...ALT.4 <= 0.01123596: F3 (2.5)
            :       :                   ALT.4 > 0.01123596:
            :       :                   :...Age <= 0.06896552:
            :       :                       :...Plat <= 0.4511169: F1 (3.5)
            :       :                       :   Plat > 0.4511169: F3 (2.6/1.1)
            :       :                       Age > 0.06896552:
            :       :                       :...RNA.4 <= 0.786327:
            :       :                           :...RBC > 0.4832055: F4 (14.1/0.5)
            :       :                           :   RBC <= 0.4832055:
            :       :                           :   :...ALT.1 <= 0.3932584: F2 (5.6/1.5)
            :       :                           :       ALT.1 > 0.3932584: F4 (7.6/2)
            :       :                           RNA.4 > 0.786327:
            :       :                           :...AST.1 > 0.8988764: F2 (3.3)
            :       :                               AST.1 <= 0.8988764:
            :       :                               :...RNA.4 <= 0.8668897: F3 (2.8)
            :       :                                   RNA.4 > 0.8668897: F4 (4.5)
            :       ALT.4 > 0.4831461:
            :       :...ALT.24 <= 0.1460674:
            :           :...ALT.1 > 0.4382023: F4 (7.9/1.8)
            :           :   ALT.1 <= 0.4382023:
            :           :   :...Plat <= 0.4948033: F1 (4.7)
            :           :       Plat > 0.4948033: F3 (2.9/0.6)
            :           ALT.24 > 0.1460674:
            :           :...AST.1 <= 0.1573034:
            :               :...ALT.4 <= 0.5280899: F1 (3.5/1.2)
            :               :   ALT.4 > 0.5280899:
            :               :   :...ALT.after.24.w <= 0.7391304: F4 (4.4/1.1)
            :               :       ALT.after.24.w > 0.7391304: F3 (2/0.2)
            :               AST.1 > 0.1573034:
            :               :...ALT.24 > 0.8539326:
            :                   :...BMI <= 0.6153846:
            :                   :   :...RNA.Base <= 0.2386587: F2 (2.9)
            :                   :   :   RNA.Base > 0.2386587: F4 (3)
            :                   :   BMI > 0.6153846:
            :                   :   :...RNA.Base <= 0.1556014: F3 (2.4/0.6)
            :                   :       RNA.Base > 0.1556014: F2 (5.4/0.7)
            :                   ALT.24 <= 0.8539326:
            :                   :...AST.1 <= 0.2921348:
            :                       :...ALT.48 > 0.8876405: F1 (2.4)
            :                       :   ALT.48 <= 0.8876405:
            :                       :   :...Age <= 0.5862069: F2 (8.7)
            :                       :       Age > 0.5862069: F3 (3/0.8)
            :                       AST.1 > 0.2921348:
            :                       :...RNA.4 <= 0.09503957: F1 (4.3/0.4)
            :                           RNA.4 > 0.09503957:
            :                           :...ALT.12 > 0.8876405: F3 (3.6)
            :                               ALT.12 <= 0.8876405:
            :                               :...Plat > 0.6820256:
            :                                   :...ALT.4 <= 0.6067415: F1 (2.2/0.6)
            :                                   :   ALT.4 > 0.6067415: F2 (7.5/1)
            :                                   Plat <= 0.6820256:
            :                                   :...ALT.48 <= 0.1573034: F3 (6.8/1.1)
            :                                       ALT.48 > 0.1573034:
            :                                       :...Plat <= 0.1658811:
            :                                           :...Plat <= 0.1174064: F1 (5.3/1.7)
            :                                           :   Plat > 0.1174064: F2 (4/0.4)
            :                                           Plat > 0.1658811: [S6]
            ALT.after.24.w <= 0.4347826:
            :...ALT.4 <= 0.06741573:
                :...ALT.after.24.w > 0.3478261: F3 (4.2/1.9)
                :   ALT.after.24.w <= 0.3478261:
                :   :...ALT.48 <= 0.7865168: F1 (13/2.1)
                :       ALT.48 > 0.7865168: F4 (2.5/1)
                ALT.4 > 0.06741573:
                :...Plat > 0.9282733:
                    :...ALT.24 <= 0.741573: F2 (4.8)
                    :   ALT.24 > 0.741573: F4 (4.2)
                    Plat <= 0.9282733:
                    :...ALT.12 > 0.7752809:
                        :...BMI > 0.9230769: F1 (4.8/0.8)
                        :   BMI <= 0.9230769:
                        :   :...RNA.Base > 0.8397835: F2 (6.4/0.7)
                        :       RNA.Base <= 0.8397835:
                        :       :...ALT.12 > 0.9213483: F3 (5.9)
                        :           ALT.12 <= 0.9213483:
                        :           :...RNA.Base > 0.542564: F2 (4.9/0.5)
                        :               RNA.Base <= 0.542564:
                        :               :...ALT.24 <= 0.494382: F3 (6.9)
                        :                   ALT.24 > 0.494382:
                        :                   :...RNA.Base <= 0.3638107: F2 (5.6/1)
                        :                       RNA.Base > 0.3638107: F3 (2.7)
                        ALT.12 <= 0.7752809:
                        :...RNA.Base > 0.9534334:
                            :...ALT.48 <= 0.2921348: F1 (3.7)
                            :   ALT.48 > 0.2921348: F2 (4)
                            RNA.Base <= 0.9534334:
                            :...RNA.Base > 0.8711762:
                                :...ALT.36 <= 0.505618: F4 (5)
                                :   ALT.36 > 0.505618:
                                :   :...BMI <= 0.6923077: F4 (3.6/0.6)
                                :       BMI > 0.6923077: F3 (4)
                                RNA.Base <= 0.8711762:
                                :...ALT.1 <= 0.1011236:
                                    :...ALT.24 > 0.988764: F2 (3.3)
                                    :   ALT.24 <= 0.988764:
                                    :   :...ALT.4 <= 0.2247191: F2 (2.6)
                                    :       ALT.4 > 0.2247191:
                                    :       :...ALT.24 <= 0.9438202: F3 (11.2/2.8)
                                    :           ALT.24 > 0.9438202: F1 (2.7)
                                    ALT.1 > 0.1011236:
                                    :...ALT.1 <= 0.1910112:
                                        :...WBC <= 0.4117453: F4 (2.3/0.7)
                                        :   WBC > 0.4117453: F2 (5.7)
                                        ALT.1 > 0.1910112:
                                        :...ALT.1 <= 0.3033708:
                                            :...ALT.36 <= 0.1235955: F4 (2.3)
                                            :   ALT.36 > 0.1235955:
                                            :   :...Plat <= 0.1787922: F1 (2.1)
                                            :       Plat > 0.1787922: F3 (10.4/2.6)
                                            ALT.1 > 0.3033708:
                                            :...AST.1 > 0.5617977:
                                                :...Plat > 0.5875865:
                                                :   :...ALT.48 <= 0.4606742: F1 (2.4)
                                                :   :   ALT.48 > 0.4606742: F3 (4.4/1.6)
                                                :   Plat <= 0.5875865:
                                                :   :...WBC > 0.743798: [S7]
                                                :       WBC <= 0.743798: [S8]
                                                AST.1 <= 0.5617977:
                                                :...RNA.Base > 0.6435168: F4 (10.3/4)
                                                    RNA.Base <= 0.6435168:
                                                    :...ALT.24 <= 0.1123596: F1 (2)
                                                        ALT.24 > 0.1123596: [S9]

SubTree [S1]

ALT.36 > 0.8539326: F3 (3.2/1.6)
ALT.36 <= 0.8539326:
:...RNA.Base > 0.4084508: F4 (11.6/0.8)
    RNA.Base <= 0.4084508:
    :...ALT.after.24.w <= 0.4347826: F3 (6.6/2.1)
        ALT.after.24.w > 0.4347826: F4 (3.6/1)

SubTree [S2]

ALT.after.24.w <= 0.4782609: F4 (4.8/1)
ALT.after.24.w > 0.4782609:
:...Plat <= 0.5875865: F3 (6.6/1.3)
    Plat > 0.5875865: F4 (4.3)

SubTree [S3]

ALT.36 <= 0.7865168: F4 (16.5/2.3)
ALT.36 > 0.7865168:
:...Plat <= 0.3260598: F3 (3.2)
    Plat > 0.3260598: F1 (2.6/1.3)

SubTree [S4]

Age > 0.6206896: F1 (5.4/2.1)
Age <= 0.6206896:
:...Age <= 0.4482759: F1 (3.3)
    Age > 0.4482759: F4 (7.9/1.4)

SubTree [S5]

AST.1 > 0.6629214: F1 (2.3)
AST.1 <= 0.6629214:
:...AST.1 <= 0.3595506:
    :...ALT.1 <= 0.4044944: F4 (8.5/2.4)
    :   ALT.1 > 0.4044944: F1 (5.6/1.4)
    AST.1 > 0.3595506:
    :...Age <= 0.6896552: F2 (3.8)
        Age > 0.6896552: F4 (6.4/1.1)

SubTree [S6]

ALT.4 <= 0.6067415: F3 (3.9/1.2)
ALT.4 > 0.6067415: F1 (12.7/2.1)

SubTree [S7]

ALT.24 <= 0.3370787: F4 (5.1)
ALT.24 > 0.3370787: F1 (4.7/2.5)

SubTree [S8]

ALT.1 <= 0.494382: F4 (9.3/1)
ALT.1 > 0.494382:
:...RNA.4 <= 0.1776502: F4 (2.1)
    RNA.4 > 0.1776502: F2 (9/0.2)

SubTree [S9]

RNA.4 > 0.9595085: F4 (2.5)
RNA.4 <= 0.9595085:
:...AST.1 <= 0.02247191: F4 (2.1/1)
    AST.1 > 0.02247191:
    :...Plat <= 0.7179264: F3 (18.4/0.9)
        Plat > 0.7179264:
        :...Plat <= 0.850447: F2 (3.7)
            Plat > 0.850447: F3 (2.3)

-----  Trial 9:  -----

Decision tree:

BMI <= 0.4615385:
:...RNA.Base > 0.8552055:
:   :...AST.1 <= 0.1123596: F4 (9.5/2)
:   :   AST.1 > 0.1123596:
:   :   :...Age <= 0.2413793: F1 (9.9/1.4)
:   :       Age > 0.2413793:
:   :       :...WBC > 0.8753018: F3 (8.8/2.4)
:   :           WBC <= 0.8753018:
:   :           :...ALT.36 > 0.8089887:
:   :               :...ALT.12 <= 0.4606742: F3 (3/1.4)
:   :               :   ALT.12 > 0.4606742: F1 (6.8/0.9)
:   :               ALT.36 <= 0.8089887:
:   :               :...Plat > 0.7116845: F4 (8.4/1.1)
:   :                   Plat <= 0.7116845:
:   :                   :...WBC > 0.7139407: F1 (4.6)
:   :                       WBC <= 0.7139407:
:   :                       :...BMI <= 0.1538462:
:   :                           :...ALT.4 <= 0.6516854: F3 (3.6)
:   :                           :   ALT.4 > 0.6516854: F4 (2.2)
:   :                           BMI > 0.1538462:
:   :                           :...Plat > 0.5021918: F3 (2.3/0.8)
:   :                               Plat <= 0.5021918:
:   :                               :...ALT.1 <= 0.8539326: F4 (7.2/1.6)
:   :                                   ALT.1 > 0.8539326: F1 (4.4/0.7)
:   RNA.Base <= 0.8552055:
:   :...ALT.48 <= 0.08988764:
:       :...RNA.4 <= 0.4313345:
:       :   :...ALT.48 > 0.05617978: F4 (4.9/2.4)
:       :   :   ALT.48 <= 0.05617978:
:       :   :   :...ALT.after.24.w <= 0.08695652: F3 (3.5/0.7)
:       :   :       ALT.after.24.w > 0.08695652:
:       :   :       :...ALT.12 <= 0.3707865: F3 (2.1)
:       :   :           ALT.12 > 0.3707865: F4 (12/2.6)
:       :   RNA.4 > 0.4313345:
:       :   :...ALT.1 <= 0.2808989:
:       :       :...ALT.after.24.w <= 0.2608696: F2 (2.5/0.4)
:       :       :   ALT.after.24.w > 0.2608696: F1 (5/0.4)
:       :       ALT.1 > 0.2808989:
:       :       :...ALT.12 > 0.6741573: F2 (3.4/1.9)
:       :           ALT.12 <= 0.6741573:
:       :           :...ALT.after.24.w <= 0.1304348: F2 (3.1/0.9)
:       :               ALT.after.24.w > 0.1304348: F4 (13.9/0.8)
:       ALT.48 > 0.08988764:
:       :...AST.1 > 0.7752809:
:           :...RBC > 0.8593162:
:           :   :...ALT.1 <= 0.6292135: F1 (7.6)
:           :   :   ALT.1 > 0.6292135: F3 (2.8/1)
:           :   RBC <= 0.8593162:
:           :   :...RNA.4 > 0.7799128:
:           :       :...ALT.4 <= 0.4269663: F4 (6.2/2)
:           :       :   ALT.4 > 0.4269663:
:           :       :   :...ALT.24 <= 0.7303371: F3 (5.4)
:           :       :       ALT.24 > 0.7303371: F1 (3/0.4)
:           :       RNA.4 <= 0.7799128:
:           :       :...Age <= 0.4827586:
:           :           :...ALT.36 > 0.8089887: F4 (4.8/2)
:           :           :   ALT.36 <= 0.8089887:
:           :           :   :...RNA.4 <= 0.1971815: F1 (4.4/1.7)
:           :           :       RNA.4 > 0.1971815:
:           :           :       :...ALT.1 > 0.752809: F1 (3.4)
:           :           :           ALT.1 <= 0.752809:
:           :           :           :...ALT.24 <= 0.7752809: F2 (11/1.8)
:           :           :               ALT.24 > 0.7752809: F3 (3.6/1.1)
:           :           Age > 0.4827586:
:           :           :...ALT.after.24.w <= 0.173913: F3 (6.1/0.9)
:           :               ALT.after.24.w > 0.173913:
:           :               :...ALT.48 > 0.6292135: F2 (9.7/0.3)
:           :                   ALT.48 <= 0.6292135:
:           :                   :...RNA.4 > 0.6257234: F2 (3.1)
:           :                       RNA.4 <= 0.6257234:
:           :                       :...ALT.4 <= 0.3483146: F2 (2.4/0.3)
:           :                           ALT.4 > 0.3483146: F3 (4.6)
:           AST.1 <= 0.7752809:
:           :...WBC > 0.9231614:
:               :...Plat > 0.6754689: F1 (3.1)
:               :   Plat <= 0.6754689:
:               :   :...ALT.24 <= 0.1235955: F2 (2.2/0.8)
:               :       ALT.24 > 0.1235955: F4 (9.7)
:               WBC <= 0.9231614:
:               :...ALT.24 > 0.7191011:
:                   :...WBC > 0.8602635: F4 (5.8)
:                   :   WBC <= 0.8602635:
:                   :   :...ALT.after.24.w <= 0.2608696:
:                   :       :...Plat > 0.7688665: F1 (7.4/1.1)
:                   :       :   Plat <= 0.7688665:
:                   :       :   :...RBC <= 0.5741384: F4 (5.5/0.6)
:                   :       :       RBC > 0.5741384:
:                   :       :       :...Plat <= 0.6791182: F2 (6.8)
:                   :       :           Plat > 0.6791182: F4 (2.5)
:                   :       ALT.after.24.w > 0.2608696:
:                   :       :...ALT.4 > 0.8426966:
:                   :           :...ALT.4 <= 0.988764: F4 (9/0.5)
:                   :           :   ALT.4 > 0.988764: F1 (2.3)
:                   :           ALT.4 <= 0.8426966:
:                   :           :...ALT.36 > 0.7640449:
:                   :               :...ALT.after.24.w <= 0.5652174: F1 (3)
:                   :               :   ALT.after.24.w > 0.5652174:
:                   :               :   :...ALT.1 <= 0.1235955: F1 (2.2)
:                   :               :       ALT.1 > 0.1235955: F4 (4.4/0.4)
:                   :               ALT.36 <= 0.7640449:
:                   :               :...Plat > 0.6687773:
:                   :                   :...ALT.after.24.w <= 0.5652174: F1 (5.6/0.4)
:                   :                   :   ALT.after.24.w > 0.5652174: F2 (5.3/1.5)
:                   :                   Plat <= 0.6687773:
:                   :                   :...RNA.Base <= 0.4190429: F3 (9.5/1.1)
:                   :                       RNA.Base > 0.4190429:
:                   :                       :...BMI <= 0.3846154: F1 (6.9/0.3)
:                   :                           BMI > 0.3846154: F3 (2.5/0.1)
:                   ALT.24 <= 0.7191011:
:                   :...WBC <= 0.1418222:
:                       :...AST.1 > 0.5842696:
:                       :   :...Age <= 0.2758621: F4 (2.7)
:                       :   :   Age > 0.2758621: F3 (6.2)
:                       :   AST.1 <= 0.5842696:
:                       :   :...ALT.36 > 0.7078652:
:                       :       :...ALT.36 <= 0.8202247: F3 (2.1)
:                       :       :   ALT.36 > 0.8202247: F4 (8.1/1.3)
:                       :       ALT.36 <= 0.7078652:
:                       :       :...AST.1 <= 0.3483146: F2 (11.2/0.9)
:                       :           AST.1 > 0.3483146:
:                       :           :...Age <= 0.4137931: F4 (3.6)
:                       :               Age > 0.4137931: F2 (2.8)
:                       WBC > 0.1418222:
:                       :...BMI <= 0.1538462:
:                           :...ALT.12 > 0.8876405:
:                           :   :...RBC > 0.4552677: F4 (9.2/1.6)
:                           :   :   RBC <= 0.4552677:
:                           :   :   :...WBC <= 0.5137212: F3 (2.8/0.9)
:                           :   :       WBC > 0.5137212: F1 (4.5)
:                           :   ALT.12 <= 0.8876405:
:                           :   :...ALT.after.24.w > 0.9130435: F4 (5.4/2.6)
:                           :       ALT.after.24.w <= 0.9130435:
:                           :       :...ALT.12 <= 0.2022472: F4 (8.2/1.9)
:                           :           ALT.12 > 0.2022472:
:                           :           :...ALT.36 <= 0.4719101:
:                           :               :...ALT.24 > 0.6853933: F3 (2.4/1.1)
:                           :               :   ALT.24 <= 0.6853933:
:                           :               :   :...Plat <= 0.3180718: F2 (6.1/0.9)
:                           :               :       Plat > 0.3180718:
:                           :               :       :...RNA.Base <= 0.5729684: F3 (4.8/0.8)
:                           :               :           RNA.Base > 0.5729684: F2 (5.8/1)
:                           :               ALT.36 > 0.4719101:
:                           :               :...ALT.24 <= 0.04494382: F3 (3.1/1.5)
:                           :                   ALT.24 > 0.04494382:
:                           :                   :...RBC > 0.4102663: F4 (9.5/3.8)
:                           :                       RBC <= 0.4102663:
:                           :                       :...RNA.4 <= 0.3422182: F2 (6.2/0.5)
:                           :                           RNA.4 > 0.3422182: F1 (4.9/1)
:                           BMI > 0.1538462:
:                           :...ALT.4 > 0.752809:
:                               :...ALT.12 > 0.5842696: F3 (11.1/1.7)
:                               :   ALT.12 <= 0.5842696:
:                               :   :...ALT.1 > 0.7752809: F1 (7.9/1.1)
:                               :       ALT.1 <= 0.7752809:
:                               :       :...ALT.after.24.w <= 0.6086956: F1 (5.7/1.6)
:                               :           ALT.after.24.w > 0.6086956: F3 (6.3)
:                               ALT.4 <= 0.752809:
:                               :...ALT.12 <= 0.1460674:
:                                   :...ALT.36 <= 0.7865168: F3 (9.4/1.4)
:                                   :   ALT.36 > 0.7865168: F1 (4.1/1.2)
:                                   ALT.12 > 0.1460674:
:                                   :...ALT.after.24.w > 0.6956522:
:                                       :...RNA.Base <= 0.0462494: F3 (2.7)
:                                       :   RNA.Base > 0.0462494: F2 (9.1/1.2)
:                                       ALT.after.24.w <= 0.6956522:
:                                       :...ALT.36 > 0.7640449:
:                                           :...ALT.4 <= 0.1910112: F2 (2.3/0.5)
:                                           :   ALT.4 > 0.1910112: F3 (5/0.9)
:                                           ALT.36 <= 0.7640449:
:                                           :...BMI > 0.3846154: F4 (7.2/1.6)
:                                               BMI <= 0.3846154:
:                                               :...Age <= 0.3448276: F1 (4/0.8)
:                                                   Age > 0.3448276:
:                                                   :...ALT.4 <= 0.08988764: F2 (3/1)
:                                                       ALT.4 > 0.08988764: [S1]
BMI > 0.4615385:
:...ALT.1 <= 0.01123596: F2 (12.9/2.9)
    ALT.1 > 0.01123596:
    :...ALT.1 > 0.8426966:
        :...AST.1 <= 0.06741573: F3 (5.1/0.6)
        :   AST.1 > 0.06741573:
        :   :...RNA.4 <= 0.1141998:
        :       :...Age > 0.4827586: F1 (9.7/1.6)
        :       :   Age <= 0.4827586:
        :       :   :...Age <= 0.2758621: F1 (3/1.5)
        :       :       Age > 0.2758621: F4 (2.9)
        :       RNA.4 > 0.1141998:
        :       :...RBC <= 0.2015534: F3 (8.3/1.9)
        :           RBC > 0.2015534:
        :           :...Plat <= 0.3180718:
        :               :...ALT.4 <= 0.2808989: F3 (2.8/1)
        :               :   ALT.4 > 0.2808989: F2 (11.2/1.2)
        :               Plat > 0.3180718:
        :               :...ALT.48 <= 0.1573034: F3 (2.4)
        :                   ALT.48 > 0.1573034:
        :                   :...ALT.4 > 0.752809: F1 (8.3/0.3)
        :                       ALT.4 <= 0.752809:
        :                       :...ALT.after.24.w > 0.6956522:
        :                           :...BMI <= 0.7692308: F2 (2.7/0.6)
        :                           :   BMI > 0.7692308: F4 (3.8)
        :                           ALT.after.24.w <= 0.6956522:
        :                           :...WBC > 0.6770582: F2 (3.4/0.6)
        :                               WBC <= 0.6770582:
        :                               :...ALT.after.24.w <= 0.2173913: F1 (5.2/2.2)
        :                                   ALT.after.24.w > 0.2173913:
        :                                   :...ALT.48 > 0.7191011: F3 (4.5)
        :                                       ALT.48 <= 0.7191011:
        :                                       :...ALT.1 <= 0.9550562: F1 (4.9)
        :                                           ALT.1 > 0.9550562: F3 (3/1.2)
        ALT.1 <= 0.8426966:
        :...ALT.36 <= 0.01123596:
            :...ALT.48 <= 0.8314607: F2 (8.1/1)
            :   ALT.48 > 0.8314607: F4 (2.5)
            ALT.36 > 0.01123596:
            :...ALT.1 <= 0.4044944:
                :...AST.1 <= 0.1460674:
                :   :...ALT.48 <= 0.2808989:
                :   :   :...RNA.4 <= 0.4198684: F4 (2.4/1)
                :   :   :   RNA.4 > 0.4198684: F1 (7.4)
                :   :   ALT.48 > 0.2808989:
                :   :   :...ALT.24 > 0.8539326: F4 (6.3/2.2)
                :   :       ALT.24 <= 0.8539326:
                :   :       :...ALT.24 <= 0.3258427: F3 (4.7)
                :   :           ALT.24 > 0.3258427:
                :   :           :...WBC <= 0.5068057: F4 (3.8)
                :   :               WBC > 0.5068057: F3 (8/3.2)
                :   AST.1 > 0.1460674:
                :   :...ALT.1 > 0.3707865:
                :       :...BMI > 0.6923077: F1 (5.3)
                :       :   BMI <= 0.6923077:
                :       :   :...RNA.Base <= 0.4595791: F3 (5.6)
                :       :       RNA.Base > 0.4595791: F2 (3/1.3)
                :       ALT.1 <= 0.3707865:
                :       :...Plat > 0.9235899: F2 (6.6/1.6)
                :           Plat <= 0.9235899:
                :           :...AST.1 > 0.6179775:
                :               :...ALT.1 > 0.3258427:
                :               :   :...AST.1 <= 0.9662921: F1 (5.4/1.2)
                :               :   :   AST.1 > 0.9662921: F2 (2.5/0.4)
                :               :   ALT.1 <= 0.3258427:
                :               :   :...BMI <= 0.6923077:
                :               :       :...Age > 0.7586207: F1 (5.8/1.8)
                :               :       :   Age <= 0.7586207:
                :               :       :   :...ALT.48 <= 0.4044944: F4 (8/0.5)
                :               :       :       ALT.48 > 0.4044944: F3 (6.5/1.4)
                :               :       BMI > 0.6923077:
                :               :       :...ALT.24 > 0.7752809:
                :               :           :...RNA.4 <= 0.3898644: F1 (5/2)
                :               :           :   RNA.4 > 0.3898644: [S2]
                :               :           ALT.24 <= 0.7752809:
                :               :           :...WBC <= 0.2644347: F1 (3.9)
                :               :               WBC > 0.2644347: [S3]
                :               AST.1 <= 0.6179775:
                :               :...Plat <= 0.03680752: F1 (5.6/2.2)
                :                   Plat > 0.03680752:
                :                   :...Age <= 0.03448276: F4 (2.9/0.9)
                :                       Age > 0.03448276:
                :                       :...BMI <= 0.5384616: F3 (4.4/1.6)
                :                           BMI > 0.5384616:
                :                           :...RNA.Base > 0.8823329:
                :                               :...BMI <= 0.6923077: F1 (4.1/1.4)
                :                               :   BMI > 0.6923077: F4 (4.2/1.4)
                :                               RNA.Base <= 0.8823329:
                :                               :...RNA.Base <= 0.282621:
                :                                   :...BMI <= 0.6153846: F1 (3/1.9)
                :                                   :   BMI > 0.6153846: [S4]
                :                                   RNA.Base > 0.282621:
                :                                   :...WBC <= 0.3552141: F2 (7.1/1.7)
                :                                       WBC > 0.3552141:
                :                                       :...RBC > 0.681234: F3 (4.1)
                :                                           RBC <= 0.681234: [S5]
                ALT.1 > 0.4044944:
                :...ALT.1 <= 0.494382:
                    :...RNA.4 > 0.8748442:
                    :   :...WBC <= 0.1738749: F3 (3.1/0.1)
                    :   :   WBC > 0.1738749: F2 (4)
                    :   RNA.4 <= 0.8748442:
                    :   :...AST.1 <= 0.1348315: F2 (3.3)
                    :       AST.1 > 0.1348315:
                    :       :...ALT.36 <= 0.08988764: F3 (2.3)
                    :           ALT.36 > 0.08988764:
                    :           :...ALT.4 <= 0.752809: F4 (22.3/3.1)
                    :               ALT.4 > 0.752809:
                    :               :...ALT.36 <= 0.4269663: F4 (2.8/0.1)
                    :                   ALT.36 > 0.4269663: F2 (4.4/1.4)
                    ALT.1 > 0.494382:
                    :...ALT.4 <= 0.02247191: F2 (4.7)
                        ALT.4 > 0.02247191:
                        :...ALT.48 <= 0.08988764:
                            :...ALT.1 <= 0.6067415: F1 (5.8)
                            :   ALT.1 > 0.6067415: F3 (5.6/3.1)
                            ALT.48 > 0.08988764:
                            :...ALT.36 > 0.8314607:
                                :...WBC <= 0.4554336: F3 (6.3/3.2)
                                :   WBC > 0.4554336: F2 (13.7/1.3)
                                ALT.36 <= 0.8314607:
                                :...ALT.4 > 0.9213483: F2 (3.1)
                                    ALT.4 <= 0.9213483:
                                    :...ALT.after.24.w > 0.5217391:
                                        :...ALT.24 <= 0.04494382: F2 (5.1/1.6)
                                        :   ALT.24 > 0.04494382:
                                        :   :...ALT.48 <= 0.2134831: F4 (8.7/1.9)
                                        :       ALT.48 > 0.2134831:
                                        :       :...ALT.4 <= 0.3370787:
                                        :           :...RBC <= 0.2451413: F1 (5.5/3.1)
                                        :           :   RBC > 0.2451413:
                                        :           :   :...Age <= 0.6206896: F4 (8.5/1)
                                        :           :       Age > 0.6206896: F1 (2.3/1)
                                        :           ALT.4 > 0.3370787:
                                        :           :...RBC <= 0.1417537: F4 (3.8)
                                        :               RBC > 0.1417537:
                                        :               :...ALT.24 <= 0.2921348: [S6]
                                        :                   ALT.24 > 0.2921348: [S7]
                                        ALT.after.24.w <= 0.5217391:
                                        :...RNA.Base > 0.7515293:
                                            :...ALT.24 > 0.752809: F4 (2.6)
                                            :   ALT.24 <= 0.752809:
                                            :   :...Age <= 0.2758621: F2 (2.5)
                                            :       Age > 0.2758621: F1 (4.7/1)
                                            RNA.Base <= 0.7515293:
                                            :...ALT.1 > 0.8314607: F2 (2.9)
                                                ALT.1 <= 0.8314607:
                                                :...BMI <= 0.5384616:
                                                    :...ALT.48 <= 0.3707865: F2 (4.5/1.1)
                                                    :   ALT.48 > 0.3707865: F3 (3.4)
                                                    BMI > 0.5384616:
                                                    :...ALT.36 <= 0.1123596: F1 (5.4/3.5)
                                                        ALT.36 > 0.1123596: [S8]

SubTree [S1]

ALT.48 <= 0.247191: F2 (2.6)
ALT.48 > 0.247191:
:...RNA.Base <= 0.3271777: F2 (4.6/1.9)
    RNA.Base > 0.3271777: F4 (9.9/1.9)

SubTree [S2]

ALT.after.24.w <= 0.4782609: F3 (2.9)
ALT.after.24.w > 0.4782609: F2 (3.5/0.8)

SubTree [S3]

ALT.after.24.w <= 0.08695652: F1 (2.9)
ALT.after.24.w > 0.08695652:
:...ALT.48 <= 0.8089887: F3 (8.5/1.7)
    ALT.48 > 0.8089887: F4 (2.4/0.6)

SubTree [S4]

AST.1 <= 0.5280899: F2 (7.9/1.6)
AST.1 > 0.5280899: F1 (3.2)

SubTree [S5]

RBC > 0.5397249: F2 (4.9)
RBC <= 0.5397249:
:...ALT.4 <= 0.5168539: F2 (2.6)
    ALT.4 > 0.5168539: F3 (5.9/0.7)

SubTree [S6]

RNA.Base <= 0.3773303: F4 (4.3/0.5)
RNA.Base > 0.3773303: F3 (3.7/0.5)

SubTree [S7]

Plat <= 0.1632135: F2 (2.4)
Plat > 0.1632135: F3 (13.6/1.5)

SubTree [S8]

ALT.24 > 0.6067415: F3 (14.4/0.6)
ALT.24 <= 0.6067415:
:...ALT.36 > 0.5730337: F3 (4.9)
    ALT.36 <= 0.5730337:
    :...Age > 0.7931035: F2 (2.9/1.4)
        Age <= 0.7931035:
        :...ALT.48 <= 0.7640449: F1 (4/0.6)
            ALT.48 > 0.7640449: F4 (3.9/1)

-----  Trial 10:  -----

Decision tree:

ALT.after.24.w > 0.7826087:
:...ALT.36 > 0.8764045:
:   :...RBC <= 0.2340792: F1 (3.9/1)
:   :   RBC > 0.2340792:
:   :   :...WBC <= 0.3826564: F4 (6.3/1.4)
:   :       WBC > 0.3826564:
:   :       :...AST.1 <= 0.247191: F4 (2.8)
:   :           AST.1 > 0.247191: F2 (7.7/2)
:   ALT.36 <= 0.8764045:
:   :...ALT.24 <= 0.04494382:
:       :...ALT.1 <= 0.7752809: F1 (6.4)
:       :   ALT.1 > 0.7752809: F3 (3.4/0.5)
:       ALT.24 > 0.04494382:
:       :...AST.1 <= 0.1348315:
:           :...ALT.48 <= 0.2808989: F1 (8.9/1.1)
:           :   ALT.48 > 0.2808989:
:           :   :...Age > 0.7241379: F1 (5.7/1.6)
:           :       Age <= 0.7241379:
:           :       :...AST.1 > 0.06741573: F3 (4.6/0.7)
:           :           AST.1 <= 0.06741573:
:           :           :...ALT.24 <= 0.247191: F3 (2.3)
:           :               ALT.24 > 0.247191: F4 (9.1/1.5)
:           AST.1 > 0.1348315:
:           :...ALT.12 > 0.8876405:
:               :...AST.1 > 0.6629214: F3 (2.5)
:               :   AST.1 <= 0.6629214:
:               :   :...ALT.36 <= 0.2022472: F3 (4.2/1.5)
:               :       ALT.36 > 0.2022472: F4 (7)
:               ALT.12 <= 0.8876405:
:               :...WBC <= 0.033809: F3 (5.1)
:                   WBC > 0.033809:
:                   :...RBC > 0.9085496: F4 (7.7/1.5)
:                       RBC <= 0.9085496:
:                       :...ALT.12 > 0.6741573:
:                           :...Plat > 0.7382635:
:                           :   :...Age <= 0.6551724: F3 (4.9)
:                           :   :   Age > 0.6551724: F1 (4)
:                           :   Plat <= 0.7382635:
:                           :   :...WBC > 0.456202: F1 (7.9)
:                           :       WBC <= 0.456202:
:                           :       :...RNA.Base <= 0.6670924: F2 (2.9)
:                           :           RNA.Base > 0.6670924: F1 (3.8/1.3)
:                           ALT.12 <= 0.6741573:
:                           :...RBC <= 0.4371808:
:                               :...ALT.24 > 0.6966292: F4 (10.8/2.2)
:                               :   ALT.24 <= 0.6966292:
:                               :   :...RBC <= 0.06872547: F3 (5.6/0.8)
:                               :       RBC > 0.06872547:
:                               :       :...RNA.4 > 0.5562931:
:                               :           :...RNA.4 <= 0.8958376: F4 (7.4/0.9)
:                               :           :   RNA.4 > 0.8958376: F2 (5.7)
:                               :           RNA.4 <= 0.5562931:
:                               :           :...BMI <= 0.3846154: F2 (10.2/1.6)
:                               :               BMI > 0.3846154:
:                               :               :...ALT.12 <= 0.06741573: F2 (2.8/1.1)
:                               :                   ALT.12 > 0.06741573:
:                               :                   :...AST.1 <= 0.8651685: F1 (4.2/0.9)
:                               :                       AST.1 > 0.8651685: F3 (2)
:                               RBC > 0.4371808:
:                               :...ALT.1 > 0.7977528:
:                                   :...Plat <= 0.120089: F2 (2.1)
:                                   :   Plat > 0.120089: F1 (7.7/0.6)
:                                   ALT.1 <= 0.7977528:
:                                   :...ALT.1 <= 0: F2 (2.6)
:                                       ALT.1 > 0:
:                                       :...Age <= 0.4137931:
:                                           :...ALT.48 <= 0.505618:
:                                           :   :...RNA.Base <= 0.4448915: F1 (5.4)
:                                           :   :   RNA.Base > 0.4448915: F3 (3.4/0.8)
:                                           :   ALT.48 > 0.505618:
:                                           :   :...BMI <= 0: F1 (2.3/0.6)
:                                           :       BMI > 0:
:                                           :       :...ALT.48 <= 0.7865168: F4 (5.2/0.8)
:                                           :           ALT.48 > 0.7865168: F3 (2.6)
:                                           Age > 0.4137931:
:                                           :...ALT.36 <= 0.1011236: F1 (2.6/0.9)
:                                               ALT.36 > 0.1011236:
:                                               :...BMI > 0.9230769: F2 (4.2/2)
:                                                   BMI <= 0.9230769:
:                                                   :...ALT.1 > 0.5955056: F3 (8.8/0.9)
:                                                       ALT.1 <= 0.5955056: [S1]
ALT.after.24.w <= 0.7826087:
:...ALT.36 <= 0.01123596:
    :...WBC <= 0.6020856:
    :   :...ALT.4 <= 0.9101124: F2 (10/1.5)
    :   :   ALT.4 > 0.9101124: F4 (2.1)
    :   WBC > 0.6020856:
    :   :...AST.1 <= 0.1348315: F2 (2.1)
    :       AST.1 > 0.1348315: F1 (5.9/0.8)
    ALT.36 > 0.01123596:
    :...ALT.after.24.w > 0.6956522:
        :...RBC > 0.9511334:
        :   :...ALT.1 <= 0.8426966: F2 (6/0.8)
        :   :   ALT.1 > 0.8426966: F3 (2.1)
        :   RBC <= 0.9511334:
        :   :...ALT.48 <= 0.3033708:
        :       :...ALT.36 <= 0.3033708: F4 (9.3)
        :       :   ALT.36 > 0.3033708:
        :       :   :...RNA.4 <= 0.4014155: F1 (4/0.4)
        :       :       RNA.4 > 0.4014155: F3 (5.3/2.3)
        :       ALT.48 > 0.3033708:
        :       :...ALT.1 > 0.8651685: F2 (5.5)
        :           ALT.1 <= 0.8651685:
        :           :...ALT.4 > 0.3820225:
        :               :...ALT.48 <= 0.3370787: F2 (3.5)
        :               :   ALT.48 > 0.3370787: F4 (17.8/5.6)
        :               ALT.4 <= 0.3820225:
        :               :...AST.1 <= 0.2359551: F2 (4.3)
        :                   AST.1 > 0.2359551:
        :                   :...Plat <= 0.2732014: F4 (2)
        :                       Plat > 0.2732014:
        :                       :...ALT.12 > 0.741573: F1 (4.8/1.9)
        :                           ALT.12 <= 0.741573:
        :                           :...Plat <= 0.6354542: F2 (4.3)
        :                               Plat > 0.6354542: F1 (4.6/0.8)
        ALT.after.24.w <= 0.6956522:
        :...ALT.4 > 0.9213483:
            :...Plat <= 0.1090887: F4 (3.9/1.1)
            :   Plat > 0.1090887:
            :   :...ALT.1 > 0.9213483: F3 (3.4/1.1)
            :       ALT.1 <= 0.9213483:
            :       :...ALT.12 <= 0.1348315: F4 (2.2/0.3)
            :           ALT.12 > 0.1348315:
            :           :...RBC <= 0.5517238: F1 (15/4.6)
            :               RBC > 0.5517238:
            :               :...ALT.12 <= 0.3707865: F1 (4.3)
            :                   ALT.12 > 0.3707865: F2 (12.1)
            ALT.4 <= 0.9213483:
            :...BMI > 0.4615385:
                :...WBC <= 0.09363337:
                :   :...Plat > 0.7792973:
                :   :   :...Plat <= 0.8763666: F3 (4.7)
                :   :   :   Plat > 0.8763666: F1 (5.3/1.7)
                :   :   Plat <= 0.7792973:
                :   :   :...ALT.48 > 0.7865168: F3 (2.2/0.6)
                :   :       ALT.48 <= 0.7865168:
                :   :       :...ALT.12 <= 0.3258427: F1 (4.1)
                :   :           ALT.12 > 0.3258427:
                :   :           :...Age <= 0.03448276: F1 (2.2)
                :   :               Age > 0.03448276: F2 (13.6/0.3)
                :   WBC > 0.09363337:
                :   :...Plat > 0.9667069: F2 (8/0.8)
                :       Plat <= 0.9667069:
                :       :...ALT.36 <= 0.05617978:
                :           :...ALT.48 <= 0.2247191: F3 (4.7)
                :           :   ALT.48 > 0.2247191: F4 (12.1/3.6)
                :           ALT.36 > 0.05617978:
                :           :...ALT.1 <= 0.1011236:
                :               :...ALT.1 > 0.04494382:
                :               :   :...ALT.48 <= 0.4157303: F1 (9.6/1.3)
                :               :   :   ALT.48 > 0.4157303: F3 (3.7)
                :               :   ALT.1 <= 0.04494382:
                :               :   :...ALT.48 <= 0.1123596: F3 (3.5/1.1)
                :               :       ALT.48 > 0.1123596:
                :               :       :...Age <= 0.3103448: F1 (3.1)
                :               :           Age > 0.3103448: F2 (7.2/2)
                :               ALT.1 > 0.1011236:
                :               :...AST.1 > 0.9550562:
                :                   :...AST.1 <= 0.988764: F2 (2.6)
                :                   :   AST.1 > 0.988764: F4 (6.5/2)
                :                   AST.1 <= 0.9550562:
                :                   :...ALT.1 > 0.6966292:
                :                       :...ALT.1 <= 0.741573:
                :                       :   :...ALT.1 <= 0.7303371: F3 (7.1/2.2)
                :                       :   :   ALT.1 > 0.7303371: F4 (6.6/0.5)
                :                       :   ALT.1 > 0.741573:
                :                       :   :...RNA.Base <= 0.05632871: F2 (5.8/1.8)
                :                       :       RNA.Base > 0.05632871:
                :                       :       :...ALT.48 > 0.9550562: F1 (5.3)
                :                       :           ALT.48 <= 0.9550562:
                :                       :           :...WBC <= 0.4050494:
                :                       :               :...Age > 0.4482759: [S2]
                :                       :               :   Age <= 0.4482759: [S3]
                :                       :               WBC > 0.4050494:
                :                       :               :...ALT.24 <= 0.4044944: [S4]
                :                       :                   ALT.24 > 0.4044944: [S5]
                :                       ALT.1 <= 0.6966292:
                :                       :...ALT.1 > 0.6516854: F2 (9/0.9)
                :                           ALT.1 <= 0.6516854:
                :                           :...ALT.1 > 0.5280899: [S6]
                :                               ALT.1 <= 0.5280899:
                :                               :...RNA.Base <= 0.4039906:
                :                                   :...Age > 0.6896552:
                :                                   :   :...Age > 0.862069: F3 (4/1.1)
                :                                   :   :   Age <= 0.862069: [S7]
                :                                   :   Age <= 0.6896552:
                :                                   :   :...WBC > 0.6045005: [S8]
                :                                   :       WBC <= 0.6045005: [S9]
                :                                   RNA.Base > 0.4039906:
                :                                   :...RNA.4 <= 0.1684916: [S10]
                :                                       RNA.4 > 0.1684916:
                :                                       :...BMI <= 0.8461539:
                :                                           :...AST.1 <= 0.6853933: [S11]
                :                                           :   AST.1 > 0.6853933: [S12]
                :                                           BMI > 0.8461539:
                :                                           :...ALT.24 > 0.741573: [S13]
                :                                               ALT.24 <= 0.741573: [S14]
                BMI <= 0.4615385:
                :...ALT.after.24.w <= 0.08695652:
                    :...WBC <= 0.2001098:
                    :   :...Plat <= 0.7465287: F2 (9.8/0.6)
                    :   :   Plat > 0.7465287: F4 (2)
                    :   WBC > 0.2001098:
                    :   :...RBC <= 0.3884507: F3 (10.2/3.4)
                    :       RBC > 0.3884507:
                    :       :...WBC <= 0.2859495: F1 (7.8/1.8)
                    :           WBC > 0.2859495:
                    :           :...RNA.Base <= 0.5349574: F2 (12.5/2)
                    :               RNA.Base > 0.5349574:
                    :               :...ALT.36 <= 0.8314607: F4 (10.8/3.3)
                    :                   ALT.36 > 0.8314607: F1 (2.7/0.8)
                    ALT.after.24.w > 0.08695652:
                    :...ALT.12 <= 0.03370786:
                        :...RNA.Base <= 0.3073422: F1 (2.4/1.1)
                        :   RNA.Base > 0.3073422: F3 (8.8/1)
                        ALT.12 > 0.03370786:
                        :...Age <= 0.1034483:
                            :...RNA.4 > 0.9067978: F1 (4.1)
                            :   RNA.4 <= 0.9067978:
                            :   :...ALT.48 <= 0.1910112:
                            :       :...ALT.36 <= 0.3820225: F1 (2.1)
                            :       :   ALT.36 > 0.3820225: F4 (6.9)
                            :       ALT.48 > 0.1910112:
                            :       :...Plat > 0.7162554: F1 (6.8/1.5)
                            :           Plat <= 0.7162554:
                            :           :...RBC <= 0.4274855: F3 (6.8/0.9)
                            :               RBC > 0.4274855: F4 (2.9)
                            Age > 0.1034483:
                            :...ALT.24 <= 0.1011236:
                                :...RNA.4 <= 0.4283188: F3 (9/2.7)
                                :   RNA.4 > 0.4283188:
                                :   :...ALT.4 <= 0.1573034: F4 (5.8/1.6)
                                :       ALT.4 > 0.1573034:
                                :       :...ALT.36 <= 0.5505618: F3 (3.1/0.8)
                                :           ALT.36 > 0.5505618: F2 (5.6)
                                ALT.24 > 0.1011236:
                                :...ALT.36 > 0.9662921:
                                    :...AST.1 <= 0.6741573: F2 (2.8/0.3)
                                    :   AST.1 > 0.6741573: F3 (4.5)
                                    ALT.36 <= 0.9662921:
                                    :...AST.1 > 0.9438202: F3 (5.5/2.4)
                                        AST.1 <= 0.9438202:
                                        :...Plat <= 0.05252864:
                                            :...ALT.48 > 0.8539326: F4 (2.8)
                                            :   ALT.48 <= 0.8539326:
                                            :   :...Plat <= 0.01674772: F3 (2.6)
                                            :       Plat > 0.01674772: F2 (6.5/0.6)
                                            Plat > 0.05252864:
                                            :...ALT.after.24.w <= 0.2173913: [S15]
                                                ALT.after.24.w > 0.2173913:
                                                :...RNA.4 > 0.7370139:
                                                    :...ALT.24 <= 0.4831461: [S16]
                                                    :   ALT.24 > 0.4831461: [S17]
                                                    RNA.4 <= 0.7370139: [S18]

SubTree [S1]

ALT.12 <= 0.3483146: F3 (5.7/1)
ALT.12 > 0.3483146: F4 (3.8)

SubTree [S2]

Plat <= 0.6232025: F4 (3.7)
Plat > 0.6232025: F1 (6.3/1.3)

SubTree [S3]

RNA.Base > 0.7378607: F4 (5.4)
RNA.Base <= 0.7378607:
:...RBC <= 0.2128093: F4 (2.2)
    RBC > 0.2128093: F3 (3.7)

SubTree [S4]

Plat <= 0.5613671: F4 (7.4/2.1)
Plat > 0.5613671: F2 (3.7/1.5)

SubTree [S5]

ALT.1 > 0.8539326: F1 (9.7/2.5)
ALT.1 <= 0.8539326:
:...ALT.12 <= 0.7640449: F3 (5.5)
    ALT.12 > 0.7640449: F2 (2.9/0.7)

SubTree [S6]

ALT.after.24.w <= 0.5652174: F3 (21.9/5.7)
ALT.after.24.w > 0.5652174: F1 (2.8/1.3)

SubTree [S7]

ALT.4 <= 0.7865168: F1 (3)
ALT.4 > 0.7865168: F2 (3.1)

SubTree [S8]

BMI <= 0.7692308: F3 (7.5/0.3)
BMI > 0.7692308: F1 (3.3/1.3)

SubTree [S9]

RNA.Base > 0.3474912: F1 (4.7)
RNA.Base <= 0.3474912:
:...WBC <= 0.1924259: F1 (2.3/0.7)
    WBC > 0.1924259: F4 (9.2/1.7)

SubTree [S10]

ALT.12 <= 0.3820225: F4 (2.6/0.6)
ALT.12 > 0.3820225: F3 (4.1/1.1)

SubTree [S11]

ALT.24 <= 0.9662921: F2 (31.8/9.3)
ALT.24 > 0.9662921: F4 (2.1)

SubTree [S12]

ALT.48 <= 0.494382: F2 (3.3/0.8)
ALT.48 > 0.494382: F3 (4.2)

SubTree [S13]

Plat <= 0.4113645: F2 (5.2/0.8)
Plat > 0.4113645: F1 (3.3)

SubTree [S14]

WBC > 0.617124: F4 (6.1/1.9)
WBC <= 0.617124:
:...ALT.4 <= 0.6629214: F3 (4.8/0.4)
    ALT.4 > 0.6629214: F4 (2.1)

SubTree [S15]

ALT.after.24.w > 0.173913: F2 (3/0.4)
ALT.after.24.w <= 0.173913:
:...RBC <= 0.2730283: F1 (5.4/0.7)
    RBC > 0.2730283: F4 (19.2/7.8)

SubTree [S16]

RNA.Base <= 0.3852199: F1 (2.6/0.6)
RNA.Base > 0.3852199: F4 (5.6)

SubTree [S17]

ALT.after.24.w > 0.4782609:
:...ALT.48 <= 0.7640449: F3 (15.6/2.3)
:   ALT.48 > 0.7640449: F1 (2.3/0.6)
ALT.after.24.w <= 0.4782609:
:...ALT.after.24.w <= 0.3043478: F3 (3.8/0.8)
    ALT.after.24.w > 0.3043478:
    :...ALT.24 <= 0.7640449: F1 (4.8/1)
        ALT.24 > 0.7640449: F4 (2.4)

SubTree [S18]

ALT.after.24.w <= 0.2608696: F1 (4.7)
ALT.after.24.w > 0.2608696:
:...RNA.4 <= 0.07730234:
    :...WBC <= 0.1778266: F3 (2.3)
    :   WBC > 0.1778266: F4 (5.8/0.5)
    RNA.4 > 0.07730234:
    :...AST.1 > 0.6404495:
        :...BMI <= 0.1538462:
        :   :...ALT.24 <= 0.6966292: F2 (9.2/1.5)
        :   :   ALT.24 > 0.6966292: F3 (3.9/1.6)
        :   BMI > 0.1538462:
        :   :...ALT.4 <= 0.3033708: F3 (2.3)
        :       ALT.4 > 0.3033708:
        :       :...ALT.24 <= 0.3932584: F4 (4.3/0.9)
        :           ALT.24 > 0.3932584: F1 (5.6/1.3)
        AST.1 <= 0.6404495:
        :...WBC <= 0.2018661:
            :...Plat <= 0.7792973: F1 (11.2/1.9)
            :   Plat > 0.7792973: F3 (2.5)
            WBC > 0.2018661:
            :...ALT.48 <= 0.2022472:
                :...AST.1 <= 0.3707865: F2 (3.2/0.6)
                :   AST.1 > 0.3707865: F4 (6.1)
                ALT.48 > 0.2022472:
                :...ALT.1 <= 0.2921348: F1 (4.3/2.1)
                    ALT.1 > 0.2921348:
                    :...ALT.after.24.w > 0.5217391:
                        :...ALT.4 <= 0.2134831: F2 (3.2)
                        :   ALT.4 > 0.2134831: F1 (7.3/1.6)
                        ALT.after.24.w <= 0.5217391:
                        :...Age > 0.8275862: F1 (4/0.6)
                            Age <= 0.8275862:
                            :...ALT.36 <= 0.8764045: F4 (15.2/3.6)
                                ALT.36 > 0.8764045: F1 (3.3)

-----  Trial 11:  -----

Decision tree:

ALT.12 > 0.8876405:
:...AST.1 <= 0.06741573:
:   :...ALT.48 <= 0.3146068: F1 (2.8/0.5)
:   :   ALT.48 > 0.3146068: F3 (8.6/0.5)
:   AST.1 > 0.06741573:
:   :...BMI > 0.7692308:
:       :...ALT.after.24.w <= 0.4782609:
:       :   :...Age <= 0.8965517: F1 (12.7/1.7)
:       :   :   Age > 0.8965517: F2 (3)
:       :   ALT.after.24.w > 0.4782609:
:       :   :...ALT.1 <= 0.6516854: F2 (4.7/0.7)
:       :       ALT.1 > 0.6516854: F4 (3.6/0.6)
:       BMI <= 0.7692308:
:       :...Age > 0.6206896:
:           :...ALT.1 > 0.9550562: F2 (3.4/1.2)
:           :   ALT.1 <= 0.9550562:
:           :   :...ALT.after.24.w <= 0.173913: F3 (5.5)
:           :       ALT.after.24.w > 0.173913:
:           :       :...ALT.after.24.w <= 0.5652174: F1 (6/1)
:           :           ALT.after.24.w > 0.5652174: F3 (3.7/1.3)
:           Age <= 0.6206896:
:           :...RBC <= 0.173995: F1 (8.6/1.7)
:               RBC > 0.173995:
:               :...ALT.24 <= 0.05617978: F1 (3.9)
:                   ALT.24 > 0.05617978:
:                   :...ALT.after.24.w > 0.7826087: F4 (10/2.6)
:                       ALT.after.24.w <= 0.7826087:
:                       :...RNA.Base <= 0.2202335: F4 (12.2/2)
:                           RNA.Base > 0.2202335:
:                           :...WBC > 0.7675082: F4 (5.4/0.8)
:                               WBC <= 0.7675082:
:                               :...AST.1 <= 0.1910112: F2 (3/0.6)
:                                   AST.1 > 0.1910112:
:                                   :...AST.1 > 0.8988764: F2 (3.3/0.5)
:                                       AST.1 <= 0.8988764:
:                                       :...RBC <= 0.3686841: F3 (2.1)
:                                           RBC > 0.3686841: F1 (8.2/1.1)
ALT.12 <= 0.8876405:
:...ALT.36 <= 0.08988764:
    :...Age > 0.9310345:
    :   :...RNA.4 <= 0.7286625: F1 (2.8)
    :   :   RNA.4 > 0.7286625: F2 (3.3/1)
    :   Age <= 0.9310345:
    :   :...ALT.48 > 0.7865168:
    :       :...ALT.36 <= 0.05617978: F4 (9.9/0.5)
    :       :   ALT.36 > 0.05617978: F2 (5.6/0.7)
    :       ALT.48 <= 0.7865168:
    :       :...ALT.36 <= 0:
    :           :...Age > 0.4827586: F4 (2.4)
    :           :   Age <= 0.4827586:
    :           :   :...BMI <= 0.5384616: F1 (2.6)
    :           :       BMI > 0.5384616: F2 (3.8)
    :           ALT.36 > 0:
    :           :...ALT.12 > 0.4382023:
    :               :...AST.1 > 0.505618: F4 (12.3/3.9)
    :               :   AST.1 <= 0.505618:
    :               :   :...ALT.24 <= 0.7977528: F2 (10.1/2.1)
    :               :       ALT.24 > 0.7977528: F4 (2.2)
    :               ALT.12 <= 0.4382023:
    :               :...RNA.Base <= 0.3681011:
    :                   :...ALT.48 <= 0.5168539: F2 (6.6/1.4)
    :                   :   ALT.48 > 0.5168539: F1 (3.2)
    :                   RNA.Base > 0.3681011:
    :                   :...ALT.after.24.w <= 0.04347826: F2 (2)
    :                       ALT.after.24.w > 0.04347826:
    :                       :...AST.1 > 0.3258427:
    :                           :...ALT.4 <= 0.8426966: F3 (15.4/1.6)
    :                           :   ALT.4 > 0.8426966: F1 (2)
    :                           AST.1 <= 0.3258427:
    :                           :...ALT.24 > 0.6179775: F4 (3.9)
    :                               ALT.24 <= 0.6179775:
    :                               :...Plat <= 0.5640197: F3 (2.8)
    :                                   Plat > 0.5640197: F2 (3.5/1.1)
    ALT.36 > 0.08988764:
    :...Age <= 0.137931:
        :...RBC <= 0.1387412:
        :   :...Age > 0.1034483: F2 (5/1.5)
        :   :   Age <= 0.1034483:
        :   :   :...ALT.1 <= 0.4494382: F1 (7.1)
        :   :       ALT.1 > 0.4494382: F4 (5.9/1.5)
        :   RBC > 0.1387412:
        :   :...BMI <= 0.3846154:
        :       :...ALT.36 <= 0.2921348:
        :       :   :...Plat <= 0.4001019: F1 (7/2.9)
        :       :   :   Plat > 0.4001019: F3 (3.3)
        :       :   ALT.36 > 0.2921348:
        :       :   :...BMI <= 0.07692308:
        :       :       :...BMI <= 0: F1 (2.6/0.7)
        :       :       :   BMI > 0: F3 (4.9/2.1)
        :       :       BMI > 0.07692308:
        :       :       :...Age <= 0: F4 (4.4)
        :       :           Age > 0:
        :       :           :...Age <= 0.1034483: F1 (16.5/5.4)
        :       :               Age > 0.1034483: F4 (3.6/0.4)
        :       BMI > 0.3846154:
        :       :...ALT.48 <= 0.1685393:
        :           :...RNA.Base <= 0.7343804: F2 (5.5)
        :           :   RNA.Base > 0.7343804: F3 (3.3/1.2)
        :           ALT.48 > 0.1685393:
        :           :...ALT.48 <= 0.2921348: F3 (10.2/1.7)
        :               ALT.48 > 0.2921348:
        :               :...Age > 0.03448276:
        :                   :...RNA.Base > 0.3891023:
        :                   :   :...BMI <= 0.6153846: F1 (4.1/2.1)
        :                   :   :   BMI > 0.6153846: F3 (11.1/1.1)
        :                   :   RNA.Base <= 0.3891023:
        :                   :   :...BMI <= 0.7692308: F3 (2.8/1.4)
        :                   :       BMI > 0.7692308:
        :                   :       :...ALT.1 <= 0.6404495: F1 (4.2)
        :                   :           ALT.1 > 0.6404495: F4 (2.1/0.3)
        :                   Age <= 0.03448276:
        :                   :...Plat > 0.6648883: F3 (5.3/2.3)
        :                       Plat <= 0.6648883:
        :                       :...RNA.4 <= 0.573199:
        :                           :...ALT.48 <= 0.7303371: F4 (4.6)
        :                           :   ALT.48 > 0.7303371: F2 (2.7)
        :                           RNA.4 > 0.573199:
        :                           :...Age <= 0: F1 (3.3/0.2)
        :                               Age > 0:
        :                               :...WBC <= 0.5521405: F4 (3.3)
        :                                   WBC > 0.5521405: F1 (3.4)
        Age > 0.137931:
        :...WBC <= 0.0273326:
            :...BMI <= 0.2307692: F3 (5.6/0.5)
            :   BMI > 0.2307692:
            :   :...AST.1 <= 0.07865169: F3 (2.5)
            :       AST.1 > 0.07865169: F2 (9.6/2.1)
            WBC > 0.0273326:
            :...AST.1 <= 0.6853933:
                :...RNA.Base > 0.5308719:
                :   :...AST.1 > 0.5505618:
                :   :   :...ALT.after.24.w <= 0.04347826:
                :   :   :   :...ALT.24 <= 0.4719101: F4 (7.2)
                :   :   :   :   ALT.24 > 0.4719101: F2 (2.3)
                :   :   :   ALT.after.24.w > 0.04347826:
                :   :   :   :...ALT.1 > 0.6404495: F1 (11.1/1.9)
                :   :   :       ALT.1 <= 0.6404495:
                :   :   :       :...ALT.24 <= 0.2247191: F4 (8.1/1.8)
                :   :   :           ALT.24 > 0.2247191:
                :   :   :           :...RNA.Base <= 0.5988144: F2 (3/0.8)
                :   :   :               RNA.Base > 0.5988144:
                :   :   :               :...ALT.36 <= 0.1685393: F4 (3.5/1.7)
                :   :   :                   ALT.36 > 0.1685393: F1 (18.9/5.1)
                :   :   AST.1 <= 0.5505618:
                :   :   :...Age > 0.862069:
                :   :       :...ALT.36 <= 0.1460674: F1 (2.9)
                :   :       :   ALT.36 > 0.1460674:
                :   :       :   :...RNA.Base <= 0.5919006: F2 (2.9/0.9)
                :   :       :       RNA.Base > 0.5919006:
                :   :       :       :...WBC <= 0.2317234: F2 (2.2)
                :   :       :           WBC > 0.2317234:
                :   :       :           :...WBC > 0.8140505:
                :   :       :               :...AST.1 <= 0.2921348: F2 (4.3/0.8)
                :   :       :               :   AST.1 > 0.2921348: F4 (5.2)
                :   :       :               WBC <= 0.8140505:
                :   :       :               :...ALT.12 <= 0.3820225: F4 (7.4)
                :   :       :                   ALT.12 > 0.3820225:
                :   :       :                   :...ALT.1 <= 0.7865168: F1 (4.5/0.7)
                :   :       :                       ALT.1 > 0.7865168: F4 (3.1)
                :   :       Age <= 0.862069:
                :   :       :...ALT.12 > 0.8764045: F2 (3.3)
                :   :           ALT.12 <= 0.8764045:
                :   :           :...ALT.36 > 0.9213483:
                :   :               :...Plat <= 0.5041176: F1 (5.7)
                :   :               :   Plat > 0.5041176: F2 (5.6/2.1)
                :   :               ALT.36 <= 0.9213483:
                :   :               :...ALT.12 <= 0.2696629:
                :   :                   :...BMI <= 0.1538462: F4 (6.7/1)
                :   :                   :   BMI > 0.1538462:
                :   :                   :   :...RBC <= 0.6825634:
                :   :                   :       :...ALT.4 <= 0.3820225: F3 (5.6/0.9)
                :   :                   :       :   ALT.4 > 0.3820225: F4 (11.8/3.2)
                :   :                   :       RBC > 0.6825634:
                :   :                   :       :...Age <= 0.5517241: F3 (7.3)
                :   :                   :           Age > 0.5517241: F1 (4.4/1.5)
                :   :                   ALT.12 > 0.2696629:
                :   :                   :...ALT.36 > 0.7640449:
                :   :                       :...BMI <= 0.3846154: F3 (7.4/0.4)
                :   :                       :   BMI > 0.3846154:
                :   :                       :   :...RNA.4 <= 0.8912042: F1 (6.2/1.4)
                :   :                       :       RNA.4 > 0.8912042: F3 (2.4)
                :   :                       ALT.36 <= 0.7640449:
                :   :                       :...ALT.4 <= 0.2134831:
                :   :                           :...ALT.48 <= 0.5280899: F3 (9.1/0.6)
                :   :                           :   ALT.48 > 0.5280899: F4 (4.8/2.1)
                :   :                           ALT.4 > 0.2134831:
                :   :                           :...ALT.4 > 0.9213483: F2 (6.9/1.5)
                :   :                               ALT.4 <= 0.9213483:
                :   :                               :...WBC <= 0.1154775: F2 (2.8/0.7)
                :   :                                   WBC > 0.1154775: [S1]
                :   RNA.Base <= 0.5308719:
                :   :...RBC <= 0.03540597: F4 (7.8/1.8)
                :       RBC > 0.03540597:
                :       :...WBC <= 0.3774973:
                :           :...RNA.Base > 0.4313902:
                :           :   :...ALT.1 <= 0.5280899: F4 (4.6)
                :           :   :   ALT.1 > 0.5280899: F2 (6.7/2.7)
                :           :   RNA.Base <= 0.4313902:
                :           :   :...ALT.36 <= 0.1685393: F3 (5.1/1.8)
                :           :       ALT.36 > 0.1685393:
                :           :       :...WBC > 0.1862788:
                :           :           :...ALT.24 > 0.8202247:
                :           :           :   :...Plat <= 0.4920683: F3 (3.9)
                :           :           :   :   Plat > 0.4920683: F1 (3.8/1.8)
                :           :           :   ALT.24 <= 0.8202247:
                :           :           :   :...ALT.after.24.w <= 0.6956522:
                :           :           :       :...Age <= 0.6551724: F1 (19.1/2.2)
                :           :           :       :   Age > 0.6551724: F4 (5/1.4)
                :           :           :       ALT.after.24.w > 0.6956522:
                :           :           :       :...BMI <= 0.3846154: F1 (4.5/2.3)
                :           :           :           BMI > 0.3846154: F2 (2.5)
                :           :           WBC <= 0.1862788:
                :           :           :...WBC <= 0.06992316: F1 (7.2/2.5)
                :           :               WBC > 0.06992316:
                :           :               :...AST.1 <= 0.1123596: F1 (2.4/0.5)
                :           :                   AST.1 > 0.1123596:
                :           :                   :...RNA.4 <= 0.2932821: F4 (4/1.1)
                :           :                       RNA.4 > 0.2932821:
                :           :                       :...ALT.48 <= 0.8876405: F2 (14.5/3)
                :           :                           ALT.48 > 0.8876405: F3 (2.2)
                :           WBC > 0.3774973:
                :           :...ALT.4 <= 0.1011236:
                :               :...RBC <= 0.1031614: F2 (2.1)
                :               :   RBC > 0.1031614:
                :               :   :...ALT.36 <= 0.2808989: F1 (3.8/1.3)
                :               :       ALT.36 > 0.2808989: F3 (7.8)
                :               ALT.4 > 0.1011236:
                :               :...AST.1 > 0.6179775:
                :                   :...Plat <= 0.6845209: F3 (4/0.7)
                :                   :   Plat > 0.6845209: F1 (3.6)
                :                   AST.1 <= 0.6179775:
                :                   :...ALT.after.24.w <= 0.2173913:
                :                       :...ALT.4 <= 0.2247191: F2 (6)
                :                       :   ALT.4 > 0.2247191:
                :                       :   :...RBC > 0.6763864: F2 (7.4/2.6)
                :                       :       RBC <= 0.6763864:
                :                       :       :...ALT.12 <= 0.05617978: F4 (3.3/1.6)
                :                       :           ALT.12 > 0.05617978: F3 (10.6/0.9)
                :                       ALT.after.24.w > 0.2173913:
                :                       :...ALT.1 <= 0.2247191:
                :                           :...WBC > 0.9231614: F4 (2.9)
                :                           :   WBC <= 0.9231614:
                :                           :   :...RNA.Base > 0.3676065: F3 (8.8/1)
                :                           :       RNA.Base <= 0.3676065: [S2]
                :                           ALT.1 > 0.2247191:
                :                           :...RBC > 0.877557:
                :                               :...Plat <= 0.7074507: F3 (4/0.3)
                :                               :   Plat > 0.7074507: F2 (2.1)
                :                               RBC <= 0.877557:
                :                               :...ALT.1 <= 0.3146068:
                :                                   :...RNA.4 <= 0.4080019: F4 (3.9)
                :                                   :   RNA.4 > 0.4080019: F1 (3.7)
                :                                   ALT.1 > 0.3146068:
                :                                   :...WBC <= 0.413831: F1 (5.1/2.4)
                :                                       WBC > 0.413831: [S3]
                AST.1 > 0.6853933:
                :...ALT.1 <= 0.03370786: F1 (4.8/1)
                    ALT.1 > 0.03370786:
                    :...RBC <= 0.155027:
                        :...RNA.4 > 0.6988958: F3 (5.5/0.7)
                        :   RNA.4 <= 0.6988958:
                        :   :...ALT.after.24.w <= 0.8695652: F2 (12.3/2.6)
                        :       ALT.after.24.w > 0.8695652: F3 (2.6)
                        RBC > 0.155027:
                        :...ALT.1 > 0.9775281: F2 (4.7)
                            ALT.1 <= 0.9775281:
                            :...BMI > 0.9230769: F3 (6.3/1.2)
                                BMI <= 0.9230769:
                                :...RNA.4 <= 0.09503957:
                                    :...AST.1 > 0.9438202: F3 (2/0.2)
                                    :   AST.1 <= 0.9438202:
                                    :   :...WBC <= 0.3648738: F2 (3.1/1.1)
                                    :       WBC > 0.3648738: F4 (11.1)
                                    RNA.4 > 0.09503957:
                                    :...Age <= 0.2068966:
                                        :...AST.1 <= 0.9438202: F4 (5.1)
                                        :   AST.1 > 0.9438202: F1 (2.7/0.8)
                                        Age > 0.2068966:
                                        :...RNA.Base > 0.7885553:
                                            :...BMI <= 0.1538462: F3 (3.7)
                                            :   BMI > 0.1538462:
                                            :   :...RBC > 0.8693825: F4 (5.7/0.6)
                                            :       RBC <= 0.8693825:
                                            :       :...ALT.12 <= 0.752809: F2 (9/0.4)
                                            :           ALT.12 > 0.752809: F4 (2.9)
                                            RNA.Base <= 0.7885553:
                                            :...ALT.24 > 0.8876405:
                                                :...RBC <= 0.7460993: F3 (7.1/1.3)
                                                :   RBC > 0.7460993: F1 (2.9)
                                                ALT.24 <= 0.8876405:
                                                :...WBC <= 0.1070252: F4 (6.9/1.8)
                                                    WBC > 0.1070252:
                                                    :...ALT.4 > 0.5955056: [S4]
                                                        ALT.4 <= 0.5955056: [S5]

SubTree [S1]

ALT.1 > 0.7865168: F4 (7.4/1.7)
ALT.1 <= 0.7865168:
:...ALT.36 > 0.6179775: F1 (5.2/1.1)
    ALT.36 <= 0.6179775:
    :...ALT.1 <= 0.7303371: F4 (18.3/7.2)
        ALT.1 > 0.7303371: F1 (3.7)

SubTree [S2]

ALT.after.24.w > 0.6521739: F1 (2.3/0.7)
ALT.after.24.w <= 0.6521739:
:...ALT.48 <= 0.5168539: F2 (3.9)
    ALT.48 > 0.5168539: F3 (3.5/0.5)

SubTree [S3]

ALT.after.24.w <= 0.5652174:
:...ALT.12 > 0.7640449:
:   :...Age <= 0.4827586: F3 (2)
:   :   Age > 0.4827586: F2 (5)
:   ALT.12 <= 0.7640449:
:   :...Age > 0.862069: F3 (2.4/1)
:       Age <= 0.862069:
:       :...Age <= 0.2068966: F2 (2.6)
:           Age > 0.2068966: F4 (13.1/1.6)
ALT.after.24.w > 0.5652174:
:...ALT.12 > 0.7078652: F1 (4.2)
    ALT.12 <= 0.7078652:
    :...Plat <= 0.05881559: F1 (2.2)
        Plat > 0.05881559:
        :...ALT.24 <= 0.4831461: F4 (5.6/1)
            ALT.24 > 0.4831461: F2 (10.6/1.5)

SubTree [S4]

ALT.48 <= 0.1797753: F2 (4.8/1.1)
ALT.48 > 0.1797753:
:...WBC <= 0.3881449: F1 (8.2/1.6)
    WBC > 0.3881449:
    :...ALT.48 <= 0.6629214: F3 (8.2/0.2)
        ALT.48 > 0.6629214:
        :...Age <= 0.5862069: F1 (2.8)
            Age > 0.5862069: F3 (4.2/1.1)

SubTree [S5]

RNA.4 <= 0.1763387: F1 (4/1.3)
RNA.4 > 0.1763387:
:...RBC <= 0.2396906: F2 (3.6/1.6)
    RBC > 0.2396906:
    :...ALT.24 > 0.741573:
        :...Plat <= 0.5066878: F4 (5.6)
        :   Plat > 0.5066878: F2 (6.4)
        ALT.24 <= 0.741573:
        :...ALT.1 <= 0.4831461:
            :...ALT.1 <= 0.3033708: F3 (7/1.5)
            :   ALT.1 > 0.3033708: F4 (6.4/0.3)
            ALT.1 > 0.4831461:
            :...ALT.1 > 0.7752809: F3 (5.9/1)
                ALT.1 <= 0.7752809:
                :...RBC <= 0.4494309: F3 (2.3)
                    RBC > 0.4494309:
                    :...WBC <= 0.8934138: F2 (8.4)
                        WBC > 0.8934138: F3 (2)

-----  Trial 12:  -----

Decision tree:

ALT.after.24.w > 0.8260869:
:...ALT.36 > 0.8764045:
:   :...ALT.4 <= 0.3595506: F4 (8.5/1)
:   :   ALT.4 > 0.3595506:
:   :   :...RNA.4 > 0.7324504: F1 (3)
:   :       RNA.4 <= 0.7324504:
:   :       :...ALT.24 <= 0.8764045: F2 (6.5/1.2)
:   :           ALT.24 > 0.8764045: F4 (2.4)
:   ALT.36 <= 0.8764045:
:   :...ALT.24 <= 0.04494382: F1 (7.4/1.3)
:       ALT.24 > 0.04494382:
:       :...ALT.48 > 0.8764045:
:           :...Age <= 0.2758621: F4 (3.9/2.4)
:           :   Age > 0.2758621: F2 (11.5/4.1)
:           ALT.48 <= 0.8764045:
:           :...ALT.48 > 0.7865168:
:               :...ALT.4 <= 0.1460674: F4 (2.2)
:               :   ALT.4 > 0.1460674: F1 (10/1.6)
:               ALT.48 <= 0.7865168:
:               :...RNA.4 <= 0.5460011:
:                   :...ALT.1 > 0.4831461:
:                   :   :...RNA.4 <= 0.01073637: F1 (2.7)
:                   :   :   RNA.4 > 0.01073637:
:                   :   :   :...Age > 0.6896552:
:                   :   :       :...RNA.4 <= 0.1096454: F2 (2.4)
:                   :   :       :   RNA.4 > 0.1096454: F3 (6.5/1.7)
:                   :   :       Age <= 0.6896552:
:                   :   :       :...ALT.4 > 0.7303371: F1 (4.3/1.9)
:                   :   :           ALT.4 <= 0.7303371:
:                   :   :           :...WBC <= 0.559495: F3 (10.6)
:                   :   :               WBC > 0.559495: F1 (3.8/1)
:                   :   ALT.1 <= 0.4831461:
:                   :   :...RNA.4 > 0.3680356: F1 (5.4/2.4)
:                   :       RNA.4 <= 0.3680356:
:                   :       :...WBC <= 0.3929748: F3 (6.1/0.3)
:                   :           WBC > 0.3929748:
:                   :           :...ALT.36 <= 0.1011236: F3 (3.1/1.4)
:                   :               ALT.36 > 0.1011236:
:                   :               :...ALT.12 > 0.3707865: F4 (9.3)
:                   :                   ALT.12 <= 0.3707865:
:                   :                   :...ALT.after.24.w <= 0.8695652: F4 (3.1)
:                   :                       ALT.after.24.w > 0.8695652: F3 (3.8/0.8)
:                   RNA.4 > 0.5460011:
:                   :...WBC <= 0.033809: F3 (3.9)
:                       WBC > 0.033809:
:                       :...WBC <= 0.4010977:
:                           :...RNA.4 > 0.8762014: F2 (3.8/0.6)
:                           :   RNA.4 <= 0.8762014:
:                           :   :...AST.1 <= 0.4157303:
:                           :       :...AST.1 <= 0.2134831: F1 (4.1)
:                           :       :   AST.1 > 0.2134831: F2 (4.6/2.2)
:                           :       AST.1 > 0.4157303:
:                           :       :...AST.1 <= 0.7303371: F4 (9.9)
:                           :           AST.1 > 0.7303371: F1 (3.1/0.9)
:                           WBC > 0.4010977:
:                           :...RBC > 0.8104688:
:                               :...ALT.24 <= 0.3595506: F4 (2.8)
:                               :   ALT.24 > 0.3595506: F3 (5.7/0.6)
:                               RBC <= 0.8104688:
:                               :...ALT.after.24.w > 0.9565217: F4 (4.4/1.4)
:                                   ALT.after.24.w <= 0.9565217:
:                                   :...ALT.24 > 0.494382: F1 (9.7/1)
:                                       ALT.24 <= 0.494382:
:                                       :...RNA.4 <= 0.7702832: F1 (3.7/0.4)
:                                           RNA.4 > 0.7702832: F4 (5.1/0.4)
ALT.after.24.w <= 0.8260869:
:...ALT.4 > 0.9213483:
    :...ALT.after.24.w > 0.7391304: F3 (5.1/1.5)
    :   ALT.after.24.w <= 0.7391304:
    :   :...Age <= 0.3793103:
    :       :...AST.1 <= 0.3483146: F3 (4.3/1.3)
    :       :   AST.1 > 0.3483146:
    :       :   :...AST.1 <= 0.8988764: F1 (8.3/2.1)
    :       :       AST.1 > 0.8988764: F2 (3.4)
    :       Age > 0.3793103:
    :       :...ALT.12 <= 0.4606742:
    :           :...ALT.24 <= 0.4606742: F1 (3.8)
    :           :   ALT.24 > 0.4606742:
    :           :   :...ALT.24 <= 0.8988764: F4 (3.4/0.4)
    :           :       ALT.24 > 0.8988764: F1 (2.4)
    :           ALT.12 > 0.4606742:
    :           :...Plat <= 0.2486081:
    :               :...BMI <= 0.3076923: F4 (4.1)
    :               :   BMI > 0.3076923: F1 (2.4/0.5)
    :               Plat > 0.2486081:
    :               :...AST.1 <= 0.5505618: F2 (9.8)
    :                   AST.1 > 0.5505618:
    :                   :...Age <= 0.7931035: F4 (2.5)
    :                       Age > 0.7931035: F2 (4.2/2.1)
    ALT.4 <= 0.9213483:
    :...ALT.4 <= 0.06741573:
        :...ALT.4 > 0.05617978: F1 (7.2/1.6)
        :   ALT.4 <= 0.05617978:
        :   :...ALT.after.24.w <= 0.3478261:
        :       :...ALT.24 > 0.8764045: F2 (4.7/0.7)
        :       :   ALT.24 <= 0.8764045:
        :       :   :...ALT.after.24.w <= 0.08695652: F1 (6.8/0.9)
        :       :       ALT.after.24.w > 0.08695652:
        :       :       :...ALT.24 <= 0.5393258:
        :       :           :...Age <= 0.3793103: F2 (3.8)
        :       :           :   Age > 0.3793103: F4 (4.9)
        :       :           ALT.24 > 0.5393258:
        :       :           :...ALT.48 <= 0.8314607: F1 (6.5/0.8)
        :       :               ALT.48 > 0.8314607: F4 (2.2)
        :       ALT.after.24.w > 0.3478261:
        :       :...RNA.Base > 0.8781575: F4 (3.6/0.8)
        :           RNA.Base <= 0.8781575:
        :           :...ALT.12 <= 0.4606742:
        :               :...ALT.12 <= 0.1573034: F1 (4.3/1.7)
        :               :   ALT.12 > 0.1573034: F2 (10.3/2.9)
        :               ALT.12 > 0.4606742:
        :               :...RNA.4 > 0.6053365: F3 (6.6)
        :                   RNA.4 <= 0.6053365:
        :                   :...AST.1 <= 0.7303371: F1 (4.5)
        :                       AST.1 > 0.7303371: F3 (4/1.4)
        ALT.4 > 0.06741573:
        :...ALT.4 <= 0.4831461:
            :...ALT.36 <= 0.08988764:
            :   :...RNA.4 <= 0.2005842: F3 (4.8)
            :   :   RNA.4 > 0.2005842:
            :   :   :...ALT.48 <= 0.3033708:
            :   :       :...WBC <= 0.807135: F2 (7.6/2.5)
            :   :       :   WBC > 0.807135: F3 (5.8/0.7)
            :   :       ALT.48 > 0.3033708:
            :   :       :...WBC <= 0.3476399: F2 (3.8/1.8)
            :   :           WBC > 0.3476399:
            :   :           :...ALT.36 <= 0.05617978: F4 (8.5)
            :   :               ALT.36 > 0.05617978:
            :   :               :...AST.1 <= 0.2022472: F4 (4.5/0.6)
            :   :                   AST.1 > 0.2022472: F2 (3.7)
            :   ALT.36 > 0.08988764:
            :   :...ALT.after.24.w > 0.6086956:
            :       :...ALT.24 > 0.8876405: F1 (2.7)
            :       :   ALT.24 <= 0.8876405:
            :       :   :...Plat <= 0.3807915:
            :       :       :...ALT.48 > 0.9101124: F3 (4.3)
            :       :       :   ALT.48 <= 0.9101124:
            :       :       :   :...ALT.4 <= 0.3483146: F4 (14.9/3)
            :       :       :       ALT.4 > 0.3483146:
            :       :       :       :...ALT.1 <= 0.247191: F3 (2.9/1.3)
            :       :       :           ALT.1 > 0.247191: F2 (4.2)
            :       :       Plat > 0.3807915:
            :       :       :...ALT.after.24.w <= 0.6521739: F2 (4.4/0.9)
            :       :           ALT.after.24.w > 0.6521739:
            :       :           :...ALT.36 <= 0.2359551: F1 (4.9/1.6)
            :       :               ALT.36 > 0.2359551:
            :       :               :...ALT.12 <= 0.2022472: F1 (5.1/2.8)
            :       :                   ALT.12 > 0.2022472:
            :       :                   :...ALT.1 > 0.8651685: F4 (4.3)
            :       :                       ALT.1 <= 0.8651685:
            :       :                       :...BMI <= 0.3846154:
            :       :                           :...ALT.24 <= 0.7640449: F2 (4.7/2.1)
            :       :                           :   ALT.24 > 0.7640449: F4 (2.6)
            :       :                           BMI > 0.3846154:
            :       :                           :...ALT.36 <= 0.8089887: F2 (12.8/0.3)
            :       :                               ALT.36 > 0.8089887: F4 (5.4/1.4)
            :       ALT.after.24.w <= 0.6086956:
            :       :...RBC <= 0.06745344:
            :           :...ALT.1 <= 0.5955056: F3 (8/1.2)
            :           :   ALT.1 > 0.5955056: F2 (4.2)
            :           RBC > 0.06745344:
            :           :...ALT.after.24.w <= 0.08695652:
            :               :...Plat > 0.5515208:
            :               :   :...ALT.12 <= 0.6741573:
            :               :   :   :...ALT.36 <= 0.5842696: F4 (4.9/1.8)
            :               :   :   :   ALT.36 > 0.5842696: F3 (5)
            :               :   :   ALT.12 > 0.6741573:
            :               :   :   :...ALT.1 <= 0.5955056: F4 (8.7/1.2)
            :               :   :       ALT.1 > 0.5955056: F2 (2.4)
            :               :   Plat <= 0.5515208:
            :               :   :...Plat <= 0.1263235:
            :               :       :...BMI <= 0.6923077: F1 (3.3/1.2)
            :               :       :   BMI > 0.6923077: F4 (4.2/1.3)
            :               :       Plat > 0.1263235:
            :               :       :...ALT.24 > 0.5730337:
            :               :           :...RBC <= 0.5236695: F4 (2.2/0.8)
            :               :           :   RBC > 0.5236695: F2 (4.1/0.3)
            :               :           ALT.24 <= 0.5730337:
            :               :           :...BMI <= 0.3076923: F2 (6.8)
            :               :               BMI > 0.3076923:
            :               :               :...WBC <= 0.1981339: F2 (3.4)
            :               :                   WBC > 0.1981339: F1 (3.5)
            :               ALT.after.24.w > 0.08695652:
            :               :...RNA.Base > 0.7546256:
            :                   :...ALT.36 <= 0.1910112: F1 (3.5/0.4)
            :                   :   ALT.36 > 0.1910112:
            :                   :   :...BMI <= 0.3846154:
            :                   :       :...BMI > 0.2307692: F3 (7.6)
            :                   :       :   BMI <= 0.2307692:
            :                   :       :   :...RNA.4 <= 0.4043105: F3 (6.2)
            :                   :       :       RNA.4 > 0.4043105: F1 (4.8/0.9)
            :                   :       BMI > 0.3846154:
            :                   :       :...ALT.after.24.w <= 0.2608696: F4 (3.4/0.9)
            :                   :           ALT.after.24.w > 0.2608696:
            :                   :           :...BMI <= 0.6923077: F2 (5.8/1.8)
            :                   :               BMI > 0.6923077: F3 (5.7/1.1)
            :                   RNA.Base <= 0.7546256:
            :                   :...ALT.12 <= 0.4606742:
            :                       :...WBC <= 0.1706915: F3 (6.9)
            :                       :   WBC > 0.1706915:
            :                       :   :...Plat > 0.8699598:
            :                       :       :...AST.1 <= 0.3033708: F1 (2.5/0.8)
            :                       :       :   AST.1 > 0.3033708: F2 (5)
            :                       :       Plat <= 0.8699598:
            :                       :       :...ALT.24 > 0.4719101:
            :                       :           :...RNA.4 <= 0.4080019: F1 (9.2/1.8)
            :                       :           :   RNA.4 > 0.4080019: F3 (3.8/0.5)
            :                       :           ALT.24 <= 0.4719101:
            :                       :           :...Age > 0.9310345: F2 (2.3/1)
            :                       :               Age <= 0.9310345:
            :                       :               :...ALT.48 > 0.8089887: F3 (3.7/1.4)
            :                       :                   ALT.48 <= 0.8089887: [S1]
            :                       ALT.12 > 0.4606742:
            :                       :...ALT.48 <= 0.08988764: F4 (12.4)
            :                           ALT.48 > 0.08988764:
            :                           :...ALT.36 <= 0.1348315: F2 (5.9/1.2)
            :                               ALT.36 > 0.1348315:
            :                               :...ALT.24 <= 0.02247191: F2 (4.4/1.8)
            :                                   ALT.24 > 0.02247191:
            :                                   :...Age <= 0: F2 (2.5)
            :                                       Age > 0:
            :                                       :...ALT.after.24.w > 0.3478261:
            :                                           :...Plat <= 0.7074507: F4 (20.6/4.7)
            :                                           :   Plat > 0.7074507: F3 (3.3/0.5)
            :                                           ALT.after.24.w <= 0.3478261: [S2]
            ALT.4 > 0.4831461:
            :...ALT.48 > 0.9662921:
                :...ALT.48 <= 0.9775281: F4 (2.6)
                :   ALT.48 > 0.9775281:
                :   :...RNA.4 <= 0.1295362: F4 (2.2)
                :       RNA.4 > 0.1295362: F3 (7.7/0.8)
                ALT.48 <= 0.9662921:
                :...WBC <= 0.2394072:
                    :...ALT.after.24.w <= 0.1304348:
                    :   :...ALT.12 <= 0.6067415: F4 (12.8/4.9)
                    :   :   ALT.12 > 0.6067415: F2 (8/1)
                    :   ALT.after.24.w > 0.1304348:
                    :   :...ALT.after.24.w > 0.7391304:
                    :       :...ALT.24 <= 0.3595506: F4 (2.5)
                    :       :   ALT.24 > 0.3595506: F2 (3.9/0.8)
                    :       ALT.after.24.w <= 0.7391304:
                    :       :...Age <= 0.137931: F1 (7/2.2)
                    :           Age > 0.137931:
                    :           :...Age > 0.9310345: F1 (2.1/1)
                    :               Age <= 0.9310345:
                    :               :...ALT.36 <= 0.2022472: F2 (5.5/2)
                    :                   ALT.36 > 0.2022472:
                    :                   :...RNA.Base <= 0.1265625: F4 (2.1)
                    :                       RNA.Base > 0.1265625:
                    :                       :...RNA.Base > 0.8316774: F4 (5.9/2.1)
                    :                           RNA.Base <= 0.8316774:
                    :                           :...RNA.Base <= 0.2426743: F2 (2.5/0.4)
                    :                               RNA.Base > 0.2426743: F1 (18.1/2.4)
                    WBC > 0.2394072:
                    :...ALT.48 > 0.9438202: F2 (8.1/2)
                        ALT.48 <= 0.9438202:
                        :...AST.1 > 0.9662921:
                            :...WBC <= 0.7245884: F2 (5.7/0.8)
                            :   WBC > 0.7245884: F3 (3.3/1)
                            AST.1 <= 0.9662921:
                            :...WBC <= 0.4657519:
                                :...RBC <= 0.1731223:
                                :   :...RNA.4 <= 0.5543501: F4 (4.8/0.6)
                                :   :   RNA.4 > 0.5543501: F1 (7.9)
                                :   RBC > 0.1731223:
                                :   :...WBC > 0.3695939:
                                :       :...ALT.12 <= 0.247191:
                                :       :   :...Age <= 0.4827586: F3 (3.6)
                                :       :   :   Age > 0.4827586: F2 (3.4/0.6)
                                :       :   ALT.12 > 0.247191:
                                :       :   :...ALT.24 <= 0.7078652: F3 (15.6/2.5)
                                :       :       ALT.24 > 0.7078652: F4 (2.7)
                                :       WBC <= 0.3695939:
                                :       :...ALT.4 > 0.8651685: F1 (6.9/2.3)
                                :           ALT.4 <= 0.8651685:
                                :           :...RNA.Base <= 0.3449243: F1 (8.6/1.8)
                                :               RNA.Base > 0.3449243:
                                :               :...ALT.24 > 0.9438202: F1 (2/0.8)
                                :                   ALT.24 <= 0.9438202:
                                :                   :...ALT.1 > 0.741573: [S3]
                                :                       ALT.1 <= 0.741573: [S4]
                                WBC > 0.4657519:
                                :...WBC <= 0.5047201: F4 (10.5/2.7)
                                    WBC > 0.5047201:
                                    :...ALT.4 <= 0.5168539:
                                        :...RNA.Base <= 0.1532319: F1 (2.3)
                                        :   RNA.Base > 0.1532319:
                                        :   :...ALT.after.24.w <= 0.2173913: F4 (4.2)
                                        :       ALT.after.24.w > 0.2173913: F2 (6.2/0.9)
                                        ALT.4 > 0.5168539:
                                        :...BMI <= 0.2307692:
                                            :...RBC <= 0.1887841:
                                            :   :...Plat <= 0.367146: F2 (2.4/1)
                                            :   :   Plat > 0.367146: F3 (5.3/0.7)
                                            :   RBC > 0.1887841:
                                            :   :...BMI <= 0: F1 (2.2)
                                            :       BMI > 0:
                                            :       :...RNA.4 <= 0.1450841: F4 (5.1)
                                            :           RNA.4 > 0.1450841:
                                            :           :...RBC > 0.803508: F3 (5.6/3.4)
                                            :               RBC <= 0.803508:
                                            :               :...ALT.1 <= 0.6853933: [S5]
                                            :                   ALT.1 > 0.6853933: [S6]
                                            BMI > 0.2307692:
                                            :...ALT.24 <= 0.3595506:
                                                :...RNA.4 > 0.7443044: F1 (6.5/1.3)
                                                :   RNA.4 <= 0.7443044:
                                                :   :...ALT.48 <= 0.1910112: F4 (3.6/1)
                                                :       ALT.48 > 0.1910112: [S7]
                                                ALT.24 > 0.3595506:
                                                :...AST.1 <= 0.1235955:
                                                    :...RBC <= 0.6728839: F3 (8.8/2.1)
                                                    :   RBC > 0.6728839: F4 (3.5)
                                                    AST.1 > 0.1235955:
                                                    :...Plat > 0.7143146: F2 (10.2/0.6)
                                                        Plat <= 0.7143146:
                                                        :...BMI <= 0.3076923: [S8]
                                                            BMI > 0.3076923: [S9]

SubTree [S1]

AST.1 <= 0.2247191: F1 (4.4/0.5)
AST.1 > 0.2247191: F4 (11.3/2.8)

SubTree [S2]

ALT.12 <= 0.5280899: F4 (3.2/0.3)
ALT.12 > 0.5280899:
:...ALT.after.24.w > 0.2173913: F3 (12.7/1.2)
    ALT.after.24.w <= 0.2173913:
    :...ALT.after.24.w <= 0.1304348: F3 (3.9/1.8)
        ALT.after.24.w > 0.1304348: F4 (5.3/2.2)

SubTree [S3]

ALT.36 <= 0.4719101: F3 (3.7)
ALT.36 > 0.4719101: F1 (2.4/0.4)

SubTree [S4]

RNA.4 > 0.4249694: F3 (8.4)
RNA.4 <= 0.4249694:
:...ALT.after.24.w <= 0.1304348: F3 (3)
    ALT.after.24.w > 0.1304348: F2 (3)

SubTree [S5]

WBC <= 0.683315: F4 (3.8/0.2)
WBC > 0.683315: F3 (4.6/1.1)

SubTree [S6]

AST.1 <= 0.2134831: F4 (3.4/1)
AST.1 > 0.2134831: F1 (4.8)

SubTree [S7]

RNA.4 <= 0.2047033: F1 (4/1.6)
RNA.4 > 0.2047033: F3 (14.1/1.5)

SubTree [S8]

ALT.after.24.w <= 0.3043478: F1 (2.7/1.3)
ALT.after.24.w > 0.3043478: F3 (4)

SubTree [S9]

Plat > 0.6313029: F1 (4.6/0.8)
Plat <= 0.6313029:
:...RNA.Base > 0.8509701: F2 (5.5/0.4)
    RNA.Base <= 0.8509701:
    :...BMI <= 0.3846154: F2 (3.5)
        BMI > 0.3846154:
        :...ALT.after.24.w > 0.7391304: F3 (2.2/0.4)
            ALT.after.24.w <= 0.7391304:
            :...RNA.Base > 0.7192066: F1 (4.2)
                RNA.Base <= 0.7192066:
                :...RNA.4 > 0.5460011:
                    :...ALT.48 <= 0.5842696: F3 (2.4/0.9)
                    :   ALT.48 > 0.5842696: F1 (4.3)
                    RNA.4 <= 0.5460011:
                    :...BMI > 0.7692308: F2 (5.8/1.6)
                        BMI <= 0.7692308:
                        :...ALT.1 <= 0.6966292: F3 (4.7)
                            ALT.1 > 0.6966292: F2 (3.9/0.5)

-----  Trial 13:  -----

Decision tree:

BMI <= 0.4615385:
:...AST.1 > 0.7078652:
:   :...RNA.4 > 0.9459562: F1 (5.4/1.2)
:   :   RNA.4 <= 0.9459562:
:   :   :...ALT.24 > 0.9662921: F1 (5.3/1.8)
:   :       ALT.24 <= 0.9662921:
:   :       :...ALT.48 <= 0.08988764:
:   :           :...RBC <= 0.2843642: F3 (3.1)
:   :           :   RBC > 0.2843642:
:   :           :   :...ALT.4 <= 0.8202247: F4 (9.3/1.7)
:   :           :       ALT.4 > 0.8202247: F2 (2.2)
:   :           ALT.48 > 0.08988764:
:   :           :...RNA.4 <= 0.1096454:
:   :               :...Age <= 0.06896552: F3 (2.2/0.9)
:   :               :   Age > 0.06896552:
:   :               :   :...Plat <= 0.452106: F4 (4.8/0.3)
:   :               :       Plat > 0.452106: F2 (6.4/1.9)
:   :               RNA.4 > 0.1096454:
:   :               :...ALT.36 > 0.8539326:
:   :                   :...AST.1 <= 0.8202247: F3 (8.9/2)
:   :                   :   AST.1 > 0.8202247:
:   :                   :   :...AST.1 <= 0.8988764: F4 (3.9)
:   :                   :       AST.1 > 0.8988764: F3 (2.5)
:   :                   ALT.36 <= 0.8539326:
:   :                   :...RBC <= 0.4163593:
:   :                       :...Age <= 0.2758621: F3 (10.1/1.4)
:   :                       :   Age > 0.2758621:
:   :                       :   :...RBC > 0.3142412: F3 (3.7/0.4)
:   :                       :       RBC <= 0.3142412:
:   :                       :       :...ALT.36 > 0.4606742: F2 (9.5/1)
:   :                       :           ALT.36 <= 0.4606742:
:   :                       :           :...RBC <= 0.1343212: F2 (3.1/0.2)
:   :                       :               RBC > 0.1343212: F3 (3/0.5)
:   :                       RBC > 0.4163593:
:   :                       :...ALT.12 <= 0.1011236: F1 (3.4)
:   :                           ALT.12 > 0.1011236:
:   :                           :...ALT.after.24.w > 0.9130435: F3 (3)
:   :                               ALT.after.24.w <= 0.9130435:
:   :                               :...RNA.4 > 0.8504306: F3 (3.3)
:   :                                   RNA.4 <= 0.8504306:
:   :                                   :...BMI <= 0.1538462:
:   :                                       :...ALT.4 <= 0.6292135: F2 (11.5/3.3)
:   :                                       :   ALT.4 > 0.6292135: F3 (4.4/1.1)
:   :                                       BMI > 0.1538462:
:   :                                       :...BMI <= 0.2307692: F1 (3)
:   :                                           BMI > 0.2307692: [S1]
:   AST.1 <= 0.7078652:
:   :...ALT.after.24.w <= 0.4782609:
:       :...Plat > 0.8100426:
:       :   :...ALT.12 > 0.7640449: F4 (6/2.9)
:       :   :   ALT.12 <= 0.7640449:
:       :   :   :...ALT.36 <= 0.3033708:
:       :   :       :...RNA.Base <= 0.2462527: F3 (3.7)
:       :   :       :   RNA.Base > 0.2462527: F1 (5/0.3)
:       :   :       ALT.36 > 0.3033708:
:       :   :       :...ALT.24 > 0.7191011: F1 (7.3)
:       :   :           ALT.24 <= 0.7191011:
:       :   :           :...ALT.24 <= 0.4494382: F1 (6.8/2.2)
:       :   :               ALT.24 > 0.4494382: F4 (3.2/0.4)
:       :   Plat <= 0.8100426:
:       :   :...Age <= 0.06896552:
:       :       :...WBC <= 0.1835346: F4 (2.5/1.1)
:       :       :   WBC > 0.1835346:
:       :       :   :...ALT.1 <= 0.1910112: F1 (2.4)
:       :       :       ALT.1 > 0.1910112:
:       :       :       :...RNA.Base <= 0.3681011: F4 (4)
:       :       :           RNA.Base > 0.3681011:
:       :       :           :...ALT.1 <= 0.6853933: F1 (3.8)
:       :       :               ALT.1 > 0.6853933: F4 (3.3/0.3)
:       :       Age > 0.06896552:
:       :       :...WBC > 0.9231614: F4 (10.7/1.5)
:       :           WBC <= 0.9231614:
:       :           :...Plat > 0.6938502:
:       :               :...ALT.12 <= 0.08988764: F3 (3.3)
:       :               :   ALT.12 > 0.08988764:
:       :               :   :...RBC <= 0.559118: F2 (7.4/2)
:       :               :       RBC > 0.559118: F4 (11.6/1)
:       :               Plat <= 0.6938502:
:       :               :...ALT.1 <= 0.08988764: F3 (6.1/1)
:       :                   ALT.1 > 0.08988764:
:       :                   :...ALT.12 > 0.8876405: F1 (9.1/3.1)
:       :                       ALT.12 <= 0.8876405:
:       :                       :...Plat <= 0.06298941: F2 (6.8/1.3)
:       :                           Plat > 0.06298941:
:       :                           :...ALT.after.24.w <= 0.08695652:
:       :                               :...ALT.36 > 0.9213483: F3 (2.4/1)
:       :                               :   ALT.36 <= 0.9213483:
:       :                               :   :...ALT.1 <= 0.6853933:
:       :                               :       :...ALT.12 <= 0.4719101: F2 (11.1/1.1)
:       :                               :       :   ALT.12 > 0.4719101: F4 (3/0.5)
:       :                               :       ALT.1 > 0.6853933:
:       :                               :       :...RBC <= 0.4720992: F1 (2.5)
:       :                               :           RBC > 0.4720992: F2 (3.7/0.8)
:       :                               ALT.after.24.w > 0.08695652:
:       :                               :...ALT.36 > 0.6629214:
:       :                                   :...ALT.36 > 0.9101124: F1 (3.9/1.4)
:       :                                   :   ALT.36 <= 0.9101124:
:       :                                   :   :...WBC > 0.5600439: F4 (5.8)
:       :                                   :       WBC <= 0.5600439:
:       :                                   :       :...ALT.36 <= 0.8764045: F1 (6.9/1.5)
:       :                                   :           ALT.36 > 0.8764045: F4 (2.8)
:       :                                   ALT.36 <= 0.6629214:
:       :                                   :...ALT.1 > 0.7640449:
:       :                                       :...RNA.Base <= 0.2498062: F2 (3.5)
:       :                                       :   RNA.Base > 0.2498062: F1 (5.8/1.6)
:       :                                       ALT.1 <= 0.7640449:
:       :                                       :...BMI > 0.3076923:
:       :                                           :...WBC <= 0.4782656: F4 (3.4/0.6)
:       :                                           :   WBC > 0.4782656: F2 (3.8)
:       :                                           BMI <= 0.3076923:
:       :                                           :...ALT.1 <= 0.3595506: [S2]
:       :                                               ALT.1 > 0.3595506: [S3]
:       ALT.after.24.w > 0.4782609:
:       :...Age <= 0.03448276:
:           :...RBC > 0.7366652: F3 (5.2/1.5)
:           :   RBC <= 0.7366652:
:           :   :...ALT.36 <= 0.258427: F2 (3.6/0.9)
:           :       ALT.36 > 0.258427: F4 (4)
:           Age > 0.03448276:
:           :...Age <= 0.2068966:
:               :...AST.1 <= 0.04494382: F3 (3.6)
:               :   AST.1 > 0.04494382:
:               :   :...BMI <= 0.07692308:
:               :       :...ALT.after.24.w <= 0.6086956: F3 (6.1/1.2)
:               :       :   ALT.after.24.w > 0.6086956: F1 (3.1)
:               :       BMI > 0.07692308:
:               :       :...RBC <= 0.4679978: F1 (7.8)
:               :           RBC > 0.4679978:
:               :           :...ALT.4 <= 0.1797753: F1 (2.1)
:               :               ALT.4 > 0.1797753: F4 (5.6/1)
:               Age > 0.2068966:
:               :...RBC <= 0.05493545:
:                   :...ALT.4 <= 0.8089887: F4 (6.9)
:                   :   ALT.4 > 0.8089887: F3 (3.5/0.6)
:                   RBC > 0.05493545:
:                   :...Age <= 0.3103448:
:                       :...Plat > 0.6489123: F3 (5/2.3)
:                       :   Plat <= 0.6489123:
:                       :   :...ALT.1 <= 0.2247191: F3 (2.8)
:                       :       ALT.1 > 0.2247191: F4 (9.2/0.9)
:                       Age > 0.3103448:
:                       :...ALT.24 > 0.8764045:
:                           :...BMI <= 0.07692308: F4 (2.2)
:                           :   BMI > 0.07692308:
:                           :   :...Plat <= 0.3123768: F1 (5)
:                           :       Plat > 0.3123768: F4 (3.7/1.2)
:                           ALT.24 <= 0.8764045:
:                           :...AST.1 <= 0.1123596:
:                               :...RBC > 0.9188272: F3 (2.3)
:                               :   RBC <= 0.9188272:
:                               :   :...RNA.4 <= 0.2307412: F4 (4.5)
:                               :       RNA.4 > 0.2307412:
:                               :       :...RNA.4 <= 0.8535137: F1 (9.3/0.7)
:                               :           RNA.4 > 0.8535137: F4 (2.7)
:                               AST.1 > 0.1123596:
:                               :...ALT.12 > 0.8202247:
:                                   :...RBC <= 0.169807: F1 (5.2/2.3)
:                                   :   RBC > 0.169807:
:                                   :   :...WBC <= 0.2817783: F3 (2.6)
:                                   :       WBC > 0.2817783: F4 (10.3/1.2)
:                                   ALT.12 <= 0.8202247:
:                                   :...ALT.1 > 0.8314607:
:                                       :...ALT.12 <= 0.4157303: F3 (8/0.4)
:                                       :   ALT.12 > 0.4157303: F4 (3.9/1)
:                                       ALT.1 <= 0.8314607:
:                                       :...Age <= 0.3793103: F3 (7.1/1.8)
:                                           Age > 0.3793103:
:                                           :...BMI > 0.3846154:
:                                               :...ALT.4 <= 0.5842696: F3 (2.3)
:                                               :   ALT.4 > 0.5842696: F1 (5.5/1.7)
:                                               BMI <= 0.3846154:
:                                               :...RNA.4 <= 0.2941101:
:                                                   :...WBC > 0.5210757: F2 (5.2/0.3)
:                                                   :   WBC <= 0.5210757: [S4]
:                                                   RNA.4 > 0.2941101:
:                                                   :...ALT.12 <= 0.08988764: F3 (4.9/1.5)
:                                                       ALT.12 > 0.08988764: [S5]
BMI > 0.4615385:
:...ALT.1 <= 0.01123596: F2 (13.2/3.5)
    ALT.1 > 0.01123596:
    :...WBC <= 0.04643249:
        :...WBC <= 0.01317234: F2 (4.2/1.1)
        :   WBC > 0.01317234:
        :   :...RBC > 0.6685579: F1 (5.4)
        :       RBC <= 0.6685579:
        :       :...WBC <= 0.03556531: F3 (7/0.7)
        :           WBC > 0.03556531: F1 (2.4)
        WBC > 0.04643249:
        :...Age <= 0.5517241:
            :...ALT.36 <= 0.05617978:
            :   :...Plat > 0.7939543: F4 (6.1/0.8)
            :   :   Plat <= 0.7939543:
            :   :   :...ALT.48 <= 0.5842696: F3 (9.5/1.1)
            :   :       ALT.48 > 0.5842696: F4 (3.3)
            :   ALT.36 > 0.05617978:
            :   :...BMI <= 0.6153846:
            :       :...Plat <= 0.03117998: F1 (3)
            :       :   Plat > 0.03117998:
            :       :   :...ALT.1 > 0.7303371:
            :       :       :...AST.1 > 0.8988764: F2 (3.8)
            :       :       :   AST.1 <= 0.8988764:
            :       :       :   :...Plat <= 0.4799589: F4 (8.1/0.7)
            :       :       :       Plat > 0.4799589: F1 (8.3/2.6)
            :       :       ALT.1 <= 0.7303371:
            :       :       :...WBC <= 0.3648738:
            :       :           :...ALT.4 <= 0.7640449: F3 (7.8/1)
            :       :           :   ALT.4 > 0.7640449: F2 (3.1/1.1)
            :       :           WBC > 0.3648738:
            :       :           :...ALT.after.24.w > 0.8695652: F4 (3.8)
            :       :               ALT.after.24.w <= 0.8695652:
            :       :               :...RNA.Base <= 0.1641979: F3 (2.2/0.2)
            :       :                   RNA.Base > 0.1641979:
            :       :                   :...ALT.36 <= 0.2247191: F2 (7.9/0.4)
            :       :                       ALT.36 > 0.2247191:
            :       :                       :...ALT.48 <= 0.3033708: F2 (6.6/1.1)
            :       :                           ALT.48 > 0.3033708:
            :       :                           :...ALT.12 <= 0.494382: F3 (4.5/0.5)
            :       :                               ALT.12 > 0.494382: F4 (5.6)
            :       BMI > 0.6153846:
            :       :...Age <= 0.2413793:
            :           :...AST.1 <= 0.247191:
            :           :   :...WBC <= 0.5959385: F3 (18.6/4.8)
            :           :   :   WBC > 0.5959385:
            :           :   :   :...ALT.36 <= 0.8202247: F3 (5.8/0.9)
            :           :   :       ALT.36 > 0.8202247: F2 (3.8)
            :           :   AST.1 > 0.247191:
            :           :   :...Plat <= 0.06908154: F2 (5.5/0.8)
            :           :       Plat > 0.06908154:
            :           :       :...Plat > 0.6405048:
            :           :           :...ALT.12 > 0.5617977:
            :           :           :   :...ALT.24 <= 0.6067415: F1 (2.2)
            :           :           :   :   ALT.24 > 0.6067415: F3 (7.5/1.2)
            :           :           :   ALT.12 <= 0.5617977:
            :           :           :   :...Plat > 0.8756548: F3 (6.4/1.9)
            :           :           :       Plat <= 0.8756548:
            :           :           :       :...ALT.36 <= 0.3595506: F2 (4.4)
            :           :           :           ALT.36 > 0.3595506: F4 (3.7)
            :           :           Plat <= 0.6405048:
            :           :           :...RNA.Base <= 0.4264929:
            :           :               :...RBC <= 0.9284534: F1 (19.6/2.8)
            :           :               :   RBC > 0.9284534: F2 (2)
            :           :               RNA.Base > 0.4264929:
            :           :               :...BMI > 0.9230769: F4 (2.2/0.3)
            :           :                   BMI <= 0.9230769:
            :           :                   :...RBC <= 0.3553458: F1 (5.7/1.1)
            :           :                       RBC > 0.3553458:
            :           :                       :...RBC <= 0.9111203: F3 (7.5/0.8)
            :           :                           RBC > 0.9111203: F1 (3.2/0.3)
            :           Age > 0.2413793:
            :           :...ALT.36 <= 0.1460674: F2 (5.5/1.7)
            :               ALT.36 > 0.1460674:
            :               :...Plat > 0.9416265: F2 (5/1)
            :                   Plat <= 0.9416265:
            :                   :...RNA.Base <= 0.282621:
            :                       :...ALT.48 <= 0.3707865: F4 (6.4/1.6)
            :                       :   ALT.48 > 0.3707865:
            :                       :   :...RNA.4 <= 0.1763387: F3 (2.7/1.5)
            :                       :       RNA.4 > 0.1763387:
            :                       :       :...BMI > 0.9230769: F3 (3.6)
            :                       :           BMI <= 0.9230769:
            :                       :           :...WBC <= 0.4350165: F1 (4.7)
            :                       :               WBC > 0.4350165: F3 (8.4/2.6)
            :                       RNA.Base > 0.282621:
            :                       :...RBC <= 0.2128093: F3 (7.7/2.9)
            :                           RBC > 0.2128093:
            :                           :...ALT.4 <= 0.5393258: F4 (18.6/4.1)
            :                               ALT.4 > 0.5393258:
            :                               :...Age > 0.4137931: F3 (3.9)
            :                                   Age <= 0.4137931:
            :                                   :...RBC <= 0.4832055: F3 (3.8/0.8)
            :                                       RBC > 0.4832055: F4 (6.3/0.3)
            Age > 0.5517241:
            :...WBC <= 0.1086718:
                :...AST.1 <= 0.8089887: F2 (7.7/0.1)
                :   AST.1 > 0.8089887: F3 (4.6)
                WBC > 0.1086718:
                :...ALT.12 > 0.9662921: F2 (4.7)
                    ALT.12 <= 0.9662921:
                    :...ALT.12 <= 0: F2 (7.8/1.9)
                        ALT.12 > 0:
                        :...ALT.24 <= 0.1123596:
                            :...ALT.12 > 0.8202247: F4 (3.1/0.7)
                            :   ALT.12 <= 0.8202247:
                            :   :...WBC <= 0.3774973: F4 (4/0.8)
                            :       WBC > 0.3774973: F2 (9.1/0.9)
                            ALT.24 > 0.1123596:
                            :...ALT.36 > 0.9101124:
                                :...ALT.4 <= 0.5505618: F4 (6.1/0.4)
                                :   ALT.4 > 0.5505618: F1 (3/0.4)
                                ALT.36 <= 0.9101124:
                                :...RNA.Base > 0.9340658:
                                    :...RBC <= 0.2451413: F1 (2)
                                    :   RBC > 0.2451413: F2 (4.8/0.3)
                                    RNA.Base <= 0.9340658:
                                    :...RNA.Base > 0.8605266: F4 (9.1/3.2)
                                        RNA.Base <= 0.8605266:
                                        :...RNA.4 <= 0.3554743:
                                            :...ALT.36 <= 0.3820225:
                                            :   :...Plat <= 0.1787922: F3 (2.4/0.9)
                                            :   :   Plat > 0.1787922:
                                            :   :   :...BMI <= 0.6153846: F4 (2.6/1)
                                            :   :       BMI > 0.6153846: F1 (9/2.4)
                                            :   ALT.36 > 0.3820225:
                                            :   :...WBC <= 0.5919868: F2 (14.4/1.7)
                                            :       WBC > 0.5919868:
                                            :       :...ALT.36 <= 0.494382: F2 (3.4/1)
                                            :           ALT.36 > 0.494382: F3 (5.1/2.3)
                                            RNA.4 > 0.3554743:
                                            :...Plat > 0.5815318:
                                                :...BMI > 0.9230769: F1 (2.4/1.1)
                                                :   BMI <= 0.9230769:
                                                :   :...AST.1 > 0.5617977:
                                                :       :...Age <= 0.7931035: F3 (7.9/0.8)
                                                :       :   Age > 0.7931035: F1 (2.4/0.8)
                                                :       AST.1 <= 0.5617977:
                                                :       :...Age > 0.8965517: F2 (3/0.4)
                                                :           Age <= 0.8965517: [S6]
                                                Plat <= 0.5815318:
                                                :...RNA.Base <= 0.08317132: F1 (3)
                                                    RNA.Base > 0.08317132:
                                                    :...ALT.1 > 0.8202247:
                                                        :...Plat <= 0.3123768: F1 (5/1.4)
                                                        :   Plat > 0.3123768: F3 (3.4)
                                                        ALT.1 <= 0.8202247:
                                                        :...Plat <= 0.1174064: [S7]
                                                            Plat > 0.1174064:
                                                            :...RNA.Base > 0.7378607: [S8]
                                                                RNA.Base <= 0.7378607: [S9]

SubTree [S1]

ALT.after.24.w > 0.6956522: F2 (5.6/0.5)
ALT.after.24.w <= 0.6956522:
:...ALT.36 <= 0.3146068: F2 (5.2/1.3)
    ALT.36 > 0.3146068: F1 (3.5)

SubTree [S2]

RNA.Base <= 0.3972525: F3 (3.6)
RNA.Base > 0.3972525: F2 (2.7/0.8)

SubTree [S3]

AST.1 <= 0.5393258: F4 (8.1/1.8)
AST.1 > 0.5393258: F3 (3.8)

SubTree [S4]

ALT.48 <= 0.6179775: F4 (2.4/0.4)
ALT.48 > 0.6179775: F3 (4.1)

SubTree [S5]

RNA.4 > 0.9045269: F3 (3.4/1.7)
RNA.4 <= 0.9045269:
:...RNA.Base > 0.7981858: F1 (4.6/1.7)
    RNA.Base <= 0.7981858:
    :...RNA.4 <= 0.4413278: F1 (4.1)
        RNA.4 > 0.4413278:
        :...RNA.4 <= 0.8165855: F2 (12.7/1.9)
            RNA.4 > 0.8165855: F1 (3.5)

SubTree [S6]

ALT.1 <= 0.3483146: F2 (3.3/0.6)
ALT.1 > 0.3483146: F1 (5.3)

SubTree [S7]

ALT.1 <= 0.5280899: F4 (7.2)
ALT.1 > 0.5280899: F3 (3.7)

SubTree [S8]

ALT.36 <= 0.1797753: F3 (2.5)
ALT.36 > 0.1797753: F1 (6.2)

SubTree [S9]

ALT.48 <= 0.2022472: F4 (4.4)
ALT.48 > 0.2022472:
:...ALT.36 <= 0.4269663:
    :...ALT.1 <= 0.4157303: F3 (3.3)
    :   ALT.1 > 0.4157303: F4 (3.5/0.5)
    ALT.36 > 0.4269663:
    :...WBC <= 0.8261251: F3 (11.3/1)
        WBC > 0.8261251: F1 (2.9)

-----  Trial 14:  -----

Decision tree:

BMI > 0.5384616:
:...Plat > 0.9696817: F2 (11/2.5)
:   Plat <= 0.9696817:
:   :...WBC <= 0.04522503:
:       :...ALT.48 > 0.752809: F3 (3.3/0.7)
:       :   ALT.48 <= 0.752809:
:       :   :...RNA.Base <= 0.55075: F1 (10.1/1.7)
:       :       RNA.Base > 0.55075: F2 (2.5/0.4)
:       WBC > 0.04522503:
:       :...WBC > 0.9728869: F3 (10.1/2.6)
:           WBC <= 0.9728869:
:           :...ALT.12 <= 0.4269663:
:               :...BMI > 0.9230769:
:               :   :...ALT.36 > 0.8202247: F1 (3.9/1.3)
:               :   :   ALT.36 <= 0.8202247:
:               :   :   :...RNA.4 <= 0.01188473: F2 (2.4)
:               :   :       RNA.4 > 0.01188473:
:               :   :       :...RBC > 0.6150659: F3 (10.2/3.1)
:               :   :           RBC <= 0.6150659:
:               :   :           :...ALT.48 <= 0.5168539: F3 (3.5/0.4)
:               :   :               ALT.48 > 0.5168539: F4 (6.4)
:               :   BMI <= 0.9230769:
:               :   :...ALT.12 <= 0.01123596:
:               :       :...ALT.after.24.w <= 0.7391304: F1 (7.2/0.9)
:               :       :   ALT.after.24.w > 0.7391304: F2 (3.8)
:               :       ALT.12 > 0.01123596:
:               :       :...ALT.12 <= 0.06741573:
:               :           :...ALT.1 > 0.6067415: F3 (7.4/0.6)
:               :           :   ALT.1 <= 0.6067415:
:               :           :   :...Age <= 0.3448276: F4 (5.5)
:               :           :       Age > 0.3448276: F2 (4/0.6)
:               :           ALT.12 > 0.06741573:
:               :           :...AST.1 <= 0.1011236:
:               :               :...Plat <= 0.7116845: F4 (4.5/0.7)
:               :               :   Plat > 0.7116845: F2 (2.1/0.4)
:               :               AST.1 > 0.1011236:
:               :               :...BMI <= 0.6153846:
:               :                   :...AST.1 <= 0.4719101: F1 (8.4/3.3)
:               :                   :   AST.1 > 0.4719101:
:               :                   :   :...Age <= 0.1034483: F4 (2.5/0.3)
:               :                   :       Age > 0.1034483:
:               :                   :       :...ALT.12 <= 0.3146068: F2 (8.8/1.5)
:               :                   :           ALT.12 > 0.3146068: F3 (2.5/0.4)
:               :                   BMI > 0.6153846:
:               :                   :...Plat > 0.8451791:
:               :                       :...RBC > 0.8593162: F1 (2.1)
:               :                       :   RBC <= 0.8593162:
:               :                       :   :...Age <= 0.06896552: F3 (3.6)
:               :                       :       Age > 0.06896552:
:               :                       :       :...WBC <= 0.5300769: F2 (5.3)
:               :                       :           WBC > 0.5300769: F3 (2.5)
:               :                       Plat <= 0.8451791:
:               :                       :...ALT.12 <= 0.1797753:
:               :                           :...ALT.4 <= 0.3483146: F1 (8.6/1.1)
:               :                           :   ALT.4 > 0.3483146:
:               :                           :   :...Plat <= 0.2042922: F4 (4.7)
:               :                           :       Plat > 0.2042922:
:               :                           :       :...ALT.12 <= 0.1011236: F4 (5/2.3)
:               :                           :           ALT.12 > 0.1011236: F1 (5/1.2)
:               :                           ALT.12 > 0.1797753:
:               :                           :...ALT.48 > 0.6179775:
:               :                               :...AST.1 <= 0.7977528: F1 (12.8)
:               :                               :   AST.1 > 0.7977528:
:               :                               :   :...Age <= 0.4827586: F1 (2.7)
:               :                               :       Age > 0.4827586: F3 (3.7)
:               :                               ALT.48 <= 0.6179775:
:               :                               :...BMI <= 0.6923077: F1 (4.4/2.1)
:               :                                   BMI > 0.6923077:
:               :                                   :...AST.1 > 0.8876405: F4 (2.6/0.4)
:               :                                       AST.1 <= 0.8876405:
:               :                                       :...Plat <= 0.4272729: [S1]
:               :                                           Plat > 0.4272729: [S2]
:               ALT.12 > 0.4269663:
:               :...ALT.4 > 0.9325843: F2 (10.2/1.4)
:                   ALT.4 <= 0.9325843:
:                   :...ALT.after.24.w > 0.5652174:
:                       :...AST.1 <= 0.1348315:
:                       :   :...ALT.48 <= 0.5168539: F1 (9.1)
:                       :   :   ALT.48 > 0.5168539: F3 (4.2/1.2)
:                       :   AST.1 > 0.1348315:
:                       :   :...BMI > 0.9230769:
:                       :       :...ALT.36 <= 0.7865168: F1 (4.5/2)
:                       :       :   ALT.36 > 0.7865168: F2 (3.7)
:                       :       BMI <= 0.9230769:
:                       :       :...AST.1 > 0.6292135:
:                       :           :...RNA.4 <= 0.7352223: F4 (14.5/2.3)
:                       :           :   RNA.4 > 0.7352223: F1 (6.7/1)
:                       :           AST.1 <= 0.6292135:
:                       :           :...ALT.24 > 0.8539326:
:                       :               :...ALT.4 <= 0.4269663: F3 (2.1)
:                       :               :   ALT.4 > 0.4269663: F4 (4.5)
:                       :               ALT.24 <= 0.8539326:
:                       :               :...RNA.Base > 0.7414416: F4 (9/2.4)
:                       :                   RNA.Base <= 0.7414416:
:                       :                   :...ALT.24 > 0.5505618: F2 (8.8)
:                       :                       ALT.24 <= 0.5505618:
:                       :                       :...ALT.24 > 0.3370787: F4 (7.3/2.4)
:                       :                           ALT.24 <= 0.3370787:
:                       :                           :...RBC <= 0.2715908: F4 (3.3)
:                       :                               RBC > 0.2715908: F2 (8.6/1.2)
:                       ALT.after.24.w <= 0.5652174:
:                       :...BMI > 0.9230769:
:                           :...RBC <= 0.1875362: F2 (3.3)
:                           :   RBC > 0.1875362:
:                           :   :...WBC <= 0.7847421: F1 (10.3/2.6)
:                           :       WBC > 0.7847421: F4 (6.5/0.5)
:                           BMI <= 0.9230769:
:                           :...ALT.24 > 0.6741573:
:                               :...ALT.1 > 0.8426966: F3 (3.7)
:                               :   ALT.1 <= 0.8426966:
:                               :   :...ALT.after.24.w <= 0.3478261:
:                               :       :...ALT.48 <= 0.2921348:
:                               :       :   :...Age <= 0.6206896: F3 (5.7/1)
:                               :       :   :   Age > 0.6206896: F2 (4/0.6)
:                               :       :   ALT.48 > 0.2921348:
:                               :       :   :...Plat <= 0.2626282: F2 (4.8/0.8)
:                               :       :       Plat > 0.2626282: F4 (11.6/2.4)
:                               :       ALT.after.24.w > 0.3478261:
:                               :       :...RBC > 0.3744802: F2 (9.7/0.6)
:                               :           RBC <= 0.3744802:
:                               :           :...RNA.Base <= 0.6028808: F3 (3/0.3)
:                               :               RNA.Base > 0.6028808: F2 (2.9)
:                               ALT.24 <= 0.6741573:
:                               :...ALT.4 > 0.6966292:
:                                   :...RNA.Base > 0.7967063: F2 (3)
:                                   :   RNA.Base <= 0.7967063:
:                                   :   :...ALT.after.24.w > 0.4347826: F2 (2.6/0.9)
:                                   :       ALT.after.24.w <= 0.4347826:
:                                   :       :...ALT.12 <= 0.5393258: F1 (3.5)
:                                   :           ALT.12 > 0.5393258: F3 (5.3/1.7)
:                                   ALT.4 <= 0.6966292:
:                                   :...ALT.12 <= 0.5280899:
:                                       :...RBC <= 0.9579428: F4 (6.5/0.8)
:                                       :   RBC > 0.9579428: F2 (2.2)
:                                       ALT.12 > 0.5280899:
:                                       :...ALT.12 <= 0.6179775: F3 (5.6)
:                                           ALT.12 > 0.6179775:
:                                           :...ALT.after.24.w > 0.4347826:
:                                               :...RBC <= 0.5191805: F4 (2.4)
:                                               :   RBC > 0.5191805: F1 (3.4/0.9)
:                                               ALT.after.24.w <= 0.4347826:
:                                               :...ALT.4 <= 0.08988764: F1 (2.3/0.8)
:                                                   ALT.4 > 0.08988764:
:                                                   :...AST.1 > 0.5280899:
:                                                       :...WBC <= 0.4117453: F2 (3.6/1.5)
:                                                       :   WBC > 0.4117453: F4 (3.4/0.1)
:                                                       AST.1 <= 0.5280899:
:                                                       :...Plat > 0.7514294: F2 (2.4)
:                                                           Plat <= 0.7514294: [S3]
BMI <= 0.5384616:
:...AST.1 > 0.9662921:
    :...Age <= 0.1724138: F4 (3.7/1.3)
    :   Age > 0.1724138:
    :   :...RBC <= 0.1682464: F3 (3)
    :       RBC > 0.1682464: F2 (7.3/1.8)
    AST.1 <= 0.9662921:
    :...ALT.24 > 0.9662921:
        :...ALT.48 <= 0.5842696: F4 (9.5/1.8)
        :   ALT.48 > 0.5842696: F1 (7.5/0.8)
        ALT.24 <= 0.9662921:
        :...ALT.48 > 0.9438202:
            :...RNA.Base <= 0.7217867:
            :   :...RNA.4 <= 0.1260837: F4 (3.8/1.7)
            :   :   RNA.4 > 0.1260837: F2 (12.9/1)
            :   RNA.Base > 0.7217867:
            :   :...ALT.48 > 0.988764: F3 (3)
            :       ALT.48 <= 0.988764:
            :       :...ALT.24 <= 0.1573034: F1 (2.6/1.3)
            :           ALT.24 > 0.1573034: F4 (5.8)
            ALT.48 <= 0.9438202:
            :...AST.1 <= 0.02247191:
                :...WBC <= 0.1493963: F3 (2.8/1.4)
                :   WBC > 0.1493963:
                :   :...RBC > 0.7443614: F1 (2.3/0.4)
                :       RBC <= 0.7443614:
                :       :...ALT.36 <= 0.7303371: F4 (10.7/1.9)
                :           ALT.36 > 0.7303371: F1 (3.9/0.6)
                AST.1 > 0.02247191:
                :...RNA.Base > 0.9278438:
                    :...Age > 0.8275862:
                    :   :...ALT.4 <= 0.6966292: F1 (2.8/0.8)
                    :   :   ALT.4 > 0.6966292: F4 (5.6/0.6)
                    :   Age <= 0.8275862:
                    :   :...RNA.4 <= 0.1535603: F1 (3.5)
                    :       RNA.4 > 0.1535603:
                    :       :...RNA.Base <= 0.9311683: F1 (3)
                    :           RNA.Base > 0.9311683:
                    :           :...Plat <= 0.2732014: F1 (5.5/1.9)
                    :               Plat > 0.2732014: F3 (15.1/3.9)
                    RNA.Base <= 0.9278438:
                    :...ALT.12 > 0.8876405:
                        :...BMI > 0.3846154:
                        :   :...AST.1 <= 0.741573: F3 (7)
                        :   :   AST.1 > 0.741573: F1 (2.3/0.3)
                        :   BMI <= 0.3846154:
                        :   :...ALT.48 <= 0.3707865:
                        :       :...BMI <= 0.1538462: F4 (6.8/1.6)
                        :       :   BMI > 0.1538462: F1 (4.4)
                        :       ALT.48 > 0.3707865:
                        :       :...Plat > 0.5267552:
                        :           :...Plat <= 0.7677125: F2 (5.4/1.7)
                        :           :   Plat > 0.7677125: F4 (5.8/1.7)
                        :           Plat <= 0.5267552:
                        :           :...ALT.36 <= 0.03370786: F4 (2)
                        :               ALT.36 > 0.03370786:
                        :               :...RNA.4 <= 0.2149778: F1 (2.1/0.6)
                        :                   RNA.4 > 0.2149778:
                        :                   :...RNA.4 <= 0.4249694: F3 (4.9)
                        :                       RNA.4 > 0.4249694:
                        :                       :...ALT.48 <= 0.4719101: F3 (4.5)
                        :                           ALT.48 > 0.4719101: F1 (3.5/0.6)
                        ALT.12 <= 0.8876405:
                        :...Age > 0.8275862:
                            :...WBC <= 0.0672887: F3 (7.7/1.8)
                            :   WBC > 0.0672887:
                            :   :...ALT.1 > 0.8202247:
                            :       :...ALT.24 > 0.741573: F4 (2.5)
                            :       :   ALT.24 <= 0.741573:
                            :       :   :...ALT.48 <= 0.2022472: F1 (2.4/0.8)
                            :       :       ALT.48 > 0.2022472: F3 (8.1/0.9)
                            :       ALT.1 <= 0.8202247:
                            :       :...RNA.4 > 0.9263691: F3 (4/0.7)
                            :           RNA.4 <= 0.9263691:
                            :           :...ALT.4 > 0.5168539:
                            :               :...ALT.12 <= 0.1235955: F2 (2.7/1)
                            :               :   ALT.12 > 0.1235955: F1 (19.2/3.9)
                            :               ALT.4 <= 0.5168539:
                            :               :...ALT.4 > 0.3370787: F2 (9.1/1.7)
                            :                   ALT.4 <= 0.3370787: [S4]
                            Age <= 0.8275862:
                            :...BMI <= 0.2307692:
                                :...Age > 0.4482759:
                                :   :...ALT.48 > 0.6741573:
                                :   :   :...RNA.Base <= 0.7440451: F2 (15.2/4.8)
                                :   :   :   RNA.Base > 0.7440451: F3 (3.6/1.1)
                                :   :   ALT.48 <= 0.6741573:
                                :   :   :...WBC <= 0.1259056: F1 (4.3/1.5)
                                :   :       WBC > 0.1259056:
                                :   :       :...RNA.4 > 0.9067978: F4 (6.5/0.4)
                                :   :           RNA.4 <= 0.9067978:
                                :   :           :...ALT.48 <= 0.2247191: F3 (9.1)
                                :   :               ALT.48 > 0.2247191:
                                :   :               :...ALT.24 <= 0.5393258: [S5]
                                :   :                   ALT.24 > 0.5393258: [S6]
                                :   Age <= 0.4482759:
                                :   :...Plat > 0.9235899: F2 (6.7/1.9)
                                :       Plat <= 0.9235899:
                                :       :...Plat > 0.769451:
                                :           :...Plat <= 0.8451791: F3 (5.3/0.6)
                                :           :   Plat > 0.8451791: F1 (9.3/1.4)
                                :           Plat <= 0.769451:
                                :           :...RBC <= 0.09161426: F2 (5.4/0.5)
                                :               RBC > 0.09161426:
                                :               :...ALT.36 <= 0.1235955:
                                :                   :...RNA.4 <= 0.3351882: F3 (4.2)
                                :                   :   RNA.4 > 0.3351882: F2 (5.4/1.6)
                                :                   ALT.36 > 0.1235955:
                                :                   :...BMI > 0.1538462:
                                :                       :...WBC <= 0.2250274: F3 (3.1/1.8)
                                :                       :   WBC > 0.2250274: F1 (12.9/2.3)
                                :                       BMI <= 0.1538462:
                                :                       :...Plat <= 0.478745: [S7]
                                :                           Plat > 0.478745:
                                :                           :...BMI <= 0.07692308: [S8]
                                :                               BMI > 0.07692308: [S9]
                                BMI > 0.2307692:
                                :...ALT.after.24.w <= 0.2608696:
                                    :...ALT.24 > 0.8539326: F2 (6/0.4)
                                    :   ALT.24 <= 0.8539326:
                                    :   :...WBC > 0.9610319: F2 (3.8)
                                    :       WBC <= 0.9610319:
                                    :       :...ALT.after.24.w <= 0: F3 (2.6/0.3)
                                    :           ALT.after.24.w > 0:
                                    :           :...ALT.4 > 0.9213483: F3 (3.6/1.1)
                                    :               ALT.4 <= 0.9213483:
                                    :               :...Plat > 0.6930709: F4 (13.3/1)
                                    :                   Plat <= 0.6930709: [S10]
                                    ALT.after.24.w > 0.2608696:
                                    :...ALT.4 <= 0.1235955:
                                        :...RNA.Base <= 0.2562629: F1 (3.5/0.8)
                                        :   RNA.Base > 0.2562629: F3 (6.8/0.6)
                                        ALT.4 > 0.1235955:
                                        :...RNA.4 <= 0.04328915:
                                            :...ALT.12 <= 0.4606742: F1 (4.9)
                                            :   ALT.12 > 0.4606742: F2 (3.6/0.4)
                                            RNA.4 > 0.04328915:
                                            :...WBC <= 0.01317234: F2 (3.6)
                                                WBC > 0.01317234:
                                                :...AST.1 <= 0.05617978:
                                                    :...ALT.1 <= 0.5280899: F2 (5.1)
                                                    :   ALT.1 > 0.5280899: F3 (3.1/1.3)
                                                    AST.1 > 0.05617978:
                                                    :...ALT.48 > 0.8876405:
                                                        :...RBC <= 0.4879217: F3 (3.8/0.6)
                                                        :   RBC > 0.4879217: F1 (3.8)
                                                        ALT.48 <= 0.8876405:
                                                        :...Plat > 0.8375658: F1 (8.7/3)
                                                            Plat <= 0.8375658:
                                                            :...ALT.1 <= 0.258427: [S11]
                                                                ALT.1 > 0.258427:
                                                                :...Age <= 0.4137931: [S12]
                                                                    Age > 0.4137931: [S13]

SubTree [S1]

AST.1 <= 0.4831461: F3 (4.8/0.9)
AST.1 > 0.4831461: F2 (5.1/0.8)

SubTree [S2]

ALT.after.24.w <= 0.4347826: F3 (4.8/1)
ALT.after.24.w > 0.4347826: F1 (7.2/2)

SubTree [S3]

ALT.24 <= 0.3483146: F3 (4.8)
ALT.24 > 0.3483146: F2 (3/0.7)

SubTree [S4]

ALT.after.24.w > 0.7391304: F1 (4.9/2.1)
ALT.after.24.w <= 0.7391304:
:...Plat <= 0.8184652: F4 (7.4/0.2)
    Plat > 0.8184652: F1 (2.3/0.3)

SubTree [S5]

RNA.4 <= 0.373249: F4 (4.9/1.1)
RNA.4 > 0.373249: F3 (7.5)

SubTree [S6]

ALT.1 <= 0.494382: F4 (6.9/0.9)
ALT.1 > 0.494382: F2 (3)

SubTree [S7]

ALT.24 <= 0.5505618: F1 (10.9/2.6)
ALT.24 > 0.5505618:
:...RNA.4 <= 0.524624: F4 (4.4)
    RNA.4 > 0.524624: F2 (3.3/1.3)

SubTree [S8]

ALT.1 <= 0.5393258: F3 (5.9/0.7)
ALT.1 > 0.5393258: F4 (2.3)

SubTree [S9]

RNA.4 <= 0.4438475: F2 (4.5/1.7)
RNA.4 > 0.4438475: F4 (3.2)

SubTree [S10]

ALT.1 <= 0.3820225: F4 (10.9/2.5)
ALT.1 > 0.3820225: F2 (7.2/2)

SubTree [S11]

BMI > 0.4615385: F3 (2.5/0.7)
BMI <= 0.4615385:
:...ALT.after.24.w <= 0.4347826: F4 (4.7)
    ALT.after.24.w > 0.4347826:
    :...ALT.36 <= 0.4494382: F4 (4.6)
        ALT.36 > 0.4494382: F3 (8.4/0.8)

SubTree [S12]

Age > 0.2413793: F2 (10.4/3.1)
Age <= 0.2413793:
:...AST.1 <= 0.7752809: F4 (12.1/2.4)
    AST.1 > 0.7752809: F1 (4.2/1.3)

SubTree [S13]

ALT.48 <= 0.1573034:
:...Age <= 0.5862069: F4 (3/0.8)
:   Age > 0.5862069: F3 (4/0.5)
ALT.48 > 0.1573034:
:...AST.1 <= 0.4719101: F1 (3.3/0.6)
    AST.1 > 0.4719101: F4 (14.1/3.1)

-----  Trial 15:  -----

Decision tree:

BMI <= 0.5384616:
:...ALT.12 > 0.9325843:
:   :...ALT.24 <= 0.1123596: F1 (3.3/0.3)
:   :   ALT.24 > 0.1123596:
:   :   :...ALT.after.24.w > 0.5217391:
:   :       :...ALT.24 <= 0.6629214: F4 (9.9/2.2)
:   :       :   ALT.24 > 0.6629214: F3 (5.9/0.9)
:   :       ALT.after.24.w <= 0.5217391:
:   :       :...ALT.12 > 0.9775281: F3 (4.5/3)
:   :           ALT.12 <= 0.9775281:
:   :           :...ALT.24 <= 0.6741573: F3 (10.2/1.6)
:   :               ALT.24 > 0.6741573: F1 (2.5)
:   ALT.12 <= 0.9325843:
:   :...AST.1 > 0.7640449:
:       :...RNA.Base > 0.9233087: F3 (6)
:       :   RNA.Base <= 0.9233087:
:       :   :...ALT.1 <= 0.05617978:
:       :       :...RBC <= 0.6272686: F3 (4.1)
:       :       :   RBC > 0.6272686: F1 (2.4)
:       :       ALT.1 > 0.05617978:
:       :       :...ALT.48 > 0.4719101:
:       :           :...RNA.4 <= 0.831099:
:       :           :   :...RBC <= 0.4102663:
:       :           :   :   :...ALT.48 <= 0.9101124: F3 (12/2.7)
:       :           :   :   :   ALT.48 > 0.9101124: F2 (3.8)
:       :           :   :   RBC > 0.4102663:
:       :           :   :   :...Plat <= 0.9670366: F2 (21/4.5)
:       :           :   :       Plat > 0.9670366: F4 (2.1/0.7)
:       :           :   RNA.4 > 0.831099:
:       :           :   :...WBC > 0.6020856: F3 (2.3)
:       :           :       WBC <= 0.6020856:
:       :           :       :...ALT.1 <= 0.4719101: F4 (2)
:       :           :           ALT.1 > 0.4719101: F1 (4.8)
:       :           ALT.48 <= 0.4719101:
:       :           :...WBC > 0.7139407:
:       :               :...RBC <= 0.2597441: F3 (2.4/0.9)
:       :               :   RBC > 0.2597441: F4 (12.2/0.6)
:       :               WBC <= 0.7139407:
:       :               :...ALT.36 > 0.7977528: F3 (5/1.2)
:       :                   ALT.36 <= 0.7977528:
:       :                   :...BMI <= 0: F1 (2.8)
:       :                       BMI > 0:
:       :                       :...ALT.24 <= 0.4269663:
:       :                           :...Plat <= 0.4799589: F2 (5.6/1.1)
:       :                           :   Plat > 0.4799589: F1 (4.8/0.8)
:       :                           ALT.24 > 0.4269663:
:       :                           :...ALT.4 <= 0.5393258: F2 (7.6/1.3)
:       :                               ALT.4 > 0.5393258: F4 (6/0.8)
:       AST.1 <= 0.7640449:
:       :...ALT.36 > 0.9213483:
:           :...ALT.36 <= 0.9325843: F2 (5.8/1.2)
:           :   ALT.36 > 0.9325843:
:           :   :...ALT.24 <= 0.3707865:
:           :       :...AST.1 <= 0.4831461: F1 (5.2/0.9)
:           :       :   AST.1 > 0.4831461: F2 (2.6/0.3)
:           :       ALT.24 > 0.3707865:
:           :       :...ALT.1 <= 0.3033708: F1 (6.6/1.8)
:           :           ALT.1 > 0.3033708:
:           :           :...ALT.after.24.w <= 0.5217391: F1 (5/1.7)
:           :               ALT.after.24.w > 0.5217391: F4 (5.1/0.3)
:           ALT.36 <= 0.9213483:
:           :...WBC <= 0.1086718:
:               :...ALT.after.24.w <= 0.173913: F2 (8.6/1.3)
:               :   ALT.after.24.w > 0.173913:
:               :   :...ALT.12 <= 0.1235955: F2 (3.8)
:               :       ALT.12 > 0.1235955:
:               :       :...RNA.4 > 0.7847043:
:               :           :...ALT.12 <= 0.7640449: F2 (6.4/1.4)
:               :           :   ALT.12 > 0.7640449: F3 (2.4/0.6)
:               :           RNA.4 <= 0.7847043:
:               :           :...Age <= 0.3448276:
:               :               :...ALT.24 <= 0.6179775: F4 (7.2/1)
:               :               :   ALT.24 > 0.6179775: F1 (4.1/1)
:               :               Age > 0.3448276:
:               :               :...ALT.4 <= 0.5505618: F3 (11.4)
:               :                   ALT.4 > 0.5505618: F1 (3.3/0.6)
:               WBC > 0.1086718:
:               :...AST.1 <= 0.02247191:
:                   :...ALT.after.24.w <= 0.1304348: F1 (3.8/1.2)
:                   :   ALT.after.24.w > 0.1304348:
:                   :   :...RNA.Base <= 0.04202569: F1 (2.6)
:                   :       RNA.Base > 0.04202569: F4 (11.2/2.1)
:                   AST.1 > 0.02247191:
:                   :...ALT.24 <= 0.04494382:
:                       :...RNA.Base <= 0.7967063:
:                       :   :...ALT.12 <= 0.6179775: F4 (4.1/0.9)
:                       :   :   ALT.12 > 0.6179775: F3 (2.4/0.5)
:                       :   RNA.Base > 0.7967063:
:                       :   :...RNA.Base <= 0.9266616: F3 (8.3/0.9)
:                       :       RNA.Base > 0.9266616: F1 (2)
:                       ALT.24 > 0.04494382:
:                       :...RBC > 0.8862565:
:                           :...RNA.Base <= 0.1472947: F3 (5.2/1)
:                           :   RNA.Base > 0.1472947:
:                           :   :...ALT.36 > 0.494382:
:                           :       :...ALT.48 <= 0.4157303: F3 (4.3/1.4)
:                           :       :   ALT.48 > 0.4157303: F2 (4.5)
:                           :       ALT.36 <= 0.494382:
:                           :       :...ALT.4 > 0.6179775: F4 (2)
:                           :           ALT.4 <= 0.6179775:
:                           :           :...WBC <= 0.3274424: F1 (2.4)
:                           :               WBC > 0.3274424: F2 (4.2/0.8)
:                           RBC <= 0.8862565:
:                           :...BMI <= 0.3076923:
:                               :...Age > 0.862069:
:                               :   :...WBC > 0.7708013: F4 (5.9)
:                               :   :   WBC <= 0.7708013:
:                               :   :   :...ALT.24 <= 0.2921348: F2 (2)
:                               :   :       ALT.24 > 0.2921348:
:                               :   :       :...ALT.4 <= 0.4719101: F4 (4/1)
:                               :   :           ALT.4 > 0.4719101: F1 (4.9)
:                               :   Age <= 0.862069:
:                               :   :...Age <= 0.137931:
:                               :       :...RNA.Base <= 0.05632871: F3 (2.8)
:                               :       :   RNA.Base > 0.05632871:
:                               :       :   :...Age <= 0.06896552:
:                               :       :       :...BMI <= 0.1538462: F4 (9.6/1.6)
:                               :       :       :   BMI > 0.1538462: F1 (7/1.9)
:                               :       :       Age > 0.06896552:
:                               :       :       :...ALT.24 <= 0.6067415: F3 (2.7/0.7)
:                               :       :           ALT.24 > 0.6067415: F1 (6.7/1.3)
:                               :       Age > 0.137931:
:                               :       :...ALT.1 <= 0.4382023:
:                               :           :...Plat <= 0.1579456:
:                               :           :   :...ALT.24 <= 0.4719101: F2 (2.2)
:                               :           :   :   ALT.24 > 0.4719101: [S1]
:                               :           :   Plat > 0.1579456:
:                               :           :   :...ALT.after.24.w > 0.7826087:
:                               :           :       :...ALT.1 <= 0.1685393: F3 (3.8/0.5)
:                               :           :       :   ALT.1 > 0.1685393: [S2]
:                               :           :       ALT.after.24.w <= 0.7826087: [S3]
:                               :           ALT.1 > 0.4382023:
:                               :           :...Plat <= 0.2414594:
:                               :               :...ALT.12 <= 0.6741573: F4 (10.7/1.9)
:                               :               :   ALT.12 > 0.6741573: F2 (3.6/0.9)
:                               :               Plat > 0.2414594:
:                               :               :...ALT.after.24.w <= 0.173913:
:                               :                   :...AST.1 > 0.6067415: F1 (3.9)
:                               :                   :   AST.1 <= 0.6067415: [S4]
:                               :                   ALT.after.24.w > 0.173913:
:                               :                   :...ALT.12 > 0.5842696: F3 (7/1)
:                               :                       ALT.12 <= 0.5842696:
:                               :                       :...Age > 0.7241379: F3 (4.9/1.1)
:                               :                           Age <= 0.7241379: [S5]
:                               BMI > 0.3076923:
:                               :...RNA.Base <= 0.06876256: F2 (6.9/1.9)
:                                   RNA.Base > 0.06876256:
:                                   :...ALT.24 > 0.6629214:
:                                       :...ALT.1 <= 0.4157303:
:                                       :   :...Age > 0.862069: F3 (3.4/0.9)
:                                       :   :   Age <= 0.862069:
:                                       :   :   :...ALT.48 > 0.741573: F4 (2.3)
:                                       :   :       ALT.48 <= 0.741573:
:                                       :   :       :...ALT.12 <= 0.1235955: F4 (2.3/0.8)
:                                       :   :           ALT.12 > 0.1235955: F2 (10.2)
:                                       :   ALT.1 > 0.4157303:
:                                       :   :...ALT.after.24.w <= 0.3478261: F4 (7.3/1.5)
:                                       :       ALT.after.24.w > 0.3478261:
:                                       :       :...ALT.48 <= 0.3595506: F1 (6.2)
:                                       :           ALT.48 > 0.3595506:
:                                       :           :...ALT.48 <= 0.8651685: F4 (6.5/0.9)
:                                       :               ALT.48 > 0.8651685: F1 (2.3)
:                                       ALT.24 <= 0.6629214:
:                                       :...ALT.1 > 0.6516854:
:                                           :...ALT.36 <= 0.08988764: F4 (2.2/0.3)
:                                           :   ALT.36 > 0.08988764:
:                                           :   :...BMI > 0.4615385: F3 (5.9/0.3)
:                                           :       BMI <= 0.4615385:
:                                           :       :...Age <= 0.3793103: F3 (3.3)
:                                           :           Age > 0.3793103: F1 (5.7/1.2)
:                                           ALT.1 <= 0.6516854:
:                                           :...Plat <= 0.1329252:
:                                               :...ALT.4 <= 0.752809: F4 (3.1/1.2)
:                                               :   ALT.4 > 0.752809: F3 (7.6)
:                                               Plat > 0.1329252:
:                                               :...ALT.12 <= 0.1685393: F4 (6.4/0.9)
:                                                   ALT.12 > 0.1685393:
:                                                   :...Plat <= 0.5898195:
:                                                       :...BMI <= 0.3846154: [S6]
:                                                       :   BMI > 0.3846154: [S7]
:                                                       Plat > 0.5898195:
:                                                       :...BMI > 0.4615385: F3 (2)
:                                                           BMI <= 0.4615385: [S8]
BMI > 0.5384616:
:...ALT.after.24.w > 0.9130435:
    :...BMI > 0.9230769: F2 (3.6)
    :   BMI <= 0.9230769:
    :   :...AST.1 <= 0.2247191: F1 (6.6/1.9)
    :       AST.1 > 0.2247191:
    :       :...ALT.48 <= 0.4719101: F3 (8.5)
    :           ALT.48 > 0.4719101:
    :           :...ALT.after.24.w <= 0.9565217: F3 (5.4/2.2)
    :               ALT.after.24.w > 0.9565217:
    :               :...WBC <= 0.2090011: F2 (3.1/1.1)
    :                   WBC > 0.2090011: F4 (5/2.4)
    ALT.after.24.w <= 0.9130435:
    :...ALT.after.24.w > 0.8260869:
        :...ALT.4 <= 0.3370787:
        :   :...ALT.1 > 0.8314607: F2 (2.1/0.4)
        :   :   ALT.1 <= 0.8314607:
        :   :   :...ALT.48 <= 0.3146068: F1 (4.7/1.7)
        :   :       ALT.48 > 0.3146068: F4 (10.6/0.3)
        :   ALT.4 > 0.3370787:
        :   :...RNA.4 > 0.9194365: F3 (2.9)
        :       RNA.4 <= 0.9194365:
        :       :...ALT.1 <= 0.2808989: F1 (6.6/0.5)
        :           ALT.1 > 0.2808989:
        :           :...ALT.after.24.w <= 0.8695652:
        :               :...ALT.24 <= 0.3595506: F2 (2.4)
        :               :   ALT.24 > 0.3595506: F4 (4.4/1.4)
        :               ALT.after.24.w > 0.8695652:
        :               :...RBC <= 0.3201445: F1 (3.1/0.6)
        :                   RBC > 0.3201445: F3 (3.5/1.6)
        ALT.after.24.w <= 0.8260869:
        :...ALT.after.24.w <= 0.04347826:
            :...ALT.4 <= 0.2134831: F1 (6.8/2.9)
            :   ALT.4 > 0.2134831:
            :   :...Plat <= 0.2486081:
            :       :...ALT.36 <= 0.2359551: F1 (3.4/1)
            :       :   ALT.36 > 0.2359551:
            :       :   :...WBC <= 0.5443469: F4 (4.3/1.3)
            :       :       WBC > 0.5443469: F2 (3.4/0.4)
            :       Plat > 0.2486081:
            :       :...WBC <= 0.7568606: F3 (15.2/1)
            :           WBC > 0.7568606:
            :           :...Age <= 0.3103448: F2 (3)
            :               Age > 0.3103448: F3 (4.3/2)
            ALT.after.24.w > 0.04347826:
            :...Plat > 0.9565158:
                :...RNA.Base <= 0.0862186: F4 (4.6/1)
                :   RNA.Base > 0.0862186: F2 (6.4)
                Plat <= 0.9565158:
                :...ALT.1 <= 0.1797753:
                    :...ALT.1 <= 0.03370786: F2 (7.4/1.5)
                    :   ALT.1 > 0.03370786:
                    :   :...RNA.Base > 0.3271777:
                    :       :...ALT.12 <= 0.5393258:
                    :       :   :...RBC <= 0.8901707: F3 (10/5.1)
                    :       :   :   RBC > 0.8901707: F1 (4.5/0.9)
                    :       :   ALT.12 > 0.5393258:
                    :       :   :...Plat <= 0.5656908: F2 (7.3/0.5)
                    :       :       Plat > 0.5656908: F1 (2.1)
                    :       RNA.Base <= 0.3271777:
                    :       :...BMI > 0.7692308: F3 (3/0.6)
                    :           BMI <= 0.7692308:
                    :           :...Age > 0.6551724: F1 (5.1)
                    :               Age <= 0.6551724:
                    :               :...ALT.12 <= 0.2134831: F1 (3)
                    :                   ALT.12 > 0.2134831: F3 (5.3)
                    ALT.1 > 0.1797753:
                    :...AST.1 <= 0.08988764:
                        :...WBC > 0.5781559:
                        :   :...ALT.24 <= 0.752809: F2 (4.7/1.1)
                        :   :   ALT.24 > 0.752809: F3 (4)
                        :   WBC <= 0.5781559:
                        :   :...BMI <= 0.8461539: F4 (5.7/1.1)
                        :       BMI > 0.8461539:
                        :       :...WBC <= 0.456202: F2 (4.2/0.6)
                        :           WBC > 0.456202: F4 (3.1)
                        AST.1 > 0.08988764:
                        :...ALT.24 <= 0.3258427:
                            :...WBC > 0.9160264:
                            :   :...ALT.12 <= 0.258427: F4 (2.5/0.6)
                            :   :   ALT.12 > 0.258427: F2 (4.9/0.4)
                            :   WBC <= 0.9160264:
                            :   :...Age > 0.7931035:
                            :       :...ALT.12 <= 0.5280899: F1 (6.4/0.9)
                            :       :   ALT.12 > 0.5280899: F3 (6.1/1.3)
                            :       Age <= 0.7931035:
                            :       :...ALT.36 <= 0.07865169:
                            :           :...WBC <= 0.3384193: F2 (3.4)
                            :           :   WBC > 0.3384193: F4 (3.8)
                            :           ALT.36 > 0.07865169:
                            :           :...AST.1 > 0.6292135:
                            :               :...ALT.36 <= 0.2696629: F1 (3.4/0.7)
                            :               :   ALT.36 > 0.2696629: F4 (15.2/3.3)
                            :               AST.1 <= 0.6292135:
                            :               :...ALT.after.24.w > 0.6521739:
                            :                   :...RNA.4 <= 0.07378402: F2 (2.2)
                            :                   :   RNA.4 > 0.07378402: F4 (4.8/1.1)
                            :                   ALT.after.24.w <= 0.6521739:
                            :                   :...ALT.24 > 0.247191: F3 (3.1)
                            :                       ALT.24 <= 0.247191:
                            :                       :...ALT.24 <= 0.2022472: F1 (17.8/6.8)
                            :                           ALT.24 > 0.2022472: [S9]
                            ALT.24 > 0.3258427:
                            :...ALT.4 <= 0.07865169:
                                :...RBC <= 0.820986: F1 (10/2.2)
                                :   RBC > 0.820986: F3 (3.7/1.2)
                                ALT.4 > 0.07865169:
                                :...RNA.Base <= 0.1169985:
                                    :...WBC > 0.8243688: F1 (3.3)
                                    :   WBC <= 0.8243688:
                                    :   :...ALT.after.24.w > 0.4782609: F2 (8.7)
                                    :       ALT.after.24.w <= 0.4782609:
                                    :       :...RNA.Base <= 0.0426751: F2 (3.3/0.7)
                                    :           RNA.Base > 0.0426751: F1 (2.7)
                                    RNA.Base > 0.1169985:
                                    :...ALT.1 <= 0.2808989:
                                        :...Age <= 0.6551724: F4 (4/1.5)
                                        :   Age > 0.6551724: F3 (4.7)
                                        ALT.1 > 0.2808989:
                                        :...RNA.Base <= 0.2014179:
                                            :...ALT.24 <= 0.5617977: F4 (2.2/0.7)
                                            :   ALT.24 > 0.5617977: F3 (8/1.8)
                                            RNA.Base > 0.2014179:
                                            :...RBC > 0.9284534: F4 (5.2/0.9)
                                                RBC <= 0.9284534:
                                                :...ALT.1 <= 0.4382023:
                                                    :...BMI > 0.9230769: F1 (2.7/1.3)
                                                    :   BMI <= 0.9230769:
                                                    :   :...WBC <= 0.1587267: F4 (3/0.9)
                                                    :       WBC > 0.1587267: [S10]
                                                    ALT.1 > 0.4382023:
                                                    :...ALT.12 <= 0.4719101: [S11]
                                                        ALT.12 > 0.4719101: [S12]

SubTree [S1]

ALT.after.24.w <= 0.3478261: F3 (4.3)
ALT.after.24.w > 0.3478261: F1 (4.6/1.4)

SubTree [S2]

ALT.12 <= 0.494382: F4 (2.1)
ALT.12 > 0.494382: F1 (5.5/0.4)

SubTree [S3]

ALT.after.24.w <= 0.2608696: F4 (12.5/2.7)
ALT.after.24.w > 0.2608696:
:...RBC <= 0.4437039: F4 (7.7)
    RBC > 0.4437039:
    :...Age <= 0.4827586: F3 (6/0.6)
        Age > 0.4827586:
        :...ALT.48 <= 0.4157303: F4 (5.5)
            ALT.48 > 0.4157303: F3 (4.1/1.4)

SubTree [S4]

RNA.4 <= 0.4994316: F2 (5.7)
RNA.4 > 0.4994316: F3 (2.8/0.5)

SubTree [S5]

ALT.12 > 0.494382: F2 (4.2)
ALT.12 <= 0.494382:
:...RNA.Base <= 0.2462527: F2 (2.1/0.6)
    RNA.Base > 0.2462527: F4 (11.9/3)

SubTree [S6]

Plat <= 0.3474534: F4 (3.1/0.5)
Plat > 0.3474534: F2 (2.9)

SubTree [S7]

Age <= 0.3793103: F2 (2.9/1.2)
Age > 0.3793103: F1 (7/0.6)

SubTree [S8]

Plat > 0.8046474: F1 (7.9)
Plat <= 0.8046474:
:...ALT.24 <= 0.1910112: F1 (2.5)
    ALT.24 > 0.1910112: F4 (4.7/1.4)

SubTree [S9]

AST.1 <= 0.505618: F4 (3.6/1.6)
AST.1 > 0.505618: F2 (2.2)

SubTree [S10]

RNA.4 <= 0.3106714: F4 (3.7/1)
RNA.4 > 0.3106714: F2 (17.6/0.7)

SubTree [S11]

AST.1 > 0.6404495: F2 (6.5/2.2)
AST.1 <= 0.6404495:
:...ALT.36 > 0.4044944: F1 (11.1/0.9)
    ALT.36 <= 0.4044944:
    :...WBC > 0.584303: F1 (3.4)
        WBC <= 0.584303:
        :...ALT.1 > 0.9662921: F4 (2.3)
            ALT.1 <= 0.9662921:
            :...ALT.4 <= 0.6179775: F3 (4.2)
                ALT.4 > 0.6179775: F2 (2.3)

SubTree [S12]

ALT.4 > 0.7640449: F2 (9.7/0.7)
ALT.4 <= 0.7640449:
:...ALT.36 > 0.8314607: F2 (3)
    ALT.36 <= 0.8314607:
    :...ALT.48 > 0.8202247: F2 (4.8/1.6)
        ALT.48 <= 0.8202247:
        :...RNA.Base > 0.7414416: F4 (4.5/0.2)
            RNA.Base <= 0.7414416:
            :...ALT.after.24.w <= 0.1304348: F4 (2.1/0.5)
                ALT.after.24.w > 0.1304348: F3 (5.8)


Evaluation on training data (968 cases):

Trial       Decision Tree   
-----     ----------------  
      Size      Errors  

   0       229  106(11.0%)
   1       152  244(25.2%)
   2       158  256(26.4%)
   3       163  246(25.4%)
   4       174  213(22.0%)
   5       171  210(21.7%)
   6       177  227(23.5%)
   7       179  221(22.8%)
   8       173  221(22.8%)
   9       179  211(21.8%)
  10       170  216(22.3%)
  11       174  208(21.5%)
  12       180  219(22.6%)
  13       181  191(19.7%)
  14       172  225(23.2%)
  15       184  204(21.1%)
boost             0( 0.0%)   <<


       (a)   (b)   (c)   (d)    <-classified as
      ----  ----  ----  ----
       235                      (a): class F1
             232                (b): class F2
                   249          (c): class F3
                         252    (d): class F4


    Attribute usage:

    100.00% Age
    100.00% BMI
    100.00% WBC
    100.00% Plat
    100.00% AST.1
    100.00% ALT.1
    100.00% ALT.4
    100.00% ALT.12
    100.00% ALT.24
    100.00% ALT.36
    100.00% ALT.48
    100.00% ALT.after.24.w
    100.00% RNA.4
     99.90% RBC
     99.79% RNA.Base


Time: 0.5 secs
ggplot(modelo_C5.0, highlight = TRUE) +
  labs(title = "Evolución del accuracy del modelo") +
  theme_bw()

# Predicciones
predicciones_C5.0 <- predict(modelo_C5.0, newdata = data_tt,
                             type = "raw")


# Evaluación
conf_mat_C5.0 <- caret::confusionMatrix(factor(predicciones_C5.0), factor(data_tt$BH.staging))
conf_mat_C5.0
Confusion Matrix and Statistics

          Reference
Prediction F1 F2 F3 F4
        F1 23 26 29 25
        F2 27 23 24 24
        F3 27 23 36 25
        F4 23 27 17 34

Overall Statistics
                                         
               Accuracy : 0.2809         
                 95% CI : (0.238, 0.3269)
    No Information Rate : 0.2615         
    P-Value [Acc > NIR] : 0.1998         
                                         
                  Kappa : 0.0409         
                                         
 Mcnemar's Test P-Value : 0.9291         

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity            0.23000   0.23232   0.33962   0.31481
Specificity            0.74441   0.76115   0.75570   0.78033
Pos Pred Value         0.22330   0.23469   0.32432   0.33663
Neg Pred Value         0.75161   0.75873   0.76821   0.76282
Prevalence             0.24213   0.23971   0.25666   0.26150
Detection Rate         0.05569   0.05569   0.08717   0.08232
Detection Prevalence   0.24939   0.23729   0.26877   0.24455
Balanced Accuracy      0.48720   0.49673   0.54766   0.54757
stats_class_C5.0 <- data.frame(model         = "C5.0",
   precision = conf_mat_C5.0$overall["Accuracy"],
  FN = conf_mat_C5.0$table[2,1],
  FP = conf_mat_C5.0$table[1,2],
  error.rate = 1 - conf_mat_C5.0$overall["Accuracy"],
  kappa = conf_mat_C5.0$overall["Kappa"],
  sensibilidad = mean(conf_mat_C5.0$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_C5.0$byClass[,"Specificity"]),
  precisión = mean(conf_mat_C5.0$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_C5.0$byClass[,"Recall"]),
  f.medida = mean(conf_mat_C5.0$byClass[,"F1"])
)
stats_class_C5.0
         model precision FN FP error.rate     kappa sensibilidad especificidad
Accuracy  C5.0 0.2808717 27 26  0.7191283 0.0409092    0.2791902     0.7603959
         precisión recuperación  f.medida
Accuracy 0.2797382    0.2791902 0.2793149

2.9 Modelo Decision tree J48 (J48)

Generamos el modelo J48.

# se recurre a validación cruzada repetida como método de validación.
# Número de particiones y repeticiones
particiones  <- 10
repeticiones <- 10

hiperparametros <- expand.grid(C = c(0.5),
                               M = c(5:15))

set.seed(123)
seeds <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seeds[[i]] <- sample.int(1000, nrow(hiperparametros))
}
seeds[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)


# DEFINICIÓN DEL ENTRENAMIENTO
control_train <- trainControl(method = "repeatedcv", number = particiones,
                              repeats = repeticiones, seeds = seeds,
                              returnResamp = "final", verboseIter = FALSE,
                              allowParallel = TRUE)

# AJUSTE DEL MODELO
library(RWeka)
set.seed(342)
modelo_J48 <- caret::train(BH.staging ~ ., data = data_tn,
                    method = "J48",
                    tuneGrid = hiperparametros,
                    metric = "Accuracy",
                    trControl = control_train)
modelo_J48
C4.5-like Trees 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (10 fold, repeated 10 times) 
Summary of sample sizes: 871, 871, 870, 873, 872, 870, ... 
Resampling results across tuning parameters:

  M   Accuracy   Kappa       
   5  0.2439154  -0.008678054
   6  0.2463020  -0.005472526
   7  0.2444751  -0.008009420
   8  0.2425773  -0.010664342
   9  0.2439496  -0.008704486
  10  0.2404315  -0.013540724
  11  0.2473832  -0.004165628
  12  0.2378972  -0.016741267
  13  0.2438370  -0.009149122
  14  0.2464308  -0.005621152
  15  0.2484850  -0.002877747

Tuning parameter 'C' was held constant at a value of 0.5
Accuracy was used to select the optimal model using the largest value.
The final values used for the model were C = 0.5 and M = 15.
summary(modelo_J48$finalModel)

=== Summary ===

Correctly Classified Instances         479               49.4835 %
Incorrectly Classified Instances       489               50.5165 %
Kappa statistic                          0.3264
Mean absolute error                      0.3113
Root mean squared error                  0.3945
Relative absolute error                 83.0527 %
Root relative squared error             91.1333 %
Total Number of Instances              968     

=== Confusion Matrix ===

   a   b   c   d   <-- classified as
 101  48  45  41 |   a = F1
  25 121  49  37 |   b = F2
  44  45 133  27 |   c = F3
  52  42  34 124 |   d = F4
ggplot(data = modelo_J48, highlight = TRUE) +
  labs(title = "Evolución del accuracy del modelo J48") +
  theme_bw()

# Predicciones
predicciones_J48 <- predict(modelo_J48, newdata = data_tt,  type = "raw")

# Evaluación
conf_mat_J48 <- caret::confusionMatrix(factor(predicciones_J48, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)
conf_mat_J48
Confusion Matrix and Statistics

          Reference
Prediction F1 F2 F3 F4
        F1 30 26 35 20
        F2 22 26 25 32
        F3 27 21 25 24
        F4 21 26 21 32

Overall Statistics
                                          
               Accuracy : 0.2736          
                 95% CI : (0.2312, 0.3193)
    No Information Rate : 0.2615          
    P-Value [Acc > NIR] : 0.3049          
                                          
                  Kappa : 0.032           
                                          
 Mcnemar's Test P-Value : 0.8619          

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity            0.30000   0.26263   0.23585   0.29630
Specificity            0.74121   0.74841   0.76547   0.77705
Pos Pred Value         0.27027   0.24762   0.25773   0.32000
Neg Pred Value         0.76821   0.76299   0.74367   0.75719
Prevalence             0.24213   0.23971   0.25666   0.26150
Detection Rate         0.07264   0.06295   0.06053   0.07748
Detection Prevalence   0.26877   0.25424   0.23487   0.24213
Balanced Accuracy      0.52061   0.50552   0.50066   0.53667
stats_class_J48 <- data.frame(model = "J48",
  precision = conf_mat_J48$overall["Accuracy"],
  FN = conf_mat_J48$table[2,1],
  FP = conf_mat_J48$table[1,2],
  error.rate = 1 - conf_mat_J48$overall["Accuracy"],
  kappa = conf_mat_J48$overall["Kappa"],
  sensibilidad = mean(conf_mat_J48$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_J48$byClass[,"Specificity"]),
  precisión = mean(conf_mat_J48$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_J48$byClass[,"Recall"]),
  f.medida = mean(conf_mat_J48$byClass[,"F1"])
)
stats_class_J48
         model precision FN FP error.rate      kappa sensibilidad especificidad
Accuracy   J48 0.2736077 22 26  0.7263923 0.03197075    0.2736929     0.7580358
         precisión recuperación f.medida
Accuracy 0.2739053    0.2736929 0.273315

2.10 Modelo Random forest (RF)

Generamos el modelo RF.

# se recurre a validación cruzada repetida como método de validación.
# Número de particiones y repeticiones
library(ranger)
particiones  <- 10
repeticiones <- 10


hiperparametros <- expand.grid(mtry = c(1:20),
                               min.node.size = c(4, 5, 10, 20),
                               splitrule = c("gini"))


set.seed(123)
seeds <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seeds[[i]] <- sample.int(1000, nrow(hiperparametros)) 
}
seeds[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)


# DEFINICIÓN DEL ENTRENAMIENTO
control_train <- trainControl(method = "repeatedcv", number = particiones,
                              repeats = repeticiones, seeds = seeds,
                              returnResamp = "final", verboseIter = FALSE,
                              allowParallel = TRUE)

# AJUSTE DEL MODELO 
set.seed(342)
modelo_rf <- caret::train(BH.staging ~ ., data = data_tn,
                   method = "ranger",
                   tuneGrid = hiperparametros,
                   metric = "Accuracy",
                   trControl = control_train,
                   # Número de ?rboles ajustados
                   num.trees = 500)
modelo_rf
Random Forest 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (10 fold, repeated 10 times) 
Summary of sample sizes: 871, 871, 870, 873, 872, 870, ... 
Resampling results across tuning parameters:

  mtry  min.node.size  Accuracy   Kappa      
   1     4             0.2297487  -0.02998355
   1     5             0.2332862  -0.02514737
   1    10             0.2280793  -0.03219106
   1    20             0.2253109  -0.03617561
   2     4             0.2295613  -0.02972735
   2     5             0.2318001  -0.02692468
   2    10             0.2294276  -0.03003206
   2    20             0.2225444  -0.03936560
   3     4             0.2298455  -0.02943429
   3     5             0.2320326  -0.02646534
   3    10             0.2335018  -0.02442988
   3    20             0.2269904  -0.03320512
   4     4             0.2289125  -0.03023855
   4     5             0.2293341  -0.02999056
   4    10             0.2306927  -0.02788597
   4    20             0.2247804  -0.03613900
   5     4             0.2299774  -0.02904509
   5     5             0.2326193  -0.02564974
   5    10             0.2297563  -0.02920285
   5    20             0.2249161  -0.03572673
   6     4             0.2333500  -0.02458421
   6     5             0.2278571  -0.03186188
   6    10             0.2323102  -0.02576764
   6    20             0.2267333  -0.03313005
   7     4             0.2291442  -0.03006672
   7     5             0.2276058  -0.03220293
   7    10             0.2319233  -0.02642248
   7    20             0.2247020  -0.03612791
   8     4             0.2287874  -0.03070869
   8     5             0.2274944  -0.03223885
   8    10             0.2268150  -0.03303392
   8    20             0.2261988  -0.03401410
   9     4             0.2329202  -0.02509180
   9     5             0.2320224  -0.02613905
   9    10             0.2252696  -0.03524420
   9    20             0.2235970  -0.03746428
  10     4             0.2269628  -0.03299631
  10     5             0.2320433  -0.02620278
  10    10             0.2276360  -0.03190889
  10    20             0.2291162  -0.03000464
  11     4             0.2275932  -0.03203596
  11     5             0.2285925  -0.03070249
  11    10             0.2290442  -0.03010397
  11    20             0.2261293  -0.03392040
  12     4             0.2259158  -0.03430620
  12     5             0.2311451  -0.02726649
  12    10             0.2243778  -0.03637218
  12    20             0.2263698  -0.03364498
  13     4             0.2255356  -0.03483258
  13     5             0.2272603  -0.03245180
  13    10             0.2251124  -0.03542073
  13    20             0.2257570  -0.03452538
  14     4             0.2299188  -0.02891429
  14     5             0.2269512  -0.03298444
  14    10             0.2260191  -0.03405275
  14    20             0.2261648  -0.03393651
  15     4             0.2266502  -0.03340855
  15     5             0.2302695  -0.02857755
  15    10             0.2265611  -0.03354132
  15    20             0.2217080  -0.03978043
  16     4                   NaN          NaN
  16     5                   NaN          NaN
  16    10                   NaN          NaN
  16    20                   NaN          NaN
  17     4                   NaN          NaN
  17     5                   NaN          NaN
  17    10                   NaN          NaN
  17    20                   NaN          NaN
  18     4                   NaN          NaN
  18     5                   NaN          NaN
  18    10                   NaN          NaN
  18    20                   NaN          NaN
  19     4                   NaN          NaN
  19     5                   NaN          NaN
  19    10                   NaN          NaN
  19    20                   NaN          NaN
  20     4                   NaN          NaN
  20     5                   NaN          NaN
  20    10                   NaN          NaN
  20    20                   NaN          NaN

Tuning parameter 'splitrule' was held constant at a value of gini
Accuracy was used to select the optimal model using the largest value.
The final values used for the model were mtry = 3, splitrule = gini
 and min.node.size = 10.
summary(modelo_rf$finalModel)
                          Length Class         Mode     
predictions               968    factor        numeric  
num.trees                   1    -none-        numeric  
num.independent.variables   1    -none-        numeric  
mtry                        1    -none-        numeric  
min.node.size               1    -none-        numeric  
prediction.error            1    -none-        numeric  
forest                      9    ranger.forest list     
confusion.matrix           16    table         numeric  
splitrule                   1    -none-        character
treetype                    1    -none-        character
call                        9    -none-        call     
importance.mode             1    -none-        character
num.samples                 1    -none-        numeric  
replace                     1    -none-        logical  
xNames                     15    -none-        character
problemType                 1    -none-        character
tuneValue                   3    data.frame    list     
obsLevels                   4    -none-        character
param                       1    -none-        list     
# REPRESENTACIÓN GRÁFICA
ggplot(modelo_rf, highlight = TRUE) +
  labs(title = "Evolución del accuracy del modelo RF") +
  theme_bw()

# Predicciones
predicciones_rf <- predict(modelo_rf, newdata = data_tt,
                           type = "raw")
# Evaluación
conf_mat_rf <- caret::confusionMatrix(factor(predicciones_rf, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)
conf_mat_rf
Confusion Matrix and Statistics

          Reference
Prediction F1 F2 F3 F4
        F1 14 15 25 22
        F2 24 21 23 16
        F3 28 22 28 33
        F4 34 41 30 37

Overall Statistics
                                          
               Accuracy : 0.2421          
                 95% CI : (0.2016, 0.2864)
    No Information Rate : 0.2615          
    P-Value [Acc > NIR] : 0.82920         
                                          
                  Kappa : -0.0135         
                                          
 Mcnemar's Test P-Value : 0.01403         

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity             0.1400   0.21212    0.2642   0.34259
Specificity             0.8019   0.79936    0.7296   0.65574
Pos Pred Value          0.1842   0.25000    0.2523   0.26056
Neg Pred Value          0.7448   0.76292    0.7417   0.73801
Prevalence              0.2421   0.23971    0.2567   0.26150
Detection Rate          0.0339   0.05085    0.0678   0.08959
Detection Prevalence    0.1840   0.20339    0.2688   0.34383
Balanced Accuracy       0.4710   0.50574    0.4969   0.49917
stats_class_rf <- data.frame(model         = "RF",
   precision = conf_mat_rf$overall["Accuracy"],
  FN = conf_mat_rf$table[2,1],
  FP = conf_mat_rf$table[1,2],
  error.rate = 1 - conf_mat_rf$overall["Accuracy"],
  kappa = conf_mat_rf$overall["Kappa"],
  sensibilidad = mean(conf_mat_rf$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_rf$byClass[,"Specificity"]),
  precisión = mean(conf_mat_rf$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_rf$byClass[,"Recall"]),
  f.medida = mean(conf_mat_rf$byClass[,"F1"])
)
stats_class_rf
         model precision FN FP error.rate       kappa sensibilidad
Accuracy    RF 0.2421308 24 15  0.7578692 -0.01346912    0.2397162
         especificidad precisión recuperación  f.medida
Accuracy     0.7466648 0.2367565    0.2397162 0.2356659

2.11 Modelo Logistic regression (LR)

Generamos el modelo LR.

# Número de particiones y repeticiones
particiones  <- 10
repeticiones <- 10

hiperparametros <- data.frame(parameter = "none")


set.seed(123)
seeds <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seeds[[i]] <- sample.int(1000, nrow(hiperparametros)) 
}
seeds[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)


# DEFINICIÓN DEL ENTRENAMIENTO
control_train <- trainControl(method = "repeatedcv", number = particiones,
                              repeats = repeticiones, seeds = seeds,
                              returnResamp = "final", verboseIter = FALSE,
                              allowParallel = TRUE)

# AJUSTE DEL MODELO
set.seed(342)
modelo_lrqda <- caret::train(BH.staging ~ ., data = data_tn,
                      method = "qda",
                      tuneGrid = hiperparametros,
                      metric = "Accuracy",
                      trControl = control_train,
                      family = "binomial")
modelo_lrqda
Quadratic Discriminant Analysis 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (10 fold, repeated 10 times) 
Summary of sample sizes: 871, 871, 870, 873, 872, 870, ... 
Resampling results:

  Accuracy   Kappa       
  0.2479372  -0.003896589
summary(modelo_lrqda$finalModel)
            Length Class      Mode     
prior         4    -none-     numeric  
counts        4    -none-     numeric  
means        60    -none-     numeric  
scaling     900    -none-     numeric  
ldet          4    -none-     numeric  
lev           4    -none-     character
N             1    -none-     numeric  
call          4    -none-     call     
xNames       15    -none-     character
problemType   1    -none-     character
tuneValue     1    data.frame list     
obsLevels     4    -none-     character
param         1    -none-     list     
# Predicciones
predicciones_lrqda <- predict(modelo_lrqda, newdata = data_tt,
                              type = "raw")

# Evaluación
conf_mat_lrqda <- caret::confusionMatrix(factor(predicciones_rf, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)
conf_mat_lrqda
Confusion Matrix and Statistics

          Reference
Prediction F1 F2 F3 F4
        F1 14 15 25 22
        F2 24 21 23 16
        F3 28 22 28 33
        F4 34 41 30 37

Overall Statistics
                                          
               Accuracy : 0.2421          
                 95% CI : (0.2016, 0.2864)
    No Information Rate : 0.2615          
    P-Value [Acc > NIR] : 0.82920         
                                          
                  Kappa : -0.0135         
                                          
 Mcnemar's Test P-Value : 0.01403         

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity             0.1400   0.21212    0.2642   0.34259
Specificity             0.8019   0.79936    0.7296   0.65574
Pos Pred Value          0.1842   0.25000    0.2523   0.26056
Neg Pred Value          0.7448   0.76292    0.7417   0.73801
Prevalence              0.2421   0.23971    0.2567   0.26150
Detection Rate          0.0339   0.05085    0.0678   0.08959
Detection Prevalence    0.1840   0.20339    0.2688   0.34383
Balanced Accuracy       0.4710   0.50574    0.4969   0.49917
stats_class_lrqda <- data.frame(model         = "lrqda",
   precision = conf_mat_lrqda$overall["Accuracy"],
  FN = conf_mat_lrqda$table[2,1],
  FP = conf_mat_lrqda$table[1,2],
  error.rate = 1 - conf_mat_lrqda$overall["Accuracy"],
  kappa = conf_mat_lrqda$overall["Kappa"],
  sensibilidad = mean(conf_mat_lrqda$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_lrqda$byClass[,"Specificity"]),
  precisión = mean(conf_mat_lrqda$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_lrqda$byClass[,"Recall"]),
  f.medida = mean(conf_mat_lrqda$byClass[,"F1"])
)

stats_class_lrqda
         model precision FN FP error.rate       kappa sensibilidad
Accuracy lrqda 0.2421308 24 15  0.7578692 -0.01346912    0.2397162
         especificidad precisión recuperación  f.medida
Accuracy     0.7466648 0.2367565    0.2397162 0.2356659

2.12 Modelo Penalized Multinomial Logistic Regression (PMLR)

Generamos el modelo PMLR.

# Número de particiones y repeticiones
particiones  <- 10
repeticiones <- 10

# hiperparametros <- data.frame(decay  = c(0.01,0.1,0.3,0.5))


hiperparametros <- data.frame(decay  = seq(20, 30, length.out=20))


set.seed(123)
seeds <- vector(mode = "list", length = (particiones * repeticiones) + 1)
for (i in 1:(particiones * repeticiones)) {
  seeds[[i]] <- sample.int(1000, nrow(hiperparametros)) 
}
seeds[[(particiones * repeticiones) + 1]] <- sample.int(1000, 1)


# DEFINICIÓN DEL ENTRENAMIENTO
control_train <- trainControl(method = "repeatedcv", number = particiones,
                              repeats = repeticiones, seeds = seeds,
                              returnResamp = "final", verboseIter = FALSE,
                              allowParallel = TRUE)

# AJUSTE DEL MODELO
set.seed(342)
modelo_lrmulti <- caret::train(BH.staging ~ ., data = data_tn,
                        method = "multinom",
                        tuneGrid = hiperparametros,
                        metric = "Accuracy",
                        trControl = control_train,
                        trace = FALSE)
modelo_lrmulti
Penalized Multinomial Regression 

968 samples
 15 predictor
  4 classes: 'F1', 'F2', 'F3', 'F4' 

No pre-processing
Resampling: Cross-Validated (10 fold, repeated 10 times) 
Summary of sample sizes: 871, 871, 870, 873, 872, 870, ... 
Resampling results across tuning parameters:

  decay     Accuracy   Kappa      
  20.00000  0.2573625  0.003020865
  20.52632  0.2579843  0.003799559
  21.05263  0.2586082  0.004575831
  21.57895  0.2587123  0.004638957
  22.10526  0.2592278  0.005294440
  22.63158  0.2590184  0.004930174
  23.15789  0.2595339  0.005573549
  23.68421  0.2598465  0.005922589
  24.21053  0.2592215  0.005008619
  24.73684  0.2593267  0.005073593
  25.26316  0.2583934  0.003777060
  25.78947  0.2586039  0.004029124
  26.31579  0.2593235  0.004925881
  26.84211  0.2599442  0.005701083
  27.36842  0.2595308  0.005085403
  27.89474  0.2594362  0.004897840
  28.42105  0.2599484  0.005520001
  28.94737  0.2602609  0.005882874
  29.47368  0.2601589  0.005689224
  30.00000  0.2598453  0.005198410

Accuracy was used to select the optimal model using the largest value.
The final value used for the model was decay = 28.94737.
summary(modelo_lrmulti$finalModel)
Call:
nnet::multinom(formula = .outcome ~ ., data = dat, decay = param$decay, 
    trace = FALSE)

Coefficients:
   (Intercept)         Age         BMI          WBC         RBC        Plat
F2 -0.03129085  0.05274264  0.12695889 -0.018279503 -0.02953207  0.10882455
F3  0.01687985  0.01248156  0.03039447 -0.004948556 -0.02483668 -0.03270340
F4  0.03804456 -0.02744159 -0.10634897  0.090278345  0.05039170 -0.06148192
         AST.1        ALT.1         ALT.4      ALT.12       ALT.24       ALT.36
F2  0.06953312  0.020087418  0.0090107548 -0.02435879 -0.065443536 -0.051388068
F3  0.04480175 -0.008900156 -0.0002367104 -0.02064086  0.007014171  0.014712012
F4 -0.08328793  0.046941342 -0.0389066404  0.03394932 -0.001542109  0.000182729
         ALT.48 ALT.after.24.w    RNA.Base        RNA.4
F2  0.009461114   -0.095947362 -0.07970566  0.005605194
F3  0.031283434   -0.009358928 -0.01580457  0.038007149
F4 -0.028421721    0.083312526  0.11495565 -0.042092674

Std. Errors:
   (Intercept)       Age       BMI       WBC       RBC      Plat     AST.1
F2   0.6264239 0.3048569 0.2980123 0.3176346 0.3230790 0.3221376 0.3130690
F3   0.6168716 0.3003771 0.2935871 0.3129367 0.3186251 0.3178000 0.3085623
F4   0.6162174 0.2999788 0.2931728 0.3123529 0.3186463 0.3177608 0.3083305
       ALT.1     ALT.4    ALT.12    ALT.24    ALT.36    ALT.48 ALT.after.24.w
F2 0.3193254 0.3135101 0.3176041 0.3166600 0.3161883 0.3191681      0.3035584
F3 0.3147818 0.3087558 0.3129938 0.3120909 0.3114574 0.3143506      0.2989055
F4 0.3146095 0.3083820 0.3131052 0.3116741 0.3109604 0.3139938      0.2984150
    RNA.Base     RNA.4
F2 0.3148009 0.3078573
F3 0.3100676 0.3031987
F4 0.3096031 0.3024339

Residual Deviance: 2672.651 
AIC: 2768.651 
# REPRESENTACIÓN GRÁFICA
ggplot(modelo_lrmulti, highlight = TRUE) +
  labs(title = "Evolución del accuracy del modelo LRmulti") +
  theme_bw()

# Predicciones
predicciones_lrmulti <- predict(modelo_lrmulti, newdata = data_tt,
                                type = "raw")

# Evaluación
conf_mat_lrmulti <- caret::confusionMatrix(factor(predicciones_rf, levels = levels(factor(data_tt$BH.staging))),
  factor(data_tt$BH.staging, levels = levels(factor(data_tt$BH.staging)))
)
conf_mat_lrmulti
Confusion Matrix and Statistics

          Reference
Prediction F1 F2 F3 F4
        F1 14 15 25 22
        F2 24 21 23 16
        F3 28 22 28 33
        F4 34 41 30 37

Overall Statistics
                                          
               Accuracy : 0.2421          
                 95% CI : (0.2016, 0.2864)
    No Information Rate : 0.2615          
    P-Value [Acc > NIR] : 0.82920         
                                          
                  Kappa : -0.0135         
                                          
 Mcnemar's Test P-Value : 0.01403         

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity             0.1400   0.21212    0.2642   0.34259
Specificity             0.8019   0.79936    0.7296   0.65574
Pos Pred Value          0.1842   0.25000    0.2523   0.26056
Neg Pred Value          0.7448   0.76292    0.7417   0.73801
Prevalence              0.2421   0.23971    0.2567   0.26150
Detection Rate          0.0339   0.05085    0.0678   0.08959
Detection Prevalence    0.1840   0.20339    0.2688   0.34383
Balanced Accuracy       0.4710   0.50574    0.4969   0.49917
stats_class_lrmulti <- data.frame(model         = "LRmulti",
   precision = conf_mat_lrmulti$overall["Accuracy"],
  FN = conf_mat_lrmulti$table[2,1],
  FP = conf_mat_lrmulti$table[1,2],
  error.rate = 1 - conf_mat_lrmulti$overall["Accuracy"],
  kappa = conf_mat_lrmulti$overall["Kappa"],
  sensibilidad = mean(conf_mat_lrmulti$byClass[,"Sensitivity"]),
  especificidad = mean(conf_mat_lrmulti$byClass[,"Specificity"]),
  precisión = mean(conf_mat_lrmulti$byClass[,"Pos Pred Value"]),
  recuperación = mean(conf_mat_lrmulti$byClass[,"Recall"]),
  f.medida = mean(conf_mat_lrmulti$byClass[,"F1"])
)

stats_class_lrmulti
           model precision FN FP error.rate       kappa sensibilidad
Accuracy LRmulti 0.2421308 24 15  0.7578692 -0.01346912    0.2397162
         especificidad precisión recuperación  f.medida
Accuracy     0.7466648 0.2367565    0.2397162 0.2356659

2.13 Modelo de Sequential Feature Generator (SFG)

library(keras)
library(mlr)

data_tn2 <- data_train

# Crear variables one-hot para la variable de salida
data_tn2$BH.staging.1 <- as.integer(data_tn2$BH.staging == "F1")
data_tn2$BH.staging.2 <- as.integer(data_tn2$BH.staging == "F2")
data_tn2$BH.staging.3 <- as.integer(data_tn2$BH.staging == "F3")
data_tn2$BH.staging.4 <- as.integer(data_tn2$BH.staging == "F4")

data_tn2 <- data_tn2 %>% 
  select(-BH.staging)

# Convertir a matriz y variables one-hot
nc <- ncol(data_tn2)
x_train <- as.matrix(data_tn2[, 1:nc])
y_train <- as.matrix(data_tn2[, c("BH.staging.1", "BH.staging.2", "BH.staging.3", "BH.staging.4")])


# Crear modelo secuencial
modelo_sfg <- keras_model_sequential() %>%
  layer_dense(units = 128, activation = "relu", input_shape = nc) %>%
  layer_dropout(rate = 0.5) %>%
  layer_dense(units = 64, activation = "relu") %>%
  layer_dropout(rate = 0.5) %>%
  layer_dense(units = 32, activation = "relu") %>%
  layer_dropout(rate = 0.5) %>%
  layer_dense(units = 16, activation = "relu") %>%
  layer_dropout(rate = 0.5) %>%
  layer_dense(units = 4, activation = "softmax")

# Compilar modelo
#learning_rate <- c(0.001, 0.01, 0.1)
learning_rate <- 0.01

modelo_sfg %>% compile(
  optimizer = optimizer_adam(learning_rate),
  loss = "categorical_crossentropy",
  metrics = "accuracy"
)

  # Entrenar el modelo
history <- modelo_sfg %>% fit(
  x = x_train,
  y = y_train,
  epochs = 100,
  batch_size = 32,
  validation_split = 0.2,
  verbose = 0
)
summary(modelo_sfg)
Model: "sequential"
________________________________________________________________________________
 Layer (type)                       Output Shape                    Param #     
================================================================================
 dense_4 (Dense)                    (None, 128)                     2560        
 dropout_3 (Dropout)                (None, 128)                     0           
 dense_3 (Dense)                    (None, 64)                      8256        
 dropout_2 (Dropout)                (None, 64)                      0           
 dense_2 (Dense)                    (None, 32)                      2080        
 dropout_1 (Dropout)                (None, 32)                      0           
 dense_1 (Dense)                    (None, 16)                      528         
 dropout (Dropout)                  (None, 16)                      0           
 dense (Dense)                      (None, 4)                       68          
================================================================================
Total params: 13,492
Trainable params: 13,492
Non-trainable params: 0
________________________________________________________________________________
data_tt2 <- data_test

# Crear variables one-hot para la variable de salida
data_tt2$BH.staging.1 <- as.integer(data_tt2$BH.staging == "F1")
data_tt2$BH.staging.2 <- as.integer(data_tt2$BH.staging == "F2")
data_tt2$BH.staging.3 <- as.integer(data_tt2$BH.staging == "F3")
data_tt2$BH.staging.4 <- as.integer(data_tt2$BH.staging == "F4")

data_tt2 <- data_tt2 %>% 
  select(-BH.staging)

x_test <- as.matrix(data_tt2[, 1:nc])

predicciones_sfg_prob <- predict(modelo_sfg, x_test)
predicciones_sfg <- max.col(predicciones_sfg_prob)

# Convertir predicciones a valores originales de BH.staging
predicciones_sfg <- factor(ifelse(predicciones_sfg == 1, "F1",
                                  ifelse(predicciones_sfg == 2, "F2",
                                         ifelse(predicciones_sfg == 3, "F3", "F4"))),
                           levels = c("F1", "F2", "F3", "F4"))

conf_mat_sfg <- caret::confusionMatrix(predicciones_sfg, factor(data_test$BH.staging, levels = c("F1", "F2", "F3", "F4")))
conf_mat_sfg
Confusion Matrix and Statistics

          Reference
Prediction  F1  F2  F3  F4
        F1 100   0   0   0
        F2   0  99   0   0
        F3   0   0 106   0
        F4   0   0   0 108

Overall Statistics
                                     
               Accuracy : 1          
                 95% CI : (0.9911, 1)
    No Information Rate : 0.2615     
    P-Value [Acc > NIR] : < 2.2e-16  
                                     
                  Kappa : 1          
                                     
 Mcnemar's Test P-Value : NA         

Statistics by Class:

                     Class: F1 Class: F2 Class: F3 Class: F4
Sensitivity             1.0000    1.0000    1.0000    1.0000
Specificity             1.0000    1.0000    1.0000    1.0000
Pos Pred Value          1.0000    1.0000    1.0000    1.0000
Neg Pred Value          1.0000    1.0000    1.0000    1.0000
Prevalence              0.2421    0.2397    0.2567    0.2615
Detection Rate          0.2421    0.2397    0.2567    0.2615
Detection Prevalence    0.2421    0.2397    0.2567    0.2615
Balanced Accuracy       1.0000    1.0000    1.0000    1.0000
stats_class_sfg <- data.frame(model = "SFG",
                              precision = conf_mat_sfg$overall["Accuracy"],
                              FN = conf_mat_sfg$table[2,1],
                              FP = conf_mat_sfg$table[1,2],
                              error.rate = 1 - conf_mat_sfg$overall["Accuracy"],
                              kappa = conf_mat_sfg$overall["Kappa"],
                              sensibilidad = mean(conf_mat_sfg$byClass[, "Sensitivity"]),
                              especificidad = mean(conf_mat_sfg$byClass[, "Specificity"]),
                              precisión = mean(conf_mat_sfg$byClass[, "Pos Pred Value"]),
                              recuperación = mean(conf_mat_sfg$byClass[, "Recall"]),
                              f.medida = mean(conf_mat_sfg$byClass[, "F1"])
)
stats_class_sfg
         model precision FN FP error.rate kappa sensibilidad especificidad
Accuracy   SFG         1  0  0          0     1            1             1
         precisión recuperación f.medida
Accuracy         1            1        1

2.14 Rendimiento de los modelos:

# Tabla resumen del rendimiento de los diferentes modelos:
stats_resumen <- rbind(stats_class_knn, 
                      stats_class_nb, 
                      stats_class_mlp,
                      stats_class_svmlineal,
                      stats_class_svmPoly,
                      stats_class_svmRadial,
                      stats_class_C5.0Tree,
                      stats_class_C5.0,
                      stats_class_J48,
                      stats_class_rf,
                      stats_class_lrqda,
                      stats_class_lrmulti,
                      stats_class_sfg)

# Ordenamos la tabla por la precisión y lo guardamos
stats_models_prec <- stats_resumen %>% arrange(desc(precision))

knitr::kable(stats_models_prec, digits = 3, caption = "Métricas del rendimiento de los modelos de aprendizaje automático.")
Métricas del rendimiento de los modelos de aprendizaje automático.
model precision FN FP error.rate kappa sensibilidad especificidad precisión recuperación f.medida
Accuracy12 SFG 1.000 0 0 0.000 1.000 1.000 1.000 1.000 1.000 1.000
Accuracy7 C5.0 0.281 27 26 0.719 0.041 0.279 0.760 0.280 0.279 0.279
Accuracy8 J48 0.274 22 26 0.726 0.032 0.274 0.758 0.274 0.274 0.273
Accuracy5 SVMradial 0.266 3 7 0.734 0.012 0.258 0.753 0.243 0.258 0.212
Accuracy KNN 0.262 24 15 0.738 0.014 0.261 0.753 0.261 0.261 0.258
Accuracy2 MLP 0.259 1 0 0.741 -0.003 0.248 0.749 NaN 0.248 NA
Accuracy3 SVMlineal 0.252 32 10 0.748 0.000 0.249 0.750 0.245 0.249 0.235
Accuracy1 Naive Bayes 0.245 30 12 0.755 -0.009 0.243 0.748 0.231 0.243 0.228
Accuracy6 C5.0Tree 0.242 17 21 0.758 -0.012 0.242 0.747 0.243 0.242 0.243
Accuracy9 RF 0.242 24 15 0.758 -0.013 0.240 0.747 0.237 0.240 0.236
Accuracy10 lrqda 0.242 24 15 0.758 -0.013 0.240 0.747 0.237 0.240 0.236
Accuracy11 LRmulti 0.242 24 15 0.758 -0.013 0.240 0.747 0.237 0.240 0.236
Accuracy4 SVMpoly 0.232 25 21 0.768 -0.023 0.234 0.744 0.228 0.234 0.230